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Association between Exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： v.shal midya Manasi Agrawal Jamil M.Lane Chris Gennings Leonid Tarassishin Libni A.Torres-Olascoaga Joseph Eggers Jill K.Gregory Mellissa Picker Inga Peter Jeremiah J.Faith Manish Arora Martha M.Tellez-Rojo Robert O.Wright Jean-Frederic Colombel Shoshannah Eggers Department of Environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)vated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of Eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDRve abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDRve higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation

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Supersymmetric microring laser arrays

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Photonics Research 2019年第3期7卷 363-367页

作者： BIKASHKALI midya HAN ZHAO XINGDU QIAO PEI MIAO WIKTOR WALASIK ZHIFENG ZHANG NATALIA M.LITCHINITSER LIANG FENG Department of Materials Science and Engineering University of Pennsylvania Department of Electrical and Systems Engineering University of Pennsylvania Department of Electrical and Computer Engineering Duke University

A coherent combination of emission power from an array of coupled semiconductor lasers operating on the same chip is of fundamental and technological importance. In general, the nonlinear competition among the array supermodes can entail incoherence and spectral broadening, leading to a spatiotemporally unstable and multimode emission pattern and thus poor beam quality. Here, by harnessing notions from supersymmetric(SUSY)quantum mechanics, we report that the strategic coupling between a class III-v semiconductor microring laser array with its dissipative superpartner can be used to limit the number of supermodes available for laser actions to one. We introduce a novel approach based on second-order SUSY transformation in order to drastically simplify the superpartner array engineering. Compared to a conventional laser array, which has a multimode spectrum, a SUSY laser array is observed to be capable of operating in a single(transverse) supermode. Enhancement of the peak output intensity of the SUSY laser array has been demonstrated with high efficiency and lower lasing threshold, compared with a single laser and a conventional laser array. Our experimental findings pave the way towards broad-area and high-power light generation in a scalable and stable fashion.

关键词： emission power coupled semiconductor lasers operating technological importance

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