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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov P.B.Ermolinskiy O.N.Scheglovitova N.N.Sklyankina A.v.Muravyov A.E.Lugovtsov A.v.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia N.F.Gamaleya National Research Center for Epidemiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(NO),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced NO on RBC aggregation and adhesion to endothelium;(2)the NO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the *** RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and Myrenne *** con¯rmed that NO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of NO production by ***,data related to L-arginine accumulation by endothelium were obtained:Necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,NO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers Myrenne flow chamber

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The effect of long-term application of nitrogen-rich fertilizers on soil resistome:A study of conventional and organic cropping systems

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Soil Ecology Letters 2024年第3期6卷 135-150页

作者： Alexey S.vasilchenko Evgenii O.Burlakov Darya v.Poshvina Denis S.Gruzdev Sergey v.Kravchenko Aleksandr v.Iashnikov Ning Ling Anastasia v.vasilchenko Laboratory of Antimicrobial Resistance Institute of Environmental and Agricultural Biology(X-BIO)Tyumen State UniversityTyumenRussia Research Institute of Mathematics Physics and Computer ScienceDerzhavin Tambov State UniversityTambovRussia International Integrated Research Laboratory for Climate Change Land Use and BiodiversityInstitute of Environmental and Agricultural Biology(X-BIO)Tyumen State UniversityTyumenRussia SciBear OU Tartu Mnt 67/1-13bKesklinna Linnaosa10115 TallinnEstonia Center for Grassland Microbiome State Key Laboratory of Grassland Agro-EcosystemsCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730000China

Metagenomic studies of various soil environments have previously revealed the widespread distribution of antibiotic resistance genes(ARGs)around the *** this study,we applied shotgun metagenomics to investigate differences in microbial communities and resistomes in Chernozem soils that have been under long-term organic and conventional cropping *** organic cropping system was seeded with Triticum spelta without any *** conventional cropping system was seeded with Tríticum durum Desf and used mineral fertilizer(NPK),that resulted in an increased amount of total and available carbon and nitrogen in *** all samples,we identified a total of 21 ARG classes,among which the dominant were vancomycin,tetracycline and *** of soil microbial communities revealed differences between the studied fields in the relative abundances of 14 and 53 genera in topsoil and subsoil,*** analysis showed significant correlations(positive and negative)among 18 genera and 6 ARGs,as well as between these ARGs and some chemical properties of *** analysis of metagenome-assembled genomes revealed that Nitrospirota,Thermoproteota,Actinobacteriota and Binatota phyla of archaea and bacteria serve as hosts for glycopeptide and fluoroquinolone/tetracycline ***,the data obtained enrich knowledge about the consequences of human agricultural activities in terms of soil microbiome modification and highlight the role of nitrogen cycling taxa,including uncultivated genera,in the formation of soil resistome.

关键词： soil microbiome inorganic fertilizer nitrogen cycle uncultured bacteria chemolithotrophs Binatia

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Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich Georgy A.Ermolaev Mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.Matveeva Dmitriy v.Grudinin Kirill v.voronin Arslan Mazitov Konstantin v.Kravtsov Alexander v.Syuy Dmitry M.Tsymbarenko Mikhail S.Mironov Sergey M.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.vyshnevyy Aleksey v.Arsenin valentyn S.volkov Kostya S.Novoselov Moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of Materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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Optimized ANN for LiFePO4 battery charge estimation using principal components based feature generation

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Green Energy and Intelligent Transportation 2024年第4期3卷 59-71页

作者： Chaitali Mehta Amit v.Sant Paawan Sharma Department of Computer Science and Engineering School of TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India Department of Electrical Engineering School of Energy TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India Department of Information and Communication Technology School of TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India

