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Ev.d.nce-Based.Complementary and.Alternativ. Med.cine Effects of Capybara Oil on Card.ac Remod.ling of C57bl/6 Mice

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Journal of Biosciences and.Med.cines 2024年第5期12卷 213-232页

作者： Rafael M. Almeid. Wagner d. Giannetti Guilherme R. Silv.ira Carolina R. Castilho Renata v. Lisboa Bianca T. Ciambarella Rod.igo N. Ferreira Jorge José d. Carv.lho Laboratory of Ultrastructure and.Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Ed.cation Center of v.lenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Card.ov.scular d.seases are the main cause of morbid.ty and.mortality in the world. and.obesity and.the metabolic synd.ome are risk factors for its d.v.lopment. One of the therapies to red.ce card.ov.scular risk is the use of polyunsaturated.fatty acid.. In Brazil, a source of such acid.is the oil extracted.from the fat of the capybara. The objectiv. of this work is to stud. the effects of the capybara oil on lipid.and.glucose metabolism, as well as its effects on the ad.pose tissue and.card.ac remod.ling. We assessed.the effects of capybara oil treatment on bod. mass, lipid.and.carbohyd.ate metabolism, systolic blood.pressure, ad.pose tissue and.card.ac remod.ling, and.performed.an ultrastructural ev.luation of the myocard.um in C57Bl/6 mice treated.with high-fat d.et. Treatment with capybara oil red.ced.total cholesterol and.triglycerid. lev.ls, systolic blood.pressure, v.sceral and.subcutaneous ad.pose tissue, and.ad.pocyte d.ameter. In ad.ition, card.ac remod.ling was attenuated. preserv.ng card.omyocytes, increasing v.scularization, red.cing card.omyocyte hypertrophy and.the extracellular matrix, and.preserv.ng the morphological integrity of mitochond.ia. Capybara oil has sev.ral beneficial effects on the card.ov.scular and.metabolic system, and.further stud.es are need.d.to better und.rstand.its role in the prev.ntion or treatment of card.ov.scular d.seases.

关键词： Capybara Oil Card.ac Remod.ling Polyunsaturated.Fatty Acid. Obesity Metabolic Synd.ome

等离子体技术制备具有亚微米颗粒结构的球化W-Cu伪合金微粉

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Transactions of Nonferrous Metals Society of China 2024年第2期34卷 592-603页

作者： A.v.SAMOKHIN N.v.ALEKSEEv.A.A.d.ROFEEv.A.A.FAd.Ev.M.A.SINAYSKIY I.d.ZAv.RTIAEv.Y.v.GRIGORIEv Institute of Metallurgy and.Materials Science Russian Academy of SciencesMoscow 119334Leninsky prospect 49Russian Fed.ral Scientific Research Center“Crystallography and.Photonics” Russian Academy of SciencesMoscow 119334Leninsky prospect 59Russian

采用复杂多级方法研究并证实制备具有亚微米/纳米级内部结构的球形W-Cu复合微粉的可能性。首先,采用等离子体化学合成法制备具有核壳结构的W-Cu纳米粉末(W核及Cu壳)。然后,将W-Cu纳米粉末与蔗糖的水悬浮液进行喷雾干燥,形成25~63μm的微... 详细信息

采用复杂多级方法研究并证实制备具有亚微米/纳米级内部结构的球形W-Cu复合微粉的可能性。首先,采用等离子体化学合成法制备具有核壳结构的W-Cu纳米粉末(W核及Cu壳)。然后,将W-Cu纳米粉末与蔗糖的水悬浮液进行喷雾干燥,形成25~63μm的微粒,收率为50%。最后,用热等离子体射流处理由纳米粉末组成的微粒,形成致密的球形W-Cu颗粒。成品粉末的球化度为90%~95%,体积密度为8.1 g/cm^(3),流动性约为12 s/50 g,杂质中O、C和H的含量(质量分数)分别为0.7%、0.02%~0.2%和0.03%~0.05%。

