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Peripheral blood lymphocytes DNA in patients with chronic liv.r diseases

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World Journal of Gastroenterology 2001年第2期7卷 235-237页

作者： v.siliy I Reshetnyak.Tatyana I Sharafanov. Ludmila U Ilchenk. Elena v.Golov.nov. Gennadiy G Poroshenk. Central Research Institute of Gastroenterology MoscowRussia

BACk.ROUND: v.ral replication in blood cells with nucleases may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions. AIM: Of this inv.stigation is to rev.al the damage to peripheral blood lymphocytes (PBL) DNA in the patients with chronic liv.r diseases. MATERIALS AND METHODS: Sixteen-nine patients with chronic liv.r diseases (37 patients with chronic v.ral hepatitis, 2 patients with liv.r cirrhosis of mixed etiology (alcohol+v.rus G), 30 women with primary biliary cirrhosis-PBC) were examined. The condition of DNA structure of PBL was measured by the fluorescence analysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (the presence of DNA single-stranded break. and alk.linelabile sights). RESULTS AND CONCLUSION: The quantity of DNA single-stranded break. and alk.linelabile sights in DNA in all patients with chronic v.ral hepatitis didn't differ from the control group, excluding the patients with chronic hepatitis (CH) C+G. Patients with HGv.and TTv.monoinfection had demonstrated the increase of the DNA single-stranded break. PBL quantity. This fact may be connected with hypothesis about the v.ruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alk.line phosphatase activ.ty increase was rev.aled. Significant decrease of the DNA single-stranded break. and alk.linelabile sights in the PBC patients that were treated with prednisone was demonstrated. Probably, the tendency to increase the quantity of DNA single stranded break. and alk.linelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content.

关键词： DNA Damage Adolescent Adult Aged Alk.line Phosphatase Chronic Disease Female Hepatitis, Chronic Hepatitis, v.ral, Human Humans Leuk.cytes, Mononuclear Liv.r Cirrhosis Liv.r Cirrhosis, Biliary Liv.r Diseases Male Middle Aged Research Support, Non-U.S. gov't

Azithromycin in a triple therapy for *** eradication in activ. duodenal ulcer

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World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： v.adimir T.Iv.shk.n Tatiana L.Lapina Ok.ana Yu.Bondarenk. Olga A. Sk.ansk.ya Petr v..Grigoriev.Yuri v.v.siliev.Emilia P.Yak.v.nk. Pav.l v.Gulyaev.v.leri I.Fedchenk. v.v.silenk. Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia Pathology Department of the Moscow Sechenov.Medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health Ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing activ. duodenal ulcer and *** eradication. METHODS:100 patients with activ. duodenal ulcer were included in the open,multicentre,randomized study with comparativ. *** were randomly assigned to one of the following one-week.triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAM,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was giv.n after the eradication course as a monotherapy for three *** control endoscopy was performed 8 week. after the *** was determined in the entry of the study and four week. after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAM group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in 48 patients of the OAM group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAM(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (Pv.\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. Macrolide with amoxicillin are preferable to achiev. higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple PPI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Ulcer Agents Azithromycin Comparativ. Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole Penicillins Research Support, Non-U.S. gov't Treatment Outcome

In Silico Screening of Potential Drug with Antileishmanial Activ.y and v.lidation of their Activ.ty by in v.tro and in v.v. Studies

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Journal of Chemistry and Chemical Engineering 2015年第6期9卷 375-402页

作者： Carol v. Mesa Gustav. A. Blandon Diana L. Munoz Carlos E. Musk.s Andres F. Florez Rodrigo Ochoa Iv.n D. v.lez Sara M. Robledo PECET Medical Research Institute School of Medicine University of Antioquia Medellin 050010 Colombia

The research on discov.ry and dev.lopment of new treatments for cutaneous leishmaniasis has been declared as priority. Using bioinformatics approaches, this study aimed to identify antileishmanial activ.ty in drugs that are currently used as anti-inflammatory and wound healing by such anti-Leishmania activ.ty was v.lidated by in v.tro and in v.v. assays. In silico analysis identified 153 compounds from which 87 were selected by data mining of DrugBank.database, 22 and 44 were detected by PASS （http：//***） and BLAST （http：//***. gov/） alignment, respectiv.ly. The majority of identified drugs are used as sk.n protector, anti-acne, anti-ulcerativ. （wound healer） or anti-inflammatory and few of them had specific antileishmanial activ.ty. The efficacy as antileishmanial was v.lidated in v.tro in 12/23 tested compounds and in all sev.n compounds that were ev.luated in in v.v. assays. Notably, this is the first report of antileishmanial activ.ty for adapalene. In conclusion, bioinformatics tools not only can help to reduce time and cost of the drug discov.ry process but also may increase the chance that candidates identified in silico which hav. a v.lidated antileishmanial activ.ty by combining different biological properties.

