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Gene transcription profiting of astheno-and normo-zoospermic sperm subpopulations

Asian Journal of Andrology 2020年第6期22卷 608-615页

作者： pedro Caballero-Campo Saul Lira-Albarran David Barrera Elizabeth Borja-Cacho Hector S Godoy-morales Claudia Rangel-Escareno Fernando Larrea mayel Chirinos Department of Reproduction Biology National Institute of Medical Sciences and Nutrition Salvador ZubiranMexico City 14080Mexico Tambre Foundation Madrid 28002Spain Reproductive medicine Unit Angeles del Ped regal HospitalMexico City 10700Mexico Computational Genomic and Integrative Biology Laboratory National Institute of Genomic MedicineMexico City 14610Mexico

Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility *** this study,the gene expression of human sperm subpopulations with high(F1)and low(F2)motility from healthy normozoospermic(N)and asthenozoospermic(A)individuals was evaluated using RNA microarray followed by functional genomic analysis of differentially expressed *** from A-F1 versus N-F1,A-F2 versus N-F2,N-F1 versus N-F2,and A-F1 versus A-F2 comparisons showed a considerably larger set of downregulated genes in tests versus *** ontology(GO)analysis of A-F1 versus N-F1 identified 507 overrepresented biological processes(Bps),several of which are associated with sperm *** addition,gene set enrichment analysis of the same contrast showed 110 Bps,36 cellular comp on ents,and 31 molecular functions,several of which are involved in sperm motility.A leadi ng・edge analysis of selected GO terms resulted in several down regulated genes encoding to dyn eins and kin esins,both related to sperm ***,the predicted activation state of asthenozoospermia was increased,while fertility,cell movement of sperm,and gametogenesis were ***,several downregulated genes characteristic of the canonical pathway protein ubiquitination were involved in asthenozoospermia ***,GO analysis of A-F2 versus N-F2 did not identify overrepresented Bps,although the gene set enrichment analysis detected six enriched Bps,one cellular component,and two molecular ***,the results show differences in gene transcription between sperm subpopulations from asthenozoospermic and normozoospermic semen samples and allowed the identification of gene sets relevant to sperm physiology and reproduction.

关键词： asthenozoospermia male in fertility microarray sperm transcriptome

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抑郁症状和不安全依恋是临床发作性和慢性偏头痛患者群体残疾的预测因素

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 19-19页

作者： Rossi p. Di Lorenzo G. malpezzi m.G. 江山 via Suvereto 250 00139 Rome Italy Dr.

Objectives.- To define predictors of migraine- related disability in patien ts with episodic and chronic migraine referred to a specialty migraine clinic, f ocusing on depressive symptoms and insecure attachment style that, because of th eir association with responses to pain and physical illness, might be predictive of greater migraine- related disability. Background.- The migraine Disability Assessment questionnaire (mIDAS) has proved to be a reliable and easy- to- us e instrument to assess migraine- related disability. As clinicians are increasi ngly using mIDAS in their diagnostic and treatment decisions for patient care, a n understanding of the factors influencing migraine- related disability is esse ntial for a rationale use of such an instrument. methods.- Two- hundred patien ts suffering from episodic migraine without aura (Em), and chronic migraine (Cm) with and without medication overuse, and referred to a specialty headache clini c were evaluated using the mIDAS, the Beck Depression Inventory (BDI), and the A ttachment Style Questionnaire (ASQ). Diagnosis of episodic and chronic migraine was operationally defined according to the International Headache Society (IHS) and Silberstein- Lipton criteria. Results.- multiple regression analysis showe d that, in the total sample, disability was higher in those patients with Cm, mo re severe depressive symptoms, an insecure style of attachment (as reflected by a lower score on the ASQ confidence scale), and experiencing more severe headach e pain intensity. In the subgroup of patients with episodic migraine, an insecur e style of attachment emerged as the most significant predictor of disability (o ther significant predictors were female sex and number of headache days per mont h). In contrast, in the subgroup of patients with Cm, the only significant predi ctor of the total mIDAS score was a greater severity of depressive symptoms. Con clusions.- Our findings demonstrate the relevance of attachment style, an end

关键词：偏头痛患者临床发作国际头痛协会头痛程度日常生活能力疼痛反应身体疾病多元回归分析诊断标准临床医师

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在二尖瓣峡部进行线性消融的技术和结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 42-42页

作者： J.s p. Hocini m. Hsu L.-F. 杜媛 Hop. Haut-Leveque 33604 Bordeaux-Pessac France Dr.

