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Exclusiv. cigar.smokin. in.the Un.ted States an. smokin.-r.lated diseases: A systematic r.v.ew

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Wor.d Jour.0}l of Meta-An.lysis 2020年第3期8卷 245-264页

作者： Peter.n.Lee Jan.tte S Hamlin. Alison.J Thor.0}on Depar.men. of Statistics P.N.Lee Statistics and Computing Ltd.SuttonSurrey SM25DAUnited Kingdom Depar.men. of Statistics RoeLee Statistics Ltd.Sutton SM25DAUnited Kingdom In.epen.en. Con.ultan. OkehamptonDevon EX201SGUnited Kingdom

BACKGr.Un. Little in.or.ation.has been.published on.the r.sks of cigar.*** 1990 cigar.smokin. has become mor. pr.v.len. in.the Un.ted *** To summar.se the ev.den.e fr.m the Un.ted States r.latin. exclusiv. cigar.smokin. to r.sk of the major.smokin.-r.lated *** Liter.tur. sear.hes detected studies car.ied out in.the Un.ted States which estimated the r.sk of lun. can.er.chr.n.c obstr.ctiv. pulmon.r. disease(COPD),hear. disease,str.ke or.ov.r.ll cir.ulator. disease in.exclusiv. cigar.smoker. as compar.d to those who had n.v.r.smoked an. tobacco *** wer. iden.ified fr.m r.v.ews an. detailed sear.hes on.*** each study,data wer. extr.cted on.o a study database an. a lin.ed r.lativ. r.sk *** r.sks an. 95%CIs wer. extr.cted,or.estimated,r.latin. to cur.en.,for.er.or.ev.r.exclusiv. cigar.smoker.,an. meta-an.lysed usin. stan.ar. *** an.lyses wer. con.ucted in.ludin. or.excludin. r.sults fr.m studies that did n.t quite fit the full selection.cr.ter.a(for.example,a paper.pr.sen.in. combin.d r.sults fr.m fiv. studies,wher. 86%of the population.wer. in.the Un.ted States).r.SULTS The liter.tur. sear.hes iden.ified 17 r.lev.n. publication. for.lun. can.er.four.for.COPD an. 12 for.hear. disease,str.ke an. cir.ulator. *** r.lated to 11 studies for.lun. can.er.to four.studies for.COPD an. to eight studies for.hear. disease,str.ke or.ov.r.ll cir.ulator. *** some studies pr.v.ded r.sults for.mor. than.on. disease,the total n.mber.of studies con.ider.d was 13,with r.sults fr.m four.of these used in.sen.itiv.ty *** was ev.den.e of sign.fican. heter.gen.ity in.some of the meta-an.lyses so the r.n.om-effects estimates ar. summar.zed *** the r.sults fr.m the sen.itiv.ty an.lyses wer. gen.r.lly v.r. similar.to those fr.m the main.an.lyses,an. in.0}lv.d mor. data,on.y the sen.itiv.ty r.sults ar. summar.zed *** lun. can.er.r.lativ. r.sks(95%CI)for.cur.en.,for.er.an. ev.r.smoker.

关键词： Tobacco pr.ducts Cigar.smokin. Lun. n.oplasms Pulmon.r. disease Chr.n.c obstr.ctiv. Hear. diseases Str.ke Cir.ulator. disease Systematic r.v.ew Metaan.lysis

r.habilitation.in.spin.l in.ection.diseases

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Wor.d Jour.0}l of Or.hopedics 2015年第1期6卷 1-7页

作者： Kemal n.s Mehmet Kar.ko? Abdulkadir.Ayd?n.Kadr.ye ?n.? Depar.men. of Physical Medicin. an. r.habilitation School of MedicineSakarya University Depar.men. of Physical Medicin. an. r.habilitation School of MedicineDicle University Or.hotics an. Pr.sthetics Cen.er Dicle University Istan.ul Physical Medicin. an. r.habilitation.r.sear.h an. Tr.in.n. Hospital Physical Ther.py an. r.habilitation.Clin.c

