检索结果-南通市图书馆

HISP-1 Inhibits HSv-1 Infection in Cultured vero Cells

Advances in Bioscience and Biotechnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams Kevin t. Bilyk Modukuri v. Ramani Gottumukkala v. Subbaraju Department of Biology Montclair State University Montclair USA Department of Chemistry Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSv-1) remains a leading cause of viral disease worldwide and is spread by direct contact with infected lesions. there is no vaccine against HSv-1 infections and there remains a need to identify therapeutics that could reduce the spread. In this study various hispolon compounds were analyzed to determine their antiviral potential against HSv-1 infections in cultured vero cells. to determine the effects on infectivity and possible mechanisms of inhibition, the following assays were conducted. In vitro cytotoxicity assays were conducted to determine the effect of the compounds on cell viability and the maximum non-cytotoxic concentrations. Antiviral assays measured cell viability, percent inhibition of infection following treatment with the compounds, and the effect on the viral infection cycle. these effects were visualized using inverted light and fluorescent microscopy. Of the 24 hispolons tested, only hispolon pyrazole-1 (HISP-1) demonstrated antiviral effects. HISP-1 was demonstrated to effect early stages in HSv-1 infection in cultured vero cells (attachment, penetration, and post-penetration). In silico modeling analyses were conducted to analyze the interactions between HISP-1 and viral glycoprotein D (gD). HISP-1 is safe at concentrations tested and is effective in inhibiting infection of HSv-1 in cultured cells. HISP-1 has potential for therapeutic use as an antiviral against HSv-1 infection, could work in synergy with other antivirals that work be a different modality, and could be developed as a component of a topical agent to reduce the spread of HSv-1 infections.

关键词： Hispolon Herpes Simplex virus-1 Antiviral Curcumin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ranking environmental and edaphic attributes driving soil microbial community structure and activity with special attention to spatial and temporal scales

引用

mLife 2024年第1期3卷 21-41页

作者： vadakattu v.S.R.Gupta James M.tiedje CSIRO Agriculture&Food UrrbraeSouth AustraliaAustralia Centre for Microbial Ecology Michigan State UniversityEast LansingMichiganUSA

the incredibly complex soil microbial communities at small scales make their analysis and identification of reasons for the observed structures *** community structure is mainly a result of the inoculum(dispersal),the selective advantages of those organisms under the habitat-based environmental attributes,and the ability of those colonizers to sustain themselves over *** soil is protective,and its microbial inhabitants have long adapted to varied soil conditions,significant portions of the soil microbial community structure are likely ***,a substantial portion of the community will not correlate to often measured soil *** suggest that the drivers be ranked on the basis of their importance to the fundamental needs of the microbes:(i)those that supply energy,i.e.,organic carbon and electron acceptors;(i)environmental effectors or stressors,i.e.,pH,salt,drought,and toxic chemicals;(ii)macro-organism associations,i.e.,plants and their seasonality,animals and their fecal matter,and soil fauna;and(iv)nutrients,in order,N,P,and probably of lesser importance,other micronutrients,and *** relevance of drivers also varies with spatial and time scales,for example,aggregate to field to regional,and persistent to dynamic populations to transcripts,and with the extent of phylogenetic difference,hence phenotypic differences in organismal *** present a summary matrix to provide guidance on which drivers are important for particular studies,with special emphasis on a wide range of spatial and temporal scales,and illustrate this with genomic and population(rRNA gene)data from selected studies.

关键词： abundance community structure diversity functional microbiome microorganisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dreicer Electric Field Definition and Runaway Electrons in Solar Flares

引用

Research in Astronomy and Astrophysics 2024年第2期24卷 180-184页

作者： Yu.t.tsap A.v.Stepanov Yu.G.Kopylova Crimean Astrophysical Observatory of the Russian Academy of Sciences Nauchny298409Russia Pulkovo Observatory of the Russian Academy of Sciences Pulkovskoje Shosse65/1St.Petersburg196140Russia

We analyze electron acceleration by a large-scale electric field E in a collisional hydrogen plasma under the solar flare coronal conditions based on approaches proposed by Dreicer and Spitzer for the dynamic friction force of *** Dreicer electric field EDr is determined as a critical electric field at which the entire electron population runs *** regimes of strong(E≲E_(Dr))and weak(E≪E_(Dr))electric field are *** is shown that the commonly used formal definition of the Dreicer field leads to an overestimation of its value by about five *** critical velocity at which the electrons of the"tail"of the Maxwell distribution become runaway under the action of the sub-Dreiser electric fields turns out to be underestimated by√3 times in some works because the Coulomb collisions between runaway and thermal electrons are not taken into *** electron acceleration by sub-Dreicer electric fields generated in the solar corona faces difficulties.

