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Journal of Magnesium and Alloys 2023年第2期11卷 462-479页

作者： Jiheon Jun vineet v.joshi Alasdair Crawford vilayanur viswanathan Donovan N.Leonard Jian Chen Piyush Updadhyay Yong Chae Lim Zhili Feng Oak Ridge National Laboratory Oak RidgeTNUSA Pacific Northwest National Laboratory RichlandWashingtonUSA

Galvanic corrosion of AZ31B joined with bare or Zn-coated DP590 steel by ultrasonic spot welding or linear friction stir welding was quantitatively studied by pre-defining anode and cathode in the lap joint samples. Corrosion volume and depth from Mg anode surfaces exposed to 0.1 M sodium chloride solution was analyzed as functions of cathode surface type and welding method. Characterization of as-welded joints was performed to identify any microstructural feature of the bonding zone that could impact galvanic corrosion *** modeling with modified user subroutine was conducted to simulate the progression of Mg corrosion in the same joint and electrode configurations used for the corrosion experiments. The experimental results indicated that Zn-coated cathode surface can reduce Mg galvanic corrosion significantly as galvanic polarization and cathodic current on Zn-coated surface remained relatively low for Mg in the weld *** modeling described the growth of Mg galvanic corrosion in a reasonable manner but showed limitation by underestimating the corrosion volume as it did not capture self-corrosion.

关键词： Mg alloy Zn coating Ultrasonic spot welding Friction stir welding Galvanic corrosion

Effect of corrosion behavior of cast and extruded ZK60 magnesium alloys processed via friction extrusion

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Journal of Magnesium and Alloys 2024年第9期12卷 3553-3573页

作者： A.Sharma v.Beura D.Zhang J.Darsell S.Niverty v.Prabhakaran N.Overman D.R.Herling v.joshi K.Solanki School for Engineering of Matter Transportand EnergyArizona State UniversityTempeAZ 85287USA Pacific Northwest National Laboratory RichlandWAUSA

The increasing demand for high-strength,corrosion-resistant magnesium alloys in transportation has led to the development of new processing *** this work,cast and extruded ZK60 magnesium alloys were processed using the innovative solid-phase process,Friction Extrusion(FE).The microstructure was analyzed using Scanning Electron Microscopy(SEM),and Energy Dispersive Spectroscopy(EDS),showing a marked reduction in grain size,uniform solute distribution(Zn and Zr),and second phases after FE ***,optical micrographs and Electron Backscatter Diffraction(EBSD)were employed to further evaluate the alloy *** corro-sion resistance and electrochemical behavior were analyzed using potentiodynamic polarization,Scanning Electrochemical Cell Impedance Microscopy(SECCIM),and atomic emission spectroelectrochemistry analysis(AESEC).Time evolution surface imaging and post-corrosion microstructures were also analyzed to support the understanding of underlying corrosion *** initiation and propagation in FE-processed samples followed grain boundary patterns,differing from cast and extruded ZK60 *** measurements and in-situ time-dependent optical imaging demonstrated that FE processing enhanced corrosion potential,reduced corrosion current,and increased cathodic ***,FE processing reduced the disparity in pitting potential between cast and extruded samples,resulting in intermediate pitting *** Mg and lower Zn dissolution was observed in the lower anodic currents for FE-processed *** aggravated anodic current cycles,Mg dissolution equalized,but the Zn/Mg dissolution ratio increased for FE-processed extruded samples,suggesting less cathodic activation and better resistance to further pitting.

