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Determination of critical state line(CSL)for silty-sandy iron ore tailings subjected to low-high confining pressures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesar Consoli João v.tor de Azambuja Carvalho Alexia Cindy Wagner Hugo Carlos Scheuermann Filho Inácio Carvalho Pedro Pazzoto Cacciari João Paulo de Sousa Silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(CD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(CSL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse S-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking Silty-sandy material Critical state soil mechanics High confining pressures Particle breakage

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Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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中国神经再生研究：英文版 2023年第8期18卷 1719-1720页

作者： v.tor Costa v.tor Teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

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Optimization of Electrical Conductivity of SA-graphene Nanocomposites Using Response Surface Methodology

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Chemical Research in Chinese Universities 2022年第2期38卷 596-602页

作者： HakanŞAHAL Gülben torĞUT Erdal CANPOLAT vocational School of Tunceli Department of Food ProcessingMunzur UniversityTunceli 62000Turkey vocational School of Tunceli Department of Chemistry and Chemical ProcessesMunzur UniversityTunceli 62000Turkey Department of Elementary Science Education Faculty of EducationFirat UniversityElazig 23119Turkey

Synthesis and characterization of 4-{(E)-[(5-bromo-2-hydroxyphenyl)methylidene]amino}-N-carbamimidoylbenzene-1-sulfonamide(SA) and its composites with graphene(SA-GF) were performed. Compound SA and SA-GF were characterized by FTIR and 1H NMR. The GF dispersion in the composites was analyzed by means of scanning electron microscopy(SEM) for morphology. Thermal properties of SA and nanocomposites were investigated using differential thermal analysis(DTA) and thermogravimetric analysis(TGA). The optimum electrical conductivity of the new sulfonamide-based Schiff base was determined to be 1.78×10–5 S/cm at a frequency of 9923 Hz, an applied voltage of –19 v, a mass fraction of 9.38% for graphene loading using a central composite design in the response surface methodology. The significance of the selected parameters(frequency, voltage and GF amount) in the model was determined by the analysis of variance(ANOvA). The results showed that frequency and graphene loading represent important model terms and have considerable effects on the conductivity of SA.

关键词： Schiff base Sulfonamide Graphene Conductivity Nanocomposite

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Dynamical Demixing of a Binary Mixture Under Sedimentation

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Communications in Computational Physics 2023年第1期33卷 1-21页

作者： Andre S.Nunes Rodrigo C.v.Coelho vasco C.braz Margarida M.Telo da Gama Nuno A.M.Araujo Centro de F´ısica Te´orica e Computacional Faculdade de CiˆenciasUniversidade de LisboaP-1749-016 LisboaPortugal Departamento de F´ısica Faculdade de CienciasUniversidade de LisboaP-1749-016 LisboaPortugal Electric Ant Lab Science Park 1061098 XGAmsterdamThe Netherlands

We investigate the sedimentation dynamics of a binary mixture,the species of which differ by their Stokes coefficients but are identical *** analyze the sedimentation dynamics and the morphology of the final deposits using Brownian dynamics simulations for mixtures with a range of sedimentation velocities of both *** addition,we use the lattice Boltzmann method to study hydrodynamic *** found a threshold in the difference of the sedimentation velocities above which the species in the final deposit are *** degree of segregation increases with the difference in the Stokes coefficients or the sedimentation velocities above the *** propose a simple analytical model that captures the main features of the simulated deposits.

关键词： Sedimentation Brownian dynamics lattice Boltzmann method

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Traction power substation balance and losses estimation in AC railways using a power transfer device through Monte Carlo analysis

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Railway Engineering Science 2022年第1期30卷 71-95页

作者： v.tor A.Morais Antonio P.Martins Department of Electrical and Computer Engineering Faculty of EngineeringUniversity of PortoPorto 4200465Portugal

The high dynamic power requirements present in modern railway transportation systems raise research challenges for an optimal operation of railway electrification. This paper presents a Monte Carlo analysis on the application of a power transfer device installed in the neutral zone and exchanging active power between two sections. The main analyzed parameters are the active power balance in the two neighbor traction power substations and the system power losses. A simulation framework is presented to comprise the desired analysis and a universe of randomly distributed scenarios are tested to evaluate the effectiveness of the power transfer device system. The results show that the density of trains and the relative branch length of a traction power substation should be considered in the evaluation phase of the best place to install a power transfer device, towards the reduction of the operational power losses, while maintaining the two substations balanced in terms of active power.