Electric vehicles(Evs)have gained prominence in the present energy transition *** adoption of Evs necessitates an accurate State of Charge estimation(SoC)*** predictive SoC estimations with smart charging strategies not only optimizes charging efficiency and grid reliability but also extends battery lifespan while continuously enhancing the accuracy of SoC predictions,marking a crucial milestone in sustainable electric vehicle *** this research study,machine learning methods,particularly Artificial Neural Networks(ANN),are employed for SoC estimation of LiFePO4 batteries,resulting in efficient and accurate estimation *** investigation first focuses on developing a custom-designed battery pack with 12v,4 Ah capacity with a facility for real-time data collection through a dedicated hardware *** voltage,current and open-circuit voltage of the battery are monitored with computerized battery *** battery temperature is sensed with a DHT22 temperature sensor interfaced with Raspberry *** components are derived for the collected battery data set and analyzed for feature *** principal components were generated as input parameters for the developed *** Stopping for the ANN was also implemented to achieve faster convergence of the *** considering eleven combinations for ten different optimizers loss function is *** analysis of hyperparameter tuning and optimizer selection revealed that the Adafactor optimizer with specific settings produced the best results with an RMSE value of 0.4083 and an R2 Score of *** proposed algorithm was also implemented for two different types of datasets,a UDDS drive cycle and a standard cell-level *** results obtained were in line with the results obtained with the ANN model developed based on the data collected from the developed experimental setup.

关键词： Battery Feature engineering Principal component analysis Artificial neural networks Optimizers

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Numerical Simulation of Thermocapillary Convection with Evaporation Induced by Boundary Heating

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1667-1686页

作者： O.N.Goncharova v.B.Bekezhanova Altai State University Institute of Mathematics and Information TechnologiesBarnaul656049Russia Institute of Computational Modelling SB RAS Department of Differential Equations of MechanicsKrasnoyarsk660036Russia

The dynamics of a bilayer system filling a rectangular cuvette subjected to external heating is *** influence of two types of thermal exposure on the flow pattern and on the dynamic contact angle is *** particular,the cases of local heating from below and distributed thermal load from the lateral walls are *** simulation is carried out within the frame of a two-sided evaporative convection model based on the Boussinesq approximation.A benzine–air system is considered as reference *** variation in time of the contact angle is described for both heating *** lateral heating,near-wall boundary layers emerge together with strong convection,whereas the local thermal load from the lower wall results in the formation of multicellular motion in the entire volume of the fluids and the appearance of transition regimes followed by a steady-state *** results of the present study can aid the design of equipment for thermal coating or drying and the development of methods for the formation of patterns with required structure and morphology.

关键词： Thermocapillary convection two-phase system numerical modeling contact angle

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Utility of fluid inclusion paleo-temperature in petroleum system modelling:A case study from western offshore,India

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Energy Geoscience 2024年第2期5卷 101-119页

作者： v.Nandakumar S.Shivapriya Silpa Thankan National Facility for Geofluids Research and Raman Analysis National Centre for Earth Science StudiesMinistry of Earth SciencesGovernment of IndiaThiruvananthapuram695011KeralaIndia Department of Geology Kerala UniversityThiruvananthapuram695581KeralaIndia

The paleo-temperature(Th)data from fluid inclusions are utilized for thermal history modelling using PetroMod ***,bottom hole temperature(BHT)and vitrinite reflectance(Ro)measurements are widely used in petroleum system modelling(PSM)in the oil industry for calibration *** representing the minimum temperature of fluid entrapment estimated from fluid-inclusion study provides extra support to build the thermal models for *** inclusion parameters along with Rock-Eval pyrolysis analysis have been used to predict the maturity of oil in terms of API gravity as well as the maturity of source rocks *** exploratory wells Rv-1(Mumbai Offshore Basin)and KK4C-A-1(Kerala-Konkan Offshore Basin),India were examined and the T_(h)from most of the fluid inclusions of wells Rv-1 and KK4C-A-1 fell in the oil window range of 60-140℃suggesting thermal conditions favourable for oil generation in both of the wells.T_(h)of coeval aqueous inclusions along with the Hydrocarbon Fluid inclusions(HCFIs)was used to calibrate *** parameters show that source rocks of well Rv-1 are mature and that of well KK4C-A-1 are *** sets of PSM are created in terms of generation and expulsion for the dry wells Rv-1 and KK4C-A-1 and calibrated each well using fluid inclusion Th and *** the fluid inclusion analysis method,it is evident that hydrocarbon generation happened in both wells and the paleo-temperature indicates that the formations of both wells were subjected to temperatures in the oil window range,even though it was designated as dry wells in the present *** present study highlights the application of fluid inclusion paleo-temperature(Th)during calibration instead of commonly used *** could obtain desirable and accurate data output from PSM using T_(h) calibration.

