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Advances in Aging Research 2016年第4期5卷 83-95页

作者： Anne Poestges ursula Gresser Barbara Maria Richartz Medical Faculty Ludwig-Maximilians University of Munich Munich Germany

In a rural area near Munich, 52 persons aged 65 years and older were interviewed in person about health and social life circumstances. Findings: Dog owners take significantly longer walks than people who do not own dogs, averaging more than 120 minutes daily (p < 0.0001). On average, people who do not own a dog walked 38 minutes, cat owners 17 minutes. 94% of the dog owners were active daily compared to 14% of those who do not own a dog. Dog owners go to the doctor on average 5.3 times per year, people who do not own a dog 7.8 times. There was no difference between the two groups in regard to the use of medication. 80% would not move to a residential home for the elderly because of the dog, and 87% would want to take the dog along. 50% of the dog owners and 41% of those who do not own a dog had on average more than 3 contacts with other people, 6% of the dog owners and 23% of those who do not own a dog had less than one contact per day. 19% of the dog owners and 36% of those who do not own a dog would describe themselves as reserved in dealings with people. 71% stated that the dog had been very useful to help them overcome the loss of a person close to them. The W-5 [Wellbeing Five score] for dog owners was an average value of 75%, for those who did not own a dog 71%. Depression was uniformly distributed in both groups. The BMIs in both groups were similar. There was no correlation to the length of the daily walk.

关键词： Elder People and Dog Physical Activity and Dog Dog Walking Dog and Life Quality Elder People Physical Activity

The industrial dynamics of water innovation:A comparison between China and Europe

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International Journal of Innovation Studies 2018年第1期2卷 14-32页

作者： MariúAbritta Moro ursula S.McKnight Barth F.Smets Yang Min Maj Munch Andersen Department of Environmental Engineering Technical University of DenmarkBygningstorvet 1152800 Kgs.LyngbyDenmark Sino-Danish Center for Education and Research(SDC) Niels Jensens Vej 28000 Aarhus CDenmark Research Center for Eco-Environmental Science.Chinese Academy of Science 18 Shuangqing RoadHaidian DistrictBeijingChina Department of Management Engineering Technical University of DenmarkDiplomvej Building 3722800 Kgs.LyngbyDenmark

The expansion of the green economy agenda has increased the attention on ecoinnovations globally,with issues related to water stress identified as one of the major bottlenecks for sustainable economic *** evolutionary economic theory,this study investigates the industrial dynamics of the water sector,comparing China and Europe using patent *** comparison feeds into the“catching up”literature,addressing the challenges of the“green economy”agenda in different regions in various stages of *** highlight the neglected micro-dynamics of water innovation,investigating the roles of different innovators in the development of water technological trajectories,with a special focus on water innovations closely related to climate change adaptation and mitigation *** water innovators(universities)were found to be more important in China than in *** were also identified between Europe and China;big companies were found to be the main innovative leaders with no substantial changes documented over the timeframe ***,the finding implies a rapid Chinese technological catching up of water technologies in the last three decades,where our research has pointed towards the role of redirection of Chinese policies with a stronger focus on sustainable *** analysis,overall,sheds light on the state and nature of the globalizing green growth agenda.

关键词： Water innovation Eco-innovation Evolutionary economics Knowledge institutions Business demography

Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

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World Journal of Gastroenterology 2010年第2期16卷 217-224页

作者： ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers Department of Hepatobiliary Surgery and Transplant Surgery University Hospital Hamburg-Eppendorf20246 HamburgGermany Department of Medicine University Hospital Hamburg-Eppendorf20246 HamburgGermany Institute of Experimental and Clinical Pharmacology and Toxicology University Hospital Hamburg-Eppendorf20246 HamburgGermany Gent University Hospital and Medical School 9000 GentBelgium

AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow *** progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent ***:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th *** 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the ***,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc *** phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for *** line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells.

