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Chirping instabilities produced by a runaway electron beam at a spherical tokamak

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Plasma Science and Technology 2023年第7期25卷 19-24页

作者： I M BALACHENkOv N N BAkHAREv v k gusev M v ILIASOvA E M kHILkEvICH P S kORENEv A E kONkOv v B MINAEv Yu v MITRIZHkIN M I PATROv Yu v PETROv N v SAkHAROv A E SHEvELEv O M SkREkEL Ioffe Institute Saint-Petersburg 194021Russia Lomonosov Moscow State University Moscow 119991Russia

Two different types of MHD instabilities with rapidly chirping frequency were found to arise in the Globus-M2 spherical tokamak in substantially different frequency *** first type arises at frequencies of an order of 1 MHz in ohmic plasmas at relatively low density(n_(e))ven waves,driven by electrons,accelerated during a sawtooth *** was found that the mode frequency is sweeping in time,according to the Berk-Breizman hole-clump nonlinear chirping *** second type of wave arises in a specific single-swing regime of the central solenoid current with a very narrow plasma column,when the plasma tends to decay at extremely low density(n_(e))ver the whole observed frequency range and are divided into several(two or three)frequency regions:approximately 0-30 MHz,60-120 MHz and sometimes 30-60 *** of the branches was also *** chirps are more rapid than for 1 MHz Alfven instability and follow an exponential *** paper,to our knowledge,is the first report of frequency chirping instabilities excited by accelerated electrons at a spherical tokamak.

关键词： Alfvén waves chirping instability spherical tokamak runaway electrons

Influence of the safety factor profile on the particle and heat transport in the Globus-M spherical tokamak

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Plasma Science and Technology 2019年第11期21卷 1-6页

作者： A YU TELNOvA G S kURSkIEv E O kISELEv N N BAkHAREv v k gusev N A kHROMOv S YU MEDvEDEv v B MIINAEv I v MIROSHNIkOv M I PATROv Yu v PETROv N v SAkHAROv A D SLADkOMEDOvA P B SHCHEGOLEv v v SOLOkHA v A TOkAREv S YU TOLSTYAkOv E A TUkHMENEvA Ioffe Institute Saint-Petersburg 194021Russia keldysh Institute Russian Academy of SciencesMoscow 125047Russia NRC'kurchatov Institute’ Moscow 123098Russia

The advanced tokamak scenario is a promising operation scenario for ITER and fusion neutron *** this scenario the minimum value of the safety factor in the center of the plasma exceeds *** the compact spherical tokamak Globus-M,the formation of such conditions is possible with neutral beam injection at the current ramp-up *** to the slower diffusion of current inside the plasma,a zone is formed with reduced heat and particle transport across the magnetic field,which affects the temperature and density profiles of the *** leads to the peaked density profile formation and improvement of the energy confinement *** achieve a high fraction of the bootstrap current,it is necessary to increase the plasma *** the same time,the maximum allowable pressure is limited to the normalized beta limit.

关键词： advanced tokamak mode transport analysis internal transport barriers

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of virology 2025年第1期14卷 108-117页

作者： Sanjay k Thakur Anil k Sinha Santosh k Sharma Aarzoo Jahan Dinesh k Negi Ruchika Gupta Sompal Singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACkGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBv),hepatitis C virus(HCv),human immunodeficiency virus(HIv)-I/II,malaria,and syphilis is mandatory before blood ***,HCv,HBv,and HIv are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIv/HCv and HIv/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBv,HCv,HIv I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIv,HBv,and HCv were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBv,HCv,HIv,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBv,HCv,HIv-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

Unveiling the impact:COvID-19's influence on bacterial resistance in the kingdom of Bahrain

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World Journal of virology 2025年第1期14卷 83-98页

作者： Nermin k Saeed Safiya k Almusawi Noor A Albalooshi Mohammed Al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACkGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COvID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COvID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COvID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within klebsiella pneumoniae and *** *** impact of the COvID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COvID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

Cosmology with an Effective Λ-Term in Lyra Manifold

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Chinese Physics Letters 2013年第11期30卷 215-219页

作者： v.k.Shchigolev Department of Theoretical Physics Ulyanovsk State UniversityUlyanovsk 432000Russia

A cosmological model in Lyra's geometry is studied under the assumption that an effective cosmological term appears in the field equations as the result of interaction between the displacement vector field and an auxiliaryΛ*** exact solutions to the model equations are obtained and preliminarily studied for the simplest cases in order to illustrate how such a model works.

