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Mayaro fever:A brief review on the immune profile

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 95-100页

作者： Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine virgínia martins de Sousa Figueiredo Jose Luizde Lima Filho Laboratório de Imunopatologia Keizo Asami-LIKA Centro de BiociênciasUniversidade Federal de Pernambuco(UFPE)50670-901RecifePernambucoBrazil Laboratório de Biologia Molecular e Expressao Genica-LABMEG Departamento de Ciências BiológicasUniversidade Federal de Alagoas(UFAL)Campus Arapiraca57300-970ArapiracaAlagoasBrazil

Mayaro virus is an emergent alphavirus that infects humans,leading to Mayaro *** fifty percent of infected patients develop arthritis symptoms in the recovery phase,a phase that can last up to a *** literature about Mayaro virus infection and its immune response is scarce,which may hamper the development of treatment *** summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients,and relate this molecular characterization with the immune *** and IL-12/p70 show pronounced changes in patients in the acute phase,suggesting the development of cellular immunity and Th1 ***-6,IL-7,CXCL8/IL-8,IL-13,IL-17,and IFN-γare elevated in patients with arthritis symptoms in the long-term recovery phase,which may be related to the continuous inflammatory process,a possible Th2 inhibiting and promoting Th17 *** few studies discuss the issue,with a small number of patients and different backgrounds,inflammatory and immune response and manifestations seem to be closely *** information may help to develop the appropriate treatment strategies in Mayaro virus ***,we analyzed and summarized data available in literature.

关键词： Emergent virus Mayaro virus Cytokines Chemokine Molecular characterization

Chemical characterisation of particulate matter in urban transport modes

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Journal of Environmental Sciences 2021年第2期33卷 51-61页

作者： v.nia martins Carolina Correia Ines Cunha-Lopes Tiago Faria Evangelia Diapouli Manousos Ioannis Manousakas Konstantinos Eleftheriadis Susana Marta Almeida Centro de Ciencias e Tecnologias N ucleares Instituto Superior TecnicoLisbonPortugal Institute of Nuclear and Radiological Sciences and Technology Energy and SafetyN.C.S.R.'Demokritos'AthensGreece

Traffic is a main source of air pollutants in urban areas and consequently daily peak exposures tend to occur during *** exposure to particulate matter(PM)was monitored while cycling and travelling by bus,car and metro along an assigned route in Lisbon(Portugal),focusing on PM_(2.5) and PM_(1)0(PM with aerodynamic diametervely)mass concentrations and their chemical *** vehicles,the indoor-outdoor interplay was also *** PM_(2.5) mean concentrations were 28±5,31±9,34±9 and 38±21μg/m 3 for bus,bicycle,car and metro modes,*** carbon concentrations when travelling by car were 1.4 to 2.0 times higher than in the other transport modes due to the closer proximity to exhaust *** are marked differences in PM chemical composition depending on transport *** particular,Fe was the most abundant component of metro PM,derived from abrasion of rail-wheel-brake *** concentrations of Zn and Cu in cars and buses were related with brake and tyre wear particles,which can penetrate into the *** the motorised transport modes,Fe,Zn,Cu,Ni and K were correlated,evidencing their common traffic-related *** average,the highest inhaled dose of PM_(2.5) was observed while cycling(55μg),and the lowest in car travels(17μg).Cyclists inhaled higher doses of PM_(2.5) due to both higher inhalation rates and longer journey times,with a clear enrichment in mineral *** presented results evidence the importance of considering the transport mode in exposure assessment studies.

关键词： Traffic Commuting Air pollution Particle chemistry Indoor-outdoor interplay Inhaled dose

Rail RCF damage quantification and comparison for different damage models

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Railway Engineering Science 2022年第1期30卷 23-40页

作者： visakh v.Krishna Saeed Hossein-nia Carlos Casanueva Sebastian Stichel Gerald Trummer Klaus Six Department of Engineering Mechanics KTH Royal Institute of TechnologyStockholmSweden virtual vehicle Research GmbH GrazAustria

There are several fatigue-based approaches that estimate the evolution of rolling contact fatigue(RCF) on rails over time and built to be used in tandem with multibody simulations of vehicle dynamics. However, most of the models are not directly comparable with each other since they are based on different physical models even though they shall predict the same RCF damage at the *** article studies different approaches to quantifying RCF and puts forward a measure for the degree of agreement between them. The methodological framework studies various steps in the RCF quantification procedure within the context of one another, identifies the ‘primary quantification step’ in each approach and compares results of the fatigue analyses. In addition to this, two quantities—‘similarity’ and ‘correlation’—have been put forward to give an indication of mutual agreement between *** widely used surface-based and sub-surface-based fatigue quantification approaches with varying complexities have been studied. Different operational cases corresponding to a metro vehicle operation in Austria have been considered for this study. Results showed that the best possible quantity to compare is the normalized damage increment per loading cycle coming from different approaches. Amongst the methods studied, approaches that included the load distribution step on the contact patch showed higher similarity and correlation in their *** the different approaches might qualitatively agree on whether contact cases are ‘damaging’ due to RCF, they might not quantitatively correlate with the trends observed for damage increment values.

