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A glycine-rich nuclear effector vdCE51 of verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhtRXH2

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the Crop Journal 2024年第4期12卷 1137-1149页

作者： Chi Li Yingqi Huang Wenjing Shang Jieyin Chen Steven J.Klosterman Krishna v.Subbarao Jun Qin Xiaoping Hu State Key Laboratory of Crop Stress Resistance and High-Efficiency Production Key Laboratory of Plant Protection Resources and Pest Management of Ministry of EducationKey Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangji 831100XinjiangChina Agricultural Research Service United States Department of AgricultureSalinasCA 93905USA Department of Plant Pathology University of CaliforniaDavisc/o United States Agricultural Research StationSalinasCA 93905USA

verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash *** of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,vdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia *** effector was a required factor for full virulence of ***,and its nuclear localization was a requisite for suppressing plant *** thioredoxin GhtRXH2,identified as a positive regulator of plant immunity,was a host target of *** findings show a virulence regulating mechanism whereby the secreted nuclear effector vdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhtRXH2,thus suppressing plant immunity.

关键词： verticillium dahliae Plant immunity Effector thioredoxin

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In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn M.Priest Jacob v.Schluns Nathania Nischal Colton L.Gattis Jeffrey C.Wolchok timothy J.Muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(tCSPC)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(vML)injuries were created in the left tibialis anterior(tA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured tA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled tCSPC has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

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Rigidity Symmetry Line for thermodynamic Fluid Equations-of-State

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Journal of Modern Physics 2024年第5期15卷 613-633页

作者： Leslie v. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discovery (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. the state functions density ρ(p,t), and Gibbs energy G(p,t), of fluids, e.g. CO2, H2O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)t, between gaseous and liquid states along any isotherm from critical (tc) to Boyle (tB) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we investigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (RS) line (ω = ρrs(t) = Rt) to gas phase virial coefficients. We show that it is continuous in all derivatives, linear within stable fluid phase, and relates analytically to the Boyle-work line (BW) (w = (p/ρ)t = Rt), and to percolation lines of gas (PB) and liquid (PA) phases by: ρBW(t) = 2ρPA(t) = 3ρPB(t) = 3ρRS(t)/2 for t tB. these simple relationships arise, because the higher virial coefficients (bn, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 t tB) within the gas phase. the Boyle-work line (p/ρBW)t is related exactly at lower densities as t → tB, and accurately for liquid densities, by ρBW(t) = −(b2/b3)t. the RS line, ω(t) = Rt, defines a new liquid-density ground-state physical constant (ρRS(0) = (2/3)ρBW(0) for argon). Given the gas-liquid rigidity symmetry, the entire thermodynamic state functions below tB are obtainable from b2(t). A BW

关键词： Liquid-State theory Cluster Physics Percolation Lines Fluid thermodynamics Boyle Line Rigidity-Symmetry Line

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Semiotics and political discourse in the post-truth era

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Language and Semiotic Studies 2024年第1期10卷 65-82页

作者： BetülÇanakpınar Murat Kalelioğlu v.Doğan Günay Istinye University IstanbulTürkiye School of Foreign Languages T C Mardin Artuklu UniversityMardinTürkiye Faculty of Literature Department of LinguisticsDokuz Eylül UniversityIzmirTürkiye

the concept of post-truth has been on the world’s agenda since *** this concept,which is frequently encountered in political life,provides the speaker with a freer speaking ***,instead of presenting the reality to their constituents as it is,want to reshape this reality according to their own ideology and present it to the *** have certain objectives in creating such a virtual *** aims can be listed as keeping the voters,increasing the voting potential,and attracting undecided voters to their *** common result of all these aims is to gain political power or to remain in the existing ***-truth reality is constructed relatively more easily in social media *** construction of reality can be through beliefs or *** such ways,the recipient is tried to be persuaded,and thus behavioral change is *** of the most necessary subjects for this artificial reality atmosphere is the *** idea that the anti-subject does not know the truth that we(you and I)know and believe and is trying to destroy it is the main theme of post-truth *** try to persuade the voters to believe in their own truth by expressing this idea to *** are many examples of this around the *** this study,firstly,the concept of post-truth is examined and its various definitions are *** distinctions between the concepts of real and truth are analyzed and then it is explained how and for what purposes the concept of post-truth is used in *** the comparison of post-truth and fake news,the concept is discussed within the framework of sender-receiver interaction in terms of *** concept is tried to be elucidated with the modalities such as/convincing/,/believing/,/being/,/appearing/.Besides,using the semiotic square,the study also tries to reveal the different purposes and forms of use of the concept of *** a result,it has been observed

关键词： semiotics discourse politics post-truth fake news

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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn taylor vivian Szymczuk Brendan Boyce Daniel Martin vardit Kram Rebeca Galisteo Kamran Melikov Leonid v.Chernomordik Michael t.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCt03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

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Interaction of photons with silver and indium nuclei at energies up to 20 Mev

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Chinese Physics C 2024年第2期48卷 135-140页

