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Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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Journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： Carlos R.Oliveira Daniel G.spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-santos soraya s.smaili Gustavo J.s.Pereira André Hinsberger Ezequiel P.viriato Maria Cristina Marcucci Alexandra C.H.F.sawaya samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto Departamento de Farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de Fitocomplexos e sinalizacao Celular Escola de Ciências da Saúde Universidade Anhembi Morumbi Faculdade de Ciências Farmacêuticas e Bioquímicas Oswaldo Cruz Laboratório de Produtos Naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Faculdade de Ciências Farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de Oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its *** study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast ***: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin v/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo ***: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated ***: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis Cell death Breast cancer Angelicin

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乡间雪景

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英语世界 2020年第12期39卷 14-18页

作者： v.s.奈保尔兰秀娟北京语言大学

v. s.奈保尔(1932—2018),印度裔英国作家,曾获布克奖、毛姆奖、英国大卫·柯恩文学奖等奖项,并于2001年获得诺贝尔文学奖。奈保尔曾在世界各地广泛游历,创作了大量以亚、非、拉等第三世界为题材的小说与游记。本文节选自奈保尔的小说...

v. s.奈保尔(1932—2018),印度裔英国作家,曾获布克奖、毛姆奖、英国大卫·柯恩文学奖等奖项,并于2001年获得诺贝尔文学奖。奈保尔曾在世界各地广泛游历,创作了大量以亚、非、拉等第三世界为题材的小说与游记。本文节选自奈保尔的小说《抵达之谜》(The Enigma of Arrival,1987)第一章"杰克的花园"(Jack’s Garden)。该小说以倒叙的手法再现了奈保尔在英国的乡村庄园以及旅行中对自我和世界的审视。小说字里行间彰显了作者对景与物的敏锐洞察力,满含他对英国乡村庄园的人与景的怀念。在作者的回忆中,他的故乡特立尼达与英国乡村的四季交替出现,展现了他作为异乡人的孤独。

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The Use of Medical Apparatus of THz-Therapy “Ka ve Tche-O2-Orbit” on 129.0 GHz on Molecular spectrum of Radiation and Absorbation of Atmospheric Oxygen in Healthy volunteers and in Patients with Involutional Macular Degeneration

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Journal of Electromagnetic Analysis and Applications 2013年第12期5卷 415-419页

作者： vyacheslav F. Kirichuk Larisa E. Fedorischeva Ksenya U. Eremenko Anatolya F. Cypyaschuk Elena v. Ponukalina Alexander A. Tsymbal Irina v. smychlyaeva Olga N. Antipova Tatyana s. velikanova Elena s. Olenko Liliana K. Tokaeva Natalia E. Babichenko saratov state Medical University Named after v.I. Razumovskiy Saratov City Russia.

The study aims at the influence of THz radiation on 129.0 GHz of atmospheric oxygen on arterial pressure (A/P) and pulse, hemodynamic parameters of orbital arteries during the irradiation of biological active points of application in healthy volunteers and in patients with involutional macular degeneration (IMD). A decrease of systolic and diastolic components of arterial pressure and pulse, and a normalization of systolic velocity of bloodstream (CvB) and of resistance index (RI) in orbital arteries in patients with IMD are noticed. The results of the research are: 1) the method of THz influence on 129.0 GHz on molecular spectrum of radiation and absorbation of atmospheric oxygen is safe and doesn’t cause any negative side effects on common state in healthy volunteers and in patients with IMD;2) single influence of THz waves on 129.0 GHz on molecular spectrum of radiation and absorbation of atmospheric oxygen is caused to statistical important improvement in vascular system of eyeball.

关键词： THz Waves Atmospheric Oxygen Dopplerography Orbital vessels Maculodystrophy

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通过日粮调控缓解鸡的跛行

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国外畜牧学（猪与禽） 2004年第1期24卷 60-63页

作者：刘伟志 s.v.Rama Rao 博士印度

营养平衡良好的日粮加上良好的管理,是获取最佳生产性能所必需的.当前,大多数家禽育种机构都采用体重或产蛋率作为选育的主要标准,以便使现代商品肉鸡和蛋鸡分别具有快速生长和高产蛋率的遗传潜力.由于鸡的主要机体资源都被用来支持其... 详细信息

营养平衡良好的日粮加上良好的管理,是获取最佳生产性能所必需的.当前,大多数家禽育种机构都采用体重或产蛋率作为选育的主要标准,以便使现代商品肉鸡和蛋鸡分别具有快速生长和高产蛋率的遗传潜力.由于鸡的主要机体资源都被用来支持其高生产率,所以只有极小一部分(如果还有的话)被用来满足其它代谢活动和免疫活动的需要.

