检索结果-南通市图书馆

Advances in Aging Research 2014年第2期3卷 130-141页

作者： Elisabeth Hanf ursula Gresser Ludwig-Maximilians University of Munich Munich Germany

Background: Semi-permanent fillers are among the most favorable fillers on the market. Through their unique mode of action and its associated lasting aesthetic effect, they take an exceptional position. Objective: To compare the two semi-permanent fillers Poly-L-Lactic Acid (PLLA) and calcium hydroxylapatite (CaHA) in reference to the aesthetic result, patient satisfaction and side effects. Methods: Studies on side effects, patient satisfaction and aesthetic results after augmentation with semi-permanent fillers were analyzed. Results: Semi-permanent fillers seem excellently suited for the augmentation of very deep wrinkles particularly in the lower half of the face. In general, high patient satisfaction can be determined with both fillers. Here, the effect from the polylactic acid can be verified for up to two years while no effect could be verified already after one year in a majority of the patients augmented with CaHA. Short-term side effects such as bleedings or erythema in the region of the augmented area have been observed in both fillers during augmentation. The incidence of nodules and granulomas seems significantly higher in augmentations with PLLA compared to CaHA. Rare side effects such as an embolization of a blood vessel caused by the implant have been described for both fillers in case reports. Conclusion: Semi-permanent fillers are superbly suited for wrinkle augmentation. Which filler is the preferred one in what case depends strongly on the individual needs of the patient and the therapist’s experience.

关键词： Polylactic Acid Calcium Hydroxylapatite Sculptra^(■) Radiesse^(■) Granuloma Semi-Permanent Fillers

Visiting Patients at Home: Reasons and Efficiency of Dental House Calls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Aging Research 2015年第6期4卷 205-211页

作者： Maria Kretsch ursula Gresser Ludwig-Maximilians University of Munich Munich Germany

This retrospective study analyzes indications for house calls by dentists in a domiciliary setting. Its database consists in 69 visits made by a dentist office in Munich from 1998 to 2013 at the homes of 29 non-institutionalized seniors (≥62 years old, 15 females, 14 males, average age 83.7 years old). The analysis focused on the patients’ general state of health, their dental and oral health, the kinds of dental treatments administered, as well as economic aspects and the quantitative development in the frequency of house calls during the study period. The most frequent pre-existing conditions that made a house call necessary were cardiovascular illnesses (60%) and dementia diseases (36%). Multi-morbidity, dependency on care, accessibility issues, and frailty because of advanced age played a central role. The patients’ oral health was acceptable, with the exception of those with dementia diseases, who were more frequently toothless (40% versus 5.6%) and had a higher percentage of carious and decayed teeth (26.3% versus 10.3%). The most frequent procedures were treatments for denture sores and the repair of removable dentures (53.6%). The main focus was on reparative dentistry. The average house call took 37 minutes including travel time. Thus, the time needed was a multiple of the time necessary for treatment in the dental office. The lack of economic efficiency may be the reason why many dentists in Germany hesitate to make house calls. Despite the introduction of additional fees for the treatment of patients in need of long-term care on April 1, 2013, the number of house calls is low and increases only slowly. At the same time, the need for house calls will rise in the future due to an increasing proportion of elderly persons in the population and a decline in the percentage of toothless elderly.

关键词： Dentist House Calls Non-Institutionalized Seniors Reparative Dentistry High Time Expenditure

Methylphenidate Misuse in Adults: Survey of 414 Primary Care Physicians in Germany and Comparison with the Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2017年第4期7卷 180-209页

作者： Ria Thier ursula Gresser Ludwig Maximilians University of Munich Medical Faculty Internal Medicine Munich Germany

Objectives: This paper deals with the methylphenidate (MPH) misuse by adults in Germany. Results of a survey among primary care physicians/internists have been supplemented by a comparison with the literature. Methods: In the period from October 5-20, 2015, a survey was sent to 414 primary care physicians/internists in four German cities (n = 10 were undeliverable). The response rate was 58% (n = 235). 34 original works on MPH abuse worldwide were found in the literature and are used in the analysis of the present data situation. The literature published before November 9, 2015 is considered in this paper. Results: 14% of the doctors who took part in the survey said that they had been asked for MPH prescriptions without any medical indication. The most frequent reason given for the request (42%) was adult attention deficit/hyperactivity disorder (ADHD) not verified by documents. According to the comparison with the literature, university students had a lifetime prevalence of MPH misuse ranging from 0.8% to 16.6% and school children had a misuse rate of 4.0%. In the civilian US population, the misuse rate was 4.2%. Among patients in possession of a current MPH prescription due to a diagnosis, the lifetime prevalence was 29% and among adolescents with suspected alcohol and/or drug problems 20%. Conclusions: MPH misuse is a major problem which has not been studied sufficiently. MPH misuse not only plays a role in the field of psychiatry, but also in other disciplines. Misuse particularly following a therapeutic prescription should be taken into account.

