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Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders

World Journal of Gastroenterology 2017年第11期23卷 2029-2036页

作者： Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre valérie Bridoux Eric Vérin Anne-Marie Leroi INSERM U1073 Service de Physiologie DigestiveCHU Rouen INSERM U1073 Service de Chirurgie DigestiveCHU Rouen EA 3830 Pole 3RCHU RouenGroupe de Recherche sur le Handicap Ventilatoire INSERM CIC 0204

AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for *** The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of *** Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI.

关键词： Neurogenic bowel dysfunction Fecal incontinence Constipation Obstructed defecation Transanal irrigation

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Inflamed phenotype of splenic marginal zone B-cell lymphomas with expression of PD-L1 by intratumoral monocytes/macrophages and dendritic cells

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Cellular & Molecular Immunology 2019年第6期16卷 621-624页

作者： Christelle Vincent-Fabert Isabelle Soubeyran valérie Velasco Marie Parrens Robin Jeannet Emilie Lereclus Nathalie Gachard Jean Feuillard Nathalie Faumont CNRS-UMR 7276 INSERM U1262 CRIBL University of Limogesand Hematology Laboratory of Dupuytren Hospital University Center(CHU)of LimogesLimogesFrance Laboratory of Pathology Institut BergoniéBordeauxFrance Pathology Department Hospital University Center of BordeauxBordeauxFrance

Splenic marginal zone lymphoma(SMZL)is an incurable indolent small B-cell lymphoma that primarily involves the spleen and arises in elderly patients,who have a median age of 65 years old at diagnosis.1 Splenomegaly is... 详细信息

关键词： lymphoma spleen patients

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How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers

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Journal of Environmental Sciences 2022年第1期34卷 412-428页

作者： Fernanda Silva dos Santos Raquel A.F.Neves Mirian Araújo Carlos Crapez valéria Laneuville Teixeira Natascha Krepsky Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Science and BiotechnologyMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Neotropical Biodiversity(PPGBIO)Pasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Marine Biology and Coastal EnvironmentsMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Ecotourism and ConservationPasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil

The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal *** presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on *** full review compiles two decades(2000–2020)of literature concerning biological effects on *** mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based *** markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon *** neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and *** perna hemocyte parameters provided a useful approach for biocide *** paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal *** integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted ***,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.

关键词： Biological indexes Biomonitoring Emerging pollutants Hydrocarbons Metals Sentinel species

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SutteARIMA:A Novel Method for Forecasting the Infant Mortality Rate in Indonesia

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Computers, Materials & Continua 2022年第3期70卷 6007-6022页

作者： Ansari Saleh Ahmar Eva Boj del val M.A.El Safty Samirah AlZahrani Hamed El-Khawaga Business School Faculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of Statistics Faculty of Mathematics and Natural ScienceUniversitas Negeri MakassarMakassar90224Indonesia Department of Economic Financial and Actuarial MathematicsFaculty of Economics and BusinessUniversitat de BarcelonaBarcelona08034Spain Department of Mathematics and Statistics Colleage of SciencesTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Statistics Mathematicsand InsuranceFaculty of CommerceTanta UniversityEgypt Department of Economics and Finance College of Business AdministrationTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

This study focuses on the novel forecasting method(SutteARIMA)and its application in predicting Infant Mortality Rate data in *** undertakes a comparison of the most popular andwidely used four forecasting methods:ARIMA,Neural Networks Time Series(NNAR),Holt-Winters,and *** data used were obtained from the website of the World *** data consisted of the annual infant mortality rate(per 1000 live births)from 1991 to *** determine a suitable and best method for predicting InfantMortality rate,the forecasting results of these four methods were compared based on the mean absolute percentage error(MAPE)and mean squared error(MSE).The results of the study showed that the accuracy level of SutteARIMA method(MAPE:0.83%andMSE:0.046)in predicting InfantMortality rate in Indonesia was smaller than the other three forecasting methods,specifically the ARIMA(0.2.2)with a MAPE of 1.21%and a MSE of 0.146;the NNAR with a MAPE of 7.95%and a MSE of 3.90;and the Holt-Winters with aMAPE of 1.03%and aMSE:of 0.083.

关键词： Forecasting infant mortality rate ARIMA NNAR holt-winters SutteARIMA

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<i>Bordetella holmesii</i>: Comparison of Two Isolates from Blood and a Respiratory Sample

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Advances in Infectious Diseases 2013年第2期3卷 123-133页

作者： valérie Bouchez Nicole Guiso Institut Pasteur Unité Prévention et Thérapie Moléculaires des Maladies Humaines Paris France

Interest in Bordetella holmesii is increasing, but very little is known about this bacterium, which can be isolated from both blood and respiratory samples. In this study, we compared a B. holmesii isolate from the blood sample of an adult with bacteremia with another isolate from a nasopharyngeal swab from an adult with whooping cough syndrome. Genetic analysis was carried out, targeting relevant genes, and virulence properties were studied in cellular and animal models. Our genomic analysis provided no evidence of traits specific to either blood or respiratory isolates of B. holmesii. Neither isolate was cytotoxic to human tracheal epithelial cells. Both isolates were only weakly invasive and they did not persist within epithelial cells for less than 48 h.