关键词： Rolling contact fatigue Rail surface damage Wedge model KTH model Surface fatigue index Multibody simulation Track-friendliness

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions

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Microsystems & Nanoengineering 2023年第5期9卷 203-217页

作者： Catarina Gonçalves Fonseca v.nia Silvério David Barata Wolfgang Giese Holger Gerhardt Susana Cardoso Claudio Areias Franco Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal INESC Microsistemas and Nanotecnologias INESC-MNLisboaPortugal Department of Physics Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal Max Delbrück Center for Molecular Medicine BerlinGermany DZHK(German Centre for Cardiovascular Research) Partner Site BerlinBerlinGermany Charité–Universitätsmedizin Berlin BerlinGermany Universidade Católica Portuguesa Católica Medical SchoolCatólica Biomedical Research CentreLisbonPortugal

The ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular *** flow responses,in particular related to high flow conditions,have been associated with atherosclerosis,stroke,arteriovenous malformations,and neurodegenerative ***,the molecular mechanisms involved in high flow response are still poorly ***,we described the development and validation of a 96-wells fluidic system,with interchangeable cell culture and fluidics,to perform high-throughput screenings under laminar high-flow *** demonstrated that endothelial cells in our newly developed 96-wells fluidic system respond to fluid flow-induced shear stress by aligning along the flow direction and increasing the levels of KLF2 and *** further demonstrate that our 96-wells fluidic system allows for efficient gene knock-down compatible with automated liquid handling for high-throughput screening ***,we propose that this modular 96-well fluidic system is an excellent platform to perform genome-wide and/or drug screenings to identify the molecular mechanisms involved in the responses of endothelial cells to high wall shear stress.

关键词： system laminar fluid

Traction power substation balance and losses estimation in AC railways using a power transfer device through Monte Carlo analysis

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Railway Engineering Science 2022年第1期30卷 71-95页

作者： vitor A.Morais Antonio P.martins Department of Electrical and Computer Engineering Faculty of EngineeringUniversity of PortoPorto 4200465Portugal

The high dynamic power requirements present in modern railway transportation systems raise research challenges for an optimal operation of railway electrification. This paper presents a Monte Carlo analysis on the application of a power transfer device installed in the neutral zone and exchanging active power between two sections. The main analyzed parameters are the active power balance in the two neighbor traction power substations and the system power losses. A simulation framework is presented to comprise the desired analysis and a universe of randomly distributed scenarios are tested to evaluate the effectiveness of the power transfer device system. The results show that the density of trains and the relative branch length of a traction power substation should be considered in the evaluation phase of the best place to install a power transfer device, towards the reduction of the operational power losses, while maintaining the two substations balanced in terms of active power.

关键词： Electric traction systems Monte Carlo analysis Power transfer device Power quality Railway power systems Smart railways

The Ideational Elements of Brazil’s Arab Strategy:An Assessment(2002-2010)

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Asian Journal of Middle Eastern and Islamic Studies 2015年第4期9卷 100-120,I0006页

作者： v.nia Carvalho PINTO Institute of International Relations University of Brasilia

Relations between the countries of Latin America and the Middle East have been an under researched topic within their respective fields.②This can be attributed,at least partly,to the fact that both regions have a comparatively low level of diplomatic and economic interactions,when contrasted,for example,with relations between Latin America and the European Union,or between the Gulf Cooperation Council and *** the specific case of Brazil,even though the latter has decades old relations with selected Arab countries,such as Iraq,very little has been written about its interactions with the Arab world in *** of the reasons for this may be attributed to the dearth of issues of high politics underscoring this relationship,issues that if present could assist in capturing media and academic *** article seeks to contribute to the study of both regions by focusing on a particular moment of Brazilian foreign policy when relations with the Arab world were at their peak in terms of visibility.

关键词： Brazil and the Middle East Latin America International Relations Brazil and the Gulf

King's College criteria and the Clichy-villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade vivian vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro martins Teixeira Daniele da Gloria Souza Paula vieira Teixeira vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-villejuif criteria

The ARQUIGRAFIA project: A Web Collaborative for Review Only Environment for Architecture and Urban Heritage Image

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Journal of Data and Information Science 2020年第1期5卷 51-67页

作者： v.nia Mara Alves Lima Ci bele Araújo Camargo Marques dos Santos Artur Simões Rozestraten Department of Information and Culture University of São PauloSão PauloBrazil Department of Architecture Technology University of São PauloSão PauloBrazil

Purpose:This paper presents the ARQUIGRAFIA project,an open,public and nonprofit,continuous growth web collaborative environment dedicated to Brazilian architectural photographic ***/methodology/approach:The ARQUIGRAFIA project promotes the active and collaborative participation among its institutional users(GLAMs,NGOs,laboratories and research groups)and private users(students,professionals,professors,researchers),both can create an account and share their digitized iconographic collections in the same Web environment by uploading their files,indexing,georeferencing and assigning a Creative Commons ***:The development of users interactions by means of semantic differentials impressions recording on visible plastic-spatial aspects of the architectures in synthetic infographics,as well as by the retrieval of images through an advanced system search based on those impressions *** gamification means,the system often invites users to review images’in order to improve images’data *** pilot project named Open Air Museum that allows users to add audio descriptions to images in *** interface for users’digital curatorship will be soon *** limitations:The ARQUIGRAFIA’s multidisciplinary team gathering professorsresearchers,graduate and undergraduate students from the Architecture and Urbanism,Design,Information Science,Computer Science faculties of the University of S?o Paulo,demands continuous financial resources for grants,for contracting third party services,for the participation in scientific events in Brazil and abroad,and for *** 2016,significant budget cuts in the University of S?o Paulo own research funds and in Brazilian federal scientific agencies can compromise the continuity of this *** implications:The open source template called+GRAFIA that can freely help other areas of knowledge to build their own visual Web collaborative ***/value:The collaborative natu

关键词： Metadata Architectural images Collaborative web environment Digital repository

Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

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Journal of Forestry Research 2019年第4期30卷 1331-1336页

作者： Rayana S.martins Anderson C.José José Marcio R.Faria Wilson v.S.Pereira Department of Forest Sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(DC.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： Candeia Drying Desiccation tolerant seeds Rehydration Scanning electron microscopy