关键词： CD133 antigen CD14 antigen c-kit protein Breast cancer resistance protein-1 protein Progenitor cells CXC chemokine receptor 4 Stromal cell-derived factor-1 Liver cirrhosis

苏鲁超高压变质岩的构造热历史:中国大陆科学钻探工程(CCSD)主孔(MH)和先导孔(PP2)的磷灰石裂变径迹约束

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岩石学报 2009年第7期25卷 1612-1618页

作者：刘顺生 GLASMACHER Ulrich 许志琴 WEBER ursula WAGNER Günther JONCKHEERE Raymond 殷秀兰中国科学院广州地球化学研究所广州510640 Max-Planck-Institut für Kernphysik Ruprecht-Karls Universitt Heidelberg 中国地质科学院地质研究所北京100037 中国地质科学院地质力学研究所北京100081

本文包括中国大陆科学钻(CCSD)主孔(MH)0～5000m和先导孔(PP2)0～1000m的磷灰石裂变径迹分折结果,先导孔PP2的裂变径迹表观年龄变化范围为79.5±5.1～50.4±6.2Ma,主孔的裂变径迹表观年龄变化范围为98.6±17.0～2.9±2.0Ma,主孔在4200m... 详细信息

本文包括中国大陆科学钻(CCSD)主孔(MH)0～5000m和先导孔(PP2)0～1000m的磷灰石裂变径迹分折结果,先导孔PP2的裂变径迹表观年龄变化范围为79.5±5.1～50.4±6.2Ma,主孔的裂变径迹表观年龄变化范围为98.6±17.0～2.9±2.0Ma,主孔在4200m以下,磷灰石样品中实际上已不存在自发裂变径迹,表明裂变径迹时钟已经"置零"。实验资料表明,裂变径迹表观年龄值随样品深度的增加而逐渐减少,直到一定深度,即达到磷灰石的裂变径迹封闭温度(～120℃)以后,年龄值为零。根据主孔0～2000m和先导孔0～1000m的裂变径迹年龄剖面,作为一级近似,计算出超高压变质岩体在90～30Ma期间,平均隆升速度为～35m/Ma。对主孔测定了9个样品的约束径迹(Confined track)长度,样品约束径迹平均长度的变化范围约为13.1μ7.4μm,总的变化趋势是:约束径迹平均长度随样品深度的增加而逐渐减少。样品的约束径迹长度分布都具有双峰型特征。根据裂变径迹年龄和约束径迹长度的资料,应用计算机模拟得到了样品的时间-温度(t-T)轨迹。结果表明,岩体从早白垩世(～120Ma)快速冷却以后,在晚白垩世和始新世又经历了两次加热作用,始新世末岩体所达到的温度大约是80℃,随后岩体则一直上升和缓慢冷却到现今所处的位置。在最后～30Ma岩体的平均隆升速度为～53m/Ma。

关键词：中国大陆科学钻探工程裂变径迹年龄测定热年代学超高压变质带磷灰石东海

Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism

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Asian Journal of Andrology 2017年第6期19卷 680-685页

作者： Jiang-Feng Mao Zhao-Xiang Liu Min Nie Xi Wang Hong-Li Xu Bing-Kun Huang Jun-Jie Zheng Le Min ursula Brigitte Kaiser Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Internal Department Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.

Both pulsatile gonadotropin-releasing hormone （GnRH） infusion and combined gonadotropin therapy （human chorionic gonadotropin and human menopausal gonadotropin [HCG/HMG]） are effective to induce spermatogenesis in male patients with congenital hypogonadotropic hypogonadism （CH H）. However, evidence is lacking as to which treatment strategy is better. This retrospective cohort study included 202 patients with CHH： twenty had received pulsatile GnRH and 182 had received HCG/HMG. Patients had received therapy for at least 12 months. The total follow-up time was 15.6 ± 5.0 months （range： 12-27 months） for the GnRH group and 28.7 ± 13.0 months （range： 12-66 months） for the HCG/HMG group. The median time to first sperm appearance was 6 months （95% confidence interval [CI]： 1.6-10.4） in the GnRH group versus 18 months （95% Ch 16.4-20.0） in the HCG/HMG group （P〈 0.001）. The median time to achieve sperm concentrations 〉5 x 106 m1-1 was 14 months （95% Ch 5.8-22.2） in the GnRH group versus 27 months （95% Ch 18.9-35.1） in the HCG/HMG group （P 〈 0.001）, and the median time to concentrations 〉10 x 106 m1-1 was 18 months （95% Ch 10.0-26.0） in the GnRH group versus 39 months （95% CI unknown） in the HCG/HMG group. Compared to the GnRH group, the HCG/HMG group required longer treatment periods to achieve testicular sizes of 〉4 ml, 〉8 ml, 〉12 ml, and 〉16 ml. Sperm motility （a ＋ b ＋ c percentage） evaluated in semen samples with concentrations 〉1 × 106 ml-1 was 43.7% ± 20.4% （16 samples） in the GnRH group versus 43.2% ± 18.1% （153 samples） in the HCG/HMG group （P= 0.921）. Notably, during follow-up, the GnRH group had lower serum testosterone levels than the HCG/HMG group （8.3 ±4.6 vs 16.2 ± 8.2 nmol 1-1, P 〈 0.001）. Our study found that pulsatile GnRH therapy was associated with earlier spermatogenesis and larger testicular size compared to combined gonadotropin therapy. Additional prospective randomized studies would be required to confirm these findings.

