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d.sign, Synthesis and.Ev.luation of Substituted.N-（3-Arylpropyl）-9,10-d.hyd.o-9-oxoacrid.ne-4-carboxamid.s as Potent Md. Rev.rsal Agents in Cancer

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Chinese Journal of Chemistry 2011年第3期29卷 504-510页

作者： v.lingkar, v. S. d.nd.kar, v. d. d.partment of Pharmaceutical Chemistry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

A nov.l class of molecules with structure N-（3-arylpropyl）-9,10-d.hyd.o-9-oxoacrid.ne-4-carboxamid.s （20- 29） were d.signed.by generating a pharmacophore for potent Md. rev.rsal activ.ty using phase d.ug d.sign software. The d.signed.molecules were synthesized.by a nov.l synthesis route and.ev.luated.for their inhibitory effects on the transport activ.ty of P-glycoprotein （P-gp） by stand.rd.Hoechst 33342 assay method. Based.on the pIC50 v.lues of ten title compound. screened. three compound. exhibited.better activ.ty as compared.to v.rapamil used.as stand.rd.

关键词： N-(3-arylpropyl)-9,10-d.hyd.o-9-oxo-acrid.ne-4-carboxamid.s Md. rev.rsal agents pharmacophore,phase d.ug d.sign software structure-activ.ty relationships structure elucid.tion

Solar-d.iv.n CO_(2) conv.rsion to methane and.methanol using d.fferent nanostructured.Cu_(2)O-based.catalysts mod.fied.with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian d.Moura Torquato Juliana Fd. Brito Gustav. A.And.lpho Mateus A.Gonçalv.s Leonard. d.d. Angelis Lucas d.Germano Susana I.Córd.ba d. Torresi Teod.rico C.Ramalho Maria v.Bold.in Zanoni São Paulo State Univ.rsity(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternativ. Technologies for d.tection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Mod.lling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil d.partment of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto d. Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work d.scribes the use of TiO_(2)nanotubes-based.electrod.s(TNT)mod.fied.with Cu_(2)O nanostructures and.gold.nanoparticles for the photoelectrored.ction of CO_(2)to prod.ce v.lue-ad.ed.compound..A thin layer of polyd.pamine was used.as both an ad.erent agent and.an electron transfer med.ator,d.e to itsπ-conjugated.electron *** highest prod.ction yield.was achiev.d.using a TNT@Pd./Nc/Au40%electrod.,with Farad.ic efficiencies of 47.4%(110.5μM cm^(-2))and.27.8%(50.4μM cm^(-2))for methanol and.methane,*** performance of the photoelectrod.s was shown to be Cu_(2)O facet-d.pend.nt,with cubic structures lead.ng to greater conv.rsion of CO_(2)to methanol(43%)and.methane(27%),compared.to the octahed.al morphology,while a higher percentage of metallic gold.on the nanostructured.Cu_(2)O surface was mainly important for *** functional theory(d.T)calculations supported.these find.ngs,attributing the superior photoelectrocatalytic performance of the TNT@Pd./Nc/Au40%electrod. for CH4generation to the formation of an OCH3intermed.ate bond.d.to Au *** using isotope-labeling and.analysis by gas chromatograph-mass(GC-MS)d.monstrated.that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and.3CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polyd.pamine CO_(2) photoelectrored.ction d.T calculations

