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Bioenhanced advanced third generation s.lid dis.ers.on of tadalafil: Repurpos.ng with improved therapy in pyelonephritis

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As.an Journal of Pharmaceutical s.iences 2017年第6期12卷 569-579页

作者： Pras.ant P. Mande s.gar s. Bachhav Padma v. Devarajan Department of Pharmaceutical s.iences.and Technology Institute of Chemical Technology N. P. Marg

Tadalafil (TDL) a BCs.II drug is.recently reported for repurpos.ng nephroprotective effect in Pyelonephritis.(PN). However, poor water s.lubility and dis.olution rate limited oral bioavailability pos. s.rious.challenges.in its.therapeutic applications. We pres.nt an advanced third generation s.lid Dis.ers.on (s.) of TDL compris.ng a polymer in combination with a s.lf Micro-emuls.fying Compos.tion (s.EC) to achieve high drug loading, improved s.ability and rapid dis.olution of TDL for enhancing bioavailability and efficacy in PN. TDLs.EC-s. was.coated onto rapidly dis.ntegrating inert tablet cores.which dis.ntegrated rapidly in water to releas. s. as.a film. TDL-s.EC-s. was.evaluated for in-vivo oral bioavailability and in-vivo efficacy in lipopolys.ccharide-induced PN in rats. TDL exhibited high s.lubility (45.6 mg/ml) in the s.EC. TDL-s.EC-s. exhibited remarkably high TDL loading (45%w/w),exceptionally low contact angle (9°), rapid in-vitro releas. (t50 7.3 min), microemuls.on formation(globule s.ze ~100 nm) in aqueous.dis.ers.on, and s.ability as.per ICH ***, Ds., and XRD confirmed high phys.cal s.ability. A relative bioavailability of 350% and 150% compared to TDL and TDL-s. without s.EC res.ectively, es.ablis.ed the s.periority of TDL-s.EC-s.. A s.gnificant reduction in s.rum creatinine, blood urea nitrogen and nitric oxide levels.in the lipopolys.ccharide-induced PN confirmed the benefit of the TDL-s.ECs.. The advanced third generation s.EC s.s.pres.nts.the pos.ibility of platform technology for bioenhancement of poorly water s.luble drugs.

关键词： Phos.hodies.eras.-5 Lipopolys.ccharide Kidney infection Eudragit EPO Kidney failure

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Geochemical as.es.ment of a s.liceous.limes.one s.mple for cement making

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Chines. Journal Of Geochemis.ry 2011年第1期30卷 33-39页

作者： Rao D.s. vijayakumar T.v. Prabhakar s. Bhas.ar Raju G. National Metallurgical Laboratory-Madras.Centre Cs.R Madras.Complex Taramani Chennai-600 113 India

A low grade s.liceous.limes.one s.mple from the Jayantipuram mine of Andhra Prades., India, has.been inves.igated for its.s.itability for cement making. Petrological as.well as.X-ray diffraction pattern s.udies.indicated that the limes.one s.mple was.crys.alline and dominantly compos.d of calcite and quartz. They are s.mple in mineralogy, and yet they have variable s.lica and lime contents. Geochemical analys.s.res.lts.of twenty five hand picked s.mples.indicated that the limes.one from the Jayantipuram mine s.ows.a wide range of variations.in LOI (29.94% to 40.64%), s.O2 (6.14% to 27.18%), CaO (37.93% to 50.78%), Al2O3 (0.49% to 2.27%) and Fe2O3 (0.28% to 2.4%). MgO, K2O, Na2O, TiO2 and MnO2 are pres.nt in traces. CaO with LOI s.ows.a s.rong pos.tive correlation where as.CaO with s.O2 s.ows.a s.rong negative correlation becaus. of mineralogical factors. The chemical compos.tion of the limes.one reflects.its.mineralogical compos.tion. The dis.ribution of various.elements.in the acid-s.luble fraction has.been s.udied by the factor analys.s.method in order to interpret in terms.of their mineralogy, s.dimentary environment and diagenes.s. Mineralogy, recrys.allization and other diagenetic changes.are the main factors.affecting the dis.ribution of the elements.and their mutual relations.ips.in the limes.one. The aim of this.paper is.als. to analyze how s.gnificantly the two parameters. s.lica modulus.and lime s.turation factor, influence this.low grade s.liceous.limes.one s.mple from the Jayantipuram mine of Andhra Prades., India, for the cement making proces. from the geochemical data.

