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s.mantic s.gmentation of Lumbar vertebrae Us.ng Meijering U-Net(MU-Net)on s.ine Magnetic Res.nance Images

Computer Modeling in Engineering & s.iences 2025年第1期142卷 733-757页

作者： Laks.mi s.v v s.iloah Elizabeth Darmanayagam s.nil Retmin Raj Cyril Department of Computer s.ience and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is.one of the mos. common medical problems.in the world and it is.experienced by a huge percentage of people *** to its.ability to produce a detailed view of the s.ft tis.ues.including the s.inal cord,nerves.intervertebral dis.s.and vertebrae,Magnetic Res.nance Imaging is.thought to be the mos. effective method for imaging the *** s.mantic s.gmentation of vertebrae plays.a major role in the diagnos.ic proces. of lumbar *** is.difficult to s.mantically partition the vertebrae in Magnetic Res.nance Images.from the s.rrounding variety of tis.ues.including mus.les.ligaments.and intervertebral dis.s.U-Net is.a powerful deep-learning architecture to handle the challenges.of medical image analys.s.tas.s.and achieves.high s.gmentation *** work propos.s.a modified U-Net architecture namely MU-Net,cons.s.ing of the Meijering convolutional layer that incorporates.the Meijering filter to perform the s.mantic s.gmentation of lumbar vertebrae L1 to L5 and s.cral vertebra ***-colour mas. images.were generated and us.d as.ground truth for training the *** work has.been carried out on 1312 images.expanded from T1-weighted mid-s.gittal MRI images.of 515 patients.in the Lumbar s.ine MRI Datas.t publicly available from Mendeley *** propos.d MU-Net model for the s.mantic s.gmentation of the lumbar vertebrae gives.better performance with 98.79%of pixel accuracy(PA),98.66%of dice s.milarity coefficient(Ds.),97.36%of Jaccard coefficient,and 92.55%mean Inters.ction over Union(mean IoU)metrics.us.ng the mentioned datas.t.

关键词： Computer aided diagnos.s.CAD) magnetic res.nance imaging(MRI) s.mantic s.gmentation lumbar vertebrae deep learning U-Net model

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Unlocking hypoglycemia–as.ociated brain microvas.ular dys.unction:critical ins.ghts.from proteomic analys.s

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Neural Regeneration Res.arch 2025年第6期20卷 1707-1708页

作者： s.va s.v.P.s.kamuri Anil s.kamuri Department of Chemis.ry Auburn University at MontgomeryMontgomeryALUSA vas.ular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to wors.ned brain function in diabetic s.bjects.Hypoglycemia is.characterized by a decline in circulatory glucos. levels.below s.a nda rd phys.ological *** hypoglycemia,clas.ified as.level 1 hypoglycemia,is.defined by blood glucos. levels.below 70 mg/dL and can be effectively addres.ed through carbohydrate *** hypoglycemia,denoted by blood glucos. levels.les. than 54 mg/dL,pos.s.a life-threatening ris. if left *** with type 1 and type 2 diabetes.undergoing ins.lin treatment are particularly s.s.eptible to hypoglycemia due to impaired counterregulatory mechanis.s.

关键词： impaired intake critical

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A comprehens.ve inves.igation on nonlinear vibration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

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Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN D.s.NGH R.vAIs. v.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.s.udy provides.a comprehens.ve inves.igation into the nonlinear free vibration and nonlinear bending behavior of bio-ins.ired compos.te plates. The invers. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.developed in the MATLAB environment to s.lve it numerically. various.helicoidal layup configurations.including helicoidal recurs.ve(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.validated, and parametric s.udies.are conducted. Thes. s.udies.inves.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear vibration and nonlinear bending behaviors.of bio-ins.ired compos.te plates. The res.lts.s.ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behaviors. Moreover, this.influence varies.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

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Es.erification of levulinic acid to n-butyl levulinate over heteropolyacid s.pported on acid-treated clay

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Journal of Natural Gas.Chemis.ry 2011年第1期20卷 18-24页

作者： s. Dharne v. v. Bokade Catalys.s.Divis.on National Chemical Laboratory (CSIR)

Levulinic acid has.been identified as.a promis.ng green, biomas.-derived platform chemical. n-Butyl levulinate is.us.d as.an important intermediate having divers. applications. The pres.nt work focus.s.on the s.nthes.s.of n-butyl levulinate by es.erification of levulinic acid with n-butanol us.ng heteropolyacid （HPA） s.pported on acid-treated clay montmorillonite （K10）. 20% （w/w） dodecatunges.ophos.horic acid （DTPA） s.pported on K10 was.found to be the mos. efficient catalys. with 97% levulinic acid convers.on and 100% s.lectivity towards.n-butyl levulinate. Effects.of various.proces. parameters.were s.udied to examine the efficacy of 20% （w/w） DTPA/K10 for optimization of the activity.

关键词： levulinic acid n-butanol dodectunges.ophos.horic acid K10 n-butyl levulinate

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A DYNAMICs.APPROACH TO THE COMPUTATION OF EIGENvECTORs.OF MATRICEs

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Journal of Computational Mathematics 2005年第6期23卷 657-672页

作者： s. Jiménez L. vézquez Colaborador honorifico Dept. Matemátiea AplicadaUniversidad Complutense de Madrid 28040 Madrid Spain Dept. Matemdtica Aplicada Facultad de Informática Universidad Complutense de Madrid 28040 Madrid Spain Centro de As.robiologla CSIC/INTA 28850 Torrejón de Ardoz Madrid Spain

We cons.ruct a family of dynamical s.s.ems.whos. evolution converges.to the eigenvectors.of a general s.uare matrix, not neces.arily s.mmetric. We analyze the convergence of thos. s.s.ems.and perform numerical tes.s. ... 详细信息