Background -This prospective clinical study evaluates the feasibility and eff icacy of combined linear mitral isthmus ablation and pulmonary vein(pv) isolatio n in patients with paroxysmal atrial fibrillation(AF). methods and Results -One hundred consecutive patients(13 women; age 55±10 years)-with drug-refractory , symptomatic paroxysmal AF underwent pv isolation and linear ablation of the ca votricuspid isthmus and the mitral isthmus(lateral mitral annulus to the left in ferior pv). They were compared with 100 consecutive patients(14 women; age, 52± 10 years) undergoing pv isolation and cavotricuspid ablation without mitral isth mus ablation. Bidirectional mitral isthmus block was confirmed by demonstrating( 1) a parallel corridor of double potentials during coronary sinus(CS) pacing,(2) an activation detour by pacing either side of the line, and(3) differential pac ing techniques. Isolation of all pvs and cavotricuspid isthmus ablation were per formed successfully in all. mitral isthmus block was achieved in 92 patients aft er 20±10 minutes of endocardial radiofrequency application and an additional 5 ±4 minutes of epicardial radiofrequency application from within the CS in 68, r esulting in a conduction delay of 151±26 ms during CS pacing. Thirty-two patie nts with mitral isthmus ablation compared with 49 without had recurrent atrial a rrhythmia (p=0.02) requiring further ablation. At 1 year after the last procedur e, 87 patients with mitral isthmus ablation and 69 without(p=0.002) were arrhyth mia free without antiarrhythmic drugs, mitral isthmus ablation being the only fa ctor associated with long-term success(RR for AF recurrence, 0.2; CI, 0.1 to 0. 4; pmitral isthmus results cons istently in demonstrable conduction block and is associated with a high cure rat e for paroxysmal AF.

关键词：二尖瓣峡部线性消融起搏技术阵发性房颤抗心律失常药物射频消融术传导阻滞分离术冠状窦和阵

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常用放射性同位素发生器简评

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核动力工程 1985年第1期 90-97页

作者：李茂良 ,G.J.依尔哈特 ,R.m.布鲁格

本文主要评述了三个反应堆生产的放射性同位素发生器(99mo/99mTc、113Sn/113mIn 和115Cd/115mIn)的优缺点和发展前景。对中国放射性同位素发生器的生产提出了建议。

关键词：同位素发生器 90mo/99mTc 113Sn/113mIn 115Cd/115mIn

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瑞典城市人群食管症状的发生发展史:一项10年问卷调查的随访研究结果

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 56-56页

作者： Ruth m. Finizia C. Lundell L. 武敏 Department of Otorhinolaryngology Sahlgrenska University Hospital SE-413 45 Gteborg Sweden Dr.

Objective. To evaluate the occurrence and changes over time of upper gastroint estinal symptoms in adult subjects randomly recruited from the general populatio n. material and methods. A questionnaire recording of upper gastrointestinal sym ptoms with a 10-year follow-up was carried out in a random sample of the adult population of Gteborg. The original sample, from 1986, comprised 441 subjects within the age span of 20-79 years. In total, 337 subjects participated in the index assessment, of which 197 (95 F) subsequently answered the second question naire 10 years later. Results. A majority of the responders (159/197, 83%) repo rted no change in their global assessment of symptoms. Neither the point prevale nce nor the severity for any symptom changed significantly over time. The preval ence of heartburn and acid regurgitation was 25 and 22%, respectively, and the corresponding yearly incidence was estimated to be 1.8 and 1.2%. The main predi ctor for the occurrence of symptoms of moderate to severe degree at follow-up w as the presence of the same symptom 10 years previously. Age or gender per se di d not significantly influence the occurrence of symptoms. Changes in body mass i ndex and anti-reflux medication co-varied with the severity of the symptoms he artburn and acid regurgitation. Conclusions. Oesophageal symptoms are common in the adult Swedish population and seem to be fairly stable over time.

关键词：城市人群随访研究胃灼热抗反流药物问卷调查点流行随机样本指数和

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