关键词： combined gonadotropin therapy congenital hypogonadotropic hypogonadism pulsatile GnRH therapy spermatogenesis

Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration

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World Journal of Gastroenterology 2008年第46期14卷 7093-7100页

作者： Jan-Peter Sowa Jan Best Tamas Benko Maximillian Bockhorn Yanli Gu Eva-Maria Niehues Agnieska Bucchi Eva-Maria Benedetto-Castro Guido Gerken ursula Rauen Jorg Friedrich Schlaak Department of Gastroenterology and Hepatology University Hospital of Essen Hufelandstr. 5545122 Essen Germany Department of General Visceral and Transplantation Surgel'y (Jniversity Hospital of Essen Hufelandstr. 55 45122 Essen Germany Institute for Physiological chemistry UniversityHospital of Essen Hufelandstr. 55 45122 Essen Germany Department of Surgery and Transplaniation Semmelweis University Baross u. 23 H-1082 Budapest Hungary

AIM： To investigate the molecular events involved in liver regeneration following subtotal hepatectomy （SH） as previous studies have largely focused on partial hepatectomy （PH）. METHODS： Male Wistar rats were subjected to 70% PH or 90% SH, respectively, and sacrificed at different times after surgery. Untreated and sham-operated animals served as controls. Serum and liver samples were obtained to investigate liver function, apoptosis （TUNEL assay） and transcription factors （NF-KB, Stat3; ELISA） or cytokines （HGF, TNF-α, IL-6, TGF-α, TGF-β; quantitative RT-PCR） involved in liver regeneration. RESULTS： Serum levels of ALT and AST in animals with 70% PH differed significantly from sham-operated and control animals. We found that the peak concentration 12 h after surgery returned to control levels 7 d after surgery. LDH was increased only at 12 h after 70% PH compared to sham. Bilirubin showed no differences between the sham and 70% resection. After PH, early NF-kB activation was detected 12 h after surgery （313.21 ± 17.22 ng/mL）, while there was no activation after SH （125.22 ± 44.36 ng/mL） compared to controls （111.43 ± 32.68 ng/mL） at this time point. In SH, however, NF-kB activation was delayed until 24 h （475.56 ± 144.29 ng/mL）. Stat3 activation was similar in both groups. These findings correlated with suppressed and delayed induction of regenerative genes after SH （i.e. TNF-α 24 h postoperatively： 2375 ± 1220 in 70% and 88 ± 31 in 90%; IL-6 12 h postoperatively： 2547 ± 441 in 70% and 173 ± 82 in 90%）. TUNEL staining revealed elevated apoptosis rates in SH （0.44% at 24 h; 0.63% at 7 d） compared to PH （0.27% at 24 h; 0.15% at 7 d）. CONCLUSION： The molecular events involved in liver regeneration are significantly influenced by the extent of resection as SH leads to suppression and delay of liver regeneration compared to PH, which is associated with delayed activation of NF-kB and suppression of proregenerative cytokines.

