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密执基莱斑岩铜矿床

地质与勘探 1975年第4期 68-73页

作者： v.f.霍利斯特黎青

秘鲁北部卡哈马卡省密执基莱(Michi-quillay)斑岩铜矿床(图1)恰好符合洛厄尔和吉伯特(1970)所描述的这类矿床的模式.密执基莱斑岩形成的时代较年青,只有20.6百万年.时间上仅能容许它发生极少的剥蚀,但其蚀变和矿化的特征表明,密执基莱... 详细信息

秘鲁北部卡哈马卡省密执基莱(Michi-quillay)斑岩铜矿床(图1)恰好符合洛厄尔和吉伯特(1970)所描述的这类矿床的模式.密执基莱斑岩形成的时代较年青,只有20.6百万年.时间上仅能容许它发生极少的剥蚀,但其蚀变和矿化的特征表明,密执基莱为一典型的斑岩铜矿床.

关键词：斑岩铜矿床瓦尔加那塔泥化带黄铁矿蚀变矿物绢云母铁矿物千枚岩化细脉断裂带断层带

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis f.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor vivian Szymczuk Brendan Boyce Daniel Martin vardit Kram Rebeca Galisteo Kamran Melikov Leonid v.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

fibrous dysplasia(fD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in fD tissue and its likely indirect effects on osteoprogenitors by evaluating human fD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in fD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal fD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces fD lesion activity by decreasing fD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of fD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp.,Ehrlichia canis,and Anaplasma phagocytophilum

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Animal Diseases 2024年第3期4卷 224-230页

作者： Claire A.vázquez‑Manzanilla María f.Cárdenas‑Marrufo Eduardo Gutiérrez‑Blanco Matilde Jiménez‑Coello Nelly R.Pech‑Sosa Antonio Ortega‑Pacheco Departamento de Salud Animal y Medicina Preventiva Facultad de Medicina Veterinaria y ZootecniaCampus de Ciencias Biológicas y AgropecuariasUniversidad Autónoma de YucatánMéridaYucatán 97100México Unidad Interinstitucional de Investigación Clínica y Epidemiológica Facultad de MedicinaUniversidad Autónoma de YucatánMéridaYucatán 97000México

Chronic kidney disease is commonly diagnosed in dogs,and clinical signs may be aggravated when infected agents are *** this case report,33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp.,Ehrlichia canis,and Anaplasma *** seroprevalence for Leptospira *** 39.4%.The most frequent serovars found were Pyrogenes,Canicola,Bratislava and Australis,with serological titers between 1:100 to 1:*** signs included fever,depression,decreased body condition,vomiting and hema‑*** laboratory fndings were anemia,leukocytosis,thrombocytopenia,increased liver enzymes,urea and creatinine,hyperbilirubinemia and *** leptospira seronegative dogs were positive for one or both monitored homoparasites(i.e.,*** and ***);only three leptospira seropositive dogs were positive for one or both *** also suggest that endemic hemoparasites of dogs should be moni‑tored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.

关键词： Anaplasma Chronic kidney disease Dog Ehrlichia Leptospira

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表面活性剂改善钻井液速溶的效果评价

煤田地质与勘探 2015年第5期43卷 117-120,124页

作者：王道宽乌效鸣朱永刚契霍特金v.f. 中国地质大学(武汉) 武汉430074 上海佳友市政建筑有限公司上海200000

针对钻井液材料溶解慢,达到理想性能时间长,提出使用表面活性剂降低配浆水的表面张力和接触角,同时对材料有润湿和增溶作用。通过分析表面活性剂的作用机理,测试表面活性剂对钻井液基本性能影响来优化表面活性剂;观察表面活性剂对土(上... 详细信息

针对钻井液材料溶解慢,达到理想性能时间长,提出使用表面活性剂降低配浆水的表面张力和接触角,同时对材料有润湿和增溶作用。通过分析表面活性剂的作用机理,测试表面活性剂对钻井液基本性能影响来优化表面活性剂;观察表面活性剂对土(上海佳友土、鄂州素土和碱土)和大分子材料的性能影响来优化表面活性剂的加量。结果表明,卵磷脂1在短时间内促进材料的水化分散效果最好,且最优加量为0.2‰,对于6%的上海佳友土、鄂州素土和碱土,表观黏度分别提高20%、20%和6%。0.2‰的卵磷脂可以促进配方(4%佳友土+1‰黄原胶+0.8%改性淀粉)表观黏度提高15%,润滑性提高37%,表面张力降低42%,大分子材料分散得更均匀,泥皮更致密。

关键词：钻井液表面活性剂速溶卵磷脂

Classification of Rings Associated with the Genus of Clean Graphs

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Algebra Colloquium 2024年第3期31卷 451-466页