关键词： equations exact auxiliary

Effect of Welding Processes on Tensile and Impact Properties,Hardness and Microstructure of AISI 409M Ferritic Stainless Joints Fabricated by Duplex Stainless Steel Filler Metal

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Journal of Iron and Steel Research International 2009年第5期16卷 66-72页

作者： A k Lakshminarayanan k Shanmugam v Balasubramanian Centre for Materials Joining and Research(CEMAJOR) Department of Manufacturing EngineeringAnnamalai University

The effect of welding processes such as shielded metal arc welding, gas metal arc welding and gas tungsten arc welding on tensile and impact properties of the ferritic stainless steel conforming to AISI 409M grade is studied. Rolled plates of 4 mm thickness were used as the base material for preparing single pass butt welded joints. Tensile and impact properties, microhardness, microstructure and fracture surface morphology of the welded joints have been evaluated and the results are compared. From this investigatio.n, it is found that gas tungsten arc welded joints of ferritic stainless steel have superior tensile and impact properties compared with shielded metal arc and gas metal arc welded joints and this is mainly due to the presence of finer grains in fusion zone and heat affected zone.

关键词： ferritic stainless steel shielded metal arc welding gas metal arc welding gas tungsten arc welding tensile impact property

Effect of Autogenous Arc Welding Processes on Tensile and Impact Properties of Ferritic Stainless Steel Joints

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Journal of Iron and Steel Research International 2009年第1期16卷 62-68,16页

作者： A k Lakshminarayanan k Shanmugam v Balasubramanian Centre of Materials Joining and Research (CEMAJOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalai Nagar-608002Tamil NaduIndia

The effect of autogeneous arc welding processes on tensile and impact properties of ferritic stainless steel conformed to AISI 409M grade is studied. Rolled plates of 4 mm thickness have been used as the base material for preparing single pass butt welded joints. Tensile and impact properties, microhardness, microstructure, and fracture surface morphology of continuous current gas tungsten arc welding （CCGTAW）, pulsed current gas tungsten arc welding （PCGTAW）, and plasma arc welding （PAW） joints are evaluated and the results are compared. It is found that the PAW joints of ferritic stainless steel show superior tensile and impact properties when compared with CCG-TAW and PCGTAW joints, and this is mainly due to lower heat input, finer fusion zone grain diameter, and higher fusion zone hardness.

关键词： ferritic stainless steel plasma arc welding continuous current gas tungsten arc welding pulsed currentgas tungsten arc welding tensile property impact property

Evaluation of Microstructure and Mechanical Properties of Laser Beam Welded AISI 409M Grade Ferritic Stainless Steel

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Journal of Iron and Steel Research International 2012年第1期19卷 72-78页

作者： A k Lakshminarayanan v Balasubramanian Department of Manufacturing Engineering Annamalai University

The microstructure analysis and mechanical properties evaluation of laser beam welded AISI 409M ferritic stainless steel joints are investigated. Single pass autogeneous welds free of volumetric defects were produced at a welding speed of 3 000 mm/min. The joints were subjected to optical microscope, scanning electron fractographe, microhardness, transverse and longitudinal tensile, bend and charpy impact toughness testing. The coarse ferrite grains in the base metal were changed into dendritic grains as a result of rapid solidification of laser beam welds. Tensile testing indicates overmatching of the weld metal is relative to the base metal. The joints also exhibited acceptable impact toughness and bend strength properties.

关键词： laser beam welding ferritic stainless steel tensile property impact property