关键词： Apoptosis Cytokines Liver regeneration Major hepatectomy

组织染色法观察灰盖鬼伞子实体发育过程（英文）

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食用菌学报 2019年第4期26卷 29-38页

作者： SUBBA Shanta WINKLER Marco KüES ursula 树木分子生物技术与菌物技术研究院哥廷根分子生物科学中心(GZMB)哥廷根大学

灰盖鬼伞(Coprinopsis cinerea)是一种嗜粪模式食用菌,可在实验室条件下快速生长并结实。子实体发育从黑暗环境下形成初级菌丝结开始,随后在光照刺激下初级菌丝结紧密聚集形成二级菌丝结,然后二级菌丝结继续分化出菌柄和菌盖。在子实体... 详细信息

灰盖鬼伞(Coprinopsis cinerea)是一种嗜粪模式食用菌,可在实验室条件下快速生长并结实。子实体发育从黑暗环境下形成初级菌丝结开始,随后在光照刺激下初级菌丝结紧密聚集形成二级菌丝结,然后二级菌丝结继续分化出菌柄和菌盖。在子实体形成培养条件下,前5天(P1-P5)为原基发育期,第6天担子及担孢子中发生核融合及减数分裂,伴随菌柄伸长和菌盖形成,子实体发育成熟。成熟的子实体在第7天自溶,含有孢子的液滴落地并释放出孢子。本文运用不同的组织染色技术观察原基组织切片,从而发现灰盖鬼伞子实体发育过程中不同的组织和细胞类型。前担子比其他组织更容易被乳酚蓝、迈尔士苏木精明矾、孔雀绿、曙红染色。菌盖皮最容易被孔雀绿和乳酚蓝染色。过碘酸雪夫氏染色(periodic acid Schiff,PAS)的菌盖皮和子实基层颜色比其他组织深,其中菌盖皮颜色很深,子实基层颜色稍深。所有切片还尝试了各种可能组合的双染。在PAS和苏木精明矾先后双染色下,子实基层和前胆子可以获得最佳区分。

关键词：子实体组织染色子实基层担子糖原灰盖鬼伞

Near-infrared spectroscopy(NIRS)as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome(OSAS):A pilot study

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 143-152页

作者： Zhongxing Zhang Maja Schneider ursula Fritschi Lsabela Lehner Ramin Khatami Sleep Center Clinic BarmelweidSwitzerland Department of Neurology Uniuersity Hospital Zurich University of ZurichSuitzerland

In obstructive sleep apnea syndrome(OSA)the periodic reduction or cessation of breathing dueto narrowing or occlusion of the upper airway during slep leads to an impaired cerebral vascularautoregulation that is associated with an increased cardiovascular risk,including ***-tinuous positive airways pressure(CPAP)therapy at night is the most effective treatment forOSA and has been shown to reduce the cardiovascular risk in OSA ***,there is nosuitable bedside monitoring method evaluating the recovery of cerebral hemodynamics duringCPAP ***-infrared spectroscopy(NiRS)is idelly suited for non-invasive monitoringthe cerebral hemodynamics during sleep due to its properties of local measurement,totally sa feapplication and good tolerance to *** this pilot study,we monitored cerebral hemody-namics during standard CPAP therapy at night in thre patients with severe OSA using *** found periodic oscllations in HbO2,HHb,tisue oxygenation index(TO1)and blood volume(BV)associa ted with periodic apnea events without CPAP in all OSA *** osillationswere eliminated under the optimal CPAP pressures in all *** results sugg ested thatthe recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedsideNIRS measurements in real time during ll night CPAP *** is a usefi bedsidemonitoring tool to evaluate the treatment elicacy of CPAP therapy in patients with OSA.

关键词： Sleep cerebral hemodynamics hemodynamic oscillations bedside monitoring.

Initiative to Improve the Health Outcomes of Those at Risk of Perinatal Depression: Referral Characteristics and Psychosocial Determinants

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Open Journal of Obstetrics and Gynecology 2016年第8期6卷 463-472页

作者： Mona Asghari-Fard ursula Hopper My Trinh Ha Valsamma Eapen Academic Unit of Child Psychiatry South Western Sydney Liverpool Hospital Sydney Australia Perinatal Mental Health Service Liverpool Hospital Sydney Australia Academic Unit of Child Psychiatry South West Sydney (AUCS) ICAMHS Mental Health Centre Liverpool Hospital Sydney Australia School of Psychiatry & Ingham Institute University of New South Wales Sydney Australia