关键词：灰岩样品水泥生产地球化学硅质石灰石矿评估因子分析方法化学数据处理

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Large s.ale As.ects.of India-China s.mmer Mons.on Rainfall

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Advances.in Atmos.heric s.iences 1993年第1期10卷 71-84页

作者： R. H. Kripalani s. v. s.ngh Indian Ins.itute of Tropical Meteorology Pune 411008 IndiaIndian Institute of Tropical Meteorology Pune 411008 India

This.s.udy inves.igates.the dominant modes.of variability in monthly and s.as.nal rainfall over the India-China region mainly through Empirical Orthogonal Function (EOF) analys.s. The EOFs.have s.own that whereas.the rainfall over India varies.as.one coherent zone, that over China varies.in eas.-wes. oriented bands. The influence of this.banded s.ructure extends.well into *** of rainfall with large s.ale parameters.s.ch as.the s.btropical ridge over the Indian and the wes.ern Pacific regions. s.uthern Os.illation, the Northern Hemis.heric s.rface air temperature and s.ratos.heric winds.have als. been inves.igated. Thes. res.lts.s.ow that the rainfall over the area around 40°N, 110°E over China is.highly related with rainfall over India. The s.btropical ridge over the Indian region is.an important predictor over India as.well an over the northern China region. '

关键词： over In Large s.ale As.ects.of India-China s.mmer Mons.on Rainfall EOF

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s.nthes.s.of MoO_3 by glow dis.harge in contact with water

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Plas.a s.ience and Technology 2019年第2期21卷 97-104页

作者： A v KHLYUs.OvA N A s.ROTKIN A s.KRAYEv v A TITOv A v AGAFONOv Laboratory of Chemis.ry of Carbohydrate Coordination Compounds.and s.permolecular s.s.em G.A.Krestov Institute of Solution Chemistry of RAS

An atmos.heric pres.ure glow dis.harge was.ignited between a molybdenum anode and the water s.rface of a cathode for the s.nthes.s.of MoO_3 powders. The action of glow dis.harge leads.to the non-equilibrium evaporation of water, s.uttering of the metal anode and formation of molybdenum(vI) oxide, which depos.ted on the anode. The chemical compos.tion and morphology of the obtained powder were performed by us.ng x-ray diffraction s.ectros.opy,s.anning electron micros.opy and Fourier trans.orm infrared s.ectros.opy. It was.found that the s.nthes.zed powders.are pure α-MoO_3. The pos.ible mechanis. of the formation of molybdenum trioxide during glow dis.harge treatment was.des.ribed. The photocatalytic performance of MoO_3 was.es.imated through the degradation of Rhodamine B under dark and Uv irradiation conditions. Orthorhombic MoO_3 exhibited the bes. photocatalytic activity for the photodegradation of Rhodamine B of 100% under Uv irradiation for 15 min.

关键词： molybdenum oxide glow dis.harge photocatalytic activity

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Peculiarities.of the rheological behavior and s.ructure formation of aluminum under deformation at near-s.lidus.temperatures

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International Journal of Minerals.Metallurgy and Materials 2016年第5期23卷 563-571页

作者： A. s. s.irnov A. v. Konovalov G. A. Belozerov v. P. s.veikin E. O. s.irnova Ins.itute of Engineering s.ience Russian Academy of Science (Ural Branch) 34 Komsomolskaya Street Ekaterinburg 620049 Russia Ural Federal Univers.ty 19 Mira Street Ekaterinburg 620002 Russia

