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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

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骨研究:英文版 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel Ina kramer Charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu Jennifer L.Harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder

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Journal of Sport and Health Science 2023年第1期12卷 73-86页

作者： Chuidan Kong Aiguo Chen Sebastian Ludyga Fabian Herold Sean Healy Mengxian Zhao Alyx Taylor Notger G.Muller Arthur F.kramer Sitong Chen Mark S.Tremblay Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518061China College of Physical Education Yangzhou UniversityYangzhou 225127China Department of Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Community Health Academic Group School of NursingPsychotherapy and Community HealthDublin City UniversityDublin 9Ireland School of Rehabilitation Sport and PsychologyAECC University CollegeBournemouthBH52DFUK Research Group Neuroprotection German Center for Neurodegenerative Diseases(DZNE)Magdeburg 39120Germany Center for Behavioral Brain Sciences(CBBS) Magdeburg 39118Germany Center for Cognitive and Brain Health Northeastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA Institute for Health and Sport Victoria UniversityMelbourne 8001Australia Healthy Active Living and Obesity Research Group CHEO Research InstituteOttawaOntario K1H8L1Canada Department of Pediatrics University of OttawaOttawaOntario K1N 6N5Canada

Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring and optimizing the health and quality of life(QoL)of children and ***,this topic has yet to be examined for children and adolescents with autism spectrum disorder(ASD)*** aim of this cross-sectional observational study was to examine the associations between meeting 24-HMB guidelines and several QoLrelated indicators among a national sample of American children and adolescents with ***:Data were taken from the 2020 *** Survey of Children’s Health ***(n=956)aged 617 years and currently diagnosed with ASD were *** exposure of interest was adherence to the 24-HMB *** were QoL indicators,including learning interest/curiosity,repeating grades,adaptive ability,victimization by bullying,and behavioral *** variables were described with unweighted sample counts and weighted ***,sex,race,preterm birth status,medication,behavioral treatment,household poverty level,and the educational level of the primary caregivers were included as *** ratio(OR)and 95%confidence interval(95%CI)were used to present the strength of association between adherence to 24-HMB guidelines and QoL-related ***:Overall,452 participants(45.34%)met 1 of the 3 recommendations,216(22.65%)met 2 recommendations,whereas only 39 participants(5.04%)met all 3 *** with meeting none of the recommendations,meeting both sleep duration and PA recommendations(OR=3.92,95%CI:1.639.48,p<0.001)or all 3 recommendations(OR=2.11,95%CI:1.034.35,p=0.04)was associated with higher odds of showing learning interest/*** both screen time and PA recommendations(OR=0.15,95%CI:0.040.61,p<0.05)or both sleep duration and PA recommendations(OR=0.24,95

关键词： 24-hour movement guidelines Autism spectrum disorder Physical activity Quality of life

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帕克活性生物砂滤脱氮工艺的设计与运行

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中国给水排水 2007年第6期23卷 50-52页

作者： kramer J P Wouters J W Rosmalen P van 荷兰帕克公司德尔夫特水务局

位于鹿特丹西部的De Groote Lucht污水厂的原处理工艺无法满足新的氮排放标准,因此进行了改扩建工程,增加了活性生物砂滤床作为三级处理工艺。改造后的处理系统既能达到很高的脱氮效率,又能较好地去除SS和COD,运行稳定,人工操作简单,可... 详细信息

位于鹿特丹西部的De Groote Lucht污水厂的原处理工艺无法满足新的氮排放标准,因此进行了改扩建工程,增加了活性生物砂滤床作为三级处理工艺。改造后的处理系统既能达到很高的脱氮效率,又能较好地去除SS和COD,运行稳定,人工操作简单,可满足年平均总氮含量<10 mg/L的标准要求。

关键词：生物砂滤脱氮三级处理运行

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羊啃食动力学模拟与内蒙古西部气候变化适应

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中国沙漠 2012年第5期32卷 1442-1450页

作者：戴新刚熊喆 K.kramer 贾根锁赵登海中国科学院东亚区域气候与环境重点实验室大气物理研究所北京100029 瓦赫宁根大学Alterra研究中心荷兰瓦赫宁根6700AA 内蒙古贺兰山国家级自然保护区管理局内蒙古阿拉善左旗750300

将定性分析、民主参与式评估和定量数值模拟方法结合起来,对阿拉善气候变化适应问题进行了简要评估并重点分析了土地退化、放牧和草原管理策略之间的关系。阿拉善主要的适应政策是禁牧和生态移民。禁牧后荒漠草原植被得到恢复,但移民增... 详细信息

将定性分析、民主参与式评估和定量数值模拟方法结合起来,对阿拉善气候变化适应问题进行了简要评估并重点分析了土地退化、放牧和草原管理策略之间的关系。阿拉善主要的适应政策是禁牧和生态移民。禁牧后荒漠草原植被得到恢复,但移民增加了绿洲压力,过度开垦又造成周边土地沙化;过度抽取地下水致使水位下降并伴随咸水入侵和地表盐碱化。禁牧的另一个副作用是造成草原鼠害加重及火灾风险增加,生物多样性也呈现先升后降趋势。一些灌木因缺乏啃食出现退化迹象等,说明一定程度的啃食有利于维持草原生态平衡。因此,动物是草原生态系统不可或缺的成员之一。我们用一个包含动物啃食等的森林生态动力模式模拟了啃食动力学,结果表明,有限的放牧有利于草场更新并能充分利用草原资源;过度放牧导致草场退化并伴随羊群死亡。因此,需要将圈养和限制性放牧结合起来,制定可持续性适应政策。