关键词： Magnesium alloys Corrosion Atomic emission spectroelectrochemistry analysis Scanning electron microscopy

rF ⅦA 和APCC治疗血友病的药物经济学分析

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中国处方药 2006年第4期5卷 41-45页

作者： Ashish v.joshi Jennifer M.Stephens vicki Munro

目的：比较使用重组活化凝血因子Ⅶ（rFⅦa）和致活的前凝血酶元复合浓缩物（APCC）对具有抗体的血友病患者轻一中度出血3种家庭治疗方案的成本效果。方法：用基于文献的决篆分析模型，用来比较rFⅦa—rFⅦa—rFⅦa、APCC-rFⅦa—rFⅦa... 详细信息

目的：比较使用重组活化凝血因子Ⅶ（rFⅦa）和致活的前凝血酶元复合浓缩物（APCC）对具有抗体的血友病患者轻一中度出血3种家庭治疗方案的成本效果。方法：用基于文献的决篆分析模型，用来比较rFⅦa—rFⅦa—rFⅦa、APCC-rFⅦa—rFⅦa和APCC-APCC—rFⅦa3种治疗方案。每个治疗方案都分为3个级别，一级治疗无效则使用二级治疗，二级治疗也也无效则使用三级；台疗。使用不久前美国已发表的分析文献中的专家观点来建立模型并录入基础数据。从已发表文献中获得rFⅦa和APCC控制出血的百分数。基础数据模型中的药品成本（2005年美国标准）根据平均批发价确定。使用单变量分析和概率敏感度分析（二级Monte Carlo模拟法）分析疗效、再次出血率、患者体重和给药剂量来探知模型耐用性。结果：在基础数据分析中，rFⅦa—rFⅦa—rFⅦa方案解决出血问题的成本是28076美元。使用APCC—rFⅦa—rFvlla方案的平均成本是30883美元，而APCC-APCC—rFⅦa方案的成本是更高，平均需要32150美元。仅使用rFⅦa的治疗方案通过避免二级和三级治疗而抵销了整体成本。通过概率灵敏度分析，超过68％的概率表明，全程治疗中仅使用rFⅦa方法的花费最少。结论：对轻一中度出血治疗的经济学思考应向初级治疗外扩展，进一步考虑到重复出血和多级治疗方案失败的因素。在大多数病例中，仅使用rFⅦa的治疗方案是最经济的选择。

关键词：药物经济学分析血友病患者治疗方案基础数据分析活化凝血因子Ⅶ 成本效果控制出血数据模型 rF 凝血酶元复合

Snow Cover variation and Streamflow Simulation in a Snow-fed River Basin of the Northwest Himalaya

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Journal of Mountain Science 2012年第6期9卷 853-868页

作者： vaibhav SHARMA v.D.MISHRA P.K.joshi Snow and Avalanche Study Establishment Him ParisarSector 37AChandigarh 160036India TERI University New Delhi-110070India

Snowmelt is an important component of any snow-fed river *** Jhelum River is one such transnational mountain river flowing through India and *** basin is minimally glacierized and its discharge is largely governed by seasonal snow cover and ***,accurate estimation of seasonal snow cover dynamics and snowmeltinduced runoff is important for sustainable water resource management in the *** present study looks into spatio-temporal variations of snow cover for past decade and stream flow simulation in the Jhelum River *** cover extent(SCE) was estimated using MODIS(Moderate Resolution Imaging Spectrometer) sensor *** Difference Snow Index(NDSI) algorithm was used to generate multi-temporal time series snow cover *** results indicate large variation in snow cover distribution pattern and decreasing trend in different sub-basins of the Jhelum *** relationship between SCE-temperature,SCE-discharge and discharge-precipitation was analyzed for different seasons and shows strong *** streamflow simulation of the entire Jhelum basin Snow melt Runoff Model(SRM) used.A good correlation was observed between simulated stream flow and in-situ *** monthly discharge contribution from different sub-basins to the total discharge of the Jhelum River was estimated using a modified version of runoff model based on temperature-index approach developed for small *** power - an indicator of the erosive capability of streams was also calculated for different sub-basins.