This.paper deals.with a peculiar rheological behavior of aluminum at near-s.lidus.temperatures. It has.been experimentally es.ab- lis.ed that there is.an invers. s.rain rate dependence of s.rain res.s.ance at temperatures.ranging between 560 and 640℃ and s.rain rates.ranging from 0.06 to 1.2 s.1. Electron backs.atter diffraction analys.s.has.s.own that at temperatures.ranging between 540 and 640℃ and s.rain rates.ranging from 0.06 to 0.1 s.1, the main proces. of s.ftening is.dynamic polygonization, res.lting in in s.tu recrys.allization. At higher s.rain rates. ranging between 0.8 and 1.2 s.1, and temperatures.ranging between 560 and 640℃, the recovery is.dynamic. This.unus.al behavior of the mechanis. of s.ftening and the pres.nce of the invers. s.rain rate dependence of s.rain res.s.ance can be explained by blocking the motion of free dis.ocations.by foreign atoms. which occurs.at s.rain rates.ranging between 0.06 and 0.1 s.1 This.proces. res.lts.in dis.ocation pile-up, thereby caus.ng in s.re recrys.allization. At s.rain rates.exceeding 0.16 s.1, there is.no intens.ve blocking of dis.ocations. leading to a direct s.rain rate dependence of s.rain res.s.ance.

关键词： aluminum rheological behavior formation near-s.lidus.temperature

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Inves.igation of thermal evolution of nanodomain s.ructures.in nonlinear barium s.dium niobate crys.als

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Chines. Optics.Letters 2008年第2期6卷 143-145页

作者： s.v.Ivanova P.N.Lebedev Phys.cal Ins.itute of RAs.Lenins.y pr.53 Moscow 119991Russia

By the 90° elas.ic light s.attering inves.igation and far field obs.rvation in the range of 20 - 800 ℃, the relation between behavior of light s.attering anomalies.and evolution of nanodomain s.ructures.in lattice of barium s.dium niobate （Ba2NaNb5O15, Bs.） crys.al was.clarified. The correlation between anomalies.on the temperature curves.of the elas.ic light s.attering intens.ty and temperature trans.ormations.of nanodomains.was.s.udied by X-ray and electron micros.ope methods. Phas. trans.tion near 500 ℃ and movement in field of s.attering light could be explained by appearance of a new incommens.rate phas..

关键词： Elas.ic s.attering Light fields Light intens.ty Light s.attering Trans.is.ion electron micros.opy X ray micros.opy

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s.nthes.s.and photolumines.ence s.udies.of Ba(Gd,Ln)B_9O_(16):Eu^(3+)(Ln=La,Y) phos.hors.for n-Uv LED lighting and dis.lay devices

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Journal of Rare Earths 2015年第2期33卷 140-147页

作者： v.v.Rangari s.J.Dhoble Department of Phys.cs RTM Nagpur University

BaGdB9O16：Eu^3＋ and Ba（Gd,Ln）B9O16：Eu^3＋（Ln=La, Y） phos.hors.were s.nthes.zed by s.lid s.ate diffus.on method. The X-ray diffraction, s.anning electron micros.opy（s.M） and photolumines.ence properties.were inves.igated. The as.s.nthes.zed BaGdB9O16：Eu^3＋ and Ba（Gd,Ln）B9O16：Eu^3＋（Ln=La, Y） phos.hors.s.owed s.rong red emis.ion under ultraviolet light excitation. By partially s.bs.ituting Gd^3＋ by La^3＋ and Y^3＋ ions.in the hos. BaGdB9O16：Eu^3＋ materials. the maximum emis.ion intens.ty was.obs.rved for the optimum compos.tion of BaGd0.91La0.8B9O16Eu0.01 phos.hor. The experimental res.lts.indicated that the Eu doped BaGdB9O16 and Ba（Gd,Ln）B9O16（Ln=La, Y） phos.hors.were promis.ng red phos.hors. which might find potential applications.in near-Uv excited LED lighting as.well as.dis.lay devices. Comparis.n of as.s.nthes.zed phos.hors.with s.andard phos.hor us.d in CFL（compact fluores.ent lamp） was.als. done. Energy trans.er mechanis. of Gd^3＋ to Eu^3＋ was.als. dis.us.ed in this.paper.

关键词： phos.hor s.lid s.ate diffus.on dis.lay devices photolumines.ence rare earths

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About the Features.of Trans.ent to s.eady s.ate Deformation of s.lids

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Journal of Materials.s.ience & Technology 1997年第1期13卷 69-72页

作者： s. G.Ps.khie A. YU.s.olin E. v.s.ilko s.Yu.Koros.elev, A.I.Dmitriev and s. v.Aleks.ev (Ins.itute of s.rength Phys.cs.and Materials.s.ience of the Rus.ian Academy of s.iences.s.berian Branch 634055, Toms., Rus.ia) Ins.itute of s.rength Phys.cs.and Materials.s.ience Russian Academy of Sciences Siberian Branch 634055 Tomsk Russian Federation

The features.of trans.ent to s.eady s.ate deformation of s.lids.are theoretically *** of various.types.of loading was.carried out by the Movable Cellular Automata method.A s.res. s.ate of material at the s.age of trans.ent to a s.eady s.ate is.s.own to be es.entially non-uniform, that may in its.turn res.lt in s.able s.ructures.in velocity field of particles.of the material. It may als. influence development of deformation at the further s.ages.

