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metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

Cellular & molecular Immunology 2024年第1期21卷 33-46页

作者： Anja meyer Stephanie R.Zack Wes Nijim Adel Burgos vishwa Patel Brian Zanotti michael v.volin m.Asif Amin myles J.Lewis Costantino Pitzalis Shiva Arami Joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown va medical Center ChicagoILUSA Department of medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AmPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated mitofusin-2 and DRP1 *** found that vEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of vEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

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A-site ordered state in manganites with perovskite-like structure based on optimally doped compounds Ln0.70Ba0.30mnO3（Ln=Pr,Nd）

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Journal of Rare Earths 2019年第11期37卷 1242-1249页

作者： S.v.Trukhanov va Khomchenko D.v.Karpinsky m.v.Silibin A.v.Trukhanov L.S.Lobanovsky H.Szymczak C.E.Botez I.O.Troyanchuk National University of Science and Technology mISiS 119049 MoscowLeninsky Av.4Russia South Ural State University 454080 ChelyabinskLenin Av.76Russia Scientific-Practical materials Research Centre of NASB 220072 MinskBelarus CFisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal National Research University of Electronic Technology"mIET 124498 ZelenogradMoscowRussia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University2-4 Bolshaya Pirogovskaya St.119991 MoscowRussia Institute of Physics Polish Academy of Sciences02-668 WarsawPoland The University of Texas at El Paso El PasoTX 79968-0515USA

In this paper,we report on the crystal structure and magnetic properties of the nano structured Baordered phases of rare-earth manganites obtained from the optimally doped solid solutions Ln0.70Ba0.30mnO3(Ln=Pr,Nd).The materials were studied by X-ray diffraction,scanning electron microscopy,energy dispersive spectroscopy and SQUID-magnetometry *** is found that states with different degrees of cation ordering in the A-sublattice of the ABO3 perovskite can be obtained by employing special conditions of chemical *** particular,reduction of the parent compounds results in the formation of a nanocomposite containing ferrimagnetic anion-deficient ordered phase *** of the composite does not change an average size of the nanocrystallites,but drastically alters their phase composition to stabilize ferromagnetic stoichiometric ordered phase LnBamn2O6 and ferromagnetic superstoichiometric disordered phase Ln0.90Ba0.10mnO3+δ.It is shown that the magnetic properties of the materials are determined by the joint action of chemical(cation ordering)and external(surface tension)pressures.

关键词： Ionic order magnetic transition Perovskite manganite Rare earths

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Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease

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Neural Regeneration Research 2021年第4期16卷 775-779页

作者： Gabriela vacínová Daniela vejražkova Robert Rusina Iva Holmerová Hana vaňková Eva Jarolímová Josef včelák Běla Bendlová markéta vaňková Department of molecular Endocrinology Institute of EndocrinologyPragueCzech Republic Department of Anthropology and Human Genetics Faculty of ScienceCharles UniversityPragueCzech Republic Department of Neurology Third Faculty of Medicine of Charles University and Thomayer Hospital PragueCzech Republic II.Internal medicine Clinic Third Faculty of MedicineCharles UniversityPragueCzech Republic Faculty of Humanitites Charles University PragueCzech Republic

Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic *** upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid *** in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a *** aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of *** levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(mTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the *** RANTES levels were not correlated with cognitive *** AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory *** levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOmA-R)and pancreatic beta cell function(HOmA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD *** levels of RANTES appear to be an interesting

关键词： Alzheimer’s disease biomarker central nervous system cognitive impairment inflammation RANTES

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Azithromycin in a triple therapy for *** eradication in active duodenal ulcer