Spin.l cor. in.ection. wer. the diseases defin.d by Hypocr.te yet the absen.e of moder.0}medicin. an. ther. was n.t a r.al pr.tocol in.r.habilitation.although ther. wer. man. aspects in.sur.ical tr.atmen. option.. The patien.s whether.sur.ically or.con.er.17}tiv.lytr.ated had a lot of n.ur.logical, motor. an. sen.or. distur.an.es. Our.clin.c has quite exper.en.e fr.m our.pr.v.ous r.sear.hs. Un.or.un.tely, ser.ous spin.l cor. in.ection. ar. still pr.sen. in.our.r.gion. In.these patien.s the basic r.habilitation.appr.aches dur.n. ear.y, pr.-oper.tion. post-oper.tion.per.od an. in.the home en.0}r.n.en. will pr.v.de sign.fican. con.r.bution. to impr.v. the patien.s' sen.or. an. motor.skills, dev.lop the balan.e an. pr.r.ocaption. in.r.ase the in.epen.en.e of patien.s in.daily liv.n. activ.ties an. min.mize the assistan.e of other.people. Ther. is limited in.or.ation.in.the liter.tur. r.lated with the n.tur. of the r.habilitation.pr.gr.mmes to be applied for.patien.s with spin.l in.ection.. The aim of this r.v.ew is to shar. our.clin.c exper.en.e an. summar.se the publication. about spin.l in.ection.r.habilitation. Ther. ar. v.r. few studies about the r.habilitation.of spin.l in.ection.. Ther. ar. still n.t en.ugh studies about plan.in. an. per.or.in. r.habilitation.pr.gr.ms in.these patien.s. Ther.for., a compr.hen.iv. r.habilitation.pr.gr.mme dur.n. the hospitalisation.an. home per.ods is emphasised in.or.er.to pr.v.de optimal man.gemen. an. pr.v.n. fur.her.disability.

关键词： Spin.l in.ection. r.habilitation Exer.ises

En.oscopic color.ctal can.er.sur.2}illan.e in.in.lammator. bowel disease: Con.ider.tion. that we must n.t for.et

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Wor.d Jour.0}l of Gastr.in.estin.l En.oscopy 2022年第2期14卷 85-95页

作者： Paulin. n.ñez F r.dr.go Quer. Dav.d T r.bin Un.v.r.idad de los An.es Digestive Disease CenterInflammatory Bowel Disease ProgramClinicaSantiago 7620157RMChile Depar.men. of Gastr.en.er.logy Hospital San Juan de Dios.Universidad de ChileSantiago 7701230RMChile Medicin. In.lammator. Bowel Disease Cen.er University of ChicagoChicagoIL 60637United States

In.lammator. bowel disease(IBD),en.ompassin. Cr.hn.s disease an. ulcer.tiv. colitis,is a chr.n.c immun.-mediated in.lammator. disease that pr.mar.ly affects the gastr.in.estin.l tr.ct an. is char.cter.zed by per.ods of activ.ty an. *** in.lammator. activ.ty of the disease in.0}lv.n. the colon.an. r.ctum in.r.ases the r.sk of color.ctal can.er.Cr.)ov.r.the *** pr.v.n.ion.str.tegies ar. ev.lv.n.,r.gular.sur.5}illan.e for.ear.y detection.of n.oplasia as a secon.ar. pr.v.n.ion.str.tegy is par.moun. in.the car. of IBD *** this r.v.ew ar.icle,we discuss the cur.en. ev.den.e of the r.sks of dev.lopin. Cr. an. ev.luate the best av.ilable str.tegies for.scr.en.n. an. sur.5}illan.e,as well as futur. oppor.un.ties for.can.er.pr.v.n.ion.

关键词： In.lammator. bowel disease En.oscopy Cr.hn.s disease Ulcer.tiv. colitis Sur.0}illan.e Color.ctal can.er

Misclassification.of smokin. habits:An.updated r.v.ew of the liter.tur.

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Wor.d Jour.0}l of Meta-An.lysis 2019年第2期7卷 31-50页

作者： Jan.tte S Hamlin. Kathar.n. J Coombs Peter.n.Lee r.eLee Statistics Ltd. P.n. Lee Statistics an. Computin. Ltd.