关键词： Bordetella holmesii Bacteremia Respiratory Isolate

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Maintenance of radiation-induced intestinal fibrosis:Cellular and molecular features

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World Journal of Gastroenterology 2007年第19期13卷 2675-2683页

作者： valérie Haydont Marie-Catherine Vozenin-Brotons UPRES EA 27-10 "Radiosensibilité des tumeurs et tissus sains" Institut de Radioprotection et de Sreté Nucléaire/Institut Gustave Roussy. Villejuif Laboratoire de Radiopathologie. SRBE/DRPH. Institut de Radioprotection et de Sreté Nucléaire Fontenay-aux-Roses France

Recent advances in cell and molecular radiobiology clearly showed that tissue response to radiation injury cannot be restricted to a simple cell-killing process, but depends upon continuous and integrated pathogenic processes, involving cell differentiation and crosstalk between the various cellular components of the tissue within the extracellular matrix. Thus, the prior concept of primary cell target in which a single-cell type (whatever it’s epithelial or endothelial cells) dictates the whole tissue response to radiation injury has to be replaced by the occurrence of coordinated multicellular response that may either lead to tissue recovery or to sequel development. In this context, the present review will focus on the maintenance of the radiation-induced wound healing and fi brogenic signals triggered by and through the microenvironment toward the mesenchymal cell compartment, and will highlight how sequential and sustained modifi cations in cell phenotypes will in cascade modify cell-to-cell interactions and tissue composition.

关键词：放射疗法辐射诱发小肠纤维性变细胞特征分子特征

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First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil

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Fungal Diversity 2012年第3期54卷 87-99页

作者： Marine Déon Ana Scomparin Aude Tixier Carlos R.R.Mattos Thierry Leroy Marc Seguin Patricia Roeckel-Drevet valérie Pujade-Renaud CIRAD UMR AGAP63000 Clermont-FerrandFrance Clermont Université UniversitéBlaise PascalUMR 547 PIAF63000 Clermont-FerrandFrance Plantações Michelin de Bahia Box 0245435-000 ItuberáBahiaBrazil CIRAD UMR AGAP34398 MontpellierFrance

Corynespora cassiicola is the causal agent of Corynespora Leaf Fall(CLF)*** is one of the most important fungal diseases of rubber trees in Asia and Africa but disease outbreaks have not been reported in South ***,a small cysteine-rich glycoprotein secreted by the pathogenic *** isolate CCP,was previously identified as a potential disease effector in rubber ***,the cassiicolin-encoding gene(Cas1)was characterized and shown to be expressed in the early phase of *** this study,we investigated whether previously undetected strains of *** are present in South American rubber plantations by examining the fungal endophyte population found in asymptomatic rubber tree *** isolates were identified as *** encoding new forms of the cassiicolin precursor protein(Cas3 and Cas4)were identified from these *** of four isolates were able to induce symptoms on the cultivar they were isolated from in a detached leaf assay,with different kinetics and *** isolate had the same pathogenicity profile as the pathogenic isolate CCP;the other two isolates developed symptoms late during the course of infection,suggesting saprotrophic ***,no Cas3 or Cas4 transcripts could be detected upon inoculation with the endophytic isolates,whereas the reference gene Cas1 was expressed upon inoculation with the CCP *** work demonstrated that *** is present in South America in an endophytic form and that it may evolve from an endophytic to a saprophytic or even potentially pathogenic life style.

关键词： Corynespora cassiicola Rubber tree Endophyte Brazil Cassiicolin

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Folfirinox in elderly patients with pancreatic or colorectal cancer-tolerance and efficacy

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World Journal of Gastroenterology 2016年第42期22卷 9378-9386页

作者： Jean-Florian Guion-Dusserre Aurélie Bertaut Fran?ois Ghiringhelli Julie Vincent valérie Quipourt Sophie Marilier Zoé Tharin Leila Bengrine-Lefevre Department of Medical Oncology Centre Georges-Fran?ois Leclerc Institut National de la Santé et de la Recherche Médicale University of Burgundy