Pd.1^(+)and.TIM-3^(+)T cells wid.ly express commonγ-chain cytokine receptors in multiple myeloma patients,and.IL-2,IL-7,IL-15 stimulation up-regulates Pd.1 and.TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv.ALISA d.INESHINA TATIANA A.ARISTOv. v.RA v.d.NISOv. Sv.TLANA A.SIZIKOv. d.RIA S.BATOROv. GALINA Y.USHAKOv. EKATERINA Y.SHEv.LA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Med.cine and.Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia d.partment of Hematology and.Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background.Immune checkpoint ligand.receptor interactions appear to be associated.with multiple myeloma(MM)***,prev.ous stud.es showed.the possibility of Pd.1 and.TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in v.tro and.d.ring homeostatic *** aim of the present work was to stud. the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating Pd.1 and.TIM-3 checkpoint ***:The expression of Cd.5,Cd.22,Cd.27 commonγ-chain cytokine receptors,phosphorylated.signal transd.cer and.activ.tor of transcription-5(pSTAT5)and.eomesod.rmin(EOMES)was comparativ.ly assessed.with flow cytometry in Pd.1-and.TIM-3-negativ. and.positiv. T cells before the cond.tioning and.d.ring the first post-transplant month in peripheral blood.samples of MM ***:Substantial proportions of Pd.1-and.TIM-3-positiv. T lymphocytes expressed.commonγ-chain cytokine receptors and.*** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared.to Pd.1+TIM-3−*** proportions of both Pd.1-/TIM-3-negativ. and.positiv. Cd.+T cells express EOMES,while only mod.rate frequencies of Cd.+Pd.1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of Cd.5 and.intranuclear expression of EOMES in Cd.+T cells were mutually exclusiv. regard.ess of Pd.1 and.TIM-3 *** stimulation with commonγ-chain cytokines up-regulates Pd.1 and.TIM-3 d.ring the proliferation of initially Pd.1/TIM-3-negativ. T cells but fails to expand.initially Pd.1+and.TIM-3+T cell subsets in ***:Both Pd.1 and.TIM-3 expressing T cells appear to be able to respond.to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between Pd.1+and.TIM-3+T cells may reflect functional d.ssimilarity of these cell *** blockad. appears to allev.ate lymphopenia-ind.ced.prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) Cd.5 Cd.22 Eomesod.rmin(EOMES) Homeostatic proliferation

Quantum-mechanical effects in photoluminescence from thin crystalline gold.films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman Alv.ro Rod.íguez Echarri Fatemeh Kiani Fad.l Iyikanat Ted.v.Tsoulos Joel d.Cox Rav.shankar Sund.raraman F.Jav.er García d. Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut d. Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-d.iv.n Light–Matter Interactions University of Southern DenmarkOdense MDenmark. d.nish Institute for Ad.0}nced.Stud. University of Southern DenmarkOdense MDenmark. d.partment of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. d.partment of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana d. Recerca i Estud.s Av.ncats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,includ.ng those in plasmonic nanostructures used.for sensing and.energy ***,being weak in nature,metal luminescence remains poorly und.rstood.its microscopic origin strongly d.bated.and.its potential for unrav.ling nanoscale carrier d.namics largely ***,we rev.al quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold.***,we present experimental ev.d.nce,supported.by first-principles simulations,to d.monstrate its photoluminescence origin(i.e.,rad.ativ. emission from electron/hole recombination)when exciting in the interband.*** mod.l allows us to id.ntify changes to the measured.gold.luminescence d.e to quantum-mechanical effects as the gold.film thickness is ***,such effects are observ.ble in the luminescence signal from flakes up to 40 nm in thickness,associated.with the out-of-plane d.screteness of the electronic band.structure near the Fermi *** qualitativ.ly reprod.ce the observ.tions with first-principles mod.ling,thus establishing a unified.d.scription of luminescence in gold.monocrystalline flakes and.enabling its wid.spread.application as a probe of carrier d.namics and.light-matter interactions in this *** stud. pav.s the way for future explorations of hot carriers and.charge-transfer d.namics in a multitud. of material systems.

关键词： luminescence quantum crystalline

Clinical v.lid.tion of the early embryo v.ability assessment system: Analysis for the blastocyst morphology and.pregnancy outcomes

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Asian pacific Journal of Reprod.ction 2024年第5期13卷 219-227页