关键词： Snow cover extent(SCE) Streamflow Snow Melt Runoff Model(SRM) Normalized Difference Snow Index(NDSI) Jhelum basin Moderate Resolution Imaging Spectrometer(MODIS)

Atomic Processes in Emission Characteristics of a Lithium Plasma Plume Formed by Double-Pulse Laser Ablation

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Plasma Science and Technology 2013年第3期15卷 204-208页

作者： v.SIvAKUMARAN AJAI KUMAR R.K.SINGH v.PRAHLAD H.C.joshi Institute for Plasma Research

High resolution spectral analysis of lithium plasma formed by single and double laser ablation has been undertaken to understand the plume-laser interaction, especially at the early stages of the plasma plume. In order to identify different atomic processes in evolving plasma, time resolved spectral emission studies at different inter-pulse delays have been performed for ionic and neutral lithium lines emitting from different levels. Along with the enhancement in emission intensity, a large line broadening and spectral shift, especially in the case of excited state transition Li I 610.3 nm have been observed in the presence of the second pulse. This broadening and shift gradually decrease with increasing time delay. Another interesting feature is the appearance of a multi-component structure in the ionic line at 548.4 nm and these components change conversely into a single structure at the later stages of the plasma. The multi-component structures are correlated with the presence of different velocity （temperature） distributions in non-LTE conditions. Atomic analyses by computing photon emissivity coefficients with an ADAS code have been used to identify the above processes.

关键词： laser ablation double pulse

Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition

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Cancer Biology & Medicine 2018年第2期15卷 137-156页

作者： Aniket v.Mali Asavari A.joshi Mahabaleshwar v.Hegde Shivajirao S.Kadam Center for Innovation in Nutrition Health and Disease (CINHD) Interactive Research School for Health Affairs (IRSHA)Bharati Vidyapeeth Deemed to be University (BVDU) Pharmaceutical Sciences Poona College of PharmacyBharati Vidyapeeth Deemed to be University (BVDU)

Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against *** transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer *** this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer ***:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),*** of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion *** effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow ***:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in *** downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and *** represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein ***:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy.

关键词： Enterolactone breast cancer metastasis EMT invasion migration

Photometric studies of two W UMa type variables in the field of distant open cluster NGC 6866

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Research in Astronomy and Astrophysics 2016年第4期16卷 87-96页

作者： Yogesh Chandra joshi Rukmini Jagirdar Santosh joshi Aryabhatta Research Institute of Observational Sciences Manora PeakNainital 263002India Center for Advanced Study in Astronomy Osmania UniversityHyderabad 500007India

We present photometric analysis of the two W UMa type binaries identified in the field of distant open star cluster NGC 6866. Although these systems, namely ID487 and ID494, were reported by joshi et al., a detailed study of these stars has not been carried out before. The orbital periods of these stars are found to be 0.415110±0.000001 day and 0.366709±0.000004 day, respectively. Based on the photometric and infrared colors, we find their respective spectral types to be K0 and K3. The photometric light vari- ations of both stars show the O＇Connell effect which can be explained by employing a dark spot on the secondary components. The v and I band light curves are analyzed using the Wilson-Devinney （WD） code and relations given by Gazeas which yield radii and masses for the binary components of star ID487 of R1 = 1.24 ± 0.01R,R2 = 1.11 4- 0.02Re, and M1 = 1.24 ± 0.02Me, M2 = 0.96 ±0.05Me and for star ID494 of R1 = 1.22 ± 0.02Re, R2 = 0.81 4- 0.01 Re, and M1 = 1.20 4- 0.06 Me, M2 = 0.47 4- 0.01 Me.

关键词： methods: observational -- techniques: photometric -- binaries: eclipsing -- stars: fundamen-tal parameters

Toluene Alkylation to Selective Formation of p-Xylene over Co-Crystalline ZSM-12/ZSM-5 Catalyst

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Journal of Natural Gas Chemistry 2007年第1期16卷 37-41页

作者： P.N.joshi P.S.Niphadkar P.A.Desai R.Patil v.v.Bokade Catalysis Division National Chemical LaboratoryPune-411008India

The alkylation of toluene with methanol to selective formation of p-xylene has been systematically studied. ZSM-12 （MTW）/ZSM-5 co-crystalline zeolite in 40：60 proportions have been synthesized by the same molar gel composition, but at different temperatures and periods than that of ZSM-12 and ZSM-5, separately. All the prepared samples are characterized by XRD, SEM, BET, and XRF. The activity of toluene alkylation was investigated with a mixture of toluene and methanol as a feed over the ZSM-12, ZSM-12/ZSM-5 co-crystalline, ZSM-5, and physical mixture of ZSM-12/ZSM-5. From characterization, it is observed that the ZSM-12/ZSM-5 co-crystalline material is different from that of ZSM-12, ZSM-5, and their physical mixture. Further, the ZSM-12/ZSM-5 co-crystalline zeolite produces the highest content of xylene and has better selectivity for p-xylene than ZSM-12, ZSM-5, and their physical mixture.