关键词：日粮调控鸡跛行症状选育营养水平

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小规模开采需要一个合适的定义

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采矿技术 1987年第14期 3-4页

作者： s.v.阿利熊宠民印度矿物开发署采矿顾问

印度采矿工业已具有相当的规模。1984年采矿量2.4亿吨,剥离量4.5亿吨,到2000年将分别达到6亿吨和24亿吨,高度机械化的马兰杰坎德露天铜矿年采剥量为1000万吨,剥采比4∶1。库德雷穆克铁矿设计规模为年产磁铁矿石2250万吨。尼加海矿的年... 详细信息

印度采矿工业已具有相当的规模。1984年采矿量2.4亿吨,剥离量4.5亿吨,到2000年将分别达到6亿吨和24亿吨,高度机械化的马兰杰坎德露天铜矿年采剥量为1000万吨,剥采比4∶1。库德雷穆克铁矿设计规模为年产磁铁矿石2250万吨。尼加海矿的年设计生产能力为1400万吨,生产采用20米3电铲和170吨汽车,剥采比5∶1,作业深度300～400米。

关键词：矿山生产小矿山投资矿物财政管理定义卢比坑口产量铁矿石

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改善砂型铸件表面质量的方法

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铸造技术 1982年第2期 67-71页

作者： s.Doroshenko v.Droblazk 王乐仪西北工业大学

铸件和粘砂层结合在一起的环节,是渗入的金属脉络和氧化铁膜。如果氧化铁膜具有足够的厚度(约100mk),那么粘砂层很容易从铸件表面除去。

关键词：粘砂层砂芯涂料层厚度金属金属材料附着强度砂型铸件氧化铁铸型材料

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Decreased plasma urotensin Ⅱ levels inversely correlate with extent and severity of coronary artery disease

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Journal of Geriatric Cardiology 2007年第2期4卷 105-110页

作者： v. Borlongan Christine E. stahl Department of Neurology Medical College of Georgia Augusta GA 30912 USA Department of Internal Medicine Dwight D. Eisenhower Army Medical Center Fort Gordon GA 30909 USA

Objective To determine the plasma urolensin Ⅱ(UII) levels in various types of coronary heart disease and to clarify how the plasma UII levels correlate with the clinical presentation, extent and severity of coronary artery atherosclerosis (CAD). Methods: One hundred and three aged patients undergoing elective diagnostic coronary angiography for proven or clinical suspected coronary heart disease were enrolled in this study. The extent and severity of coronary artery disease were evaluated by vessel score and Gensini score, respectively. Plasma UII levels were measured by radioimmunoassay. Results: The plasma UII levels in the patients with modest to severe coronary stenosis (3.03±0.34 pg/ml, 1.83±0.67 pg/ml) were significantly lower than that in subjects with normal coronary artery (4.80±1.11 pg/ml, Psma UII levels in patients with coronary heart disease were also significantly lower than that in patients with insignificant coronary stenosis (P s with stable angina pectoris, plasma UII levels in patients with acute coronary syndrome were significantly decreased (1.89±0.51 pg/ml vs 2.42±0.77 pg/ml, P sma UII levels were found to be negatively correlated with the severity of coronary artery stenosis (r = -0.488, Ps well as the vessel score (r = -0.408, Ps with CAD. Conclusion: significant inverse correlations exist between the plasma UII levels, and the extent and severity of coronary artery stenosis. These findings suggest that plasma UII contribute to the development and progression of coronary artery stenosis, and may be a novel marker to predict clinical types, as well as the extent and severity of coronary artery disease in the patients.

关键词： Urotensin Ⅱ Coronary artery atherosclerosis Coronary heart disease

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Analysis of interrelationship between pedestrian flow parameters using artificial neural network

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Journal of Modern Transportation 2015年第4期23卷 298-309页

作者： Pritikana Das M.Parida v.K.Katiyar Centre for Transportation systems Indian Institute of Technology Roorkee Department of Civil Engineering Transportation Engineering Group Indian Institute of Technology Roorkee Department of Mathematics Indian Institute of Technology Roorkee

