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Neurogenic potential of NG2 in neurotrauma:a systematic review

Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Benvenutti Luis v.Portela Nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDLINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

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A stability evaluation method for deep-seated toppling in the upper Lancang river,Southwestern China

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2388-2410页

作者： Yibing Ning Huiming Tang Jianbing Peng Yanjun Shen John v.Smith Bocheng Zhang College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China Academy of Yellow River Sciences of Shaanxi Province Chang’an UniversityXi’an710054China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China School of Engineering RMIT UniversityMelbourne3001Australia

Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in *** slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river *** this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary *** system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation *** on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole *** stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled ***,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation *** results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river *** considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected *** toppled rock blocks mainly suffer sliding failures beyond the layer symmetry *** factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.

关键词： Stability evaluation Deep-seated toppling Evolutionary process Reservoir impoundment Rock slope

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An examination of thematic research,development,and trends in remote sensing applied to conservation agriculture

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International Soil and Water Conservation Research 2024年第1期12卷 77-95页

作者： Zobaer Ahmed Aaron Shew Lawton Nalley Michael Popp v.Steven Green Kristofor Brye Center for Advanced Spatial Technologies University of ArkansasFayettevilleARUSA Environmental Dynamics Program University of ArkansasFayettevilleARUSA Department of Agricultural Economics and Agribusiness University of ArkansasFayettevilleARUSA College of Agriculture Arkansas State UniversityJonesboroARUSA University of Arkansas System Division of Agriculture Little RockARUSA Department of Crop Soiland Environmental SciencesUniversity of ArkansasFayettevilleARUSA

Conservation agriculture seeks to reduce environmental degradation through sustainable management of agricultural *** the 1990s,agricultural research has been conducted using remote sensing technologies;however,few previous reviews have been conducted focused on different conservation management *** of the previous literature has focused on the application of remote sensing in agriculture without focusing exclusively on conservation practices,with some only providing a narrative review,others using biophysical remote sensing for quantitative estimates of the bio-geo-chemical-physical properties of soils and crops,and few others focused on single agricultural management *** paper used the preferred reporting items for systematic review(PRISMA)methodology to examine the last 30 years of thematic research,development,and trends associated with remote sensing technologies and methods applied to conservation agriculture research at various spatial and temporal scales.A set of predefined key concepts and keywords were applied in three databases:Scopus,Web of Science,and Google Scholar.A total of 188 articles were compiled for initial examination,where 68 articles were selected for final analysis and grouped into cover crops,crop residue,crop rotation,mulching,and tillage *** on conservation agriculture research using remote sensing have been increasing since 1991 and peaked at 10 publications in *** the 68 articles,94%used a pixel-based,while only 6%used an object-based classification *** to 2005,tillage practices were abundantly studied,then crop residue was a focused theme between 2004 and *** 2012 to 2020,the focus shifted again to cover *** spectral indices were used in 76%of the 68 *** examination offered a summary of the new potential and identifies crucial future research needs and directions that could improve the contribution of remote sensing to the provision of long-term operat

关键词： Remote sensing Conservation agriculture Classification algorithm Spatial resolution Satellite Spectral indices PRISMA

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Freeze-thaw cycles and associated geomorphology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,Mexico

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Journal of Mountain Science 2024年第6期21卷 1954-1977页

作者： víctor SOTO Carlos M.WELSH R. Kenji YOSHIKAWA Hugo DELGADO GRANADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial Maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m *** retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction *** geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction Mountain mechanical erosion Periglacial geomorphology Postglacial scenarios

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Early selective enteral feeding in treatment of acute pancreatitis: A case report

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World Journal of Clinical Cases 2024年第3期12卷 637-642页

作者： Aleksei A Kashintsev Sergey v Anisimov Anastasya Nadeeva vitali Proutski Sergey v Anisimov Anastasya NadeevaVitali ProutskiPANDICA LTDLondon WC1N 3ESUnited Kingdom

BACKGROUND Early initiation of enteral feeding is recognized to play a crucial role in improving the outcomes of treatment of acute ***,the method of adminis-tration of enteral nutrition remains *** present the experience of treating a patient with moderate-severe acute pancreatitis,at high risk of progressing to a severe or fatal condition,using a novel method of selective feeding with duodenal *** SUMMARY A 27-year-old female patient presented to the emergency unit of the hospital with a typical manifestation of acute *** a conventional treatment,the patient’s condition deteriorated by day 2 of *** an endoscopic approach,a novel catheter PandiCathffwas placed to the duodenum of the patient,isolating its segment between the duodenal bulb and the ligament of *** the isolated area created,a negative pressure was applied,followed by introduction of early selective enteral *** patient’s condition subsequently improved in a rapid manner,and no complications often associated with moderate-to-severe acute pancreatitis *** Within 48 h of starting treatment with the novel method,it can prevent the development of multiple organ failure and,when combined with minimally invasive drainage methods,help prevent infection.