关键词： ZSM-12 ZSM-5 co-crystalline toluene alkylation p-xylene

Thin Films for Coating Nanomaterials

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Tsinghua Science and Technology 2005年第6期10卷 709-717页

作者： S. M. Mukhopadhyay P. joshi R. v. Pulikollu Department of Mechanical and Materials Engineering Wright State University Dayton OH 45435 USADepartment of Mechanical and Materials Engineering Wright State University Dayton OH 45435 USADepartment of Mechanical and Materials Engineering Wright State University Dayton OH 45435 USA

For nano-structured solids （those with one or more dimensions in the 1-100 nm range）, attempts of surface modification can pose significant and new challenges. In traditional materials, the surface coating could be several hundreds nanometers in thickness, or even microns and millimeters. In a nano-structured material, such as particle or nanofibers, the coating thickness has to be substantially smaller than the bulk dimensions （100 nm or less）, yet be durable and effective. In this paper, some aspects of effective nanometer scale coatings have been discussed. These films have been deposited by a non-line of sight （plasma） techniques; and therefore, they are capable of modifying nanofibers, near net shape cellular foams, and other high porosity materials. Two types of coatings will be focused upon：（a） those that make the surface inert and （b） those designed to enhance surface reactivity and bonding. The former has been achieved by forming 1-2 nm layer of --CF2- （and/or CF3） groups on the surface, and the latter by creating a nano- layer of SiO2-type compound. Nucleation and growth studies of the plasma-generated film indicate that they start forming as 2-3 nm high islands that grow laterally, and eventually completely cover the surface with 2-3 nm film. Contact angle measurements indicate that these nano-coatings are fully functional even before they have achieved complete coverage of 2-3 nm. They should therefore be applicable to nano-structural solids. This is corroborated by application of these films on vapor grown nanofibers of carbon, and on graphitic foams. Coated and uncoated materials are infiltrated with epoxy matrix to form composites and their microstructure, as well as mechanical behaviors are compared. The results show that the nano-oxide coating can significantly enhance bond formation between carbon and organic phases, thereby enhancing wettability, dispersion, and composite behavior. The fluorocarbon coating, as expected, reduces bond formation, an

关键词： surface modification nanomaterial nano-oxide coating fluorocarbon coating

A stochastic SIR model for analysis of testosterone suppression of CRH-stimulated cortisol in men

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 223-229页

作者： A.Manickam Pushpendra Kumar K.Dasunaidu v.Govindaraj Dheeraj Kumar joshi School of Advanced Sciences 8 Languages Department of Mathematics vIT Bhopal University Kottri Kalan(village)466114 Sehore(District) Madhya PradeshIndia Department of Mathematics National Institute of Technology Puducherry Karaikal 609609 India Department of Basic Sciences 8 Humanities GMR Institute of Technology Rajam 532127 Srikakulam(Dt)Andhra PradeshIndia DIT University Dehradun 248009 UttarakhandIndiamanickammaths2011@***.kxumarsaraswatpk@*****dasunaidu.k@gmrit.edu.in ttgovindaraj.maths@*** t+maths.dj44010@***

A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are *** determine whether testosterone regulates lower sintering HPA axis function in males,we used a stochastic SIR epidemic procedure with divergent influences on ACTH and *** suppressive effects on cortisol can be attributed to a peripheral(adrenal)*** that,we came to the conclusion that experimental solutions have been discovered and the requisite statistical findings have been ***,we deduce that the given mathematical model and the results are relevant to medical *** the future,this research can be further extended to simulate more results in the medical field.

关键词： ACTH cortisol CRH estradiol HPA SIR model testosterone