Pedestrian flow parameters are analysed in this study considering linear and non-linear relationships between stream flow parameters using conventional and soft computing approach. speed-density relationship serves as a fundamental relationship, single-regime con- cepts and deterministic models like Greenshield and Underwood were applied in the study to describe bidirec- tional flow characteristics on sidewalks and carriageways around transport terminals in India. Artificial Neural Net- work （ANN） approach is also used for traffic flow mod- elling to build a relationship between different pedestrian flow parameters. A non-linear model based on ANN is suggested and compared with the other deterministic models. Out of the aforesaid models, ANN model demonstrated good results based on accuracy measure- ment. Also these ANN models have an advantage in terms of their self-processing and intelligent behaviour. Flow parameters are estimated by ANN model using MFD （Macroscopic Fundamental Diagram）. Estimated mean absolute error （MAE） and root mean square error （RMsE）values for the best fitted ANN model are 3.83 and 4.73 m/ min, respectively, less than those for the other models for sidewalk movement. Further estimated MAE and RMsE values of ANN model for carriageway movement are 4.02 and 4.98 m/min, respectively, which are comparatively less than those of the other models. ANN model gives better performance in fitness of model and future prediction of flow parameters. Also when using linear regression model between observed and estimated values for speed and flow parameters, performance of ANN model gives better fitness to predict data as compared to deterministic model. R value for speed data prediction is 0.756 and for flow data pre- diction is 0.997 using ANN model at sidewalk movement around transport terminal.

关键词： ANN Pedestrian flow modelling Macroscopic flow diagram MAE RMsE

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Anomalously enhanced thermal stability of phosphorene via metal adatom doping: An experimental and first-principles study

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Nano Research 2016年第9期9卷 2687-2695页

作者： Xuewei Feng vadym v.Kulish Ping Wu xinke Liu Kah-Wee Ang Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Singapore Entropic Interface Group(EIG) Engineering Product DevelopmentSingapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore College of Materials science and Engineering Shenzhen Engineering Laboratory for Advanced Technology of CeramicsNanshan District Key Lab for Biopolymer and Safety EvaluationShenzhen University3688 Nanhai AvenueShenzhen 518060China

Atomically thin black phosphorus, also known as phosphorene, is an emerging two-dimensional (2D) material, which has attracted increasing attention due to its unique electronic and optoelectronic properties. However, the reduced thermal stability of phosphorene limits its suitability for high-temperature fabrication processes, which could be detrimental for the performance of phosphorenebased devices. Here, we investigate the impact of doping by Al and Hf transition metal adatoms on the thermal stability of phosphorene. The formation of Al–P covalent bonds was found to significantly improve the thermal coefficients of the Ag1, B2g, and Ag2phonon modes to 0.00044, 0.00081, and 0.00012 cm–1·°C–1, respectively, which are two orders of magnitude lower than those observed for pristine P–P bonds (~0.01 cm–1·°C–1). First-principles calculations within the density functional theory framework reveal that the observed thermal stability enhancement in the Al-doped material reflects a significantly higher Al binding energy, due to the stronger Al–P bonds compared to the weak van der Waals interactions between adjacent P atoms in the undoped material. The present work thus paves the way towards phosphorene materials with improved structural stability, which could be promising candidates for potential nanoelectronic and optoelectronic applications. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and springer-verlag Berlin Heidelberg.

关键词： phosphorene black phosphorus adatom doping transition metals thermal stability

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Endoscopic ultrasound guided gastrojejunostomy for gastric outlet obstruction

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World Journal of Gastrointestinal surgery 2021年第7期13卷 620-632页

作者： sebastian stefanovic Peter v Draganov Dennis Yang Department of Gastroenterology and Hepatology University Medical Center LjubljanaLjubljana 1000Slovenia Division of Gastroenterology Hepatologyand NutritionUniversity of Florida College of MedicineGainesvilleFL 32608United States

Gastric outlet obstruction(GOO)is a clinical syndrome secondary to luminal obstruction at the level of the stomach and/or *** can be caused by either benign or malignant etiologies,often resulting in early satiety,nausea,vomiting and poor oral *** is associated with decreased quality of life and has been shown to significantly impact survival in patients with advanced *** treatment options for GOO can be broadly divided into surgical[surgical gastrojejunostomy(GJ)]and endoscopic interventions(dilation and/or placement of luminal self-expanding metal stents).While surgical GJ has been shown to provide a more lasting relief of symptoms when compared to luminal stenting,it has also been associated with a higher rate of adverse ***,many patients with advanced metastatic disease are not good surgical *** recently,endoscopic ultrasound(EUs)-guided GJ has emerged as a potential alternative to traditional surgical and endoscopic *** review focuses on the new advances and technical aspects of EUs-GJ and clinical outcomes in the management of both benign and malignant disease.

关键词： Gastric outlet obstruction Interventional endoultrasonography Gastrojejunostomy Duodenal stenting Balloon dilatation

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