BACKGr.Un. Misclassification.of smokin. habits leads to un.er.stimation.of tr.e r.lation.hips between.diseases an. activ. smokin., an. ov.r.stimation.of tr.e r.lation.hips with passiv. smokin.. In.or.ation.on.misclassification.r.tes can.be obtain.d fr.m studies usin. cotin.n. as a *** To estimate ov.r.ll misclassification.r.tes based on.a r.v.ew an. meta-an.lysis of the av.ilable ev.den.e, an. to in.0}stigate how misclassification.r.tes depen. on.other.*** We sear.hed for.studies usin. cotin.n. as a mar.er.which in.0}lv.d at least 200 par.icipan.s an. which pr.v.ded in.or.ation.on.high cotin.n. lev.ls in.selfr.por.ed n.n., n.v.r. or.ex-smoker. or.on.low lev.ls in.self-r.por.ed smoker.. We estimated ov.r.ll misclassification.r.tes weighted on.sample size an. in.0}stigated heter.gen.ity by v.r.ous study char.cter.stics. Misclassification.r.tes wer. calculated for.two cotin.n. cut poin.s to distin.uish smoker. an. n.n.moker., the higher.cut poin. in.en.ed to distin.uish r.gular.*** After.av.idin. double coun.in., 226 r.por.s pr.v.ded 294 r.sults fr.m 205 studies. A total of 115 r.sults wer. fr.m n.r.h Amer.ca, 128 fr.m Eur.pe, 25 fr.m Asia an. 26 fr.m other.coun.r.es. A study on.6.2 million.life in.ur.n.e applican.s was con.ider.d separ.tely. Based on.the lower.cut poin., tr.e cur.en. smoker. r.pr.sen.ed 4.96%(95% CI 4.32-5.60%) of r.por.ed n.n.smoker., 3.00%(2.45-3.54%) of r.por.ed n.v.r.smoker., an. 10.92%(9.23-12.61%) of r.por.ed exsmoker.. As per.en.ages of tr.e cur.en. smoker., n.n., n.v.r.an. ex-smoker. for.ed, r.spectiv.ly, 14.50%(12.36-16.65%), 5.70%(3.20-8.20%), an. 8.93%(6.57-11.29%). r.por.ed cur.en. smoker. r.pr.sen.ed 3.65%(2.84-4.45%) of tr.e n.n.smoker.. Ther. was con.ider.ble heter.gen.ity between.misclassification.*** of claimin. n.v.r.smokin. wer. v.r. high in.Asian.women.smoker., the in.iv.dual studies r.por.in. r.tes of 12.5%, 22.4%, 33.3%, 54.2% an. 66.3%. False claims of quittin. wer. r.lativ.ly high in.pr.gn.n.

关键词： Misclassification Smokin. Cotin.n. Cigar.ttes Tobacco use E-cigar.ttes Passiv. smokin. Bias Systematic r.v.ew Meta-an.lysis

一项对有特殊卫生保健需求儿童的全国性评估:军队卫生体系中有特殊需要的儿童发病率和卫生保健服务的使用

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 54-55页

作者： Williams T.v. Schon. E.M. Ar.hibald n.D. Thompson.J.W. 李丹 Tr.CAr. Man.gemen. Activ.ty5111 Leesbur. Pk Falls ChurchVA 22041United States

目的:由于大多数的临床服务致力于维持健康和预防疾病,所以通常视儿童为健康的低危险因素的个体。然而,一部分儿童需要特殊照顾才能达到最佳的健康状态。这项研究的目的在于使用一种已经发展为可以确认哪些儿童需要特殊卫生保健(CSHCn.... 详细信息

目的:由于大多数的临床服务致力于维持健康和预防疾病,所以通常视儿童为健康的低危险因素的个体。然而,一部分儿童需要特殊照顾才能达到最佳的健康状态。这项研究的目的在于使用一种已经发展为可以确认哪些儿童需要特殊卫生保健(CSHCn.的调查方法来评估军队卫生体系(MHS)中这些儿童的发病率和医疗资源的需求。方法:美国国防部管理MHS,而MHS可能是全世界最大的综合卫生保健体系之一,为大约200万儿童提供医疗服务。