AIM To study the tolerance and the efficiency of FOLFIRINOX in elderly patients diagnosed with colorectal or pancreatic *** This retrospective study included elderly patients aged over 70 years of age treated at Georges-Francois Leclerc Center by FOLFIRINOX for histological proved colorectal or pancreatic cancer between January 2009 and January 2015. Chemotheapy regimen consisted of oxaliplatin(85 mg/m2 in over 120 min) followed by leucovorin(400 mg/m2 in over 120 min), with the addition, after 30 min of irinotecan(180 mg/m2 in over 90 min) then 5 fluorouracil(5FU)(400 mg/m2 administred intravenous bolus), followed by 5FU(2400 mg/m2 intraveinous infusion over 46 h) repeated every 2 wk. Geriatric parameters were recorded at the beginning. Toxicities were evaluated with the Common Terminology Criteria for Adverse Events 4.03. Tumor response was evaluated by CT scan. Treatment continued until disease progression, unacceptable toxicities or patient *** Fifty-two patients aged from 70 to 87 years were treated by FOLFIRINOX, 34 had colorectal cancer and 18 had pancreatic cancer. Most of them were in good general condition, 82.7% had a 0-1 performance status and 61.5% had a Charlson Comorbidity Index valuated by RECIST criteria showed a controlled disease for 25 patients(48.1%), a stable disease for 13 and a partial response for 12 patients. Time under treatment was higher for colorectal cancer with a median time of 2.44 mo(95%CI: 1.61-3.25). Overall survival was 43.88 mo for colorectal cancer and 12.51 mo for pancreatic cancer. In univariate or multivariate analysis, none of geriatric pa

关键词：老病人可行性治疗胰腺的癌症 Colorectal 癌症 FOLFIRINOX

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Influence of Mango Feed-Based Diets on the Production and Economic Profitability of Montbeliarde Cows’ Milk at the End of Lactation in Burkina Faso

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Open Journal of Animal Sciences 2022年第2期12卷 239-250页

作者： Xavier D. Milogo Timbilfou Kiendrebeogo Isidor Z. Ouedraogo Harouna Koara Désiré P. Sawadogo valérie M. C. Bougouma-Yameogo Ministère des Ressources Animales et Halieutiques (MRAH) Bobo-Dioulasso Burkina Faso Institut de l’Environnement et de Recherches Agricoles (INERA) Station de Farako-B&#226 Bobo-Dioulasso Burkina Faso Institut du Développement Rural Université Nazi BONI Bobo-Dioulasso Burkina Faso

The study evaluated the effects of a diet incorporating a mango-based feed on the technical-economic performance of milk production of Montbeliard cows at the end of lactation in a dairy farm in Bobo-Dioulasso, Burkina Faso. To do so, 14 cows were subjected to 3 diets, including an experimental diet incorporating mango (ED) in comparison to a balanced control diet (BCD) and to the feeding practice of the farmer (FCD) during 60 days. Results show that the average amount of milk milked per day from ED (10.93 ± 0.17 L) was significantly higher (p valorization of mango residues is an alternative for a greater availability of feed at lower cost for the animals. It could contribute to a better management of processing residues that pollute the environment and to the reduction of fruit flies that affect orchard yields through reinfestation. The increased use of mango in dairy cattle feed should be encouraged.

关键词： Mango-Based Feed Montbeliarde Cows Milk Production Technical and Economic Performance Burkina Faso

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Work Engagement of Nursery School Nurses and Its Related Factors in Japan

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Open Journal of Nursing 2022年第7期12卷 481-495页

作者： Kozue Mochizuki rie Wakimizu Graduate School University of Tsukuba Ibaraki Japan Tender Loving Nursery School Myogadani Tokyo Japan Department of Child Health and Development Nursing Faculty of Medicine University of Tsukuba Ibaraki Japan

Purpose: This study aimed to clarify nursery school nurses’ work engagement and their pertinent related factors. Method: We conducted a survey of 136 nursery school nurses using an anonymous, self-administered questionnaire. Questionnaires were distributed to 186 people at licensed daycare centers in Ibaraki Prefecture. The following conclusions were obtained by analyzing 136 participants, excluding deficiencies: A multiple regression analysis (forced entry method) was performed. Results: The survey results show that most of the nurses in the nursery school were female, about 90$ were married, and about 70$ had children. Work engagement was generally high compared with other occupations. Moreover, it was influenced by their work-self balance (positive), the meaning of their work, and the leadership of bosses. It was suggested that there is a need for an environment where nurses can maintain a work-life balance, a place where childcare health activities can be carried out, and opportunities to participate in training and liaison meetings for nursery nurses to further enhance work engagement. Conclusion: It was influenced by work self-balance (positive), the meaning of their work, and boss leadership. It is suggested that nursery nurses further enhance their work engagement, and they need an environment where they can maintain a work-life balance, a place where they can engage in health activities in childcare, and opportunities for training and liaison meetings.

关键词： Nursery School Nurse Work Engagement

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