作者： v.Ramanathan C.Selvaraj Aaqib Altaf S.Pirzada Department of Mathematics Periyar UniversitySalem 636011Tamil NaduIndi Department of Mathematics University of KashmirHazratbalSrinagarKashmirIndia

Let R be a ring(not necessarily commutative)with identity 1 and let CL(R)be its clean *** this paper,we investigate the genus number of the compact Riemann surface in which CL(R)can be embedded and explicitly determine all commutative rings R(up to isomorphism)such that CL(R)has genus at most *** is shown that for any Artinian ring R,CL(R)is a projective graph if and only if R is isomorphic to ***,we determine all isomorphism classes of commutative rings whose clean graphs have crosscap two.

关键词： clean graph commutative ring planar graph genus crosscap

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth v.f.wler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch francesca Strutt Karen f.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

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马朗陶四段破碎厂:设计与实践

国外选矿快报 1998年第19期 17-20页

作者： v.f.斯旺森钱鞠梅美国贝特曼工程公司

扎拉福尚-纽蒙特(Zarafshan-Newmont)联合公司最近在乌兹别克斯坦共和国境内、塔什干西部400km的基朱尔库姆(Kyzykum)地区投入生产。纽蒙特与两个政府机构(州地质和矿物资源委员会;内维尔(Navoi)矿山和冶金公司)各投资50%。成立此联合... 详细信息

扎拉福尚-纽蒙特(Zarafshan-Newmont)联合公司最近在乌兹别克斯坦共和国境内、塔什干西部400km的基朱尔库姆(Kyzykum)地区投入生产。纽蒙特与两个政府机构(州地质和矿物资源委员会;内维尔(Navoi)矿山和冶金公司)各投资50%。成立此联合企业的目的在于开发马朗陶(Muruntau)露天金矿旁低品位氧化矿石资源。马朗陶金矿是世界最大的露天金矿之一,它与RIP厂每年生产170万盎司金。联合公司每年处理1380t低品位矿石,可产出400000盎司金。储量接近20000t。

关键词：选矿厂破碎厂设计破碎回路破碎机

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H3亚型禽流感流行的潜在危害和防控建议

科学通报 2024年第10期69卷 1315-1319页

作者：刘金华孙洪磊高福中国农业大学动物医学院兽医公共卫生安全全国重点实验室农业农村部禽流感等家禽重大疾病防控重点实验室北京100193 中国科学院微生物研究所病原微生物与免疫学重点实验室北京100101 中国疾病预防控制中心病毒病预防控制所中国国家流感中心北京102206

21世纪短短的20年间,人类已经历了两次大流行传染病,即2009年甲型H1N1大流行流感和2019年新型冠状病毒感染.另外发生了5次世界卫生组织宣布的“全球关注的公共卫生应急事件”,给全球经济发展、社会稳定和人类健康造成了严重危害(https:/... 详细信息

21世纪短短的20年间,人类已经历了两次大流行传染病,即2009年甲型H1N1大流行流感和2019年新型冠状病毒感染.另外发生了5次世界卫生组织宣布的“全球关注的公共卫生应急事件”,给全球经济发展、社会稳定和人类健康造成了严重危害(https://***/emergencies/situations).大流行传染病的频繁出现警示我们,人兽共患性病毒是引发大流行疫病的重要病原.动物源性流感病毒在历史上导致了至少5次流感大流行,尤其是最近几年,动物流感病毒频繁跨种感染人类的现象让人们担忧其可能催生下一次人类流感大流行[1].

关键词：冠状病毒感染流感病毒防控建议禽流感 H3亚型跨种感染动物源性流感大流行

vapor phase methylation of phenol on fe-substituted ZrO_2 catalyst

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Chinese Journal of Catalysis 2016年第11期37卷 1991-1996页

作者： Celia f.Braganza A.v.Salker 果阿大学化学系

fe-doped ZrO2 compounds were prepared by a co-precipitation *** compounds were characterized by X-ray diffraction,N2 adsorption-desorption,ultraviolet diffuse reflectance infrared fourier transform spectroscopy,scanning electron microscopy-energy-dispersive X-ray spectroscopy,transmission electron microscopy,NH3 temperature-programmed desorption,X-ray photoelectron spectroscopy,and in situ fourier transform infrared *** incorporation of fe into ZrO2 lattice favored and effectively stabilized the formation of purely ZrO2 tetragonal ***,the catalytic activity of the fe-doped ZrO2 compounds was evaluated toward vapor phase methylation of *** catalytic activity was governed by fe content and related to the Lewis acidity of the prepared catalyst.

关键词： Zirconia Iron doped Methylation Phenol Xylenol