关键词： acceleration of particles-Sun flares-Physical Data and Processes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

引用

High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.vishnyakov A.Sagisaka K.Ogura t.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong t.A.Pikuz S.A.Pikuz W.Yan t.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.velyhan t.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.v.Nosach D.Khikhlukha I.P.tsygvintsev D.Kumar J.Nejdl D.Margarone P.v.Sasorov S.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.v.Bulanov t.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine IStEQ AR YerevanArmenia

tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hybrid bimetallic cluster ZrO2/Rh@N,S co-doped porous carbon nanosheets for efficient hydrogen evolution in acid electrolytes

引用

tungsten 2024年第4期6卷 657-662页

作者： Xin-Yi Zhang Igor v.Zatovsky Jun-Ming Cao Xing-Long Wu Faculty of Chemistry Northeast Normal University F.D.Ovcharenko Institute of Biocolloidal Chemistry NAS Ukraine MOE Key Laboratory for Uv Light-Emitting Materials and technology Northeast Normal University

Acid hydrogen evolution reaction (HER) is a critical energy conversion process,which is significantly important in hydrogen energy manufacturing and storage [1].Although the performance of noble metal platinum (Pt)-based catalysts in acidic HER is well known,the challenges are high cost,limited reserves,poor stability,and susceptibility to toxic substances [2].therefore,it is urgent to design and manufacture acidic HER catalysts with high reactivity,high stability,and low cost.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ion Channel Dysregulation Following Intracerebral Hemorrhage

引用

Neuroscience Bulletin 2024年第3期40卷 401-414页

作者： Xiangyu Zhang Yan Zhang Qiuyang Su Yang Liu Zhe Li v.Wee Yong Mengzhou Xue Department of Cerebrovascular Diseases The Second Afliated Hospital of Zhengzhou UniversityZhengzhou 450000China Academy of Medical Science Zhengzhou UniversityZhengzhou 450000China Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAB T2N 1N4Canada

Injury to the brain after intracerebral hemorrhage(ICH)results from numerous complex cellular *** present,effective therapy for ICH is limited and a better understanding of the mechanisms of brain injury is necessary to improve *** is increasing evidence that ion channel dysregulation occurs at multiple stages in primary and secondary brain injury following *** channels such as tWIK-related K+channel 1,sulfonylurea 1 transient receptor potential melastatin 4 and glutamate-gated channels affect ion homeostasis in *** in turn participate in the formation of brain edema,disruption of the blood-brain barrier,and the generation of *** this review,we summarize the interaction between ions and ion channels,the effects of ion channel dysregulation,and we discuss some therapeutics based on ion-channel modulation following ICH.

关键词： Intracerebral hemorrhage Ion dyshomeostasis Sulfonylurea 1 transient receptor potential melastatin 4 tWIK-related K+channel 1 N-methyl-Daspartate receptor transient receptor potential vanilloid 4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural correlation and chemistry of molten NaF-ScF_(3) with dissolved metal aluminium:tG/DtA,XRD,NMR and molecular dynamics simulations

引用

Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Frantisek Simko Didier Zanghi Zuzana Netriová Ilya BPolovov Ayrat Dimiev Konstantin v.Maksimtsev Catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences84536 BratislavaSlovakia Centre of Excellence for Advanced Materials Application-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia Alexander Butlerov Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF_(3) eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis(DtA),high temperature and solid-state nuclear magnetic resonance(NMR),and X-ray diffraction(XRD) coupled with the molecular dynamic *** formation of an insoluble Al_(3)Sc alloy in molten(NaF-ScF_(3))_(eut)system was proven,and the chemical mechanism of this aluminothermic Al_(3)Sc alloy production was *** ex situ examinations bring to light the formation of NaScF_4 and solid solution of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity,density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasma electrolytic formation and characterization of MnWO_(4)/WO_(3) film heterostructures

引用

ChemPhysMater 2024年第3期3卷 293-302页

作者： M.S.vasilyeva I.v.Lukiyanchuk Yu.B.Budnikova v.G.Kuryavyi D.H.Shlyk G.A.Zverev Department of Chemistry and Materials of Institute of High technology and Advanced Materials Far Eastern Federal UniversityFEFU CampusVladivostok 690922Russia Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia

MnWO_(4)/WO_(3) p-n heterojunction films were fabricated using a one-step method consisting of the plasma electrolytic oxidation(PEO)of titanium in homogeneous electrolytes containing paratungstate ions and stable watersoluble EDtA-chelated *** influences of the formation current density and W:Mn molar ratio of the electrolyte,which was varied from 1:2 to 2:1,on the composition,morphology,and optical and photocatalytic properties of the resulting coatings were studied.X-ray diffraction analysis,scanning electron microscopy,energy dispersive X-ray analysis,Raman spectroscopy,and ultraviolet diffuse reflectance spectroscopy were used to characterize the formed *** of the W:Mn ratio of the electrolyte,the coatings contained crystalline t-WO_(3) and m-MnWO_(4).Depending on the formation conditions,the optical band gap energies of the composites varied from 2.63 to 3.01 *** largest absorption red shift and lowest band gap energy were observed in the film composite formed in an electrolyte with W:Mn=2:1,at a current density of 0.2 A cm^(−2).Composites obtained in electrolytes with W:Mn ratios of 2:1 and 1:1 exhibited photocatalytic activity in the degradation of rhodamine C and methyl orange dyes in the presence of 10 mmol L^(–1) H2O_(2) under ultraviolet and visible light *** role of hydrogen peroxide in this dye degradation on PEO-coated composites under light irradiation is discussed.

