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Induction of Autologous Bone-Marrow Stem Cells by Low-Level Laser Therapy Has Beneficial Effects on the Kidneys Post-Ischemia-Reperfusion Injury in the Rat

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Journal of Biomedical Science and Engineering 2014年第8期7卷 453-463页

作者： Hana Tuby Lidya Maltz uri oron Department of Zoology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel

Acute renal failure has a 50% - 80% mortality rate. Currently, treatment options for this life-threatening disease are limited. Low-level laser therapy (LLLT) has been found to modulate biological activity. The aim of the present study was to investigate the possible beneficial effects of laser application to stem cells in the bone marrow, on the kidneys of rats that had undergone ischemia-reperfusion injury (IRI). IRI was induced by occlusion of the renal artery to 3- and 7-month-old rats for 15 or 30 minutes. In an additional experiment IRI was applied to both kidneys for 20 min each in 2-3-month-old rats. Rats were then divided randomly into two groups of control and laser-treated. Laser therapy (Ga-Al-As 810 nm, 200 mW output for 2 min) was applied to the bone marrow 1 and 7 days post-IRI to the kidneys, and rats were sacrificed 2 weeks later. Histomorphometry and immunohistochemistry were performed on kidney sections and blood markers for kidney function. Quantitative histomorphometric analysis revealed a reduction in dilatation of the renal tubules, restored structural integrity of the renal tubules, and reduced necrosis in the laser-treated rats as compared to the control, non-laser-irradiated group. C-kit positive cell density in kidneys post-IRI and laser-treatment was significantly (p = 0.015) 3.2-fold higher compared to the control group. Creatinine and blood urea nitrogen content were significantly lower in the laser-treated rats as compared to control. It is concluded that LLLT application to the bone marrow (BM) causes a significant increase in the density of mesenchymal stem cells in the kidneys post-IRI, probably by induction of stem cells in the BM, which subsequently migrate to the IRI kidney, significantly reducing the pathological features of the kidney and increasing kidney function post IRI.

关键词： Kidney Mesenchymal Stem Cells (MSCs) Low-Level Laser Therapy (LLLT) Ischemia-Reperfusion Injury (IRI)

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Effect of autologous mesenchymal stem cells induced by low level laser therapy on cardiogenesis in the infarcted area following myocardial infarction in rats

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Journal of Biomedical Science and Engineering 2013年第8期6卷 24-31页

作者： Hana Tuby Tali Yaakobi Lidya Maltz Yaakov Delarea Orit Sagi-Assif uri oron Department of Cell Biology and Immunology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel Department of Zoology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel

In this study, we investigated the hypothesis that photobiostimulation by low-energy laser therapy (LLLT) applied to the bone marrow (BM) of myocardial infarcted rats may attenuate the scarring processes that follow myocardial infarction (MI). Wistar rats underwent experimental MI. LLLT (Ga-Al-As diode laser) was applied to the BM of the exposed tibia at different time intervals post-MI (4 hrs, 48 hrs and 5 days). Sham-operated infarcted rats served as control. Infarct size was significantly reduced (55%) in the laser-treated rats as compared to the control non-treated rats, at 2 weeks post-MI. A significant 3-fold increase was observed in the density of desmin immunopositive stained cells 14 days post-MI in the infarcted area of the laser-treated rats as compared to the non-laser-treated controls. The electron microscopy from the control infarcted rat hearts revealed a typical interphase area between the intact myocardium and the infarcted area, with conspicuous fibroblasts with collagen deposition dispersed among them. In rats that were laser treated (to BM), the interphase zone demonstrated cells with different intracellular structures. There was also a significant increase in the percentage of c-kit positive cells and macrophages in the circulating blood of the laser treated rats as compared to control non treated ones. In the majority of the cells clusters of myofibrils anchored to well-developed Z-lines and structures resembling the morphological characteristics of mature intact cardiomyocytes were evident. In conclusion, LLLT to the BM of rats post-MI induces cardiogenesis mainly at the borders of the infarcted area in the heart.

关键词： Low-Level Laser Therapy Myocardial Infarction Macrophage Desmin Ultrastructure c-Kit Positive Cells

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Variational Approach to Heat Conduction Modeling

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Journal of Applied Mathematics and Physics 2024年第1期12卷 234-248页

作者： Slavko Đurić Ivan Aranđelović Milan Milotić Faculty of Traffic Engineering University of East Sarajevo Doboj Bosnia and Herzegovina Faculty of Mechanical Engineering University of Belgrade Belgrade Republic of Serbia

It is known that Fourier’s heat equation, which is parabolic, implies an infinite velocity propagation, or, in other words, that the mechanism of heat conduction is established instantaneously under all conditions. This is unacceptable on physical grounds in spite of the fact that Fourier’s law agrees well with experiment. However, discrepancies are likely to occur when extremely short distances or extremely short time intervals are considered, as they must in some modern problems of aero-thermodynamics. Cattaneo and independently Vernotte proved that such process can be described by Heaviside’s telegraph equation. This paper shows that this fact can be derived using calculus of variations, by application of the Euler-Lagrange equation. So, we proved that the equation of heat conduction with finite velocity propagation of the thermal disturbance can be obtained as a solution to one variational problem.

