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Chinese physics Letters 2005年第2期22卷 413-415页

作者：徐荣昆李正宏宁佳敏郭存许泽平杨建伦李林波夏广新毕欣生丁宁刘强顾元朝 E.v.Grabovsky G.M.Oleynic S.L.Nedoseev v.v.Alexandrov K.N.Mitrofanov M.v.Zurin G.S.volkov I.A.porofeev I.N.Frolov v.p.smirnov ChinaAcademyofEngineeringphysics POBox919-212Mianyang621900 TroitskInstituteforInnovationandThermonuclearResearches Troitsk142190Russia

We report and discuss the results of x-ray radiation measurements in the Sino-Russian joint Z-pinch experiments on Angara-5-1 facility with a load current of 2.5–3.6MA. The measurements were conducted by using an x-ray power meter (XRpM) and a time-resolved one-dimensional x-ray imaging system developed in China Academy of Engineering physics. The experimental results indicate that an x-ray power-platform prior to a main peak and a less intensive sub-peak after the main peak in the waveform exist for the nested-wire array implosions, and the radiation process is relatively faster than that in the case of the single array. Laser shadowgraph of the imploding plasma suggests that the prior power-platform is a result of the collision of the inner-outer plasma layers. The faster radiation process of nested array implosion can be explained by analysing the corresponding result of the time-resolved one-dimensional imaging system, which demonstrates a better axial imploding uniformity and synchronization. In comparison with x-ray diode, the XRpM yields a higher height of x-ray power-platform due to its flat energy response. The sub-peak after the main peak is proposed to be a result of the later-time additional implosion of plasma.

关键词： Z-箍缩 X-线放射特征测量方法激光投影等离子体

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中俄Z-pinch联合实验新进展

物理学报 2011年第4期60卷 400-405页

作者：徐荣昆李正宏杨建伦丁宁周秀文蒋世伦章法强王真许泽平宁家敏李林波 E.v.Grabovsky G.M.Oleynic v.v.Alexandrov v.p.smirnov 核物理与化学研究所绵阳621900 北京应用物理与计算数学研究所北京100094 中国工程物理研究院激光与聚变研究中心绵阳621900 Troitsk Institute for Innovation and Thermonuclear Researches Troitsk 142190Russia

在Angara-5-1装置Z-pinch实验中,研究了双层丝阵内爆动力学模式和动态黑腔,获得高产额X射线辐射能量和功率,X射线辐射功率达5.6TW,泡沫X射线辐射温度达63ev,本文给出主要实验设计方法和结果.

关键词： Z箍缩双层丝阵 X射线辐射动态黑腔

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铝-钨丝混编阵的Z-箍缩实验研究

物理学报 2004年第7期53卷 2244-2249页

作者：宁成李正宏华欣生徐荣昆彭先觉许泽平杨建伦郭存蒋世伦丰树平杨礼兵晏成立宋凤军 v.p.smirnov Yu.G.Kalinin A.S.Kingsep A.S.Chernenko E.v.Grabovsky 中国工程物理研究院绵阳621900 Russia Research Center "Kurchatov Institute " Troitsk Institute for Innovation and Fusion Research

利用铝丝和钨丝混合编制的丝阵作为Z 箍缩的负载 ,在俄罗斯Kurchatov研究所的S 30 0强流装置上对其Z 箍缩过程进行了实验研究 ,并与纯铝丝阵和纯钨丝阵的实验结果进行了比较 .不同材料组成的丝阵的Z 箍缩x射线能谱之间有明显差异 ,混编... 详细信息

利用铝丝和钨丝混合编制的丝阵作为Z 箍缩的负载 ,在俄罗斯Kurchatov研究所的S 30 0强流装置上对其Z 箍缩过程进行了实验研究 ,并与纯铝丝阵和纯钨丝阵的实验结果进行了比较 .不同材料组成的丝阵的Z 箍缩x射线能谱之间有明显差异 ,混编丝阵的铝K壳层的x射线辐射强度比纯铝丝阵的弱 ,在纯钨丝阵Z 箍缩中没有发现波长小于 1 6nm的线辐射 .混编丝阵Z 箍缩的x射线发光区域比纯铝丝阵的小 ,但比纯钨丝阵的大 ,混编丝阵的x射线产额比纯铝丝阵的大 ,但比纯钨丝阵的略低 .在驱动电流为 2 5— 2 8MA条件下 ,Z 箍缩的径向收缩比为 4— 5 ,x射线辐射脉冲脉宽为 2 5ns左右 ,峰值为 0 3— 0 5TW ,总能量为 10— 2 0kJ.激光探针的阴影像显示了丝阵等离子体形成的细致过程 ,还表明了等离子体的边界面不够清晰 ,其不稳定性有明显的发展 ,内部有丰富的结构 .