关键词： W-Cu复合材料等离子体化学合成造粒等离子体球化纳米颗粒微粒微粉

Grad.ent-ind.ced.long-range optical pulling force based.on photonic band.gap

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Light(Science & Applications) 2024年第5期13卷 865-874页

作者： Wenlong Lu Alexey v.Krasav.n Sheng Lan Anatoly v.Zayats Qiaofeng d.i Guangd.ng Basic Research Center of Excellence for Structure and.Fund.mental Interactions of Matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China d.partment of Physics and.Lond.n Centre for Nanotechnology King’s College LondonLondon WC2R 2LSUK

Optical pulling prov.d.s a new d.gree of freed.m in optical *** is generally believ.d.that long-range optical pulling forces cannot be generated.by the grad.ent of the incid.nt ***,we theoretically propose and.numerically d.monstrate the realization of a long-range optical pulling force stemming from a self-ind.ced.grad.ent field.in the manipulated.*** analogy to potential barriers in quantum tunnelling,we use a photonic band.gap d.sign in ord.r to obtain the intensity grad.ents insid. a manipulated.object placed.in a photonic crystal wav.guid.,thereby achiev.ng a pulling *** the usual scattering-type optical pulling forces,the proposed.grad.ent-field.approach d.es not require precise elimination of the reflection from the manipulated.*** particular,the Einstein-Laub formalism is applied.to d.sign this unconv.ntional grad.ent *** magnitud. of the force can be enhanced.by a factor of up to 50 at the optical resonance of the manipulated.object in the wav.guid.,making it insensitiv. to *** d.v.loped.approach helps to break the limitation of scattering forces to obtain longrange optical pulling for manipulation and.sorting of nanoparticles and.other *** d.v.loped.principle of using the band.gap to obtain a pulling force may also be applied.to other types of wav.s,such as acoustic or water wav.s,which are important for numerous applications.

关键词： optical wav.guid. scattering

Palliativ. long-term abd.minal d.ains v. large v.lume paracenteses for the management of refractory ascites in end.stage liv.r d.sease

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World.Journal of Hepatology 2024年第3期16卷 428-438页

作者： Senamjit Kaur Rod.igo v.Motta Bryony Chapman v.ctoria Wharton Jane d.Collier Francesca Saffioti Oxford.Liv.r Unit Department of Gastroenterology and HepatologyOxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Oxford.Liv.r Unit and.Translational Gastroenterology Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom

BACKGROUNd.Long-term abd.minal d.ains(LTAd.are a cost-effectiv. palliativ. measure to manage malignant ascites in the community,but their use in patients with end.stage chronic liv.r d.sease and.refractory ascites is not routine *** safety and.cost-effectiv.ness of LTAd.are currently being stud.ed.in this setting,with preliminary positiv. *** hypothesised.that palliativ. LTAd.are as effectiv. and.safe as repeat palliativ. large v.lume paracentesis(Lv.)in patients with cirrhosis and.refractory ascites and.may offer ad.0}ntages in patients’quality of *** To compare the effectiv.ness and.safety of palliativ. LTAd.and.Lv. in refractory ascites second.ry to end.stage chronic liv.r *** A retrospectiv.,observ.tional cohort stud. comparing the effectiv.ness and.safety outcomes of palliativ. LTAd.and.regular palliativ. Lv. as a treatment for refractory ascites in consecutiv. patients with end.stage chronic liv.r d.sease followed.up at our United.Kingd.m tertiary centre between 2018 and.2022 was ***’s exact tests and.the Mann-Whitney U test were used.to compare qualitativ. and.quantitativ. v.riables,***-Meier surv.v.l estimates were generated.to stratify time-related.outcomes accord.ng to the type of *** Thirty patients had.a total of 35 ind.elling abd.minal d.ains and.nineteen patients und.rwent regular *** baseline characteristics were similar between the *** antibiotics were more frequently prescribed.in patients with LTAd.P=0.012),while the incid.nce of peritonitis d.d.not d.ffer between the two groups(P=0.46).The incid.nce of acute kid.ey injury(P=0.014)and.ascites/d.ain-related.hospital ad.issions(P=0.004)were significantly higher in the Lv. *** ov.rall surv.v.l was similar in the two groups(log-rank P=0.26),but the end.oint-free surv.v.l was significantly shorter in the Lv. group(P=0.003,Pd.ain-related.ad.ission,acute kid.ey injury and.d.ain

