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Damage mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia

Journal of Biosciences and medicines 2024年第4期12卷 49-59页

作者： Ignacio vélez-Rodríguez victoria Carranza-Aranda Facultad mexicana de medicina Universidad La Salle Tlalpan M&#233xico Hospital General de mé xico Cuauht&#233moc M&#233xico

Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lymphoid progenitor cells, pro-B cells, pre-B cells, and mature cells). The process of B cell maturation depends on precise communication within the cell: signals activate specific genes that are essential for proper development. Errors in this intricate signaling network can lead to issues with B cell function and contribute to disease. B-lineage acute lymphoid leukemias, malignancies of precursor-stage B lymphoid cells inhibit lymphoid differentiation, leading to abnormal cell proliferation and survival. The process of developing leukemia (leukemogenesis) can be triggered by an overproduction of both hematopoietic stem cells (the cells that form all blood cells) and the immature versions of white blood cells called lymphoblasts. Acute lymphoblastic leukemia (ALL) with the presence of the Philadelphia chromosome (ALL Ph) is classified as a high-risk manifestation of the disease, this chromosome is the product of the reciprocal translocation, whose product is a BCR-ABL fusion protein. It is a highly active tyrosine kinase that can transform hematopoietic cells into cytokine-independent. Hyperphosphorylation cascades inhibit the differentiating function of IKZF1 as a tumor suppressor gene which leads to an abnormal proliferation of B cells due to the presence of the Philadelphia chromosome;it inhibits the differentiating process, leukemogenesis involving immature B cells in the bloodstream can result from the uncontrolled growth and division of hematopoietic stem cells and immature lymphoblasts (the precursors to B cells).

关键词： Acute Lymphoblastic Leukemia IKAROS Dephosphorylation Philadelphia Chromosome CK2

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A new perspective on intervertebral disc calcification—from bench to bedside

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Bone Research 2024年第1期12卷 50-61页

作者： Emanuel J.Novais Rajkishen Narayanan Jose A.Canseco Koen van de Wetering Christopher K.Kepler Alan S.Hilibrand Alexander R.vaccaro makarand v.Risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Institute at Thomas Jefferson University PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict vasculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conservative *** is frequently seen as a consequence of disc aging and progressive degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeostasis;and local *** studies in mouse models have provided a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics,and environmental stressors,such as aging or trauma,govern the predisposition to ***,the systemic regulation of calcium and Pi metabolism is less important than the local activity of PPi modulated by the ANK-ENPP1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways governing local intervertebral disc calcification may lead to developing disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism intervertebral

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产蛋母鸡氨基酸需要量

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国外畜牧学（猪与禽） 2024年第4期44卷 1-6,7-14,15-18页

作者：冯占雨(译) 张配配(校) macelline S P Toghyani m Chrystal P v 不详

本综述的主要目的是整合已发表的有关产蛋母鸡氨基酸需要量的数据,并根据这些数据提出一套新的推荐标准。自1994年以来,产蛋母鸡对赖氨酸、含硫氨基酸、苏氨酸、色氨酸、支链氨基酸和精氨酸需要量的推荐值不尽一致。本综述还发现,试验... 详细信息

本综述的主要目的是整合已发表的有关产蛋母鸡氨基酸需要量的数据,并根据这些数据提出一套新的推荐标准。自1994年以来,产蛋母鸡对赖氨酸、含硫氨基酸、苏氨酸、色氨酸、支链氨基酸和精氨酸需要量的推荐值不尽一致。本综述还发现,试验所用产蛋母鸡的品种、年龄、基础日粮组成和评估方法会影响产蛋母鸡氨基酸需要量的推荐值。目前,由于对可持续生产的需求,产蛋母鸡低粗蛋白(crude protein,CP)日粮的开发正受到越来越多的关注。这涉及到日粮成分的彻底改变,包括非结合氨基酸(nonbound amino acid)、必需氨基酸和非必需氨基酸。在产蛋母鸡日粮中添加更多的非结合氨基酸,会改变蛋白质的消化动力学,并可能会影响产蛋母鸡对氨基酸的需要量。本综述讨论了目前对产蛋母鸡氨基酸需要量的推荐值,并提出了一些未来可更好地满足蛋鸡业需求的改进方案。

关键词：氨基酸需要量产蛋母鸡非结合氨基酸蛋白质消化动力学

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Harvesting Energy via Water movement and Surface Ionics in microfibrous Ceramic Wools

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Energy & Environmental materials 2024年第6期7卷 332-341页