关键词： Telegraph Equation Heat Equation Heat Conduction Calculus of Variations

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Variational Approach to 2D and 3D Heat Conduction Modeling

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1383-1400页

The paper proposes an approximate solution to the classical (parabolic) multidimensional 2D and 3D heat conduction equation for a 5 × 5 cm aluminium plate and a 5 × 5 × 5 cm aluminum cube. An approximate solution of the generalized (hyperbolic) 2D and 3D equation for the considered plate and cube is also proposed. Approximate solutions were obtained by applying calculus of variations and Euler-Lagrange equations. In order to verify the correctness of the proposed approximate solutions, they were compared with the exact solutions of parabolic and hyperbolic equations. The paper also presents the research on the influence of time parameters τ as well as the relaxation times τ ∗ to the variation of the profile of the temperature field for the considered aluminum plate and cube.

关键词： Classical Equation of Heat Conduction Generalized Equation of Heat Conduction Calculus of Variations Approximate Solution

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Structure and properties of graphullerene: a semiconducting two-dimensional C_(60) crystal

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npj Computational Materials 2023年第1期9卷 197-202页

作者： uri Argaman Guy Makov Dept.of Materials Engineering Ben-Gurion University of the NegevBeer-ShevaIsrael

Graphullerene is a recently discovered,two-dimensional allotrope of carbon formed from C_(60) *** has been synthesized in the form(C_(60)Mg4)n and subsequently transformed into(C_(60))n by removal of the Mg *** initio calculations are employed to examine the structure and properties of this ***,graphullerene is composed of strained C_(60) *** of these molecules is connected to six neighbors in a hexagonal network with a total of eight chemical *** find this structure to be meta-stable,owing to the strain produced by the covalent bonding of the ***,the inclusion of Mg atoms transforms the cohesion energy from negative to positive values by forming additional C-Mg bonds,creating an energetically stable *** the absence of Mg,this allotrope is a pure carbon semiconductor with an indirect band *** spectrum calculations confirm the dynamical stability of the material and yield its in-and out-of-plane sound *** addition,symmetry breaking of the C_(60) molecules results in a distribution of bond lengths and creates vibrational modes that serve as a signature of graphullerene.

关键词： material bonds crystal

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Rate and yield of repeat upper endoscopy in patients with dyspepsia

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World Journal of Gastroenterology 2010年第20期16卷 2520-2525页

作者： uri Ladabaum Viam Dinh Division of Gastroenterology and Hepatology Department of MedicineStanford University School of MedicineRedwood CityCA 94063United States Division of Gastroenterology Department of MedicineUniversity of CaliforniaSan FranciscoCA 94143United States

AIM: To determine the rate and yield of repeat esophagogastroduodenoscopy (EGD) for dyspepsia in clinical practice,whether second opinions drive its use,and whether it is performed at the expense of colorectal cancer ***: We performed a retrospective cohort study of all patients who underwent repeat EGD for dyspepsia from 1996 to 2006 at the University of California,San Francisco endoscopy ***: Of 24 780 EGDs,5460 (22%) were performed for dyspepsia in 4873 *** these,451 patients (9.3%) underwent repeat EGD for dyspepsia at a median 1.7 (interquartile range,0.8-3.1) years after initial *** icant f indings possibly related to dyspepsia were more likely at initial (29%) vs repeat EGD (18%) [odds ratio (OR),1.45;95% confidence interval (CI): 1.20-1.75,P < 0.0001],and at repeat EGD if the initial EGD had reported such f indings (26%) than if it had not (14%) (OR,1.32;95% CI: 1.08-1.62,P = 0.0015).The same endoscopist performed the repeat and initial EGD in 77% of *** patients aged 50 years or older,286/311 (92%) underwent lower ***: Repeat EGD for dyspepsia occurred at a low but substantial rate,with lower yield than initial *** endoscopy use remains a public health priority.

