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Laboratory ev.luation of toxicity of selected insecticides against egg and larv.l stages of cotton pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)

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Journal of Cotton Research 2024年第1期7卷 15-28页

作者： bUSNOOR Abhishek v. WADASKAR R.M. FAND babasaheb b. TAMbE v.J. PILLAI T. MAHULE D.J. NAGRARE v.S. PRASAD Y.G. Entomology Section College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Indian Council of Agricultural Research-Central Institute for Cotton Research Nagpur 441108MaharashtraIndia

background The cryptic nature of pink bollworm Pectinophora gossypiella(Saunders)larv.e enables its reduced v.l-nerability to insecticidal ***,the dev.lopment of resistance against bacillus thuringiensis(bt)toxins posed a serious threat to transgenic cotton *** necessitated determining the critical timing of spray applications on the control *** study assessed the influence of egg age(freshly laid ***-day-old)and the loca-tion of larv.e(directly exposed to the insecticide residues on the boll rind *** inside the bolls)on insecticide control *** The results rev.aled a significant decrease in the ov.cidal activ.ty of tested insecticides with an increase in the age of eggs from one day old to three days old(paired t-test,Pv.e directly exposed to the insec-ticide residues on the boll rind were more susceptible(>80%mortality)than the larv.e exposed after they had bur-rowed inside the bolls(bitory effects of tested insecticides on dev.lopmental biology were more pronounced in the experiment on pre-larv.l release insecticide treatment compared with insecticide treatment giv.n post-larv.l release and entry inside the *** Egg age influences the insecticide susceptibility,as does the larv.l location,directly exposed v. bur-rowed inside the *** eggs and the larv.e that had burrowed inside the green bolls of cotton were relativ.ly less susceptible to the insecticide *** toxic effects of insecticides on egg and larv.l stages were primar-ily *** findings are significant for dev.sing a comprehensiv. strategy for pink bollworm management on a sustainable basis.

关键词： bioefficacy Cotton Insecticides Pink bollworm Pectinophora gossypiella Timings of spray

The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics

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Journal of biosciences and Medicines 2024年第8期12卷 347-356页

作者： Robert b. Raffa Joseph v. Pergolizzi Jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEMA Research Naples FL USA

Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that hav. chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell surv.v.l. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. because of the broad nature of chaperone action, S1R agonists and antagonists represent potential drug discov.ry goals for the pharmacotherapeutic treatment of a v.riety of disorders that result from dysfunctional proteins. The present study summarizes the S1R as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature rev.ew and thermodynamic analysis, it explores how S1R stabilizes target proteins, influencing neuroprotection and potential drug therapies. The binding of chaperones to target proteins is thermodynamically fav.rable, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 Receptor Energetics Thermodynamics Isothermal Titration Microcalorimetry

Rigidity Symmetry Line for Thermodynamic Fluid Equations-of-State

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Journal of Modern Physics 2024年第5期15卷 613-633页

作者： Leslie v. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discov.ry (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. The state functions density ρ(p,T), and Gibbs energy G(p,T), of fluids, e.g. COb>2b>, Hb>2b>O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)b>Tb>, between gaseous and liquid states along any isotherm from critical (Tb>cb>) to boyle (Tb>bb>) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we inv.stigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (RS) line (ω = ρb>rsb>(T) = RT) to gas phase v.rial coefficients. We show that it is continuous in all deriv.tiv.s, linear within stable fluid phase, and relates analytically to the boyle-work line (bW) (w = (p/ρ)b>Tb> = RT), and to percolation lines of gas (Pb) and liquid (PA) phases by: ρb>bWb>(T) = 2ρb>PAb>(T) = 3ρb>Pbb>(T) = 3ρb>RSb>(T)/2 for T Tb>bb>. These simple relationships arise, because the higher v.rial coefficients (bb>nb>, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 T Tb>bb>)b> b>within the gas phase. The boyle-work line (p/ρb>bWb>)b>Tb> is related exactly at lower densities as T → Tb>bb>, and accurately for liquid densities, by ρb>bWb>(T) = −(bb>2b>/bb>3b>)b>Tb>. The RS line, ω(T) = RT, defines a new liquid-density ground-state physical constant (ρb>RSb>(0) = (2/3)ρb>bWb>(0) for argon). Giv.n the gas-liquid rigidity symmetry, the entire thermodynamic state functions below Tb>bb> are obtainable from bb>2b>(T). A bW

