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Daily Physical Activity Improves Vascular Function and Motor Skills in Children

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Journal of Sports Science 2017年第2期5卷 78-88页

作者： Sascha Ketelhut Kerstin Ketelhut Claudia hacke Reinhard g.nter Ketelhut Charité-University Medicine Berlin Berlin 10117 Germany Institute of Sports Science Martin-Luther-University Halle-Wittenberg Halle (Saale) 06120 Germany Medical School Berlin Berlin 12247 Germany Institute of Medical Biometry and Epidemiolog. University Medical Centre Hamburg-Eppendorf Hamburg 20251 Germany Medical Center Berlin (MCB) Berlin 10559 Germany Institute of Sports Medicine Humboldt-University Berlin Berlin 10115 Germany

The literature is consistent that reg.lar physical activity in children has to be increased in order to compensate the neg.tive health effects resulting.from g.owing.sedentary lifestyle. Thus, we analyzed in 45 students （ag.d 6.6 ± 0.7 years） the effects of a reg.lar exercise intervention, on top of the normal physical education classes, on motor performance （MP） and hemodynamic parameters. The students were randomized either to an intervention （INT）（n = 23） or a control （CON）（n = 22） g.oup. Throug.out a 9 months period, INT received additional exercise interventions two days a week for 45 minutes. The main outcome measures were MP, peripheral and central blood pressure （BP）, aug.entation index （Alx） and aortic pulse wave velocity （aPWV）. After the exercise intervention, we found sig.ificant （P 〈 0.05） positive effects on various test items of MP and sig.ificant decreases in peripheral and central systolic BP in INT. In contrast, in CON the respective parameters increased in CON alter the observation period. Moreover, aPWV decreased sig.ificantly in INT （P = 0.047） and increased in CON, thus resulting.in a sig.ificant difference in the mean chang. （P = 0.043）. There were no considerable chang.s in AIx in both g.oups. In conclusion, we demonstrated that an increase in reg.lar physical activity has a positive influence on development of MP and hemodynamic parameters even in early childhood. The finding. of this study sug.est that an increase in exercise time should be initiated as early as possible to improve motor ability and prevent future cardiovascular risk.

关键词： Physical fitness in children exercise and blood pressure arterial stiffness motor performance.

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Assistants

电子与电脑 1997年第2期4卷 43-45页

作者： hacke.,S

去氨普酶治疗急性缺血性脑卒中的II期试验研究:基于MRI的静脉注射去氨普酶溶栓治疗急性卒中的9h时间窗试验

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 53-54页

作者： hacke W. Albers g. Al- RawiY. 赵正卿 Department of Neurolog. University of Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Germany Dr.

Backg.ound and Purpose - Most acute ischemic stroke patients arrive after the 3- hour time window for recombinant tissue plasminog.n activator (rtPA) administration. The Desmoteplase In Acute Ischemic Stroke trial (DIAS) was a dose- finding.randomized trial desig.ed to evaluate the safety and efficacy of intravenous desmoteplase, a hig.ly fibrin- specific and nonneurotoxic thrombolytic ag.nt, administered within 3 to 9 hours of ischemic stroke onset in patients with perfusion/diffusion mismatch on MRI. Methods - DIAS was a placebo- controlled, double- blind, randomized, dose- finding.phase II trial. Patients with National Institute of Health Stroke Scale (NIHSS) scores of 4 to 20 and MRI evidence of perfusion/diffusion mismatch were elig.ble. Of 104 patients, the first 47 (referred to as Part 1) were randomized to fixed doses of desmoteplase (25 mg. 37.5 mg. or 50 mg. or placebo. Because of an excessive rate of symptomatic intracranial hemorrhag. (sICH), lower weig.t- adjusted doses escalating.throug. 62.5 μ g.kg. 90 μ g.kg. and 125 μ g.kg.were subsequently investig.ted in 57 patients (referred to as Part 2). The safety endpoint was the rate of sICH. Efficacy endpoints were the rate of reperfusion on MRI after 4 to 8 hours and clinical outcome as assessed by NIHSS, modified Rankin scale, and Barthel Index at 90 days. Results - Part 1 was terminated prematurely because of hig. rates of sICH with desmoteplase (26.7% ). In Part 2, the sICH rate was 2.2% . No sICH occurred with placebo in either part. Reperfusion rates up to 71.4% (P=0.0012) were observed with desmoteplase (125 μ g.kg. compared with 19.2% with placebo. Favorable 90- day clinical outcome was found in 22.2% of placebo- treated patients and between 13.3% (62.5 μ g.kg. P=0.757) and 60.0% (125 μ g.kg. P=0.0090) of desmote- plase- treated patients. Early reperfusion correlated favorably with clinical outcome (P=0.0028). Favorable outcome occurred in 52.5% of patients experiencing.reperfusion versus 24.6% of p

关键词： II MRI 急性卒中试验研究安慰剂对照缺血性脑卒中巴塞尔指数弥散障碍静脉给药量效关系

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急性缺血性卒中的重症监护

国外医学（脑血管疾病分册） 1996年第2期4卷 104-108页

作者： hacke W 王宏毅

总结急性缺血性卒中重症监护治疗的一些问题,特别强调急性缺血性卒中时颅内压增高的处理,溶栓治疗及一般处理程序,如血压控制与代谢监测,对有明显占位效应的脑梗塞外科处理的指征,并对其他问题进行讨论。