关键词： Methylphenidate Misuse Students Prescription Drugs

European Species of Hebeloma Section Theobromina

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2013年第1期58卷 103-126页

作者： ursula Eberhardt Henry J.Beker Jan Vesterholt Karolina Dukik Grit Walther Jordi Vila Samantha Fernández Brime CBS-KNAW Fungal Biodiversity Centre Centraalbureau voor SchimmelculturesUppsalalaan 83584 CT UtrechtNetherlands Rue Père de Deken 19 1040 BruxellesBelgium Natural History Museum of Denmark Gothersgade 1301123 Copenhagen K.Denmark Microbial Resource Collection Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute and Institute of MicrobiologyDepartment of Microbiology and Molecular BiologyUniversity of JenaBeutenbergstraße 11a07745 JenaGermany Department Biologia Vegetal(Botànica) Fac.BiologiaUniversitat de BarcelonaDiagonal 64508028 BarcelonaSpain

This paper addresses section Theobromina within the genus Hebeloma(Agaricales).We recognise seven European species within this section,three of which are described as new:Hebeloma alboerumpens,*** and *** first two of these species appear to be ectomycorrhizal with Cistaceae:Cistus and *** parvicystidiatum is more likely to be in mycorrhizal association with Quercus *** also provide a key to the European species within *** and an updated key of known Hebeloma associates of *** analyses based on multiple loci further illustrate the distinctness of the newly described taxa and provide molecular evidence,supporting the morphological evidence,for the relationship that exists among species of this *** ITS is the only one from the sequenced loci that,alongside with morphology,distinguishes among all of the species of *** section gains most of its molecular support from the MCM7 locus,followed by RPB2.

关键词： Host specificity Fungi Hebeloma plesiocistum Hebeloma theobrominum Hebeloma vesterholtii DNA barcode

Perioperative challenges in management of diabetic patients undergoing non-cardiac surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第8期12卷 1255-1266页

作者： ursula Galway Praveen Chahar Marc T Schmidt Jorge A Araujo-Duran Jeevan Shivakumar Alparslan Turan Kurt Ruetzler Department of General Anesthesiology Anesthesiology InstituteCleveland ClinicClevelandOH 44195United States Department of Intensive Care and Resuscitation Anesthesiology InstituteCleveland ClinicClevelandOH 44195United States Department of Outcomes Research Anesthesiology InstituteCleveland ClinicClevelandOH 44195United States

Prediabetes and diabetes are important disease processes which have several perioperative *** one third of the United States population is considered to have *** prevalence in surgical patients is even *** is due to the associated micro and macrovascular complications of diabetes that result in the need for subsequent surgical procedures.A careful preoperative evaluation of diabetic patients and patients at risk for prediabetes is essential to reduce perioperative mortality and *** preoperative evaluation involves an optimization of preoperative *** also includes optimization of antidiabetic medication regimens,as the avoidance of unintentional hypoglycemic and hyperglycemic episodes during the perioperative period is *** focus of the perioperative management is to ensure euglycemia and thus improve postoperative ***,prolonged preoperative fasting should be avoided and close monitoring of blood glucose should be initiated and continued throughout *** can be accomplished with either analysis in blood gas samples,venous phlebotomy or point-of-care *** capillary and arterial whole blood glucose do not meet standard guidelines for glucose testing,they can still be used to guide insulin dosing in the operating *** glycemic control goals may vary slightly in different protocols but overall the guidelines suggest a glucose range in the operating room should be between 140 mg/dL to 180 mg/*** hyperglycemia is detected in the operating room,blood glucose management may be initiated with subcutaneous rapid-acting insulin,with intravenous infusion or boluses of regular *** and electrolyte management are other perioperative *** diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic state are the two most serious acute metabolic complications of diabetes that must be recognized early and treated.

