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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

effects of small additions of Zn on the microstructure, mechanical properties and corrosion resistance of We43B Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第7期26卷 858-868页

作者： A.v. Koltygin v.e. Bazhenov R.S. Khasenova A.A. Komissarov A.I. Bazlov v.A. Bautin Foundry Department National University of Science and Technology “MISiS” Moscow 119049 Russia Laboratory of Hybrid Nanostructured Materials National University of Science and Technology “MISiS” Moscow 119049 Russia Laboratory of Advanced Green Materials National University of Science and Technology “MISiS” Moscow 119049 Russia Department of Metallurgy Steel New Production Technologies and Protection of Metals National University of Science and Technology “MISiS” Moscow 119049 Russia

Zn is a commonly used alloying element for Mg alloys owing to its beneficial effects on mechanical properties. To improve the mechanical and corrosion properties of We43B Mg alloys, the effects of 0–0.7wt% Zn addition on the microstructure and properties of sample alloys were investigated. Addition of Zn to as-cast We43B alloy promoted the formation of the Mg12Nd phase;by contrast, after T6 heat treatment, the phase composition of We43B alloys with and without Zn addition remained mostly the same. A long-period stacking ordered phase was predicted by CALPHAD calculation, but this phase was not observed in either the as-cast or heat-treated Zn-containing We43B alloys. The optimum temperature and duration of T6 heat treatment were obtained using CALPHAD calculations and hardness measurements. Addition of Zn resulted in a slight reduction in the average grain size of the as-cast and T6 heat-treated We43B alloys and endowed them with increased corrosion resistance with little effect on their mechanical properties.

关键词： magnesium alloys corrosion resistance mechanical properties Zn addition

empirical pairing gaps and neutron-proton correlations

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Chinese Physics C 2019年第1期43卷 109-121页

作者： B.S.Ishkhanov S.v.sidorov T.Yu.Tretyakova e.v.vladimirova Faculty of Physics Lomonosov Moscow State University Skobeltzyn Institute of Nuclear Physics Lomonosov Moscow State University

Analysis of various mass formulas related to neutron-proton correlations in atomic nuclei is carried *** the example of the N =Z chain it is shown that for self-adjoint nuclei various formulas proposed in literature for estimating the np pairing energy lead to similar results. Significant differences between the calculation methods arise when nuclei with N = Z are considered, which allows to reveal the complexity of neutron-proton correlations in different types of atomic nuclei and to make assumptions on the correspondence of the mass relation to the real effect of np pairing. The Shell Model parametrization of the binding energy makes it possible to draw additional conclusions on the structure of mass formulas and their relationship.

关键词： nucleon interaction models of atomic nuclei nucleon pairing in atomic nuclei

Mass differences and neutron pairing in Ca, Sn and Pb isotopes

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Chinese Physics C 2017年第9期41卷 83-89页

作者： B. S. Ishkhanov S. v. sidorov T. Yu. Tretyakova e. v. vladimirova Faculty of Physics M.V. Lomonosov Moscow State University Moscow 119991 Russia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State University Moscow 119991 Russia

Abstract： various estimates of the even-odd effect of the mass shell of atomic nuclei are considered. Based on the experimental mass values of the Ca, Sn, and Pb isotopes, the dependence of the energy gap on the neutron number is traced and the relationship of this characteristic to the properties of external neutron subshells is shown. In nuclei with closed proton shells, effects directly related to neutron pairing and effects of nucleon shells are discussed.

关键词： nucleon interaction models of atomic nuclei nucleon pairing in atomic nuclei

Tensor force impact on shell evolution in neutron-rich Si and Ni isotopes

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Chinese Physics C 2024年第4期48卷 95-106页

作者： S.v.sidorov A.S.Kornilova T.Yu.Tretyakova Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tensor interaction of nucleons on the characteristics of neutron-rich silicon and nickel isotopes was studied in this *** forces are considered within the framework of the Hartree-Fock approach with the Skyrme *** addition of a tensor component of interaction is shown to improve the description of the splittings between different single-particle states and decrease nucleon-nucleon pairing correlations in silicon and nickel *** attention was directed toward the role of isovector tensor forces relevant to the interaction of like nucleons.

关键词： nuclear shell model tensor interaction silicon isotopes nickel isotopes

environmental and biological factors affecting the abundance of Prosopis flexuosa saplings in the central-west Monte of Argentina

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Forest ecosystems 2022年第1期9卷 103-110页

作者： Cappa F.M. Campos v.e. Barri F.R. Ramos L. Campos C.M. INTeRBIODeS(Interacciones Biologicas del Desierto) Facultad Ciencias ExactasFísicas y Naturales(Universidad Nacional de San Juan)San JuanArgentina CIGeOBIO-CONICeT(Centro de Investigaciones de la Geosfera y Biosfera Consejo Nacional de Investigaciones Científicas y Tecnicas)San JuanArgentina Instituto de Diversidad y ecología Animal CONICET–UNCCordobaArgentina IADIZA Instituto Argentino de Investigaciones de las Zonas AridasUniversidad Nacional de CuyoGobierno de MendozaCONICETMendozaArgentina