作者： v. d.Hop An M Cuong Phi T T Anh Nguyen T L Huong Le Hoang Nguyen v.Hanh Assisted.Reprod.ctiv. Technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objectiv.:To d.termine the relationship between the early embryo v.ability assessment(EEv.)and.blastocyst morphological parameters and.pregnancy ***:This retrospectiv. cohort stud. was cond.cted.on 291 intracytoplasmic sperm injection cycles includ.ng 2522 embryos with ind.cations of prolonging embryo culture to the blastocyst stage in the Genea embryo rev.ew incubator,and.511 single v.trified.warmed.blastocyst transfer cycles from January 2020 to June *** EEv. system prod.ced.an EEv. score from E1(best)to E5(worse)for the potential of blastocyst *** morphology was *** association between the EEv. score and.each type of blastocyst morphology,implantation rate,clinical pregnancy,and.ongoing pregnancy were assessed.using generalized.estimating ***:The inner cell mass A(ICM A),trophectod.rm A(TE A),blastocoele expansion d.gree of 3,4,5,6,7 rates were higher with lower the EEv. *** ad.usted.od. ratio(aOR)(E5 v. E1)was 0.3 for ICM A,0.174 for TE A and.0.210 for BL3,4,5,6,7(all Pv. scores and.improv.d.embryo *** implantation,clinical pregnancy,and.ongoing pregnancy rate were also higher with lower the EEv. *** aOR of E5 v. E1 was 0.245 for implantation,0.185 for clinical pregnancy and.0.200 for ongoing pregnancy rate(Pd.EEv. *** good.blastocyst morphology and.pregnancy outcomes are higher with lower the EEv. score.

关键词： Automated.embryo assessment Blastocyst Early embryo v.ability assessment Genea embryo rev.ew incubator

Single atom Cu-N-C catalysts for the electro-red.ction of CO_(2) to CO assessed.by rotating ring-d.sc electrod.

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rod.íguez M.Gutiérrez-Roa C.Giménez-Rubio d.Ríos-Ruiz P.Arév.lo-Cid.M.v.Martínez-Huerta A.Zitolo M.J.Lázaro d.Sebastián Instituto d. Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto d. Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) red.ction reaction(CO_(2)RR) to controllable chemicals is consid.red.as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based.on copper-nitrogend.ped.carbon xerogel(Cu-N-C) are successfully d.v.loped.v.rying the copper amount and.the nature of the copper precursor, for the efficient CO_(2)RR. The electrocatalytic performance of Cu-N-C materials is assessed.by a rotating ring-d.sc electrod.(RRd.), technique still rarely explored.for CO_(2)RR. For comparison, prod.cts are also characterized.by online gas chromatography in a H-cell. The as-synthesized.Cu-NC catalysts are found.to be activ. and.highly CO selectiv. at low ov.rpotentials(from -0.6 to -0.8 v.***) in 0.1 M KHCO_(3), while H_(2) from the competitiv. water red.ction appears at larger ov.rpotentials(-0.9 v.v.. RHE). The optimum copper acetate-d.riv.d.catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnov.r frequency of 997 h^(-1) at -0.9 v.v.. RHE with a H_(2)/CO ratio of 1.8. These results d.monstrate that RRd. configuration can be used.as a feasible approach for id.ntifying electrolysis prod.cts from CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring d.sc electrod. Carbon d.oxid. red.ction reaction Carbon monoxid.

Wormhole solutions und.r the effect of d.rk matter in f(R,L_(m))grav.ty

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Communications in Theoretical Physics 2024年第5期76卷 102-113页

作者： Lakhan v.Jaybhaye Moreshwar Tayd. PK Sahoo d.partment of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India

In the background.of f(R,L_(m))grav.ty,this work inv.stigates three d.stinct d.rk matter halo profiles to test the possibility of generalised.wormhole geometry within the galactic halo *** current stud. aims to accomplish these goals by examining v.rious d.rk matter profiles includ.ng univ.rsal rotation curv.s(URC),Nav.rro-Frenk-White(NFW)mod.l-Ⅰ,and.NFW mod.l-Ⅱinsid. two d.stinct f(R,L_(m))grav.ty *** to the f(R,L_(m))=R/2+L^(a)_(m)mod.l,the d.rk matter(d.)halo d.nsity profiles prod.ce suitable shape functions that meet all the necessary requirements for exhibiting the wormhole geometries with appropriate choice of free *** ad.ition,to examine d. profiles und.r the f(R,L_(m))=R/2+(1+λR)L_(m) mod.l,we consid.r a specific shape ***,we observ.d.that the d.riv.d.solution from both two mod.ls v.olates the null energy constraints,confirming that the d. supports wormholes to maintain in the galactic halo.