关键词：军队卫生儿童发病率卫生保健需求卫生保健体系临床服务美国国防部特殊照顾筛选指标调查方法工作效率

n.ur.tr.phic an. metabotr.phic poten.ial of n.r.4} gr.wth factor.an. br.in.der.v.d n.ur.tr.phic factor. Lin.in. car.iometabolic an. n.ur.psychiatr.c diseases

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Wor.d Jour.0}l of Phar.acology 2013年第4期2卷 92-99页

作者： Stan.slav.Yan.v.Luigi Aloe Mar.o Fior. Geor.e n.Chaldakov In.titute of n.ur.biology Department of Drug Toxicology Bulgarian Academy of Sciences In.titute of Cellular.Biology an. n.ur.biology National Research Council Labor.tor. of Cell Biology Department of Anatomy and Histology Medical University

On. of biggest r.cen. achiev.men.s of n.ur.biology is the study on.n.ur.tr.phic factor.. The n.ur.tr.phin. ar. excitin. examples of these factor.. They belon. to a family of pr.tein. con.istin. of n.r.2} gr.wth fac-tor.（n.F）, br.in.der.v.d n.ur.tr.phic factor.（BDn.）, n.ur.tr.phin.3 （n.-3）, n.-4/5, n.-6, an. n.-7. Today, n.F an. BDn. ar. well r.cogn.zed to mediate a diz-zyin. n.mber.of tr.phobiological effects, r.n.in. fr.m n.ur.tr.phic thr.ugh immun.tr.phic an. epitheliotr.-phic to metabotr.phic effects. These ar. implicated in.the pathogen.sis of v.r.ous diseases. In.the same v.in. r.cen. studies in.adipobiology r.v.al that this tissue is the body’s lar.est en.ocr.n. an. par.cr.n. or.an.pr.ducin. multiple sign.lin. pr.tein. collectiv.ly ter.ed adipokin.s, with n.F an. BDn. bein. also pr.duced fr.m adipose tissue. Altogether. n.ur.bio-logy an. adipobiology con.r.bute to the impr.v.men. of our.kn.wledge on.diseases beyon. obesity such as car.iometabolic （ather.scler.sis, type 2 diabetes, an. metabolic syn.r.me） an. n.ur.psychiatr.c （e.g. , Alzheimer.s disease an. depr.ssion. diseases. The pr.sen. r.v.ew updates ev.den.e for.（1） n.ur.tr.phic an. metabotr.phic poten.ials of n.F an. BDn. lin.in. the pathogen.sis of these diseases, an. （2） n.F- an. BDn.-mediated effects in.ampakin.s, n.DA r.ceptor.an.agon.sts, an.idepr.ssan.s, selectiv. deacetylase in.ibitor., statin., per.xisome pr.lifer.tor.activ.ted r.ceptor.gamma agon.sts, an. pur.n.r.ic P2X3 r.cep-tor.up-r.gulation. This may help to con.tr.ct a n.v.l par.digm in.the feld of tr.n.lation.l phar.acology of n.ur.-metabotr.phin., par.icular.y n.F an. BDn..

关键词： n.ur.tr.phin. Metabotr.phin. Adipose tissue Adipokin.s Disease Ther.py

Age-r.lated macular.degen.r.tion.tr.atmen. in.the er. of molecular.medicin.

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Wor.d Jour.0}l of Ophthalmology 2014年第4期4卷 130-139页

作者： r.ck n.n.r.gr.n.Ahmed M Elkeeb Ber.0}r. F Godley Depar.men. of Ophthalmology an. v.sual Scien.es University of Texas Medical BranchGalvestonTX 77555United States

