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Phylogeny,genetics,and the partial life cycle of Oncomegas wageneri in the Gulf of mexico

Current Zoology 2020年第3期66卷 275-283页

作者： Andrés martinez-AQUINO víctor m.vidal-martinez F.Sara CECCARELLI Oscar mENDEZ Lilia C.SOLER-JImENEZ m.Leopoldina AGUIRRE-mACEDO Facultad de Ciencias Universidad Autonoma de Baja CaliforniaCarretera Transpeninsular 3917Fraccionamiento PlayitasEnsenadaBaja California 22860Mexico Laboratorio de Patologia Acuatica Departamento de Recursos del MarCentro de Investigacion y de Estudios Avanzados del Instituto Politecnico NacionalUnidad MeridaCordemexCarretera Antigua a Progreso Km.6MeridaYucatan 97310Mexico Departamento de Biologia de la Conservacion CONACYT-Centro de Investigacion Cientifica y de Educacion Superior de EnsenadaCarretera Ensenada-TjuanaEnsenadaBaja California 22860Mexico Laboratorio de Hidrobiologia Facultad de Biologia-XalapaUniversidad VeracruzanaCircuito Gonzalo Aguirre Beltran S/N Zona UniversitariaXalapaVeracruz 91090Mexico

Despite the diversity and ecological importance of cestodes,there is a paucity of studies on their life stages(i.e.,complete lists of intermediate,paratenic,and definitive hosts)and genetic *** example,in the Gulf of mexico(Gom)98 species of cestodes have been reported to date;however,data on their intraspecific genetic variation and population genetic studies are *** trypanorhynch cestode,Oncomegas wageneri,is found(among other places)off the American Western Atlantic Coast,including the Gom,and has been reported as an adult from stingrays and from several teleost species in its larval form(as plerocerci).This study represents the first report of 2 previously unregistered definitive hosts for ***,namely the Atlantic sharpnose shark Rhizoprionodon terraenovae and the southern stingray Hypanus *** this work,partial sequences of the 28S(region D1-D2)ribosomal DNA were analyzed to include *** within an eutetrarhynchoid phylogenetic *** *** individuals(which included plerocerci and adults)were recovered as monophyletic and Oncomegas celatus was identified as the sister species of ***,population genetic analyses of *** from the southern Gom were carried out using DNA sequences of the mitochondrial cytochrome c oxi-dase subunit 1(COI)gene,which reflected high genetic variation and a lack of genetic structure among the 9 oceanographic sampling *** on these results,*** is panmictic in the southern *** extensive sampling along the species entire distribution is necessary to make more accurate inferences of population genetics of ***.

关键词： barcode Cyclopsetta chittendeni population genetics Hypanus americanus Oncomegas Rhizoprionodon terraeno-vae 28S rDNA(D1-D2)

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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multi-objective optimization design of bridge piers with hybrid heuristic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： Francisco J. martinez-mARTIN Fernando GONZALEZ-vIDOSA Antonio HOSPITALER víctor YEPES Department of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Department of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid multi- objective simulated annealing (SA) algorithm with a neighborhood move based on the mutation operator from the genetic algorithms (GAs), namely mOSAmO1, mOSAmO2 and mOSAmO3. The procedure is applied to three objective functions: the economic cost, the reinforcing steel congestion and the embedded CO 2 emissions. Additional results for a random walk and a descent local search multi-objective algorithm are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The methodology was applied to a typical bridge pier of 23.97 m in height. This example involved 110 design variables. Results indicate that algorithm mOSAmO2 outperforms other algorithms regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures multi-objective optimization Simulated annealing (SA) Structural design

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Bedrock outcropping in the accumulation zone of the largest glacier in mexico(Glaciar Norte of Citlaltépetl),as evidence of a possible accelerated extinction

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Journal of mountain Science 2023年第2期20卷 338-354页

作者： SOTO víctor Colegio de Geografía Facultad de EconomíaUniversidad VeracruzanaAv.Xalapa s/nObrero Campesina91020XalapaVer.México