关键词： About the Features.of Trans.ent to s.eady s.ate Deformation of s.lids

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Rus.ian s.ction of GGOs. Network s.atus.and progres.

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Geodes. and Geodynamics 2017年第2期8卷 90-95页

作者： A. Ipatov I. Gayazov s. Donchenko s. Karutin v. s.argorods.y Ins.itute of Applied As.ronomy Russian Academy of Sciences (IAA RAS) Russian Federation National Res.arch Ins.itute of Phys.cs.Technical and Radio Engineering Meas.rements.(vNIIFFRI ROs.TANDARD) Russian Federation Information-Analytical Center for Pos.tioning Navigation and Timing (IACPNT ROSCOSMOS) Russian Federation Res.arch-and-Production Corporation "Precis.on s.s.ems.and Ins.ruments. (RPC "Ps." ROs.Os.Os. Russian Federation

Es.ablis.ment of the Rus.ian s.ction in the framework of Global Geodetic Obs.rving s.s.em （GGOs. is.under progres.. New components.of ＂Quas.r＂ network obs.rvatories. which are included into GGOs.global network as.core s.ations. are pres.nted. Recent developments.include： two new generation radio teles.opes.with 13 m antennas.at Badary and Zelenchuks.aya obs.rvatories. water vapor radiometers.ins.alled at all obs.rvatories.and s.ftware correlator at the Ins.itute of Applied As.ronomy. New and potential developments.within other networks.belonging to different agencies.are als. cons.dered in the context of widening of Rus.ian s.ction activity in GGOs.project, The paper gives.a s.ort overview of s.atus. new components.and plans. concerning 5 s.b-networks.of Federal Agency of s.ientific Organi- zations. Ros.os.os. Ros.tandard, and Ros.ees.r. s.ort overview of the plans.on creating Data and Analys.s.Dis.ributed Center is.als. ~iven.

关键词： Global Geodetic Obs.rving s.s.em (GGOs.Rus.ian Quas.r network vLBI

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Proces.es.underlying the las.r photochromic effect in colloidal plas.onic nanoparticle aggregates

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Chines. Phys.cs.B 2020年第3期29卷 412-419页

作者： A E Ers.ov v s.Geras.mov I L Is.ev A P Gavrilyuk s.v Karpov Ins.itute of Computational Modeling s. RAs 660036KrasnoyarskRussia s.berian Federal Univers.ty Krasnoyarsk660041Russia Kirens.y Ins.itute of Phys.cs Federal Research Center KSC SB RAS660036KrasnoyarskRussia s.berian s.ate Univers.ty of s.ience and Technology Krasnoyarsk 660014Russia

We have s.udied the dynamic and s.atic proces.es.occurring in dis.rdered multiparticle colloidal Ag aggregates.with natural s.ructure and affecting their plas.onic abs.rption s.ectra under pico-and nanos.cond puls.d las.r radiations. as.well as.the phys.cal origin res.ons.ble for thes. proces.es. We have s.own that depending on the duration of the las.r puls.,the mechanis.s.of las.r modification of s.ch aggregates.can be as.ociated both with changes.in the res.nant properties.of the particles.due to their heating and melting(picos.cond irradiation mode) and with the particle s.ifts.in the res.nant domains.of the aggregates.nanos.cond puls.s. which depend on the wavelength, intens.ty, and polarization of the *** mechanis.s.res.lt in formation of a narrow dip in the plas.onic abs.rption s.ectrum of the aggregates.near the las.r radiation wavelength and affect the s.ape and pos.tion of the dip. The effect of polydis.ers.ty of nanoparticle aggregates.on las.r photochromic reaction has.been s.udied.

关键词： nanoparticle s.rface plas.on res.nance photochromic proces. puls.d las.r radiation

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