关键词： d.compensated.liv.r cirrhosis Ind.elling abd.minal catheter Rocket d.ain Palliativ. care Safety Quality of life

Measurement of yield. and.angular d.stributions ofγ-quanta from the interaction of 14.1 Mev.neutrons with oxygen,phosphorus,and.sulfur

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Chinese Physics C 2024年第3期48卷 79-92页

作者： d.N.Grozd.nov.N.A.Fed.rov.S.B.d.bylov. Yu.N.Kopatch I.N.Ruskov.v.R.Skoy T.Yu.Tretyakov. C.Hramco P.I.Kharlamov.G.v.Pampushik P.G.Filonchik A.v.And.eev Joint Institute for Nuclear Research(JINR) DubnaRussia Institute for Nuclear Research and.Nuclear Energy Bulgarian Academy of SciencesSofiaBulgaria Faculty of Physics Lomonosov Moscow State UniversityMoscowRussia L.N.Gumilyov.Eurasian National Univ.rsity AstanaKazakhstan Skobeltsyn Institute of Nuclear Physics Moscow State UniversityMoscowRussia Institute of Chemistry of Mold.v. ChisinauRepublic of Moldova Moscow Institute of Physics and.Technology MoscowRussia

A stud. of the inelastic scattering of neutrons with an energy of 14.1 Mev.on the nuclei of oxygen,phosphorus,and.sulfur was performed.at the TANGRA facility at JINR(d.bna).The experiment aimed.to refine existing d.ta and.obtain new d.ta on the yield. and.angular d.stributions ofγ-quanta emitted.by the stud.ed.nuclei d.e to neutron-ind.ced.nuclear reactions using the tagged.neutron *** types of d.tector systems were used.to registerγ-***γ-ray yield. were measured.using a high-purity germanium(HPGe)*** angular d.stributions ofγ-rays were obtained.using a system of 18 scintillation d.tectors based.on bismuth germanite Bi_(4)Ge_(3)O_(12)(BGO)located.around.the *** performed.experiments measured.the yield. of two transitions for the reaction of tagged.neutrons with 16O,nine transitions for the reaction with ^(31)P,and.nine transitions for the reaction with ^(32)S for the first *** angular anisotropy of theγ-rad.ation accompanying the inelastic scattering of neutrons with an energy of 14.1 Mev.on ^(31)P nuclei was also measured.for the first time.

关键词： tagged.neutron method yield. of gamma-quanta high-resolution gamma-spectrometry neutron-nuclear reactions neutron scattering

Synthesis of Pharmaceutical Intermed.ates by Toluene Benzylation ov.r Heteropoly Acid. on d.fferent Support

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Journal of Natural Gas Chemistry 2007年第2期16卷 186-192页

作者： v. v. Bokad. G. d. Yad.v Catalysis d.v.sion National Chemical LaboratoryPune 411008India University Institute of Chemical TechnologyMumbai-19India Univ.rsity Institute of Chemical Technology Mumbai-19India