关键词： Plasma electrolytic oxidation Manganese tungstate tungsten oxide titanium Optical properties p-n heterojunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Superior comprehensive properties of LaFe_(11.8)Si_(1.2)/Ce_(60)Co_(40) magnetocaloric composites

引用

Journal of Rare Earths 2024年第6期42卷 1073-1086,I0003页

作者： Xichun Zhong Yuanxin Li Yucai Wu Jiaohong Huang Cuilan Liu Jian Liu Zhongwu Liu Minglong Zhong Zhenchen Zhong R.v.Ramanujan School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Baotou Research Institute of Rare Earths Baotou014030China Center for Advanced Solidification technology School of Materials Science and EngineeringShanghai UniversityShanghai200444China Jiangxi KeyLaboratory for Rare Earth Magnetic Materials and Devices&Institute for Rare Earth Magnetic Materials and Devices(IREMMD) Jiangxi University of Science and TechnologyGanzhou341000China School of Materials Science and Engineering Nanyang Technological University639798Singapore Singapore-HUJ Alliance for Research and Enterprise(SHARE) The Smart Grippers for Soft Robotics(SGSR)ProgrammeCampus for Research Excellence and Technological Enterprise(CREATE)138602Singapor

LaFe_(11.8)Si_(1.2)/10 wt%Ce_(60)Co_(40) composites were prepared by spark plasma sintering and subsequent diffusion annealing.A novel core-shell structure is observed with the LaFe11.8Si1.2 particles as the core and the(La,Ce)_(2)(Fe,Co,Si)_(17)(2:17)phase as the *** diffusion annealing time(t_(a))increases,this core-shell structure is replaced by the formation of the(La,Ce)_(1)(Fe,Co,Si)_(13) *** at 1323 K for 12 h results in samples with(-ΔSM)^(max) of 9.30 J/(kg·K)(Δμ0H=2 t),good mechanical properties((σbc)^(max)=402 MPa,ε=4.21%)and thermal conductivity of 8.7 W/(m·K).thus,bulk composites with excellent comprehensive properties for magnetic refrigeration are obtained in this work.

关键词： LaFe_(11.8)Si_(1.2)/Ce_(60)Co_(40)composites Spark plasma sintering Diffusion annealing Microstructure evolution Magnetocaloric effect Rareearths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

越南铁路及机车车辆的现状及展望

引用

铁道标准设计 2024年

作者：樊子暄丁军君 CHIEN v t 吕涵李芾西南交通大学机械工程学院交通与运输大学机械工程学院

随着“一带一路”倡议的不断推进，中国与东南亚国家在铁路技术方面的联系越发密切。本文对越南铁路线路和机车车辆的技术指标、面临的挑战进行了介绍和思考。历经140余年的发展，越南铁路形成了以七条干线为主，总长约3?200?km的铁路... 详细信息

随着“一带一路”倡议的不断推进，中国与东南亚国家在铁路技术方面的联系越发密切。本文对越南铁路线路和机车车辆的技术指标、面临的挑战进行了介绍和思考。历经140余年的发展，越南铁路形成了以七条干线为主，总长约3?200?km的铁路网，其中共有2?500?km米轨线路、500?km准轨线路及200?km混合轨线路。目前共有383?辆机车以及6?094?辆各式车辆，其中机车大部分依靠进口，少量为本土生产，车辆绝大部分为本土生产。越南铁路技术标准与中国铁路标准相近，铁路系统较为完善，但由于长久以来缺乏足够重视及专业维护，导致越南铁路普遍存在钢轨磨损严重、线路条件较差、曲线过多、轮对磨耗严重等问题，制约了越南铁路的发展。越南交通部最新的发展规划中将有2?400?000?亿越南盾的新铁路项目，包括对2?440?km既有铁路线路的维护及新规划的9?条线路建设，将使越南铁路产生巨大变化。中越铁路连接已有百年历史，有良好的合作基础，在“一带一路”迅速发展的当下，应充分关注中越铁路轨距不同、运营环境不同等问题，进一步加强中越双方在铁路技术、机车车辆、铁路标准方面的合作，为中越铁路的建设与发展提供强而有力的支持。

关键词：越南铁路米轨铁路机车车辆线路条件线路标准发展规划

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：