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Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

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Cellular & Molecular Immunology 2021年第11期18卷 1290-1304页

作者： Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud villacreces Frédéric vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance CHU Bordeaux Service d’Hématologie Clinique et de Thérapie CellulaireBordeauxFrance Bordeaux University BordeauxFrance Institut National de la Santéet de la Recherche Médicale U1035BordeauxFrance APHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Établissement Français du Sang Nouvelle Aquitaine BordeauxFrance Innate Pharma Research Laboratories Innate PharmaMarseilleFrance

Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor *** human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and *** the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone *** analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological *** profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell *** marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate.

关键词： NK cells scRNASeq AML

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Assessment of Genetic Relationship and Application of Computational Algorithm to Assess Functionality of Non-Synonymous Substitutions in DQA2 Gene of Cattle, Sheep and Goats

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Open Journal of Genetics 2015年第4期5卷 145-158页

作者： Steven B. Ugbo Abdulmojeed Yakubu Jude N. Omeje Bwaseh S. Bibinu Ibrahim S. Musa Joseph O. Egahi N. I. dim Department of Animal Breeding and Physiology University of Agriculture Makurdi Nigeria Department of Animal Science Faculty of Agriculture Nasarawa State University Keffi Shabu-Lafia Campus Lafia Nigeria Department of veterinary Medicine and Surgery University of Abuja Abuja Nigeria

The major histocompatibility complex (MHC) is a fundamental part of the immune system in nearly all vertebrates. DQA2 is a member of the MHC complex and an important candidate gene involved in susceptibility/resistance to various diseases. Therefore, the present study aimed at investigating computationally molecular genetic variation of DQA2 gene of cattle, sheep and goats especially on its evolution and differentiation within and among species as well as the attendant effects of the polymorphism on the function of DQA2 gene. A total of thirty three DQA2 nucleotide sequences comprising cattle (10), sheep (12) and goats (11) were retrieved from the GenBank. Forty seven amino acid substitutions of the wild type alleles located in the putative peptide coding region of caprine DQA2 alleles were obtained from the alignment of deduced amino acid sequences of goats. Out of these, eleven amino acid substitutions (H14L, H14R, L34M, E35L, G56S, G56R, 161v, A62E, D69Q, T72N and T72G) were returned neutral;an indication that they did not impair protein function. The Expected Accuracy (EA) ranged from 53% - 87%. For sheep, sixteen amino acid substitutions (A11P, A11T, A11G, A11M, L14S, L14T, v27L, v27S, G35S, S46T, D55E, L57T, L57A, L57G, K65Q and v68I) appeared beneficial while the rest forty seven appeared harmful (EA ranged from 53% - 93%). Twenty four amino acid substitutions did not impair the function of protein while seventy seven substitutions appeared to have a negative effect on the function of protein of cattle (EA ranged from 53% - 94%). The phylogeny based on nucleotide and amino acid sequences of DQA2 gene revealed the close relatedness of the caprine, ovine and bovine species. The present knowledge would be relevant for performing further genotype-phenotype research as well as pharmacogenetics studies in order to show association between caprine, ovine and bovine DQA2 allelic variation and the clinical progression of infectious diseases especially in a developing

关键词： DQA2 Genetic Relationship Amino Acid Substitution Phylogeny Ruminants

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结合多媒体、虚拟现实技术的三维地图在儿童教育中的应用

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导航定位学报 2004年第1期 18-19页

作者： Papadopoulos K Tsioukas v Daniil M 李翔 National Centre for Maps and Cartographic Heritage dim. Poliorkitou 37 GR 546 33 Thessaloniki Greece

在学校的地理教育中使用可视化工具是很自然的,目的是使用各种媒体信息促使知识的寻求、灵活性的创造、结论的形成以及知识结构的构建。这些媒体在完成学生和现实世界的交互方面获得了巨大的成功。可视化的技术有助于使用和发展与地理... 详细信息

在学校的地理教育中使用可视化工具是很自然的,目的是使用各种媒体信息促使知识的寻求、灵活性的创造、结论的形成以及知识结构的构建。这些媒体在完成学生和现实世界的交互方面获得了巨大的成功。可视化的技术有助于使用和发展与地理课程有关的技能。为了达到这样的目标。

关键词：教学地图多媒体虚拟现实

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