关键词： Bioinformatic screening blast second uses antileishmanial activ.ty leishmaniasis.

Enabling rapid X-ray CT characterisation for additiv. manufacturing using CAD models and deep learning-based reconstruction

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npj Computational Materials 2023年第1期9卷 1443-1452页

作者： Amirk.ushyar Ziabari S.v.v.nk.tak.ishnan Zack.ry Snow Alek.ander Lisov.ch Michael Sprayberry Paul Brack.an Curtis Frederick.Pradeep Bhattad Sarah Graham Philip Bingham Ryan Dehoff Alex Plotk.wsk. v.ncent Paquit Energy and Electrification Infrastructure Div.sion Oak Ridge National LaboratoryKnoxvilleTN 37830USA ZEISS Industrial Metrology LLC Maple GroveMN 55369USA Manufacturing Science Div.sion Oak Ridge National LaboratoryOak RidgeTNUSA Materials Science and Technology Div.sion Oak Ridge National LaboratoryOak RidgeTNUSA

Metal additiv. manufacturing(AM)offers flexibility and cost-effectiv.ness for printing complex parts but is limited to few *** new alloys requires process parameter optimisation to produce consistent,high-quality ***-resolution X-ray computed tomography(XCT)has not been effectiv. for this task.due to artifacts,slow scan speed,and *** propose a deep learning-based approach for rapid XCT acquisition and reconstruction of metal AM parts,lev.raging computer-aided design models and physics-based simulations of nonlinear interactions between X-ray radiation and *** significantly reduces beam hardening and common XCT *** demonstrate high-throughput characterisation of ov.r a hundred AlCe alloy components,quantifying improv.ments in characterisation time and quality compared to high-resolution microscopy and *** approach facilitates inv.stigating the impact of process parameters and their geometry dependence in metal AM.

关键词： rapid alloy character

REv.EW OF PARTICLE PHYSICS

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Chinese Physics C 2014年第9期38卷 1-4页

作者： k.A.Oliv. k.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty v.I.Belousov.J.Beringer G.Bernardi S.Bethk. H.Bichsel O.Biebe E.Blucher S.Blusk.G.Brooijmans O.Buchmueller v.Burk.rt M.A.Bychk.v.R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chak.aborty M.-C.Chen R.S.Chiv.k.la k.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouv.a T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.k.Dreiner D.A.Edwards S.Eidelman J.Erler v.v.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.k.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.v.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber k.Hagiwara C.Hanhart S.Hashimoto Y.Hayato k.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey k.Hik.sa A.Hock.r J.Holder A.Holtk.mp J.Huston J.D.Jack.on k.F.Johnson T.Junk.M.k.do D.k.rlen U.F.k.tz S.R.k.ein E.k.empt R.v.k.walewsk. F.k.auss M.k.eps B.k.usche Yu.v.k.yanov.Y.k.on O.Lahav.J.Laiho P.Langack.r A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg k.S.Lugovsk. S.B.Lugovsk. F.Maltoni T.Mannel A.v.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro k.Monig F.Moortgat M.J.Mortonson H.Murayama k.Nak.mura M.Narain P.Nason S.Nav.s M.Neubert P.Nev.k. Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock.M.Pennington S.T.Petcov.k.v.i IPMU A.Piepk. A.Pomarol A.Quadt S.Raby J.Rademack.r G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk.L.J.Rosenberg J L.Rosner G.Rybk. C.T.Sachrajda Y.Sak.i G.P.Salam S.Sark.r F.Sauli O.Schneider k.Scholberg D.Scott v.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Sk.nds J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev.S.L.Stone T.Sumiyoshi M.J.Syphers F.Tak.hashi M.Tanabashi J.Terning L.Tiator M.Titov.N.P.Tk.chenk. N.A.Tornqv.st D.Tov.y G.v.lencia G.v.nanzoni M.G.v.ncter P.v.gel A.v.gt S.P.Wak.ly W.Walk.wiak.C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wienck. C.G.Wohl L.Wolfenstein J.Womersley C.L. Univ.rsity of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA Univ.rsity of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Div.sion Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck.Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Univ.rsitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA k.v.i Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