作者： manpreet Kaur Avinash Alagumalai Omid mahian Sameh m.Osman Tadaaki Nagao Zhonglin Wang Research Center for materials Nanoarchitectonics(WPI-mANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukuba 305-0044IbarakiJapan Department of Chemical and Petroleum Engineering University of Calgary2500 University Dr.NWCalgaryAB T2N 1N4Canada Department of mechanical Engineering GMR Institute of TechnologyRajamAndhra Pradesh 532127India Faculty of mechanical Engineering and mechanics Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and PipelineNingbo UniversityNingbo 315211China Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China Chemistry Department College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Condensed matter Physics Hokkaido UniversitySapporoHokkaido 060-0810Japan School of materials Science and Engineering Georgia Institute of TechnologyAtlanta 30332GAUSA Laboratory on Convective Heat and mass Transfer Tomsk State UniversityTomsk 634045Russia

Due to the push for carbon neutrality in various human activities,the development of methods for producing electricity without relying on chemical reaction processes or heat sources has become highly ***,the challenge lies in achieving microwatt-scale outputs due to the inherent conductivity of the materials and diverting electric *** address this challenge,our research has concentrated on utilizing nonconductive mediums for water-based low-cost microfibrous ceramic wools in conjunction with a NaCl aqueous solution for power *** main source of electricity originates from the directed movement of water molecules and surface ions through densely packed microfibrous ceramic wools due to the effect of dynamic electric double *** occurrence bears resemblance to the natural water transpiration in plants,thereby presenting a fresh and straightforward approach for producing electricity in an ecofriendly *** generator module demonstrated in this study,measuring 12×6 cm^(2),exhibited a noteworthy open-circuit voltage of 0.35 v,coupled with a short-circuit current of 0.51 *** low-cost ceramic wools are suitable for ubiquitous,permanent energy sources and hold potential for use as self-powered sensors and systems,eliminating the requirement for external energy sources such as sunlight or heat.

关键词： ceramic microfibers energy harvesting power generation self-powered systems water evaporation

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Some mean Convergence Theorems for the maximum of Normed Double Sums of Banach Space valued Random Elements

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Acta mathematica Sinica,English Series 2024年第7期40卷 1727-1740页

作者： Andrew ROSALSKY Le van THANH Nguyen Thi THUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random *** of the results pertain to random elements which are *** expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simplify and improve a recent result of Li,Presnell,and Rosalsky[Journal of mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of m-dependent random elements is proved which may be of independent *** sharpness of the results is illustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space valued random element m-dependent random elements

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Phanerozoic co-evolution of O2-CO2 and ocean habitability

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National Science Review 2024年第6期11卷 18-21页

作者： Zunli Lu Rosalind E.m.Rickaby Jonathan L.Payne Ashley N.Prow Department of Earth & Environmental Sciences Syracuse University Department of Earth Sciences University of Oxford Department of Earth and Planetary Sciences Stanford University

Atmospheric carbon dioxide and oxygen concentrations are partially linked via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active components, controls on their concentrations, and implications for the complexity of the biosphere and habitability of Earth have been hotly debated, but are generally considered independently.

关键词： CO2-CONCENTRATING mECHANISm OXYGEN EvOLUTION ANOXIA

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Oryza CLImtools:A genome–environment association resource reveals adaptive roles for heterotrimeric G proteins in the regulation of rice agronomic traits

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Plant Communications 2024年第4期5卷 145-165页

作者： Angel Ferrero-Serrano David Chakravorty Kobie J.Kirven Sarah m.Assmann Biology Department Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Intercollege Graduate Degree Program in Bioinformatics and Genomics Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

modern crop varieties display a degree of mismatch between their current distributions and the suitability of the local climate for their *** address this issue,we present Oryza CLImtools(https://***/CLImtools/oryza_v1.0/),thefirst resource for pan-genome prediction of climate-associated genetic variants in a crop *** CLImtools consists of interactive web-based databases that enable the user to(1)explore the local environments of traditional rice varieties(landraces)in South-East Asia and(2)investigate the environment by genome associations for 658 Indica and 283 Japonica rice landrace accessions collected from georeferenced local environments and included in the 3K Rice Ge-nomes *** demonstrate the value of these resources by identifying an interplay betweenflowering time and temperature in the local environment that is facilitated by adaptive natural variation in OsHD2 and disrupted by a natural variant in *** quantitative trait locus analysis has suggested the impor-tance of heterotrimeric G proteins in the control of agronomic ***,we analyzed the climate associations of natural variants in the different heterotrimeric G protein *** identified a coordi-nated role of G proteins in adaptation to the prevailing potential evapotranspiration gradient and revealed their regulation of key agronomic traits,including plant height and seed and panicle *** conclude by highlighting the prospect of targeting heterotrimeric G proteins to produce climate-resilient crops.