In Australia, perinatal depression affects 15% - 20% of pregnant women. Depression does not go away on its own, getting help at early stages shown to be effective in treating antenatal depression. Aim of this study is to assess and describe the screening of women through the antenatal clinic and measure the outcome of services provided (such as counselling, social assistance) for those at risk of depression, in a general hospital setting in an ethnically diverse part of Sydney, Australia. Data from 193 women were obtained through accessing the psychosocial and screening assessments completed at the antenatal clinic between 2007 and 2008. Data regarding patients’ psychosocial characteristics, referrals and interventions were also gathered from hospital records. Data revealed that 60.4% of women screened scored ≥10 on the Edinburgh Postnatal Depression Scale (EDPS) which is indicative of significant depressive symptomatology. Of these women, 39.4% went on to receive a formal diagnosis. Women who indicated that they had planned their pregnancies (47.2%) were significantly less likely to report having major worries and stressors over the last 12 months (p < 0.05) in comparison to those who indicated that their pregnancies were unplanned. Data showed while screening methods are effective, regrettably a high proportion of women, despite presenting with “at risk” symptomatology levels, do not engage in intervention programs. Further research is required to explore the barriers in accessing both screening and intervention services (particularly in a culturally diverse area such as this), and how services can improve processes and patient participation.

关键词： Antenatal Depression Routine Screening Early Identification

升华、重塑、互补 ——基于案例浅析文学自译中的不忠实

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升华、重塑、互补 ——基于案例浅析文学自译中的不忠实

作者： ursula Deser Friedman（冯爱苏）北京外国语大学

学位级别：硕士

自译文学作品的作者兼译者通过创新翻译技巧对原文进行升华、扩展和补充,给整个翻译界注入了一股革新的活力。但直到本世纪初,文学文本的自译被翻译界所忽略,目前研究自译案例的翻译文献极少,分析比较自译译本与他译译本的学术论文就更... 详细信息

自译文学作品的作者兼译者通过创新翻译技巧对原文进行升华、扩展和补充,给整个翻译界注入了一股革新的活力。但直到本世纪初,文学文本的自译被翻译界所忽略,目前研究自译案例的翻译文献极少,分析比较自译译本与他译译本的学术论文就更稀缺了。但自译研究逐渐受到西方学者的关注,许多学者都对塞缪尔·贝克特和弗拉基米尔·纳博科夫两位作家的文学自译作品进行了系统性的研究。然而,在中国,自译的案例研究和相关理论处于边缘地带,学者对于自译的关注度还远远不够。译者、作者和读者三者间的关系常用"一仆二主"来形容:译者即"仆人",不仅要"伺候"原著作者,还要"伺候"读者。而"自译者"(作者兼译者)对这种传统的翻译关系构成了挑战,因为自译要同时忠实于原语文化、目标读者的审美标准以及个人的写作风格这三个"主"。自译能够突破作者与译者、原文与译文之间的界限,赋予译文独立的生命。显然,自译加宽翻译的目标和标准,使得翻译不再被视为原文衍生产物,能够重新回到翻译史中世纪的崇高地位。理论框架上,本文运用德里达的解构主义、勒菲弗尔的改写理论、博尔赫斯以及林语堂对于翻译中忠实性的诠释,以便证明自译是堂堂正正的翻译学分支学科,也给自译中的忠实问题带来新的启示。基于这些理论,笔者提炼出自译的三个基本原则:(一)实现原文的升华,而不仅仅是语言层次的转换;(二)重写原文;(三)通过"不忠实''手段补充原文,与原文建立起互补关系。本文的主体部分是剖析比较罗萨里奥·费雷西班牙文短篇小说《La Muneca Menor》(1991)的英文自译版《The Youngest Doll》和格雷戈里奥·拉巴萨的英文译本(1980)之间的异同,以及比较张爱玲所撰写的英文短篇小说《Stale Mates》(1956)与她的中文自译译文《五四遗事》(1958)。基于对西英和英中自译案例的研究,笔者分析作者兼译者所使用的创新技巧和不忠实手段,说明自译者如何通过自译来实现原文的升华、重塑和互补,期望对他译也有所启示。

关键词：自译罗萨里奥·费雷张爱玲四五遗事最小的洋娃娃