作者： J.H.Khushvaktov M.A.Demichev D.L.Demin S.A.Evseev M.I.Gostkin v.v.Kobets F.A.Rasu-lova S.v.Rozov E.t.Ruziev A.A.Solnyshkin t.N.tran E.A.Yakushev B.S.Yuldashev Joint Institute for Nuclear Research(JINR) DubnaRussia Institute of Nuclear Physics of the Academy of Sciences of the Republic of Uzbekistan(INP ASRU) TashkentUzbekistan Institute of Physics of the vietnam Academy of Science and technology(IP vASt) HanoiVietnam

the yields of photonuclear reactions in the 107Ag,113In,and 115In nuclei were *** Carlo simulations were performed using the Geant4 code,and the results were compared with the experimental *** isomeric ratios of the yields in the reactions 107Ag(γ,n)106m,gAg and 113In(γ,m)112m,gIn were determined,and the cross sections for the reactions 107Ag(γ,n)106gAg and 107Ag(γ,2n)105Ag at an energy of 20 Mev were calculated based on the experimental data.

关键词： 107Ag(γ,n)10mgAg and I13In(γ,n)12m-2In reactions cross section yield isomeric ratio simula-tion Geant4 tALYS

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Energy exchange between charged relativistic fluids in f(t) gravity

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Communications in theoretical Physics 2024年第10期76卷 108-120页

作者： Z Yousaf U A Khokhar Nasser Bin turki t Suzuki Department of Mathematics University of the Punjab Quaid-i-Azam Campus Department of Mathematics College of Science King Saud University Department of Regional Management Faculty of Management Fukushima College

this study focuses on the effects of a polytropic fluid on a charged gravitational source within f(t) gravity, where t is the torsion scalar. We investigate how the electromagnetic field affects the flow of energy in spherically symmetric and static celestial objects that contain relativistic fluids. By using the gravitational decoupling technique, we analyze the effects of polytropic fluid on the dynamics of the gravitational source, accompanied by the matching of the interior geometry with an exterior at the hypersurface Σ. Finally, with the help of the tolman Ⅱv solution, we observe the conduct of energy conditions with the existence of charge using f(t)field equations and got the intended outcomes.

关键词： anisotropy complexity energy exchange hydrodynamics self-gravitating systems

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen t.K.thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei v.Zvyagin Hao De Min tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

the administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCt)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICt)*** Keller-Segel model and histological analysis further demonstrated that DCt altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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Indoor Formaldehyde Removal techniques through Paints: Review

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Green and Sustainable Chemistry 2024年第1期14卷 1-15页

作者： Prajyot Dhawale Ravindra v. Gadhave Department of Polymer and Surface Engineering Institute of Chemical Technology Mumbai India

Due to its ability to cause illnesses and discomfort even at low concentrations, formaldehyde pollution of indoor air poses a significant risk to human health. Sources of formaldehyde in indoor environments include textiles, paints, wallpapers, glues, adhesives, varnishes, and lacquers;furniture and wooden products like particleboard, plywood, and medium-density fiberboard that contain formaldehyde-based resins;shoe products;cosmetics;electronic devices;and other consumer goods like paper products and insecticides. According to the World Health Organisation, indoor formaldehyde concentrations shouldn’t exceed 0.1 mg/m3. the methods include membrane separation, plasma, photocatalytic decomposition, physisorption, chemisorption, biological and botanical filtration, and catalytic oxidation. Materials based on metal oxides and supported noble metals work as oxidation catalysts. Consequently, a paint that passively eliminates aldehydes from buildings can be developed by adding absorbents and formaldehyde scavengers to the latex composition. It will be crucial to develop techniques for the careful detection and removal of formaldehyde in the future. Additionally, microbial decomposition is less expensive and produces fewer pollutants. the main goal of future research will be to develop a biological air quality control system that will boost the effectiveness of formaldehyde elimination. the various methods of removing formaldehyde through paints have been reviewed here, including the use of mixed metal oxides, formaldehyde-absorbing emulsions, nano titanium dioxide, catalytic oxidation, and aromatic formaldehyde abating materials that can improve indoor air quality.

关键词： Formaldehyde Absorption Paints Catalytic Oxidation Nanofillers

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Disorders of potassium homeostasis after kidney transplantation

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World Journal of transplantation 2024年第3期14卷 40-51页

作者： Abdelhamid Aboghanem G v Ramesh Prasad School of Medicine University of TorontoToronto M5C 2T2OntarioCanada Kidney transplant Program St.Michael's HospitalToronto M5C 2T2OntarioCanada

Disturbances of potassium balance are often encountered when managing kidney transplant recipients(KtR).Both hyperkalemia and hypokalemia may present either as medical emergencies or chronic outpatient *** the high incidence of hyperkalemia and its potential life-threatening implications,consensus on its management in KtR is *** in KtR is also well-described,although it is given less attention by clinicians compared to *** article discusses the etiology,pathophysiology and management of both types of potassium disorders in *** any emergent situation has been corrected,treatment approaches include correcting insulin deficiency if present,adjusting non-immunosuppressive and immunosuppressive medications,elimi-nating or supplementing potassium as needed,and dietary *** commonly of multifactorial etiology,ascertaining the specific cause in a particular patient will help guide successful *** KtR through regular laboratory testing is essential to detect serious disturbances in potassium balance since patients are often asymptomatic.

关键词： Balance Dialysis Hyperkalemia Hypokalemia Kidney Metabolism Potassium

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