关键词： Diabetes mellitus Perioperative management Insulin Hyperglycaemia Anaesthesia Surgery

中文社科文献外译的挑战、对策与建议——以《20世纪中国古代文化经典在域外的传播与影响研究》英译为例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国翻译 2019年第2期40卷 149-156页

作者：姚斌 ursula Deser Friedman 北京外国语大学

中文社科文献的外译是精彩纷呈的中华学术走向世界的钥匙。本文以《20世纪中国古代文化经典在域外的传播与影响研究》一书的英译为例,展示了在中文社科文献外译中出现的一些典型性问题,并提出相应对策。本文认为,要保证外译文本的质量,... 详细信息

中文社科文献的外译是精彩纷呈的中华学术走向世界的钥匙。本文以《20世纪中国古代文化经典在域外的传播与影响研究》一书的英译为例,展示了在中文社科文献外译中出现的一些典型性问题,并提出相应对策。本文认为,要保证外译文本的质量,增强传播的效果,应尽量采取中外合作的翻译模式,保持与原作者密切沟通的翻译习惯,并且努力在忠实原作与适应读者期待之间实现有效平衡。

关键词：社科文献学术外译翻译模式传播效果

Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第40期20卷 14855-14864页

作者： Christina Klaus ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke Kaemmerer Institute of Pathology RWTH Aachen University 52074 Aachen Germany Department of Chemical Biology Max Planck Institute of Molecular Physiology 44227 Dortmund Germany Department of Biochemistry and Molecular Cell Biology RWTH Aachen University 52074 Aachen Germany Department of Pediatrics RWTH Aachen University 52074 Aachen Germany

AIM: To investigate the role of acyl-CoA synthetase 5 (ACSL5) activity in Wnt signaling in intestinal surface epithelia.

关键词： Acyl-CoA synthetases Wnt signaling Palmitoylation Intestinal barrier Carcinogenesis

18 mots pour comprendre Ce que dit l'islam

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

法语国家与地区研究 2002年第2期 82-86页

作者： ursula Gauthier ,Marie Lemonnier

Reproducing indolent B-cell lymphoma transformation with T-cell immunosuppression in LMP1/CD40-expressing mice

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第4期16卷 412-414页

作者： Christelle Vincent-Fabert Alexis Saintamand Amandine David Mehdi Alizadeh François Boyer Nicolas Arnaud ursula Zimber-Strobl Jean Feuillard Nathalie Faumont CNRS-UMR 7276 INSERM U1262 CRIBL University of Limogesand Hematology Laboratory of Dupuytren Hospital University Center(CHU)of LimogesLimogesFrance INSERM U917 University of Rennes 1RennesFrance LNPRM EFS BretagneRennesFrance Research Unit Gene Vectors Helmholtz Center MunichGerman Research Center for Environmental Health GmbHMunichGermany

Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling *** transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor *** least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.

关键词： lymphoma Richter transformation

PLEIOTROPIC REGULATORY LOCUS 1 （PRL1） Integrates the Regulation of Sugar Responses with Isoprenoid Metabolism in Arabidopsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2010年第1期3卷 101-112页

作者： ursula Flores-Perez Jordi Perez-Gil Marta Closa Louwrance R Wright Patricia Botella-Pavia Michael A. Phillips Albert Ferrer Jonathan Gershenzon Manuel Rodriguez-Concepcion Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB Jordi Girona 18 08034 Barcelona Spain Departament de Bioquimica i Biologia Molecular Facultat de Farmacia Universitat de Barcelona Avda. Diagonal 643 08028 Barcelona Spain Department of Biochemistry Max Planck Institute for Chemical Ecology D-07745 Jena Germany Present address: Department of Biology University of Leicester Leicester LE1 7RH United Kingdom

The biosynthesis of isoprenoids in plant cells occurs from precursors produced in the cytosol by the mevalonate （MVA） pathway and in the plastid by the methylerythritol 4-phosphate （MEP） pathway, but little is known about the mechanisms coordinating both pathways. Evidence of the importance of sugar signaling for such coordination in Arabi- dopsis thaliana is provided here by the characterization of a mutant showing an increased accumulation of MEP-derived isoprenoid products （chlorophylls and carotenoids） without changes in the levels of relevant MEP pathway transcripts, proteins, or enzyme activities. This mutant was found to be a new loss-of-function allele of PRL1 （Pleiotropic Regulatory Locus 1）, a gene encoding a conserved WD-protein that functions as a global regulator of sugar, stress, and hormone responses, in part by inhibition of SNFl-related protein kinases （SnRK1）. Consistent with the reported role of SnRK1 kinases in the phosphorylation and inactivation of the main regulatory enzyme of the MVA pathway （hydroxymethylglutaryl coenzyme-A reductase）, its activity but not transcript or protein levels was reduced in prll seedlings. However, the accumulation of MVA-derived end products （sterols） was unaltered in mutant seedlings. Sucrose supplementation to wild- type seedlings phenocopied the prll mutation in terms of isoprenoid metabolism, suggesting that the observed isoprenoid phenotypes result from the increased sugar accumulation in the prll mutant. In summary, PRL1 appears to coordinate isoprenoid metabolism with sugar, hormone, and stress responses.

关键词： Carbohydrate metabolism metabolic regulation secondary metabolism--terpenoids, isoprenoids, and carotenoids Arabidopsis.