关键词： Electric traction systems Monte Carlo analysis Power transfer device Power quality Railway power systems Smart railways

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Mechanical behavior of iron ore tailings under standard compression and extension triaxial stress paths

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1883-1894页

作者： Alexia Cindy Wagner João Paulo de Sousa Silva João v.tor de Azambuja Carvalho Ana Luisa Cezar Rissoli Pedro Pazzoto Cacciari Helder Mansur Chaves Hugo Carlos Scheuermann Filho Nilo Cesar Consoli Universidade Federal do Rio Grande do Sul Porto Alegre90035-190Brazil Mineral Development Centre Vale S.A.Santa Luzia33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealMontrealH3C 3A7Canada

The disposal of mining tailings has increasingly focused on the use of dry *** structures offer more security since they use filtered and compacted *** of the construction method and the heights achieved,the material that compounds the structure can be subjected to different stress paths along the failure *** theoretical framework considered in the design of these structures generally is the critical state soil mechanics(CSSM).However,the data in the literature concerning the uniqueness of critical state line(CSL)is still controversial as the soil is subjected to different stress *** respect to tailings,this question is even more *** paper studies two tailings with different gradings due to the beneficial processes over extension and compression paths.A series of drained and undrained triaxial tests was conducted over a range of initial densities and stress *** the q-p'plane,different critical stress ratio(M)values were obtained for compression and extension stress ***,the critical state friction angle is very similar with a slightly higher critical state friction angle for extension *** stress path dependent CSLs were obtained in the n-lnp0 plane with the extension tests below the CSL defined in *** the fines content,the studied tailings presented very similar M and critical state friction angle ***,the fines content af-fects the volumetric behavior of the studied tailings and the CSLs on the n-lnp0 plane shift downwards with the increasing fines content for compression and extension *** relation to dilatancy analysis,the fines content did not present an evident influence on the dilatancy of the ***,different values of mean stress ratio N were obtained between compression and extension tests and can corroborate the existence of non-unique CSLs for these materials.

关键词： Iron ore tailings(IOTs) Dry stacking Critical state soil mechanics Extension tests Stress path

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Monolithic LC method applied to fesoterodine fumarate low dose extended-release tablets:Dissolution and release kinetics

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Journal of Pharmaceutical Analysis 2015年第2期5卷 137-141页

作者： Maximiliano S.Sangoi v.tor Todeschini Martin Steppe Faculty of Pharmacy Federal University of Rio de Janeiro Faculty of Pharmacy Federal University of Rio Grande do Sul

A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic（LC） method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature（40 1C） using a mobile phase of acetonitrile：methanol：0.03 M ammonium acetate（p H 3.8）（30：15：55, v/v/v）, run at a flow rate of 1.5 m L/min and detected at 208 nm. The best dissolution conditions for this formulation were achieved using a USP apparatus 2（paddle） at 100 rpm and 900 m L of phosphate buffer at p H 6.8 as the dissolution *** parameters such as the specificity, linearity, accuracy, precision, and robustness were evaluated according to international guidelines, giving results within the acceptable range. The kinetic parameters of drug release were also investigated using model-dependent methods and the dissolution profiles were best described by the Higuchi model. The validated dissolution test can be applied for quality control of this formulation.

关键词： Fesoterodine Dissolution test Low dose extendedrelease tablets Monolithic LC Release kinetics

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Presence of blaOXA-48-carrying IncF plasmid in an Escherichia fergusonii strain isolated from a sugarcane soil

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Pedosphere 2020年第2期30卷 293-294页

作者： Jessica Aparecida Silva MORETTO Joao Pedro Rueda FURLAN vania Santos braz Tamires Aparecida BITENCOURT Eliana Guedes STEHLING Departamento de Analises Clinicas Toxicologicas e BromatologicasFaculdade de Ciencias Farmaceuticas de Ribeirao PretoUniversidade de Sao PauloRibeirao Preto SP 14040-903(Brazil Departamento de Genetica Faculdade de Medicina de Ribeirao PretoUniversidade de Sao PauloRibeirao Preto SP 14040-903(Brazil

Dear Editor,A large number of antimicrobial agents used for the treatment of humans and animals reach water sources and agricultural soils in different ways,including animal ***,antimicrobial-resistant bacteria,carrying important antimicrobial resistance genes(ARGs),circulate between humans,animals,and the environment,giving attention to the concept of One Health(Topp,2017;Tiedje et al.,2019).