Background:Trees and forests in drylands help mitigate the challenges through provision of economic products and vital environmental services such as habitat for biodiversity,prevention of erosion and desertification,regulation of water,microclimate,and soil *** condition and changes in dry forests can be assessed by using ecological indicators able to quantify spatial and temporal changes in *** of the ways to determine the condition of the forest is to study the dominant tree species and its *** study aimed to assess whether the abundance of Prosopis flexuosa saplings is affected by environmental and biological ***:To evaluate the first variables we used data from remote sensing such as satellite images and Aster Global Digital Model(GDeM).The second set of variables was about exotic and native ungulates and we used feces of these animals and camera traps to take *** found that sapling abundance related positively to sandy substrates and negatively to Wetness *** the other hand,in relation to biological variables,the abundance of saplings was positively affected by density of adult trees and by number of seeds dispersed by equines,but space use by Lama guanicoe had a negative relationship with *** research shows that *** saplings are benefited from sandy substrates and the conditions around adult *** addition to this,we found that exotic ungulates in low densities have neutral(***)or positive(***)effects on sapling ***:Based on these findings,we conclude that regeneration of the population of *** in our study area has no major *** addition,we corroborated that the presence of exotic and domestic ungulates in low densities does not have deleterious consequences for saplings of the dominant tree,***.

关键词： Bos primigenius taurus Dry forests equines exotic and domestic ungulates Lama guanicoe Prosopis flexuosa Remote sensing Saplings Seed dispersal

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

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Journal of Innovative Optical Health Sciences 2018年第1期11卷 65-79页

作者： Irina N.Makovik Andrey v.Dunaev victor v.Dremin Alexander I.Krupatkin viktor v.sidorov Lyudmila S.Khakhicheva vadim F.Muradyan Olga v.Pilipenko Ilya e.Rafailov Karina S.Litvinova Biomedical Photonics Instrumentation Group Scientic-educational Centre of"Biomedical engineering"Orel State University named after I.S.Turgenev Orel 302026 Russian Federation Priorov Central Research Institute of Traumatology and Orthopaedics Moscow 127299 Russian Federation SPe"LAZMA"Ltd Moscow 125252Russian Federation Orel Regional Clinical Hospital Orel 302028 Russian Federation School of engineering and Applied Sciences Aston Institute of Photonic Technologies Aston University BirminghamB47ETUK Optoelectronics and Biomedical Photonics Group Aston Institute of Photonic Technologies Aston University BirminghamB47ETUK Aston Medical School Aston University BirminghamB47ETUK

The evaluation of the microcirculatory bed functional state and the identification of angiospastic disorders with related complications,when the pathological changes are reversible,have an important role in medical *** aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem.A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the *** Doppler flowmetry,tissue reflectance oximetry and pulse oximetry were used as optical noninvasive *** parameters were recorded before,immediately after and 20 min after the cold pressor *** on the measured parameters,the complex parameters of the microcirculatory bed were calculated.A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure,with differing recovery of parameters after *** diagnostic criteria were proposed for the identification of angiospastic *** to the proposed criteria,27 people of the volunteers group were confirmed to not display any *** the patient group,however,18 people were observed to have a relatively normal functional state of the microcirculatory bed,while 15 people were observed to have a possible tendency to *** highlight the diferences between a relatively normal state and presence of angiospastic disorders,statistical analysis of experimental data was carried out,which revealed significant *** analysis of data with angiospastic disorders identified a relationship between their diagnoses and the results of labo-ratory ***,the evaluation of combined noninvasive optical diagnostic method use,the cold pressor test and proposed diagnostic criteria showed a positive *** approach can be used to detect the presence of possible angiospastic disorders and related complications,as

关键词： Noninvasive diagnostics laser Doppler flowmetry tissue relctance oximetry pulse oximetry cold pressor test microcirculatory bed angiospasm

Seniority and (9/2)^(n) configurations in neutron-rich Nickel isotopes

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Chinese Physics C 2022年第7期46卷 103-111页

作者： S.sidorov D.Zhulyaeva T.Tretyakova Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Rusia Skobeltsyn Institute of Nuelear Physicso Moscow State University Moscow 119991Rssia

excited states in low-energy spectra of ^(70-76) Ni are considered. Accordingly, pairing forces in the form of surface delta interaction are employed to account for the formation of the ground state multiplet with seniority v= 2 states. The multiplet splitting is described with mass relationships of masses of neighboring nuclei. Subsequently, the seniority model is adopted to reproduce or predict the states v= 3 in odd-even isotopes and v= 4 in even-even isotopes. The correct account of the 2^(+)_(1) state should allow for the description of the reversed order of J = 4 states with v= 2 and v= 4 observed in experiments. The results obtained are compared with the structure of similar multiplets in N=50 isotones.

关键词： shell model nucleon pairing seniority scheme neutron-rich isotopes