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World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya Petr va.Grigoriev Yuri v.vasiliev Emilia P.Yakovenko Pavel v.Gulyaev valeri I.Fedchenko v.vasilenko Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia Pathology Department of the moscow Sechenov medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIm:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing active duodenal ulcer and *** eradication. mETHODS:100 patients with active duodenal ulcer were included in the open,multicentre,randomized study with comparative *** were randomly assigned to one of the following one-week triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAm,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was given after the eradication course as a monotherapy for three *** control endoscopy was performed 8 weeks after the *** was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAm group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in 48 patients of the OAm group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAm(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (Pmeprazole, amoxicillin and metronidazole failed to eradicate ***'vc\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. macrolide with amoxicillin are preferable to achieve higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple PPI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Ulcer Agents Azithromycin Comparative Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans male metronidazole middle Aged Omeprazole Penicillins Research Support, Non-U.S. Gov't Treatment Outcome

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Autoimmune pancreatitis: Functional and morphological recovery after steroid therapy

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World Journal of Gastroenterology 2006年第11期12卷 1810-1812页

作者： László Czakó (E|')va Hegyk(o|¨)zi Attila Pálinkás János Lonovics First Department of medicine University of Szeged SzegedHungary Elizabeth Hospital Hódmez(o|″)vásárhely Hungary

Autoimmune pancreatitis, a recently recognized type of chronic pancreatitis, is not rare in Japan, but reports of it elsewhere are relatively uncommon. We report the first preoperatively diagnosed case of autoimmune pancreatitis in Hungary, which responded well to steroid treatment and provided radiographic and functional evidence of this improvement. A 62-year-old female presented with a 4-month history of recurrent epigastric pain and a 5-kg weight loss. The oral glucose tolerance test （OGTT） indicated diabetes mellitus and the result of the fecal elastase test was abnormal. Ultrasonography （US） and the CT scan demonstrated a diffusely enlarged pancreas, and endoscopic retrograde cholangiopancreatography （ERCP） an irregular main pancreatic duct with long strictures in the head and tail. Autoimmune pancreatitis was diagnosed. The patient was started on 32 mg prednisolone daily, After 4 wk, the OGTT and faecal elastase test results had normalized. The repeated US and CT scan revealed a marked improvement of the diffuse pancreatic swelling, while on repeated ERCP, the main pancreatic duct narrowing was seen to be ameliorated. It is important to be aware of this disease and its diagnosis, because AIP can clinically resemble pancreatobiliary malignancies, or chronic or acute pancreatitis, However, in contrast with chronic pancreatitis, its symptoms and morphologic and laboratory alterations are completely reversed by oral steroid therapy.

关键词： Autoimmune pancreatitis Steroid therapy Chronic pancreatitis Pancreatic endocrine function Pancreatic exocrine function

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Analyzing Changes in maize Leaves Orientation due to GxExm Using an Automatic method from RGB Images

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Plant Phenomics 2023年第2期5卷 239-252页

作者： mario Serouart Raul Lopez-Lozano Gaëtan Daubige maëva Baumont Brigitte Escale Benoit De Solan Frédéric Baret Arvalis Institut du végétal228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France Arvalis Ecophysiology21 Chemin de Pau64121 MontardonFrance

The sowing pattern has an important impact on light interception efficiency in maize by determining the spatial distribution of leaves within the *** orientation is an important architectural trait determining maize canopies light *** studies have indicated how maize genotypes may adapt leaves orientation to avoid mutual shading with neighboring plants as a plastic response to intraspecific *** goal of the present study is 2-fold:firstly,to propose and validate an automatic algorithm(Automatic Leaf Azimuth Estimation from midrib detection[ALAEm])based on leaves midrib detection in vertical red green blue(RGB)images to describe leaves orientation at the canopy level;and secondly,to describe genotypic and environmental differences in leaves orientation in a panel of 5 maize hybrids sowing at 2 densities(6 and 12 plants.m^(−2))and 2 row spacing(0.4 and 0.8 m)over 2 different sites in southern *** ALAEm algorithm was validated against in situ annotations of leaves orientation,showing a satisfactory agreement(root mean square[RmSE]error=0.1,R^(2)=0.35)in the proportion of leaves oriented perpendicular to rows direction across sowing patterns,genotypes,and *** results from ALAEm permitted to identify significant differences in leaves orientation associated to leaves intraspecific *** both experiments,a progressive increase in the proportion of leaves oriented perpendicular to the row is observed when the rectangularity of the sowing pattern increases from 1(6 plants.m^(−2),0.4 m row spacing)towards 8(12 plants.m^(−2),0.8 m row spacing).Significant differences among the 5 cultivars were found,with 2 hybrids exhibiting,systematically,a more plastic behavior with a significantly higher proportion of leaves oriented perpendicularly to avoid overlapping with neighbor plants at high *** in leaves orientation were also found between experiments in a squared sowing pattern(6 plants.m^(−2),0.4 m