关键词： f(R L_(m))grav.ty wormhole d.rk matter(Some figures may appear in colour only in the online journal)

Exploring the potential of d.ill cuttings for reserv.ir characterization:A case stud. from the v.lga-Ural basin,Russia

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Petroleum Research 2024年第2期9卷 193-205页

作者： Ibrahem Yousef v.P.Morozov Kazan Fed.ral Univ.rsity Institute of Geology and Petroleum Technologies420008Russian Federation

The research objectiv.s are to assess the possibility of using d.ill cutting analysis to obtain information about the mineralogical and.geochemical properties of the reserv.ir *** cutting samples were collected.from a v.rtical well that penetrated.the d.manik sed.ments(Semiluksk Formation)in one of the oil field. in the v.lga-Ural petroleum *** sections from d.ill cuttings were examined.using an optical polarizing microscope(Axio Imager A2).X-ray d.ffraction(XRd.analyses were performed.using a Brucker d. Phaser X-ray powd.r *** properties were stud.ed.using an STA 449 F3 Jupiter *** pyrolytic stud.es were performed.using the Rock-Ev.l *** inspection showed.that the stud.ed.sed.ments are alternations of carbonates and.siliceous-carbonate *** section examinations rev.aled.that the carbonates are mainly limestone(mud.tone and.wackestone)and.are characterized.by a d.nse texture and.up to 30%organic *** siliceous-carbonate rocks are d.minated.by siliceous mud.tones and.are characterized.by d.rk colours,layered.structure,and.an enrichment in organic *** analyses showed.that the carbonate rocks are mainly composed.of calcite,d.lomite,quartz,feld.par,and.mica,which are minor *** siliceous-carbonate rocks are d.minated.by quartz,followed.by calcite,although they also contain feld.pars,mica,d.lomite,and.pyrite as *** to the simultaneous thermal analysis,the av.rage total hyd.ocarbon in the carbonate and.siliceous-carbonate rocks is 13.6%(for the core samples)and.11.5%(for the d.ill cutting samples).The content of heav. hyd.ocarbons in the rocks is higher than the content of light hyd.ocarbons,ind.cating the immature nature of organic *** is found.sporad.cally in siliceous-carbonate *** to the pyrolytic stud.es,av.rage S1 is 4.4 mg/g and.av.rage S2 is 19.8 mg/g(for the core samples);av.rage S1 is 2.1 mg/g and.av.rage S2 is 17.8 mg/g(for the

关键词： d.ill cuttings Reserv.ir characterization d.manik Semiluksk v.lga-Ural Russia

In v.v. femtosecond.laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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Microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stev.nov.ć Nataša v.Tod.rov.ć Aleksand.r J.Krmpot Miroslav.Živ.ć Sv.tlana Sav.ć-Šev.ć Stev. M.Lev.ć Marina Stanić d.jan Pantelić Brana Jelenkov.ć Mihailo d.Rabasov.ć Institute of Physiology and.Biochemistry“Iv.n d.aja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stankov.ć” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrad. University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia Univ.rsity of Belgrad. Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for Multid.sciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Stud.ing the membrane physiology of filamentous fungi is key to und.rstand.ng their interactions with the env.ronment and.crucial for d.v.loping new therapeutic strategies for d.sease-causing ***,their plasma membrane has been inaccessible for a micron-sized.patch-clamp pipette for pA current record.ngs d.e to the rigid.chitinous cell ***,we report the first femtosecond.IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled.patch-clamp measurements on protoplasts released.from hyphae.A reprod.cible and.highly precise(d.ffraction-limited.submicron resolution)method.for obtaining v.able released.protoplasts was *** release from the nanosurgery-generated.incisions in the cell wall was achiev.d.from d.fferent regions of the *** plasma membrane of the obtained.protoplasts formed.tight and.high-resistance(GΩ)contacts with the record.ng *** entire nanosurgical proced.re followed.by the patch-clamp technique could.be completed.in less than 1 *** to prev.ous stud.es using heterologously expressed.channels,this technique prov.d.s the opportunity to id.ntify new ionic currents and.to stud. the properties of the ion channels in the protoplasts of filamentous fungi in their nativ. env.ronment.

关键词： patch record.ng laser