The highest volcano in mexico,at the same time the third largest mountain in North America(Citlaltépetl,5610 m a.s.l.),is home to the largest glacier in the *** of the extinction of the Popocatépetl glacier(5500 m a.s.l.)caused by eruptive activity,and the almost disappearance of the Iztaccíhuatl glaciers(5220 m a.s.l.)due to the lower elevation of the mountain,the Glaciar Norte of Citlatépetl has been the only glacier that has shown a certain degree of stability as a response to the altitude in which it is ***,as occurs in almost all glaciers on the planet,the retreat of its glacier terminus has been ***,during the last years the thickness of its upper part began to decrease rapidly until its bedrock was exposed for the first time in *** to its ecosystem importance and because it is the main glacier in mexico,as well as the only one in the world located at latitude 19°N,in this work its current dimensions are updated,as well as the local climatology that governs the current state of the glacier is pointed *** study was based on the analysis of high-resolution Sentinel-2 optical images,as well as through Sentinel-1 SAR images,with the support of climatological information from the study ***,the outcropping of the bedrock in the accumulation zone and the consequent horizontal retreat of the upper part of the glacier are documented;at the same time,the decrease in the thickness of the ice along it is *** rocky outcrop in the accumulation zone suggests that the flow dynamics of the ice towards the ablation zone will be considerably less,accelerating the retreat of the glacier ***,the ascent of the glacial front to 5102 m *** the modelled altitude of the equilibrium line to 5276 m *** reported as a warning signal in terms of snow catchment and mass balance;likewise,the decrease of 23%of its surface is also indicated regarding the surface reduction monitoring that has been done

关键词： Bedrock outcrop Citlaltépetl glacier Glacial accumulation zone Glacier retreat Glacial thickness

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Freeze-thaw cycles and associated geomorphology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,mexico

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Journal of mountain Science 2024年第6期21卷 1954-1977页

作者： víctor SOTO Carlos m.WELSH R. Kenji YOSHIKAWA Hugo DELGADO GRANADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m *** retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction *** geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction mountain mechanical erosion Periglacial geomorphology Postglacial scenarios

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Proteomic dynamics revealed sex-biased responses to combined heat-drought stress in marchantia

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Journal of Integrative Plant Biology 2024年第10期66卷 2226-2241页

作者： Sara Guerrero víctor Roces Lara García-Campa Luis valledor mónica meijón Department of Organisms and Systems BiologyFaculty of Biology/BiotechnologyInstitute of AsturiasUniversity of OviedoOviedoAsturias 33071Spain

Recent studies have documented plant responses to climate change extensively, particularly to single-stress exposures. However, critical factors for stress survival, such as sexual differentiation,are not often considered. The dioicous marchantia polymorpha stands as an evolutionary milestone,potentially preserving ancestral traits from the early colonizers. In this study, we employed proteomic analyses complemented with physiological monitoring to investigate combined heat and drought responses in Tak-1(male) and Tak-2(female)accessions of this liverwort. Additionally, targeted transcriptomics was conducted using different natural populations from contrasting *** findings revealed sex-biased dynamics among natural accessions, particularly evident under control conditions and during early stress responses. Although Tak-2 exhibited greater diversity than Tak-1 under control conditions, male accession demonstrated distinct and more rapid stress sensing and signaling. These differences in stress response appeared to be strongly related to sex-specific plasticity influenced by geoclimatic origin. Furthermore, we established distinct protein gene ages and genomic distribution trends, underscoring the importance of protein diversification over time. This study provides an evolutionary perspective on sexual divergence and stress emergence employing a systems biology approach, which allowed for the establishment of global and sex-specific interaction networks in the stress response.

关键词： abiotic stress land adaptation liverwort sex-biased response systems biology

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Non-Canonical Functions of the E2F/DP Pathway with Emphasis in Plants

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 307-330页

作者： víctor A.Sánchez-Camargo Samantha Romero-Rodríguez Jorge m.vázquez-Ramos Facultad de Química Departamento de BioquímicaUniversidad Nacional Autónoma de MéxicoAvenida Universidad y CopilcoCiudad de México04510México Plant Development and(Epi)Genetics Group Swammerdam Institute for Life SciencesUniversiteit van AmsterdamAmsterdam1098XHNetherlands

The E2F/DP pathway is a widely conserved regulatory mechanism in pluricellular *** family of E2F and DP transcription factors was originally described having a role in the transition from the G1 to the S phase of the cell ***,the discovery of hundreds of possible gene targets and their involvement in many other biochemical processes,soon showed that they participated in cell development and differentiation,chromatin remodeling,DNA repair and *** E2F/DP transcription factors can act as either activators or repressors of transcription depending on their association to other regulatory proteins,particularly the retinoblastoma protein,or even depending to their protein structure that can define their *** plants the E2F/DP pathway also regulates endoreduplication,a process present along the life cycle,from organ elongation to root differentiation and *** transcription factors also help plant cells to respond to environmental disturbances such as those caused by different types of radiation,or by *** review focuses on the“so called”non-canonical functions of the E2F/DP family proteins in animal and plant cells,that are in fact essential activities that connect regulatory circuits among multiple metabolic pathways by means of their atypical functions.