关键词： cultivar spacing pattern

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Effect of welding parameters on semisolid stir welding of mg-9Al-1Zn magnesium alloy

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Transactions of Nonferrous metals Society of China 2016年第10期26卷 2586-2594页

作者： v.A.HOSSEINI H.AASHURI A.H.KOKABI Department of Engineering Science University West materials Science and Engineering Department Sharif University of Technology

Semisolid stir welding of AZ91 was investigated with focus on the joining temperature and rotational speed. An mg-25%Zn interlayer was located between two AZ91 pieces and the system was heated up to the semisolid state of base metal and interlayer. The weld seam was stirred using a drill-tip at different joining temperatures and rotational speeds. Optical and scanning electron microscopes were employedto study microstructure, cavity formation, and segregation. Hardness profile and shear punch test werealso employed to rank the welds based on their quality and homogeneity. Results showed that the lowest cavity content （2.1%） withthemaximum ultimate shear strength （about 188 mPa） was obtained in weld with the joining temperatureof530℃ and the rotational speedof1600 r/min. Low quality welds and a reduction of ultimate shear strength were observed at very high orlow rotational speeds and joining temperatures. The process, in conclusion, produced close mechanical properties to those of thebase metal and homogenous quality throughout the joint, when the intermediate temperature and rotational speeds were employed.

关键词： mg-Al-Zn alloy mechanical stirring semisolidstir welding

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Genomic,Lipidomic,and metabolomic Analysis of Cyclooxygenase-null Cells:Eicosanoid Storm,Cross Talk,and Compensation by COX-1

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Genomics, Proteomics & Bioinformatics 2016年第2期14卷 81-93页

作者： Abul B.m.m.K.Islam mandar Dave Sonia Amin Roderick v.Jensen Ashok R.Amin Department of Genetic Engineering and Biotechnology University of DhakaDhaka 1000Bangladesh Department of Rheumatology New York University Hospital for Joint DiseasesNew YorkNY 10003USA Department of Biology and Chemistry Essex County CollegeNewarkNJ 07102USA Department of Biological Sciences College of ScienceVirginia Tech BlacksburgVA 24060USA Department of Pathology New York University School of MedicineNew YorkNY 10016USA Rheumatrix Inc. BlacksburgVA 24060USA

The constitutively-expressed cyclooxygenase 1（COX-1） and the inducible COX-2 are both involved in the conversion of arachidonic acid（AA） to prostaglandins（PGs）.However,the functional roles of COX-1 at the cellular level remain *** hypothesized that by comparing differential gene expression and eicosanoid metabolism in lung fibroblasts from wild-type（WT） mice and COX-2^（-/-） or COX-1^（-/-） mice may help address the functional roles of COX-1 in inflammation and other cellular *** to WT,the number of specifically-induced transcripts were altered descendingly as follows：COX-2^（-/-）〉 COX-1^（-/-）〉 WT ＋ IL-1β.COX-1^（-/-） or COX-2^（-/-） cells shared about 50%of the induced transcripts with WT cells treated with IL-1β,*** interactive ＂anti-inflammatory,proinflammatory,and redox-activated＂ signature in the protein-protein interactome map was observed in COX-2^（-/-） *** augmented COX-1mRNA（in COX-2^（-/-） cells） was associated with the upregulation of mRNAs for glutathione S-transferase（GST）,superoxide dismutase（SOD）,NAD（P）H dehydrogenase quinone 1（NQO1）,aryl hydrocarbon receptor（AhR）,peroxiredoxin,phospholipase,prostacyclin synthase,and prostaglandin E synthase,resulting in a significant increase in the levels of PGE2,PGD2,leukotriene B4（LTB4）,PGF（1α）,thromboxane B2（TXB2）,and PGF（2α）.The COX-1 plays a dominant role in shifting AA toward the LTB4 pathway and anti-inflammatory *** to WT,the upregulated COX-1 mRNA in COX-2^（-/-） cells generated an ＂eicosanoid storm＂.The genomic characteristics of COX-2^（-/-） is similar to that of proinflammatory cells as observed in IL-1β induced WT ***-1^（-/-） and COX-2^（-/-） cells exhibited compensation of various eicosanoids at the genomic and metabolic levels.