关键词： soil soils sugarcane

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中国咖啡主栽区咖啡种质资源圃中咖啡驼孢锈菌致病类型鉴定和分析

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云南农业大学学报:自然科学版 2023年第5期38卷 755-763页

作者：李乐易克贤吴伟怀 v.tor Manuel Pinto várzea Ana Paula Pereira Maria do Céu Machado Lavado da Silva 唐天乐海南医学院国家卫生健康委员会热带病防治重点实验室/教育部热带转化医学重点实验室/热带医学院海南海口571199 中国热带农业科学院三亚研究所海南三亚572025 中国热带农业科学院海南省热带农业害虫监测与控制重点实验室/环境与植物保护研究所海南海口571101 海南大学热带农林学院海南海口570208 里斯本大学咖啡锈病工程研究中心葡萄牙里斯本2784-505

【目的】研究中国咖啡主栽区咖啡种质资源圃中由专性寄生病原真菌咖啡驼孢锈菌(Hemileia vastatrix *** Br.)引起的咖啡黄锈病(coffee leaf rust,CLR)致病类型,对保护中国咖啡种质资源以及指导主栽区抗性品种的布局和选育具有重要意义... 详细信息

【目的】研究中国咖啡主栽区咖啡种质资源圃中由专性寄生病原真菌咖啡驼孢锈菌(Hemileia vastatrix *** Br.)引起的咖啡黄锈病(coffee leaf rust,CLR)致病类型,对保护中国咖啡种质资源以及指导主栽区抗性品种的布局和选育具有重要意义。【方法】收集分布在中国咖啡主栽区4个具有代表性的咖啡种质资源圃CLR病样,在超感病基因型寄主上进行扩繁及单孢分离,在特定基因型寄主上对咖啡驼孢锈菌的毒力基因进行鉴定,并推导出相应的致病类型。【结果】57份样品中,有42份样品(占73.68%)被成功扩繁,有27份样品(占64.29%)被保存。根据样品信息录入23个CIFC条目,共鉴定出3种致病类型:XXXⅦ(v_(2,5,6,7,9)),占86.96%,为优势致病类型;New race(v_(2,5,6,7)),占8.69%,为在中国种质资源圃CLR调查的首次报道;XXXIv(v_(2,5,7,9)),占4.35%。【结论】中国咖啡主栽区咖啡驼孢锈菌群体遗传结构正在发生改变,原有致病类型已渗入位于主栽区内的种质资源圃,并在基因型相近的寄主上加速进化;新的致病类型在主栽区内的咖啡基地和种质资源圃之间随机流动,并对当前主栽品种的抗性造成威胁。研究结果将为中国咖啡种质资源圃的科学管理提供重要依据,为CLR防控提供理论支持。

关键词：咖啡咖啡驼孢锈菌种质资源圃致病类型毒力基因

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Molecular docking of DS-3032B,a mouse double minute 2 enzyme antagonist with potential for oncology treatment development

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World Journal of Clinical Oncology 2022年第6期13卷 496-504页

作者： v.tor Hugo Sales da Mota Fabrício Freire de Melo Breno Bittencourt de Brito Filipe Antônio França da Silva Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND It is known that p53 suppression is an important marker of poor prognosis of cancers,especially in solid tumors of the breast,lung,stomach,and esophagus;liposarcomas,glioblastomas,and *** p53 has mouse double minute 2(MDM2)as its primary negative regulator,this molecular docking study seeks to answer the following hypotheses:Is the interaction between DS-3032B and MDM2 stable enough for this drug to be considered as a promising neoplastic inhibitor?AIM To analyze,in silico,the chemical bonds between the antagonist DS-3032B and its binding site in *** For molecular docking simulations,the file containing structures of MDM2(receptor)and the drug DS-3032B(ligand)were *** three-dimensional structure of MDM2 was obtained from Protein Data Bank,and the one for DS-3032B was obtained from PubChem *** location and dimensions of the Grid box was determined using AutoDock Tools *** this case,the dimensions of the Grid encompassed the entire *** ligand DS-3032B interacts with the MDM2 receptor in a physiological environment with pH 7.4;thus,to simulate more reliably,its interaction was made with the calculation for the prediction of its protonation state using the MarvinSketch®*** ligands,with and without the protonation,were prepared for molecular docking using the AutoDock Tools *** software detects the torsion points of the drug and calculates the angle of the *** docking simulations were performed using the tools of the AutoDock platform connected to the vina *** analyses of the amino acid residues involved in the interactions between the receptor and the ligand as well as the twists of the ligand,atoms involved in the interactions,and type,strength,and length of the interactions were performed using the PyMol software(***/2)and Discovery Studio from BIOvIA®.RESULTS The global alignment indicated crystal structure 5SWK was more suitable for docking simulati

关键词： DS-3032B Mouse double minute 2 antagonist Molecular docking Tumor suppressor p53

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