关键词： E2F DP transcription factors atypical functions plant cells

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Recent Advances in Synthesis and Properties of Hybrid Halide Perovskites for Photovoltaics

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Nano-micro Letters 2018年第4期10卷 167-200页

作者： C.C.vidyasagar Blanca m.muoz Flores víctor m.Jimnez Prez Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Ciudad Universitaria School of Basic Sciences and Research in Chemistry Rani Channamma University

The progress made by the scientific community in emerging photovoltaic technologies over the past two decades has been outstanding. Numerous methods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum deposition technique. A serious concern is the toxicity of the materials. In this review, several methods aimed at resolving these problems to some extent have been compiled, including eco-friendly synthesis. Further efficiency enhancements are expected following optimization, and a better fundamental understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a simple low-cost model called‘‘dispersed photovoltaic cells' ' is presented.

关键词： Perovskites Solar cells Organic–inorganic perovskites Synthetic routes Fluorescence

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How does high-intensity intermittent training affect recreational endurance runners? Acute and chronic adaptations: A systematic review

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Journal of Sport and Health Science 2017年第1期6卷 54-67页

作者： Felipe García-Pinillos víctor m.Soto-Hermoso Pedro A.Latorre-Román Department of Corporal Expression University of Jaen Department of Sports Sciences University of Granada

Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training(HIIT) affects recreational endurance runners in the short-and ***: Electronic databases were searched for literature dating from January 2000 to October 2015. The search was conducted using the key words "high-intensity intermittent training" or "high-intensity interval exercise" or "interval running" or "sprint interval training" and "endurance runners" or "long distance runners". A systematic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The methodological quality of the studies was evaluated using the Physiotherapy Evidence Database(PEDro) scale(for intervention studies) and the modified Downs and Black Quality Index(for cross-sectional studies).Results: Twenty-three studies met the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional(n = 15) and intervention studies(n = 8). In the 15 cross-sectional studies selected, endurance runners performed at least 1 HIIT protocol, and the acute impact on physiological, neuromuscular, metabolic and/or biomechanical variables was assessed. Intervention studies lasted a minimum of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. most of these studies combined HIIT sessions with continuous run(CR) sessions; 2 studies' subjects performed HIIT ***: HIIT-based running plans(2 to 3 HIIT sessions per week, combining HIIT and CR runs) show athletic performance improvements in endurance runners by improving maximal oxygen uptake and running economy along with muscular and metabolic adaptations. To maximize the adaptations to training, both HIIT and CR must be part of training programs for endurance runners.

关键词： Endurance High-intensity training Intermittent exercises Interval running Long-distance runners Running

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Pathological aspects of so called "hilar cholangiocarcinoma"

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 159-170页

作者： víctor m Castellano-megías Carolina Ibarrola-de Andrés Francisco Colina-Ruizdelgado Department of Pathology Hospital Universitario de Fuenlabrada28041 MadridSpain. Department of Pathology Hospital Universitario "12 de Octubre"28041 MadridSpain.

Cholangiocarcinoma(CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a ***,"hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or,more commonly,the extrahepatic hilar ***,a major distinction can be made between papillary and non-papillary ***,most hilar CCs are well to moderately differentiated conventional type(biliary) ***,CK7,CK20,CEA and mUC1 are normally expressed,being mUC2 positive in less than 50% of *** main premalignant lesions are known:biliary intraepithelial neoplasia(BilIN) and intraductal papillary neoplasm of the biliary tract(IPNB).IPNB includes the lesions previously named biliary papillomatosis and papillary carcinoma.A series of 29 resected hilar CC from our archives is ***(82.8%) were conventional type adenocarcinomas,mostly well to moderately differentiated,although with a broad morphological spectrum;three cases exhibited a poorly differentiated cell component resembling signet ring *** was observed in 5(17.2%),four of them with an associated invasive carcinoma.A clear cell type carcinoma,an adenosquamous carcinoma and two gastric foveolar type carcinomas were observed.

关键词： Cholangiocarcinoma Bile duct carcinoma Hilar cholangiocarcinoma Perihilar cholangiocarcinoma Klatskin tumor Extrahepatic bile duct carcinoma Hepatic hilum

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