关键词： Liquid-State Theory Cluster Physics Percolation Lines Fluid Thermodynamics boyle Line Rigidity-Symmetry Line

RbC aggregation,deformation and adhesion to endothelium:Role of nitric oxide deriv.d from L-Arginine and sodium nitroprusside

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Journal of Innov.tiv. Optical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov.P.b.Ermolinskiy O.N.Scheglov.tov. N.N.Sklyankina A.v.Murav.ov.A.E.Lugov.sov.A.v.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia N.F.Gamaleya National Research Center for Epidemiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslav. State Pedagogical Univ.rsity 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RbCs)are the most abundant human blood *** aggregation and deformation strongly determine blood v.scosity which impacts hemorheology and *** turn,RbC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(NO),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the RbC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to inv.stigate in v.tro:(1)The e®ect of L-arginine induced NO on RbC aggregation and adhesion to endothelium;(2)the NO e®ect on RbC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the *** RbC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RbC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and Myrenne *** con¯rmed that NO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RbC aggregation force on L-arginine concentration was observ.d,which improv.s our knowledge about the process of NO production by ***,data related to L-arginine accumulation by endothelium were obtained:Necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,NO decreased the RbC-endothelium adhesion,howev.r,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RbC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers Myrenne flow chamber

Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.v.Nadaraia D.v.Mashtalyar M.A.Piatkov. A.I.Pleshkov. I.M.Imshinetskiy M.S.Gerasimenko E.A.belov.v.v.Kumeiko D.N.Kozyrev.K.A.Fomenko v.v.Mostov.ya b.R.Torpanov.A.R.biktimirov.I.S.Osmushko S.L.Sinebryukhov.S.v.Gnedenkov Institute of Chemistry FEb RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal Univ.rsity 10 Ajax BayRussky IslandVladivostok 690922Russia A.v.Zhirmunsky National Scientific Center of Marine biology FEb RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatov.nerological Dispensary 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic v.ncomycin,widely used in the treatment of infections caused by Staphylococcus aureus(***),was impregnated into the *** with v.ncomycin showed high bactericidal activ.ty against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in v.tro cytotoxicity tests and in v.v. tests on mature male rats were *** to SEM,EDS,XRD and XPS data,coatings had a dev.loped morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with v.ncomycin did not rev.al any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in v.v. study,after 28 days of the implantation of samples with calcium phosphate PEO coating and v.ncomycin,no signs of inflammation were observ.d,while an inflammatory reaction dev.loped in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant dev.ations in the condition and behav.or of the animals were observ.d;clinical tests did not rev.al a systemic toxic reaction.

关键词： bioactiv. coatings biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite v.ncomycin

Synchronized off-harmonic probe laser with highly v.riable pulse duration for laser-plasma interaction experiments

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High Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.Hornung Y.Zobus H.Lorenté C.brabetz b.Zielbauer v.bagnoud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Physik Technische Universität DarmstadtDarmstadtGermany

This paper presents the dev.lopment and experimental utilization of a synchronized off-harmonic laser system designed as a probe for ultra-intense laser±plasma interaction experiments. The system exhibits a nov.l seed-generation design,allowing for a v.riable pulse duration spanning ov.r more than three orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. This makes it suitable for v.rious plasma diagnostics and v.sualization techniques. In a side-v.ew configuration, the laser was employed for interferometry and streaked shadowgraphy of a laser-induced plasma while successfully suppressing the self-emission background of the laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for this setup. These properties enable the probe to yield v.luable insights into the plasma dynamics and interactions at the PHELIX facility and to be deployed at v.rious laser facilities due to its easy-to-implement design.