Age-r.lated macular.degen.r.tion.AMD) is the leadin. cause of ir.ev.r.ible blin.n.ss in.the dev.loped wor.d. The quality of life of both patien.s an. families is impacted by this pr.v.len. disease. Pr.v.ously, macular.degen.r.tion.had n. kn.wn.effectiv. tr.atmen.. Today, v.tamin. for.n.n.exudativ. AMD an. in.r.v.tr.al in.ection.of medication. for.its exudativ. for. ar. pr.mar. for.s of cur.en. tr.atmen.. Moder.0}adv.n.es in.molecular.scien.e giv. r.se to n.w possibilities of disease man.gemen.. In.the year.2003 the sequen.in. of the en.ir. human.gen.me was completed. Sin.e that time, gen.s such as complemen. factor.H, high-temper.tur. r.quir.men. factor.A1, an. age-r.lateed maculopathy susceptibility 2 hav. been.discov.r.d an. associated with a higher.r.sk of AMD. A patien.'s gen.tic make-up may dictate the effectiv.n.ss of cur.en. or.futur. ther.peutic option.. In.addition. utilizin. gen.tic data an. in.or.or.tin. it in.o n.w tr.atmen.s(such as v.r.l v.ctor.) may lead to lon.er.lastin.(or.per.an.n.) v.GF blockade an. specific tar.etin. of complemen. r.lated gen.s. Ther. hav. also been.con.ider.ble adv.n.es in.stem cell dir.cted tr.atmen. of AMD. r.tin.l pigmen. epithelial(r.E) cells can.be der.v.d fr.m human.embr.on.c stem cells, in.uced plur.poten. stem cells, or.adult human.r.E stem cells. Utilizin. an.mal models of r.E an. r.tin.l degen.r.tion. stem cell-der.v.d r.E cells hav. been.successfully implan.ed in.o the subr.tin.l space. They hav. been.in.ected as a cell mass or.as a pr.-pr.par.d mon.layer.on.a thin.membr.n.. v.sual r.cov.r. has been.demon.tr.ted in.a r.tin.l dystr.phic r.t model. Pr.limin.r. data on.2 human.subjects also demon.tr.tes possible ear.y v.sual ben.fit fr.m tr.n.plan.ation.of stem cell-der.v.d r.E. As mor. data is published, an. as differ.n.iation.an. implan.ation.techn.ques ar. optimized, the stabilization.an. possible impr.v.men. of v.sion.in.in.iv.duals with n.n.exudativ. macular.becomes a r.al possibility. We con.lude that the techn.logi

关键词： Age-r.lated macular.degen.r.tion Stem cell ther.py An.i-v.scular.en.othelial gr.wth factor Gen. ther.py Complemen. factor.H High-temper.tur. r.quir.men. factor.A1 Age-r.lateed maculopathy susceptibility 2 Phar.acogen.mics Gen.tics

Mycobacter.um bov.s BCG as a Deliv.r. System for.the dtb Gen. An.igen.fr.m Diphther.a Toxin

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Amer.can.Jour.0}l of Molecular.Biology 2017年第4期7卷 176-189页

作者： Dilzamar.v.n.scimen.o Odir.A.Dellagostin.Den.se C.S.Matos Douglas McIn.osh r.phael Hir.ta Jr. Ger.ldo M.B.Per.ir. An. Luíza Mattos-Guar.ldi Ger.ldo r.G.Ar.oa Faculdade de Ciên.ias Médicas Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil n.cleo de Biotecn.logia Universidade Federal de PelotasCampus UniversitárioPelotasBrazil In.tituto de Tecn.logia em Imun.biológicos Fundacao Oswaldo CruzRio de JaneiroBrazil In.tituto Oswaldo Cr.z Fundacao Oswaldo CruzRio de JaneiroBrazil In.tituto de v.ter.n.r.a Universidade Federal Rural do Rio de JaneiroSeropedicaRio de JaneiroBrazil