关键词： Acute pancreatitis Enteral feeding Infectious complications Systemic inflammatory response syndrome MODS

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Output feedback adaptive super twisting sliding mode control for quadrotor UAvs

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Control Theory and Technology 2024年第1期22卷 92-105页

作者： Oscar Salas-Peña Jesus DeLeón-Morales Susana v.Gutiérrez-Martínez École Centrale de Nantes-LS2N UMR 6004 CNRS44300NantesFrance Facultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this paper, a sliding mode control with adaptive gain combined with a high-order sliding mode observer to solve the tracking problem for a quadrotor UAv is addressed, in presence of bounded external disturbances and parametric uncertainties. The high order sliding mode observer is designed for estimating the linear and angular speed in order to implement the proposed scheme. Furthermore, a Lyapunov function is introduced to design the controller with the adaptation law, whereas an analysis of finite time convergence towards to zero is provided, where sufficient conditions are obtained. Regarding previous works from literature, one important advantage of proposed strategy is that the gains of control are parameterized in terms of only one adaptive parameter, which reduces the control effort by avoiding gain overestimation. Numerical simulations for tracking control of the quadrotor are given to show the performance of proposed adaptive control–observer scheme.

关键词： Adaptive super twisting controller High-order sliding modes observer UAv

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Review on dynamic analysis of road pavements under moving vehicles and plane strain conditions

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Journal of Road Engineering 2024年第1期4卷 54-68页

作者： Edmond v.Muho Niki D.Beskou Department of Disaster Mitigation for Structures Tongji UniversityShanghai 200092China Department of Civil Engineering University of the PeloponnesePatras 26334Greece School of Science and Technology Hellenic Open UniversityPatras 26335Greece

This paper reviews works on the dynamic analysis of flexible and rigid pavements under moving vehicles on the basis of continuum-based plane strain models and linear *** purpose of this review is to provide in-formation about the existing works on the subject,critically discuss them and make suggestions for further *** reviewed papers are presented on the basis of the various models for pavement-vehicle systems and the various methods for dynamically analyzing these *** pavements are modeled by a homogeneous or layered half-plane with isotropic or anisotropic and linear elastic,viscoelastic or poroelastic material *** pavements are modeled by a beam or plate on a homogeneous or layered half-plane with material properties like the ones for flexible *** vehicles are modeled as concentrated or distributed over a finite area loads moving with constant or time dependent *** above pavement-vehicle models are dynamically analyzed by analytical,analytical/numerical or purely numerical methods working in the time or frequency *** examples are presented to illustrate the models and methods of analysis,demonstrate their merits and assess the effects of the various parameters on pavement *** paper closes with con-clusions and suggestions for further research in the *** significance of this research effort has to do with the presentation of the existing literature on the subject in a critical and easy to understand way with the aid of representative examples and the identification of new research areas.

关键词： Flexible pavements Rigid pavements Moving vehicles Plane strain models Dynamic analysis

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Hybrid Optimization Algorithm for Handwritten Document Enhancement

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Computers, Materials & Continua 2024年第3期78卷 3763-3786页

作者： Shu-Chuan Chu Xiaomeng Yang Li Zhang václav Snášel Jeng-Shyang Pan College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Information and Control Engineering Qingdao University of TechnologyQingdao266520China Faculty of Electrical Engineering and Computer Science VŠB-TU OstravaOstrava70080Czech Republic Department of Information Management Chaoyang University of TechnologyTaichung41349Taiwan

The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of the CEC2013 benchmark, the AIWGOA demonstrates notable advantages across various metrics. Subsequently, an evaluation index was employed to assess the enhanced handwritten documents and images, affirming the superior practical application of the AIWGOA compared with other algorithms.

关键词： Metaheuristic algorithm gannet optimization algorithm hybrid algorithm handwritten document enhancement

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Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny Serra-vinardell Wendy J.Introne May Christine v.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

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Laboratory evaluation of toxicity of selected insecticides against egg and larval stages of cotton pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)

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Journal of Cotton Research 2024年第1期7卷 15-28页

作者： BUSNOOR Abhishek v. WADASKAR R.M. FAND Babasaheb B. TAMBE v.J. PILLAI T. MAHULE D.J. NAGRARE v.S. PRASAD Y.G. Entomology Section College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Indian Council of Agricultural Research-Central Institute for Cotton Research Nagpur 441108MaharashtraIndia

Background The cryptic nature of pink bollworm Pectinophora gossypiella(Saunders)larvae enables its reduced vul-nerability to insecticidal ***,the development of resistance against Bacillus thuringiensis(Bt)toxins posed a serious threat to transgenic cotton *** necessitated determining the critical timing of spray applications on the control *** study assessed the influence of egg age(freshly laid ***-day-old)and the loca-tion of larvae(directly exposed to the insecticide residues on the boll rind *** inside the bolls)on insecticide control *** The results revealed a significant decrease in the ovicidal activity of tested insecticides with an increase in the age of eggs from one day old to three days old(paired t-test,Pvae directly exposed to the insec-ticide residues on the boll rind were more susceptible(>80%mortality)than the larvae exposed after they had bur-rowed inside the bolls(velopmental biology were more pronounced in the experiment on pre-larval release insecticide treatment compared with insecticide treatment given post-larval release and entry inside the *** Egg age influences the insecticide susceptibility,as does the larval location,directly exposed vs bur-rowed inside the *** eggs and the larvae that had burrowed inside the green bolls of cotton were relatively less susceptible to the insecticide *** toxic effects of insecticides on egg and larval stages were primar-ily *** findings are significant for devising a comprehensive strategy for pink bollworm management on a sustainable basis.

关键词： Bioefficacy Cotton Insecticides Pink bollworm Pectinophora gossypiella Timings of spray

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