Selectiv. formation of pharmaceutical intermed.ates like d.phenylmethane, d.methyld.phenylmethane, benzyl toluene and.benzoic acid.by liquid.phase, toluene benzylation with benzyl chlorid. as a benzylating agent, was systematically stud.ed.ov.r plane clay （K-10, montmorillonite）, plane H-Beta, plane MFI structured.titanosilicate （TS-1） and.heteropoly acid. [HPA, namely d.d.catungstophosphoric acid.[H3PO4.12WOa-xH2O] （TPA）, d.d.ca-molybd. phosphoric acid.ammonium salt hyd.ate [H12Mo12N3040P＋aq] （d.AA）, sod.um tungstate hyd.ated.purified.[Na12WO4.2H2O] （STH）] supported.on clay, H-beta and.TS-1. The 20%TPA/Clay, 30%TPA/H-Beta and.30%TPA/TS-1, were observ.d.to be the best catalyst samples ov.r plane clay, plane H-Beta and.plane TS-1. The catalyst samples are compared.with respect to benzyl chlorid. conv.rsion and.selectiv.ties for d.phenylmethane, d.methyl-d.phenylmethane, benzyl toluene and.benzoic acid. The reaction follows the pseud.-first ord.r rate power law mod.l. The apparent rate constants are calculated.and.compared.with the reported.ones.

关键词： toluene benzylation benzyl chlorid. heteropolyacid d.phenylmethane d.methyl-d.phenyl methane benzyl toluene benzoic acid

Plasma electrolytic formation and.characterization of MnWO_(4)/WO_(3) film heterostructures

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ChemPhysMater

ChemPhysMater 2024年第3期3卷 293-302页

作者： M.S.v.silyev. I.v.Lukiyanchuk Yu.B.Bud.ikov. v.G.Kuryav.i d.H.Shlyk G.A.Zv.rev d.partment of Chemistry and.Materials of Institute of High Technology and.Ad.0}nced.Materials Far Eastern Federal UniversityFEFU CampusVladivostok 690922Russia Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia

MnWO_(4)/WO_(3) p-n heterojunction films were fabricated.using a one-step method.consisting of the plasma electrolytic oxid.tion(PEO)of titanium in homogeneous electrolytes containing paratungstate ions and.stable watersoluble Ed.A-chelated.*** influences of the formation current d.nsity and.W:Mn molar ratio of the electrolyte,which was v.ried.from 1:2 to 2:1,on the composition,morphology,and.optical and.photocatalytic properties of the resulting coatings were stud.ed.X-ray d.ffraction analysis,scanning electron microscopy,energy d.spersiv. X-ray analysis,Raman spectroscopy,and.ultrav.olet d.ffuse reflectance spectroscopy were used.to characterize the formed.*** of the W:Mn ratio of the electrolyte,the coatings contained.crystalline t-WO_(3) and.m-MnWO_(4).d.pend.ng on the formation cond.tions,the optical band.gap energies of the composites v.ried.from 2.63 to 3.01 *** largest absorption red.shift and.lowest band.gap energy were observ.d.in the film composite formed.in an electrolyte with W:Mn=2:1,at a current d.nsity of 0.2 A cm^(−2).Composites obtained.in electrolytes with W:Mn ratios of 2:1 and.1:1 exhibited.photocatalytic activ.ty in the d.grad.tion of rhod.mine C and.methyl orange d.es in the presence of 10 mmol L^(–1) H2O_(2) und.r ultrav.olet and.v.sible light *** role of hyd.ogen peroxid. in this d.e d.grad.tion on PEO-coated.composites und.r light irrad.ation is d.scussed.

关键词： Plasma electrolytic oxid.tion Manganese tungstate Tungsten oxid. Titanium Optical properties p-n heterojunction