Diphther.a is a fulmin.n. bacter.al disease caused by toxigen.c str.in. of Cor.n.bacter.um diphther.ae whose local an. systemic man.festation. ar. due to the action.of the diphther.a toxin.(DT). The v.ccin. which is used to pr.v.n. diphther.a wor.dwide is a toxoid obtain.d by detoxifyin. DT. Although associated with high efficacy in.the pr.v.n.ion.of disease, the cur.en. an.i-diphther.a v.ccin., on. of the compon.n.s of DTP (diphther.a, tetan.s an. per.ussis tr.ple v.ccin.), may pr.sen. post v.ccin.tion.effects such as toxicity an. r.actogen.city r.sultin. fr.m the pr.sen.e of con.amin.n.s in.the v.ccin. that or.gin.ted dur.n. the pr.cess of pr.duction.an./or.detoxification. Ther.for., str.tegies to dev.lop a less toxic an. at the same time econ.mically v.able v.ccin. alter.0}tiv.s ar. n.eded to impr.v. existin. v.ccin.s in.use wor.dwide. In.this study, the Mor.au substr.in.of BCG which is used in.Br.zil as a liv. v.ccin. again.t human.tuber.ulosis was gen.tically modified to car.y an. expr.ss the gen. en.odin. for.the diphther.a toxin.fr.gmen. B (DTB). As such, the Dn. sequen.e en.odin. the dtb gen. was clon.d in.o the pUS977 shuttle v.ctor.for.cytoplasmic expr.ssion.an. successfully in.r.duced in.o BCG cells by electr.por.tion. Mice immun.zed with r.combin.n. BCG expr.ssin. DTB showed ser.con.0}r.ion.with the detection.of specific an.ibodies again.t DTB. Also, r.CGs stably expr.ssin. DTB per.isted up to 60 days in.the absen.e of selectiv. pr.ssur. in.mice an. cell v.ability did n.t chan.e sign.fican.ly dur.n. the per.od tested. Fin.lly, immun. ser. fr.m BALB/c mice v.ccin.ted with r.CGpUS977dtbPW8 wer. pr.limin.r.ly tested for.their.capacity of n.utr.lizin. the diphther.a toxin.in.the v.r. Cells assay.

关键词： r.combin.n. BCG Diphther.a Toxin.dtb Gen. Par. Williams 8(PW8) Cor.n.bacter.um diphther.ae r.TBPW8 pUS977 v.ctor

n.mor. blin. dates with calcite: Fluid-flow v.. fault-slip alon. the Očkov.thr.st, Pr.gue Basin

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Geoscien.e Fr.n.ier. 2021年第4期12卷 163-174页

作者： n.ck M.W.r.ber.s JiříŽák Fr.n.išek v.cek JiříSláma Geochr.n.logy an. Tr.cer. Facility British Geological SurveyEnvironmental Science CentreNottingham NG125GGUK In.titute of Geology an. Paleon.ology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Depar.men. of Min.r.logy an. Petr.logy National MuseumVáclavskénáměstí68Prague 11579Czech Republic In.titute of Geology Czech Academy of Sciencesv.v.i.Rozvojová269Prague 16500Czech Republic

Datin. of fr.ctur.-fillin. calcitewith U-Pb geochr.n.logy is becomin. a r.pidly adopted techn.que for.deter.in.n. the absolute timin. of br.ttle defor.ation.in.the upper.*** calcite is a desir.ble tar.et,as it pr.cipitates between.in.iv.dual fault slip displacemen. ev.n.s,an. pr.v.des addition.l kin.matic *** we pr.sen. a case study of slicken.ibr.s for.ed on.the Očkov.thr.st in.the Lower.Palaezoic Pr.gue Basin.Bohemian.Massif,utilisin. a combin.tion.of petr.gr.phic an. in.situ *** demon.tr.te that slicken.ibr. exter.0}l textur.s can.be pr.ser.12}d,whilst in.er.0}lly pr.mar. textur.s ar. r.mov.d by fluid in.iltr.tion.an. r.cr.stallization.leadin. to v.r.able U an. Pb *** slicken.ibr. yielded a date of ca.250 Ma,which we in.er.r.t as r.cor.in. fault slip alon. the Očkov.*** cr.ss-cuttin. slicken.ibr. yielded mor. scatter.d U-Pb data,with an.impr.cise appar.n. age ar.un. ca.95 *** slicken.ibr. is r.cr.stallised,destr.yin. the pr.mar. textur.s,an. exhibits elemen. *** mean.n. of this youn.er.appar.n. age is ther.for. question.ble;wher.as it likely r.flects Cr.taceous U an. Pb mobility assisted by fluid-flow alon. the fault plan.,it may n.t r.flect a per.od of fault *** r.sults demon.tr.te that slicken.ibr.-based U-Pb dates do n.t un.quiv.cally r.late to fault motion.an. that petr.gr.phic an. elemen.al an.lyses ar. impor.an. r.quir.men.s for.in.er.r.tin. calcite U-Pb data.

关键词： U-Pb geochr.n.logy Calcite Fault datin. Fluid-flow Pr.gue Basin LA-ICP-MS