关键词： Z-箍缩混编丝阵 S-300强流装置铝丝钨丝等离子体物理

Investigation of Al plasmas from thin foils irradiated by high-intensity extreme ultraviolet

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Matter and Radiation at Extremes 2017年第3期2卷 129-138页

作者： E.v.Grabovski p.v.Sasorov A.p.Shevelko v.v.Aleksandrov S.N.Andreev M.M.Basko A.v.Branitski A.N.Gritsuk G.S.volkov Ya.N.Laukhin K.N.Mitrofanov G.M.Oleinik A.A.Samokhin v.p.smirnov I.Yu.Tolstikhina I.N.Frolov O.F.Yakushev State Research Center of the Russian Federation Troitsk Institute for Innovation and Fusion Research 108840TroitskMoscowRussia Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences Miusskaya pl.4125047MoscowRussia p.N.Lebedev physical Institute of the Russian Academy of Sciences Leninsky pr.53Moscow119991Russia

Dynamics and spectral transmission of Al plasma produced by extreme ultraviolet(EUv)irradiation of 0.75-mm thick Al foil is *** EUv radiation with the peak power density in the range of 0.19-0.54 TW/cm 2 is provided by Z-pinch formed by W multiwire array implosion in the Angara-5-1 *** of the experiment ensures that there are no plasma fluxes from the pinch toward the Al foil and *** same EUv source is used as a back illuminator for obtaining the absorption spectrum of Al plasma in the wavelength range of 5e24 *** comprises absorption lines of ions Al^(4+),Al^(5+),Al^(6+),Al^(7+).Analysis of relative intensities of the lines shows that those ions are formed in dense Al plasma with a temperature of~20 *** of Al plasma has been investigated with transverse laser *** have also performed radiation-gas-dynamics simulations of plasma dynamics affected by external radiation,which includes self-consistent radiation transport in a plasma *** simulations show good agreement with an experimental absorption spectrum and with experimental data concerning plasma dynamics,as well as with the analysis of line absorption *** confirms the correctness of the physical model underlying these simulations.

关键词： Z-pinch Dense plasma transparency

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Semantic Segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v v Shiloah Elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(pA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez philip v.peplow Department of pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a pubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a pubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a pubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(pTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in pTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for pTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

Ion-conducting Membranes Based on Bacterial Cellulose Nanofibers Modified by poly(sodium acrylate-co-2-acrylamido-2-methylpropanesulfonic acid)

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Chinese Journal of polymer Science 2024年第3期42卷 333-343,I0007页

作者： Elizaveta v.Batishcheva Nikolay N.smirnov Natalya v.Bobrova Maria p.Sokolova Michael A.smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

Green method for preparation of ion-conducting membranes(ICM) based on bacterial cellulose nanofibers(CNF) modified by a copolymer of sodium acrylate and 2-acrylamido-2-methylpropanesulfonic acid was elaborated. FTIR and NMR data confirmed grafting of polyacrylate onto cellulose surface. Formation of porous structure of the ICM was controlled by SEM and AFM. The maximal ionic conductivity of the membranes reaches 1.5 and 3.1 mS·cm^(-1)(60 ℃ and 98% relative humidity) when they are saturated with water or H_2SO_4(1 mol·L^(-1)) electrolyte,respectively. prepared ICM was tested as a separator in a symmetrical supercapacitor with electrodes based on polyaniline hydrogel. The assembled cell demonstrate ability to operate at high current density up to 100 A·g^(-1) maintaining specific capacitance 165 F·g^(-1). Maximal specific capacitance of 289 F·g^(-1) was achieved at current density 1 A·g^(-1). Retaining of 90% of initial capacitance after 10000 of charge-discharge cycles proves high electrochemical stability of prepared ICM.

关键词： Bacterial cellulose Ion conductivity porous membrane Supercapacitor