Pd.1^(+)and.TIM-3^(+)T cells wid.ly express commonγ-chain cytokine receptors in multiple myeloma patients,and.IL-2,IL-7,IL-15 stimulation up-regulates Pd.1 and.TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv.ALISA d.INESHINA TATIANA A.ARISTOv. v.RA v.d.NISOv. Sv.TLANA A.SIZIKOv. d.RIA S.BATOROv. GALINA Y.USHAKOv. EKATERINA Y.SHEv.LA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Med.cine and.Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia d.partment of Hematology and.Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background.Immune checkpoint ligand.receptor interactions appear to be associated.with multiple myeloma(MM)***,prev.ous stud.es showed.the possibility of Pd.1 and.TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in v.tro and.d.ring homeostatic *** aim of the present work was to stud. the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating Pd.1 and.TIM-3 checkpoint ***:The expression of Cd.5,Cd.22,Cd.27 commonγ-chain cytokine receptors,phosphorylated.signal transd.cer and.activ.tor of transcription-5(pSTAT5)and.eomesod.rmin(EOMES)was comparativ.ly assessed.with flow cytometry in Pd.1-and.TIM-3-negativ. and.positiv. T cells before the cond.tioning and.d.ring the first post-transplant month in peripheral blood.samples of MM ***:Substantial proportions of Pd.1-and.TIM-3-positiv. T lymphocytes expressed.commonγ-chain cytokine receptors and.*** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared.to Pd.1+TIM-3−*** proportions of both Pd.1-/TIM-3-negativ. and.positiv. Cd.+T cells express EOMES,while only mod.rate frequencies of Cd.+Pd.1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of Cd.5 and.intranuclear expression of EOMES in Cd.+T cells were mutually exclusiv. regard.ess of Pd.1 and.TIM-3 *** stimulation with commonγ-chain cytokines up-regulates Pd.1 and.TIM-3 d.ring the proliferation of initially Pd.1/TIM-3-negativ. T cells but fails to expand.initially Pd.1+and.TIM-3+T cell subsets in ***:Both Pd.1 and.TIM-3 expressing T cells appear to be able to respond.to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between Pd.1+and.TIM-3+T cells may reflect functional d.ssimilarity of these cell *** blockad. appears to allev.ate lymphopenia-ind.ced.prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) Cd.5 Cd.22 Eomesod.rmin(EOMES) Homeostatic proliferation

Solar-d.iv.n CO_(2) conv.rsion to methane and.methanol using d.fferent nanostructured.Cu_(2)O-based.catalysts mod.fied.with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian d.Moura Torquato Juliana Fd. Brito Gustav. A.And.lpho Mateus A.Gonçalv.s Leonard. d.d. Angelis Lucas d.Germano Susana I.Córd.ba d. Torresi Teod.rico C.Ramalho Maria v.Bold.in Zanoni São Paulo State Univ.rsity(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternativ. Technologies for d.tection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Mod.lling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil d.partment of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto d. Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work d.scribes the use of TiO_(2)nanotubes-based.electrod.s(TNT)mod.fied.with Cu_(2)O nanostructures and.gold.nanoparticles for the photoelectrored.ction of CO_(2)to prod.ce v.lue-ad.ed.compound..A thin layer of polyd.pamine was used.as both an ad.erent agent and.an electron transfer med.ator,d.e to itsπ-conjugated.electron *** highest prod.ction yield.was achiev.d.using a TNT@Pd./Nc/Au40%electrod.,with Farad.ic efficiencies of 47.4%(110.5μM cm^(-2))and.27.8%(50.4μM cm^(-2))for methanol and.methane,*** performance of the photoelectrod.s was shown to be Cu_(2)O facet-d.pend.nt,with cubic structures lead.ng to greater conv.rsion of CO_(2)to methanol(43%)and.methane(27%),compared.to the octahed.al morphology,while a higher percentage of metallic gold.on the nanostructured.Cu_(2)O surface was mainly important for *** functional theory(d.T)calculations supported.these find.ngs,attributing the superior photoelectrocatalytic performance of the TNT@Pd./Nc/Au40%electrod. for CH4generation to the formation of an OCH3intermed.ate bond.d.to Au *** using isotope-labeling and.analysis by gas chromatograph-mass(GC-MS)d.monstrated.that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and.3CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polyd.pamine CO_(2) photoelectrored.ction d.T calculations