关键词： Paleo-temperature(T_(h)) Hydrocarbon fluid inclusion Petroleum system modelling Petroleum generation and expulsion Western offshore basin

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Joint Rain Streaks & Haze Removal Network for Object Detection

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Computers, Materials & Continua 2024年第6期79卷 4683-4702页

作者： Ragini Thatikonda Prakash Kodali Ramalingaswamy Cheruku Eswaramoorthy K.v Department of Electronics and Communication Engineering National Institute of TechnologyWarangal506004India Department of Computer Science and Engineering National Institute of TechnologyWarangal506004India Department of Electronics and Communication Engineering Indian Institute of Information TechnologyDesign and ManufacturingKurnool518008India

In the realm of low-level vision tasks,such as image deraining and dehazing,restoring images distorted by adverse weather conditions remains a significant *** emergence of abundant computational resources has driven the dominance of deep Convolutional Neural Networks(CNNs),supplanting traditional methods reliant on prior ***,the evolution of CNN architectures has tended towards increasing complexity,utilizing intricate structures to enhance performance,often at the expense of computational *** response,we propose the Selective Kernel Dense Residual M-shaped Network(SKDRMNet),a flexible solution adept at balancing computational efficiency with network accuracy.A key innovation is the incorporation of an M-shaped hierarchical structure,derived from the U-Net framework as M-Network(M-Net),within which the Selective Kernel Dense Residual Module(SDRM)is introduced to reinforce multi-scale semantic feature *** methodology employs two sampling techniques-bilinear and pixel unshuffled and utilizes a multi-scale feature fusion approach to distil more robust spatial feature map *** the reconstruction phase,feature maps of varying resolutions are seamlessly integrated,and the extracted features are effectively merged using the Selective Kernel Fusion Module(SKFM).Empirical results demonstrate the comprehensive superiority of SKDRMNet across both synthetic and real rain and haze datasets.

关键词： Image deraining Selective Dense Residual Module(SDRM) Selective Kernel Fusion Module(SKFM) Selective KernelDense Residual M-Shaped Network(SKDRMNet)

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Juvenile survival curves in a solitary ground squirrel with a prolonged hibernation:effects of individual characteristics,environment,and maternal investment

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Current Zoology 2024年第1期70卷 13-23页

作者： Nina A.vasilieva Liudmila E Savinetskaya Andrey v.Tchabovsky A.N.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow 119071Russia

Juvenile survival is a key life-history influence on population dynamics and adaptive *** analyzed the effects of individual chara-cteristics,early environment,and maternal investment on juvenile survival in a large solitary hibernating rodent-yellow ground squirrel Spermophilus fulvus using Cox mixed-effects *** 48%of weaned pups survived to dispersal and 17%survived to *** life expectancy was primarily determined by individual characteristics and,to a lesser extent,by the early *** strongest and pos-itive predictor of juvenile survival was body mass which crucially affected mortality immediately after *** suffered higher mortality than females after the onset of dispersal;however,the overall difference between sexes was partly masked by high rates of mortality in the first days after emergence in both *** emerged juveniles had lower life expectancy than the earliest *** overall effect of local juvenile density was *** lactation did not enhance juvenile survival:Pups nursed longer survived shorter than the young nursed for a shorter *** findings support the hypothesis that females of *** cannot effectively regulate maternal expenditures to mitigate the effects of unfavorable conditions on their *** strategy to deal with seasonal time constraints on life history in female *** suggests an early termination of maternal care at the cost of juvenile quality and *** female reproductive strategy corresponds to a"fast-solitary"life of folivorous desert-dwelling *** and other solitary ground squirrels with prolonged hibernation.

关键词： early-life conditions ground squirrels hibernation juvenile mortality maternal investment survival curves

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Use of an immunocapture device to detect cytokine release in discrete brain regions

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Neural Regeneration Research 2024年第4期19卷 703-704页

作者： Matthew G.Frank Michael v.Baratta Department of Integrative Physiology University of Colorado BoulderBoulderCOUSA(Frank MG)Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderCOUSA(Baratta MV)

Production of proinflammatory cytokines in the central nervous system is a key process in the neuroinflammatory response to trauma,infection,and neurodegenerative diseases(Kumar,2019).These intercellular signaling molecules play multiple roles in the immune response in the central nervous system including the orchestration of the sickness response to innate immune perturbations in the brain(Dantzer et al.,2008).

关键词： system release innate

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Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

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Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

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