关键词： Dyspepsia Esophagogastroduodenoscopy Health resources Diagnostic techniques and procedures Repeat Treatment outcome

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Economic cost-benefit analysis for the agricultural use of sewage sludge treated with lime and fly ash

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International Journal of Coal Science & Technology 2021年第5期8卷 1099-1107页

作者： Efrat Hadas uri Mingelgrin Pinchas Fine Investment Financing Department Ministry of Agriculture and Rural Development68 Hamakabim RoadP.O.Box 151597505101 Rishon LeZionIsrael Agricultural Research Organization Volcani CenterInstitute of SoilsWater and Environmental Sciences68 Hamakabim RoadP.O.Box 151597505101 Rishon LeZionIsrael

A tool for calculating the economic and environmental impacts of the use of byproducts of industrial processes that can substitute for perishable resources was *** was exemplified by fly ash(the fine fraction of ash originating from coal burned to generate electricity and collected by filtering exhaust gases leaving the furnace),added to soil as a component of sewage sludge stabilized with fly ash and lime(NVS).Application to soil of NVS has potential agricultural and environmental advantages and *** costs and benefits of such application were calculated using both a database and expert *** calculations assumed a representative assemblage of soils and crops,with weights assigned to each crop type and soil *** annual weighted benefits(additional income for the farmer)and costs per hectare reached 324$/ha and 131$/ha *** potential benefits include:Chemical fertilizer replacement,159$/ha;Improvement to the soil’s physical properties,75$/ha;Supply of vital trace elements,33$/*** potential costs were:Regulatory limitations on marketing of crops pending proof of absence of risk of heavy metals or radionuclides accumulation in these crops,(17$/ha and 36$/ha respectively);Application and incorporation cost,50$/*** presented estimates of the costs and benefits refer to the array of soils and conditions typical to *** is possible to maximize potential benefits by applying fly ash only to the most suitable agricultural soils while improper use of fly ash will increase the costs incurred from its use.

关键词： Byproducts recycling Cost-benefit analysis Fly ash Liming Sewage sludge

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Optical materials and metamaterials from nanostructured soft matter

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Nano Research 2019年第9期12卷 2172-2183页

作者： uri R. Gabinet Chinedum O. Osuji Chemical and Biomolecular Engineering University of PennsylvaniaPhiladelphiaPA 19104USA

Soft materials such as block copolymers,liquid crystals and colloidal assemblies are excellent candidates for use in optical applications due to their ability to spontaneously self-assemble into ordered structures on optically-relevant length *** of these applications rely or optical properties that are intrinsic to the structure and chemical composition of the soft material itself,while others are reliant on the presence of inorganic nanomaterials within the soft material to produce the properties of ***,soft materials can be used to *** phenomena that originate not just from the intrinsic properties of the nanomaterials,but from their spatial organization as *** the latter case,exotic optical phenomena such as light focusing beyond the diffraction limit,negative index of refraction and nonlinear photonics *** properties originate from the collective response of multiple nanostructures organized to produce an ordered *** materials,being an excellent medium to convey order on the nanoscale,can be utilized in next generation optical applications to create this kind of ***,we survey how soft matter can be leveraged in optical applications by exploiting self-assembly and directed self-assembly as methods to produce ordered structures with desirable *** highlight applications where the soft material is the optically active component,and others where it's used in tandem with ***,we focus on how soft materials can be used to spatially organize inorganic nanomaterials for use in optical applications where the controlled assembly of such nanomaterials is crucial.

关键词： soft matter metamaterials block copolymers optical properties photonic band gaps

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Role of capsule endoscopy in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1155-1164页

作者： uri Kopylov Ernest G Seidman Division of Gastroenterology McGill University Health Center

Videocapsule endoscopy (VCE) has revolutionized our ability to visualize the small bowel mucosa. This modality is a valuable tool for the diagnosis of obscure small bowel Crohn’s disease (CD), and can also be used for monitoring of disease activity in patients with established small-bowel CD, detection of complications such as obscure bleeding and neoplasms, evaluation of response to anti-inflammatory treatment and postoperative recurrence following small bowel resection. VCE could also be an important tool in the management of patients with unclassified inflammatory bowel disease, potentially resulting in reclassification of these patients as having CD. Reports on postoperative monitoring and evaluation of patients with ileal pouch-anal anastomosis who have developed pouchitis have recenty been published. Monitoring of colonic inflammatory activity in patients with ulcerative colitis using the recently developed colonic capsule has also been reported. Capsule endoscopy is associated with an excellent safety profile. Although retention risk is increased in patients with small bowel CD, this risk can be significanty decreased by a routine utilization of a dissolvable patency capsule preceding the ingestion of the diagnostic capsule. This paper contains an overview of the current and future clinical applications of capsule endoscopy in inflammatory bowel disease.

关键词： Small bowel videocapsule endoscopy, Crohn’ s disease, Pouchitis, Indeterminate inflammatory bowel disease, Ileal pouch-anal anastomosis, Patency capsule

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Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

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Neural Regeneration Research 2018年第5期13卷 817-818页

作者： Ronit Shapira Shai Efrati uri Ashery Department of Neurobiology the George S. Wise Faculty of Life Sciences Tel Aviv University Sackler School of Medicine Tel Aviv University Sagol Center for Hyperbaric Medicine & Research Assaf Harofeh Medical Center Sagol School of Neuroscience Tel Aviv University

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the *** ... 详细信息

关键词： Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease AD

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