关键词：急性脑血卒中 ICU 重症脑血管疾病

零能耗媒体立面——莫尔效应产生的丰富变化与LCD立面媲美

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照明设计 2008年第3期 28-33页

作者： Joachim Rifler Mila hacke（摄影）赵晓波（译）

提到“媒体立面”我们通常会联想到那些由先进控制系统指挥工作的极其高深的技术，头脑中会呈现出投影设备制造的变化影像以及那些由或大或小的光源像素点构成的动态画面。难道就没有非智能解决方案制造的媒体墙吗？其买可以通过光学幻... 详细信息

提到“媒体立面”我们通常会联想到那些由先进控制系统指挥工作的极其高深的技术，头脑中会呈现出投影设备制造的变化影像以及那些由或大或小的光源像素点构成的动态画面。难道就没有非智能解决方案制造的媒体墙吗？其买可以通过光学幻象而非依靠LED和DMX产生动态效果。

关键词：新媒体莫尔效应 LCD 零能耗先进控制系统设备制造动态画面动态效果

JAMA:急性缺血性卒中血管内治疗应该选择全身麻醉?

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中国卒中杂志 2017年第7期12卷 624-625页

作者：杨中华 Schonenberg.r S Uhlmann L hacke W 首都医科大学附属北京天坛医院神经病学中心脑血管病中心神经重症医学科北京100050 不详

几项随机对照研究（randomized controlled trial,RCT）临床试验和meta分析显示前循环大动脉闭塞严重急性缺血性卒中可回收支架取栓术联合标准治疗优于标准治疗（大部分包括静脉溶栓治疗）。目前,国际指南也推荐此治疗策略。血管内治疗... 详细信息

几项随机对照研究（randomized controlled trial,RCT）临床试验和meta分析显示前循环大动脉闭塞严重急性缺血性卒中可回收支架取栓术联合标准治疗优于标准治疗（大部分包括静脉溶栓治疗）。目前,国际指南也推荐此治疗策略。血管内治疗围手术期镇静和气道模式选择的问题一直没有解决,这些选择包括全身麻醉（简称全麻）联合气管插管,轻度镇静（清醒镇静）或局麻无气管插管。

关键词：急性缺血性卒中 JAMA 血管内治疗清醒镇静气管插管静脉溶栓围手术期前循环临床试验 NIHSS

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中风病人的溶栓治疗

德国医学 1999年第3期16卷 133-135页

作者： H.C.Diener W.hacke 施琪嘉 Klinik und Poliklinik für Neurolog.e der Universitt Hufelandstr.55 D-45122 EssenGermany 同济医科大学附属同济医院

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓... 详细信息

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓治疗的目的在于尽早恢复脑血流,以减少由缺血引起的脑组织损害。

关键词：中风溶栓疗法疗效

氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： Bhatt D.L. Fox K.A.A. hacke W. E.J. Topol 罗亮 Department of g.netics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKg.OUND: Dual antiplatelet therapy with clopidog.el plus low-dose aspirin has not been studied in a broad population of patients at hig. risk for atherothrombotic events. METHODS: We randomly assig.ed 15,603 patients with either clinically evident cardiovascular disease or multiple risk factors to receive clopidog.el(75 mg.per day) plus low-dose aspirin(75 to 162 mg.per day) or placebo plus low-dose aspirin and followed them for a median of 28 months. The primary efficacy end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes. RESULTS: The rate of the primary efficacy end point was 6.8 percent with clopidog.el plus aspirin and 7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confidence interval, 0.83 to 1.05; P=0.22). The respective rate of the principal secondary efficacy end point, which included hospitalizations for ischemic events, was 16.7 percent and 17.9 percent(relative risk, 0.92; 95 percent confidence interval, 0.86 to 0.995; P=0.04), and the rate of severe bleeding.was 1.7 percent and 1.3 percent(relative risk, 1.25; 95 percent confidence interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end point among.patients with multiple risk factors was 6.6 percent with clopidog.el and 5.5 percent with placebo(relative risk, 1.2; 95 percent confidence interval, 0.91 to 1.59; P=0.20) and the rate of death from cardiovascular causes also was hig.er with clopidog.el(3.9 percent vs. 2.2 percent, P=0.01). In the subg.oup with clinically evident atherothrombosis, the rate was 6.9 percent with clopidog.el and 7.9 percent with placebo(relative risk, 0.88; 95 percent confidence interval, 0.77 to 0.998; P=0.046). CONCLUSIONS: In this trial, there was a sug.estion of benefit with clopidog.el treatment in patients with symptomatic atherothrombosis and a sug.estion of harm in patients with multiple risk factors. Overall, clopidog.el plus aspirin was not sig.ificantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

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急性脑缺血损伤的治疗

德国医学 2000年第1期17卷 32-34页

作者： Korl Max Einhupl Hans Christoph Diener Werner hacke Michael Hennerici Bernd Ring.lstein 张明敏郭东升 Hans Christoph Diener Neurolog.sche Universitt sklinik Essen Hufelandstraβe 55 45122 Essen Germany 同济医科大学附属同济医院

随着中风治疗前瞻性研究的广泛开展,出现了许多治疗设想。基础治疗与实际应用中风的基础治疗尤其重要,包括:①维持高于正常值的血压;②保持呼吸道通畅,控制呼吸功能;③调整血糖到正常水平;④优化心输出量;⑤降低体温;⑥预防肺部感染护理... 详细信息

随着中风治疗前瞻性研究的广泛开展,出现了许多治疗设想。基础治疗与实际应用中风的基础治疗尤其重要,包括:①维持高于正常值的血压;②保持呼吸道通畅,控制呼吸功能;③调整血糖到正常水平;④优化心输出量;⑤降低体温;⑥预防肺部感染护理;⑦降低脑压;⑧早期活动。

关键词：脑缺血体温控制血液稀释神经保护剂