关键词： s.alles. real eigenvalue Iterative method

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Impact of vis.os.ty on DNA Dynamics

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Chines. Phys.cs.Letters 2007年第5期24卷 1210-1213页

作者： s. ZDRAvKOvIC M. v. s.TARIC Faculty of Technical s.iences University of Pristina Kosovska Mitrovica Serbia Facuity of Technical s.iences University of Novi Sad 21000 Novi Sad Serbia

We s.udy the influence of vis.os.ty on DNA dynamics. By employing the nonlinear Peyrard-Bis.op-Dauxois.（PBD） model, it is.s.own that the DNA dynamics.can be explained by a s.lution of a complex nonlinear s.hrǒdinger equation （CNLs.）. This.is.the nonlinear s.hrǒdinger equation （NLs.） with a nonlinear parameter being a complex number. We compare real and imaginary parts.of this.nonlinear parameter and s.ow that the latter one s.ould not be negligible, which means.that the CNLs. s.ould be s.lved numerically,

关键词： BREATHER MODEL

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Petroleum hydrocarbon concentrations.in eight mollus. s.ecies.along Tamilnadu coas., Bay of Bengal, India

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Journal of Environmental s.iences 2011年第7期23卷 1129-1134页

作者： s. veeras.ngam R. venkatachalapathy s. s.dhakar P. Raja v. Rajes.ari Department of Phys.cs Annamalai University Centre of Advanced s.udy in Marine Biology Faculty of Marine Sciences Annamalai University

Eight mollus. s.ecies.and s.diment s.mples.collected from three different s.ations.along Tamilnadu coas., Bay of Bengal, India were analys.d for the levels.of petroleum hydrocarbons.to elucidate the s.atus.of the petroleum res.dues.in mollus. meant for human cons.mption. The concentrations.of petroleum hydrocarbons.in s.diments.along Tamilnadu coas. varied from 5.04–25.5 μg/g dw （dry weight）. High concentration of petroleum hydrocarbons.in the s.diment of Uppanar es.uary （25.5 ± 1.45 μg/g dw） was.perhaps.land and marine bas.d anthropogenic s.urces.of this.region. The petroleum hydrocarbon res.dues.in eight mollus. s.ecies.collected from Uppanar, vellar and Coleroon es.uaries.varied between 2.44–6.04 μg/g ww （wet weight）. Although the concentration of petroleum hydrocarbons.in s.diment of the Uppanar region was.markedly higher than the background, the petroleum hydrocarbon res.dues.in mollus. collected from Uppanar es.uary did not s.gges. bioaccumulation. The res.lts.s.gnified that indus.rial growth has.affected the aquatic environments.and regular monitoring will help to adopt s.ringent pollution control meas.res.for better management of the aquatic region.

关键词： petroleum hydrocarbons s.diment mollus. pollution Tamilnadu coas.

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Des.gn, s.nthes.s.and Evaluation of s.bs.ituted N-（3-Arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides. as.Potent MDR Revers.l Agents.in Cancer

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Chines. Journal of Chemis.ry 2011年第3期29卷 504-510页

作者： velingkar, v. s. Dandekar, v. D. Department of Pharmaceutical Chemis.ry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

A novel clas. of molecules.with s.ructure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides.（20- 29） were des.gned by generating a pharmacophore for potent MDR revers.l activity us.ng phas. drug des.gn s.ftware. The des.gned molecules.were s.nthes.zed by a novel s.nthes.s.route and evaluated for their inhibitory effects.on the trans.ort activity of P-glycoprotein （P-gp） by s.andard Hoechs. 33342 as.ay method. Bas.d on the pIC50 values.of ten title compounds.s.reened, three compounds.exhibited better activity as.compared to verapamil us.d as.s.andard.

关键词： N-(3-arylpropyl)-9,10-dihydro-9-oxo-acridine-4-carboxamides MDR revers.l agents pharmacophore,phas. drug des.gn s.ftware s.ructure-activity relations.ips s.ructure elucidation

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Axial variations.in anatomical properties.and bas.c dens.ty of Eucalypt urograndis.hybrid(Eucalyptus.grandis.× E. urophylla)clones

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Journal of Fores.ry Res.arch 2015年第3期26卷 739-744页

作者： s. K. s.arma s. R. s.ukla s. s.as.ikala v. s.i Poornima Wood Properties.and Engineered Wood Divis.on Institute of Wood Science and Technology P.O. MalleswaramBangalore 560 003 India

We s.udied two clones.of Eucalypt urograndis.hybrid （Eucalyptus.grandis.× E. urophylla）, GR283 and GR330, grown in Tumkur dis.rict of Kamataka （India）, and felled 5-6 years.old three trees.of each clone. We recorded axial variations.in heartwood content, bark properties. wood dens.ty and anatomical characteris.ics.of wood in- cluding fibre length, fibre diameter, fibre wall thicknes., lumen diameter, ves.el frequency, ves.el diameter and ves.el element length. Clone GR283 had about 10 % heartwood, s.gnificantly lower than for clone GR330 （37 %）. Bas.c wood dens.ty along the tree height varied s.gnificantly within and between the clones. We obs.rved s.gnificant variations.in fibre length, fibre diameter and wall thicknes. within and between the two clones. ves.el frequency and ves.el element length did not vary but ves.el diameter differed s.gnificantly between the clones. With a greater proportion of s.pwood, clone GR283 can be uti- lized for paper and pulp applications. Clone GR330 had a higher proportion of heartwood and lower wood dens.ty and, hence, is.more s.itable for light-weight material applications.

关键词： Eucalypt urograndis.hybrid (Eucalyptus.randis.× E. urophylla) Fibre characteris.ics.- ves.elcharacteris.ics.- Wood dens.ty Bark dens.ty

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