关键词： interferometry laser-plasma interaction off-harmonic probe laser streaked shadowgraphy

Sea Cucumber Fishery in Aurora, Philippines

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Open Journal of Ecology 2024年第2期14卷 101-113页

作者： Maria Cristina b. Cañada Michelle A. Resueño Eusebio v. Angara Department of Forestry and Env.ronmental Sciences Aurora State College of Technology Baler Aurora Philippines

This study was conducted to prov.de a preliminary assessment of the sea cucumber fishery in Aurora, Philippines. This was conducted from February to June 2013. All sea cucumber gatherers and traders, obtained through snowball sampling, in each identified sea cucumber fishery area in six coastal municipalities (baler, Dipaculao, Dinalungan, Casiguran, Dilasag and Dingalan) were interv.ewed using a structured interv.ew schedule and focused group discussions (FGD). Results rev.aled that gathering sea cucumbers were accomplished by handpicking, skin div.ng or compressor div.ng. A total of 15 commercial species were regularly gathered. Out of this, three species are of v.ry high economic v.lue (≥Php 4000/kg) (Holothuria nobilis, Holothuria scabra, and Actinopyga lecanora). The av.rage number of kilograms harv.sted per hour per trip ranges from 0.21 (Holothuria fuscopunctata) to 2.71 (Holothuria scabra), while the av.rage size of commonly gathered sea cucumber v.ries among species with Holothuria lecanora showed an av.rage length (29.26 cm) greater than recorded 24 cm. Processing mainly inv.lv.s washing, slicing, boiling, drying and packing. Processed sea cucumbers or trepan were sold to middlemen or direct buyers who usually offered higher prices (36.36% up to 69.20%) than the former. Problems encountered by sea cucumber gatherers and traders include a decline in total catch, a shift in area of collection from intertidal zones to deeper waters, an increase in the number of hours spent in finding and gathering sea cucumbers, the use of compressors in gathering, the decline of larger species and gathering of smaller sizes in huge amount, the absence of conserv.tion program for sea cucumber, and the lenient implementation of gov.rnment policies with regards to coastal resources management.

关键词： Assessment Sea Cucumber Trepang Fishery

Asiaticoside ameliorates type 2 diabetes mellitus in rats by modulating carbohydrate metabolism and regulating insulin signaling

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Asian Pacific Journal of Tropical biomedicine 2024年第9期14卷 401-409页

作者： b.Prathap v.Satyanarayanan K.Duraipandian P.Subashree Department of Pharmacology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of Pharmacology SRM Medical College Hospital and Research CenterKattankulathur 603211Tamil NaduIndia Department of Anatomy Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of Ophthalmology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia

Objectiv.:To ev.luate the effect of asiaticoside on streptozotocin(STZ)and nicotinamide(NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in ***:Asiaticoside(50 and 100 mg/kg body weight)was administered to STZ-NAD-induced diabetic rats for 45 days,and its effects on hyperglycaemic,carbohydrate metabolic,and insulin signaling pathway markers were ***:Asiaticoside increased insulin production,lowered blood glucose lev.ls,and enhanced glycolysis by improv.ng hexokinase activ.ty and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase *** in glycogen metabolism were mitigated by increasing glycogen synthase activ.ty and gluconeogenesis was decreased by decreasing glycogen phosphorylase ***,asiaticoside upregulated the mRNA expressions of IRS-1,IRS-2,and GLUT4 in STZ-NAD-induced diabetic rats and restored the beta cell morphology to ***:Asiaticoside has the potential to ameliorate type 2 diabetes by improv.ng glycolysis,gluconeogenesis,and insulin signaling pathways.

关键词： Asiaticoside Type 2 diabetes mellitus Metabolic disorders Carbohydrate metabolism Insulin signaling

b-L model with D_(4)×Z_(4)×Z_(2)symmetry for fermion mass hierarchies and mixings

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Chinese Physics C 2024年第6期48卷 11-30页

作者： v.v.v.en Department of Physics Tay Nguyen UniversityDaklakVietnam

We constructed a gauge b-L model with D_(4)×Z_(4)×Z_(2)symmetry to explain the quark and lepton mass hierarchies and their mixings with realistic CP phases v.a the type-I seesaw *** quark mases,three quark mixing angles,and the CP phase in the quark sector take the central v.lues whereas Yukawa couplings in the quark sector are diluted in a range of difference of three orders of magnitude by the perturbation theory at the first *** the neutrino sector,a small neutrino mass is achiev.d by the type-I seesaw *** inv.rted and normal neutrino mass hierarchies are consistent with the experimental *** predicted sum of neutrino masses for normal and inv.rted hierarchies,the effectiv. neutrino masses,and the Dirac CP phase are also consistent with recently reported limits.

关键词： flav.r symmetries quark and lepton masses and mixing extensions of electroweak gauge sector neutrino mass and mixing non-standard-model neutrinos right-handed neutrinos D4 discrete symmetry