关键词： Prostaglandins metabolomics Lung fibroblasts Genomies Inflammation

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Is autophagy induction by PARP inhibitors a target for therapeutic benefit?

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Oncology Research 2022年第1期30卷 1-12页

作者： AHmED m.ELSHAZLY TUONG vI v.NGUYEN DAvID A.GEWIRTZ Department of Pharmacology and Toxicology Virginia Commonwealth UniversityMassey Cancer CenterRichmondVA23298USA Department of Pharmacology and Toxicology Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh33516Egypt

PARP inhibitors have proven to be effective in conjunction with conventional therapeutics in the treatment of various solid as well as hematologic malignancies,particularly when the tumors are deﬁcient in DNA repair ***,as the case with other chemotherapeutic agents,their effectiveness is often compromised by the development of *** inhibitors have consistently been reported to promote autophagy,a process that maintains cellular homeostasis and acts as an energy source by the degradation and reutilization of damaged subcellular organelles and *** can exhibit different functional properties,the most prominent being *** addition,both cytotoxic and non-protective functions forms have also been identiﬁ*** this review,we explore the available literature regarding the different roles of autophagy in response to clinically-used PARP inhibitors,highlighting the possibility of targeting autophagy as an adjuvant therapy to potentially increase the effectiveness of PARP inhibition and to overcome the development of resistance.

关键词： Olaparib Niraparib Rucaparib Talazoparib Autophagy Cytoprotective Cytotoxic Non-protective

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Removal of As(v)in the presence of Cr(vI)in contaminated water from the Bajio region of mexico using ferrihydrite-functionalized graphene oxide(GOFH):A case study

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Emerging Contaminants 2024年第3期10卷 134-144页

作者： D.R.Joya-Cardenas J.P.Rodríguez-Caicedo m.A.Corona-Rivera N.Saldana-Robles C.E.Damian-Ascencio A.Saldana-Robles Graduate Program in Biosciences University of GuanajuatoIrapuato36500Mexico Facultad de Ingenierías y Tecnologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia Chemical Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico Department of Agricultural Engineering University of GuanajuatoIrapuato36500Mexico Department of mechanical Engineering University of GuanajuatoSalamanca36800Mexico mechanical Engineering Department Virginia TechBlacksburgVA24061USA

The presence of heavy metals such as arsenic(As)and chromium(Cr)can be considered one of the most toxic heavy *** study aims to develop and evaluate a graphene oxide(GO)based material functionalized with ferrihydrite for the removal of As(v)in the presence of Cr(vI).The adsorbent ferrihydrite-functionalized graphene oxide(GOFH)was characterized by SEm,FTIR,XRD,XPS,surface charge,BET and *** adsorption capacities for As(v)and Cr(vI)were 160 and 66 mg g^(-1)respectively at pH 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(v)with an adsorption capacity of 137 mg g^(-1)in the presence of 20 mg L^(-1)Cr(vI)at room *** analysis revealed an exothermic and spontaneous ***,GOFH effectively removed several coexisting anions from groundwater,including SO_(4)^(2-),CO_(3)^(2-)and Cl^(-).This work evidences the potential of GOFH for competitive adsorption of priority pollutants from complex *** GOFH material represents a technically and economically viable technology for application in groundwater decontamination,as it requires inexpensive precursors and ambient conditions during synthesis and operation.

关键词： Competition Ions Contamination Groundwater Adsorption capacity

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