关键词： Oryza sativa rice G by E adaptation flowering time GWAS OsHD2 OsSOC1 heterotrimeric G pro-tein OsRGA1 d1 OsGS3 OsDEP1 OsGGC2

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Global pattern of conodont similarity and faunal constraints during the highstand of the Evae eustatic event(late Floian, Lower Ordovician)

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Journal of Palaeogeography 2024年第4期13卷 883-905页

作者： Gisella m.Della Costa Guillermo L.Albanesi CIGEA Facultad de Ciencias Exactas Físicas y Naturales Universidad Nacional de C ordoba Av.V elez Sarsfield 299

One of the largest Ordovician sea-level rises is the Evae transgression, which occurs in the lower part of the Oepikodus evae Biozone, indicative of a late Floian age. Specifically, the characteristics associated with the highstand of this event included: a higher proportion of specimens of the index species O. evae than other species, a diversity acme in the evae Biozone, and a reduction of biogeographic barriers that resulted in a high proportion of species with cosmopolitan distribution. In the present contribution, the pattern of species similarity among Laurentia, Argentine Precordillera, Baltica, Kazakhstania, South China, and Australia is evaluated with a multiple coefficient analysis including only the sections that recorded the highstand of the Evae transgression. moreover, the effect of possible terrestrial, latitudinal, physicochemical barriers and palaeogeographic distance on the species distribution is statistically analysed. Our results show a global pattern of conodont species distribution that is highly constrained by the tested palaeoenvironmental *** suggests that contrary to what was expected for a prominent transgression, faunal barriers did not decrease significantly during the Evae drowning peak.

关键词： Evae transgression Oepikodus evae Biozone Statistical analyses Faunal similarities Palaeoenvironmental barriers

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Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

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matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach m.Schorner v.Bagnoud R.Belikov P.Drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist C.Qu R.Redmer D.Riley G.Schaumann S.Schumacher A.Tauschwitz D.varentsov K.Weyrich X.Yu B.Zielbauer Zs.major P.Neumayer D.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

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Electrokinetic-mechanism of water and furfural oxidation on pulsed laser-interlaced Cu_(2)O and CoO on nickel foam

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Journal of Energy Chemistry 2024年第4期91卷 145-154页

作者： Yewon Oh Jayaraman Theerthagiri m.L.Aruna Kumari Ahreum min Cheol Joo moon myong Yong Choi Department of Chemistry(BK21 FOUR) Research Institute of Natural SciencesGyeongsang National UniversityJinju 52828Republic of Korea Department of Chemistry The Oxford College of ScienceBengaluruKarnataka 560102India Core-Facility Center for Photochemistry&Nanomaterials Gyeongsang National UniversityJinju 52828Republic of Korea

The electrocatalytic oxidation of biomass-derived furfural(FF)feedstocks into 2-furoic acid(FA)holds immense industrial potential in optics,cosmetics,polymers,and ***,we fabricated Co O/Ni O/nickel foam(NF)and Cu_(2)O/Ni O/NF electrodes via in situ pulsed laser irradiation in liquids(PLIL)for the bifunctional electrocatalysis of oxygen evolution reaction(OER)and furfural oxidation reaction(FOR),*** oxidation of NF surface to NiO and deposition of CoO and/or Cu_(2)O on NF during PLIL offer distinct advantages for enhancing both the OER and ***/NiO/NF electrocatalyst provides a consistently low overpotential of~359 m v(OER)at 10 m A/cm^(2),achieving the maximum FA yield(~16.37 m m)with 61.5%selectivity,79.5%carbon balance,and a remarkable Faradaic efficiency of~90.1%during 2 h of FOR at 1.43 v(*** hydrogen electrode).mechanistic pathway via in situ electrochemical-Raman spectroscopy on CoO/NiO/NF reveals the involvement of phase transition intermediates(NiOOH and CoOOH)as surface-active centers during electrochemical *** carbonyl carbon in FF is attacked by hydroxyl groups to form unstable hydrates that subsequently undergo further oxidation to yield FA *** method holds promise for large-scale applications,enabling simultaneous production of renewable building materials and fuel.

关键词： Pulsed laser irradiation in liquids Water and furfural oxidation In situ Raman spectroscopy CoO/NiO/nickel foam Cu_(2)O/Nio/nickel foam 2-furoic acid

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