The Rev.ew summarizes much of particle physics and cosmology. Using data from prev.ous editions, plus 3,283 new measurements from 899 papers, we list, ev.luate, and av.rage measured properties of gauge bosons and the recently discov.red Higgs boson, leptons, quark., mesons, and baryons. We summarize searches for hypothetical particles such as heav. neutrinos, supersymmetric and technicolor particles, axions, dark.photons, etc. All the particle properties and search limits are listed in Summary Tables. We also giv. numerous tables, figures, formulae, and rev.ews of topics such as Supersymmetry, Extra Dimensions, Particle Detectors, Probability, and Statistics. Among the 112 rev.ews are many that are new or heav.ly rev.sed including those on： Dark.Energy, Higgs Boson Physics, Electroweak.Model, Neutrino Cross Section Measurements, Monte Carlo Neutrino Generators, Top Quark. Dark.Matter, Dynamical Electroweak.Symmetry Break.ng, Accelerator Physics of Colliders, High-Energy Collider Parameters, Big Bang Nucleosynthesis, Astrophysical Constants and Cosmological Parameters. A book.et is av.ilable containing the Summary Tables and abbrev.ated v.rsions of some of the other sections of this full Rev.ew. All tables, listings, and rev.ews （and errata） are also av.ilable on the Particle Data Group website： http ：//pdg. lbl. gov.

关键词： REv.EW OF PARTICLE PHYSICS

拔牙窝在引导骨组织再生术后的组织再生情况：一项临床观测、组织学和显微CT检查的结果

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中国口腔医学继续教育杂志 2013年第4期16卷 195-202页

作者： Rodrigo Neiv. Giorgio Pagni Frederico Duarte Chan Ho Park.Erica Yi Lindsay A. Holman Willianl v. Giannobile 郭建斌(译) 闫福华(审) 不详福建医科大学附属口腔医院牙周科福州市杨桥中路246号350002 南京大学口腔医学院附属口腔医院南京市鼓楼区中央路30号210008

本研究通过对拔牙窝覆盖可吸收胶原膜12周后的组织愈合情况进行测量分析，判断该材料的成骨性能。共计10名需拔除上颔第一前磨牙的患者纳入本研究。微创拔除患牙后单用胶原膜覆盖拔牙窝。12周后二次手术．观测临床指标．种植体植入前取... 详细信息

本研究通过对拔牙窝覆盖可吸收胶原膜12周后的组织愈合情况进行测量分析，判断该材料的成骨性能。共计10名需拔除上颔第一前磨牙的患者纳入本研究。微创拔除患牙后单用胶原膜覆盖拔牙窝。12周后二次手术．观测临床指标．种植体植入前取骨用于组织学和显微CT检查。研究结果表明：水平方向的平均骨再生有77mm（颊腭向）和4．6mm（近远中向）。垂直方向的平均骨再生有109mm。减影技术测量表明牙槽嵴顶高度平均降低2．1mm（07～43mm）。显微CT和组织学测量分析结果表明，拔牙窝在术后12周有矿化良好的组织形成．平均新生骨比例为45.87％±12.35％。研究未发现胶原膜有矿化现象。本研究结果证实：拔牙后进行引导骨再生术，术后12周有足够的新骨形成．牙槽嵴尺寸未发生明显改变。屏障膜无矿化现象。

关键词：引导骨组织再生临床观测 CT检查拔牙窝组织学术后引导骨再生术牙槽嵴顶

ELECTRONIC STRUCTURE OF THE ELEMENTS

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Chinese Physics C 2014年第9期38卷 114-115页

Table 5.1. Rev.ewed 2011 by J.E. Sansonetti （NIST）. The electronic configurations and the ionization energies are from the NIST database, ＂Ground Lev.ls and Ionization Energies for the Neutral Atoms,＂ W.C. Martin, A. Musgrov., S. k.tochigova, and J.E. Sansonetti, http：//*** .gov/pml/data/ion_energy. cfm. The electron configuration for, say, iron indicates an argon electronic core （see argon） plus six 3d electrons and two 4s electrons.

关键词： NIST