关键词：动物啃食气候变化影响与适应草地退化政策评估

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国立癌症研究所主持的前列腺、肺、结直肠和卵巢癌的筛选试验

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国外医学（肿瘤学分册） 1993年第5期20卷 294-296页

作者： kramer BS 李延斌何焬

介绍几条标准将用于大量无症状患者的常规筛选.首先,卵巢癌给人们带来严重后果,有些疾病在人群中还存在着明显的临床前期流行,包括卵巢癌在内的一些新生物则知之甚少或一无所知.其次,对该病将可认识其临床前早期症状.最后。

关键词：前列腺肿瘤肺肿瘤筛选试验

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Concomitant Chronic Lymphocytic Leukemia and Multiple Myeloma: Proof of Common Clonal Origin

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The Chinese-German Journal of Clinical Oncology 2004年第2期3卷 81-84,125页

作者： Christoph Sucker Alwin kramer Marion Moos Hartmut Goldsehmidt 德国海德堡大学内科学院 69115

We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin heavy chain genes showed identical gene rearrangements in the CLL- and the MM-cell population. Our findings prove a common clonal tumor origin of both B-cell diseases in this patient.

关键词： chronic lymphocytic leukemia multiple myeloma clonal origin immunoglobulin gene

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Mathematics for electricity and electronics 2nd ed.

Mathematics for electricity and electronics

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2002年

作者： Arthur D. kramer

来源：畅想之星图书光盘版（南... 评论

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Integrating Test Data and ATBM Simulations into Dose Propagation Uncertainty Formulation for Bone Fracture Risk Assessment

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Health 2019年第10期11卷 1426-1472页

作者： Hongyun Wang Corinne kramer Jessica Swallow Wesley A. Burgei Hong Zhou Department of Applied Mathematics University of California Santa Cruz CA USA Institute for Defense Analyses Alexandria VA USA U.S. Department of Defense Joint Non-Lethal Weapons Directorate Quantico VA USA Department of Applied Mathematics Naval Postgraduate School Monterey CA USA.

We consider the problem of assessing bone fracture risk for a subject hit by a blunt impact projectile. We aim at constructing a framework for integrating test data and Advanced Total Body Model (ATBM) simulations into the risk assessment. The ATBM is a finite element model managed by the Joint Non-Lethal Weapons Directorate for the purpose of assessing the risk of injury caused by blunt impacts from non-lethal weapons. In ATBM simulations, the quantity that determines arm bone fracture is the calculated maximum strain in the bone. The main obstacle to accurate prediction is that the calculated strain is incompatible with the measured strain. The fracture strain measured in bending tests of real bones is affected by random inhomogeneity in bones and uncertainty in measurement gauge attachment location/orientation. In contrast, the strain calculated in ATBM simulations is based on the assumption that all bones are perfectly elastic with homogeneous material properties and no measurement uncertainty. To connect test data and ATBM simulations in a proper and meaningful setting, we introduce the concept of elasticity-homogenized strain. We interpret test data in terms of the homogenized strain, and build an empirical dose-injury model with the homogenized strain as the input dose for predicting injury. The maximum strain calculated by ATBM has randomness due to uncertainty in specifications of ATBM setup parameters. The dose propagation uncertainty formulation accommodates this uncertainty efficiently by simply updating the shape parameters in the dose-injury model, avoiding the high computational cost of sampling this uncertainty via multiple ATBM runs.

关键词： Blunt Impact Bone Fracture Effects of Loading Rate Elasticity-Homogenized Strain Dose Propagation Uncertainty Formulation ATBM Simulations

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GC和HPLC对共轭亚油酸的测定

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中国油脂 2005年第3期30卷 36-39页

作者：邓泽元余迎利 John K G kramer 教育部食品科学重点实验室(南昌大学) 加拿大农业部Quelph食品研究中心

　　比较GC和Ag+-HPLC对共轭亚油酸测定的异同点。将经TLC鉴定为游离脂肪酸的样品用三甲基硅重氮甲烷甲基化,用100 m×0 25 mm的GC毛细管柱和Ag+-HPLC来测定和比较共轭亚油酸(CLA)的组成。GC和HPLC这两种方法所得的结果很相近,但各有特... 详细信息

　　比较GC和Ag+-HPLC对共轭亚油酸测定的异同点。将经TLC鉴定为游离脂肪酸的样品用三甲基硅重氮甲烷甲基化,用100 m×0 25 mm的GC毛细管柱和Ag+-HPLC来测定和比较共轭亚油酸(CLA)的组成。GC和HPLC这两种方法所得的结果很相近,但各有特色。GC不能将t, t-CLA异构体8t10t、9t11t 和10t12t-CLA等分离,也不能很好地分离8t10c-CLA和9c11t-CLA;Ag+-HPLC则可以将这几种GC互相不能分离的CLA异构体分离,GC还可以将8c10t、10c12t和9t11c-CLA分离。测定CLA时最好能将两种方法结合使用。测定的两种样品CLA组成有较大的差异,反映其合成工艺有较大的不同。

关键词： GC HPLC CLA 分离 TLC 游离脂肪酸甲基化 Ag^+ 共轭亚油酸合成工艺

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Climate change and its association with the expansion of vectors and vector-borne diseases in the Hindu Kush Himalayan region:A systematic synthesis of the literature

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Advances in Climate Change Research 2021年第3期12卷 421-429页

作者： Meghnath DHIMAL Isabelle Marie kramer Parbati PHUYAL Shyam Sundar BUDHATHOKI Juliane HARTKE Bodo AHRENS Ulrich KUCH David AGRONEBERG Santosh NEPAL Qi-Yong LIU Cun-Rui HUANG Gueladio CISSE Kristie LEBI Doris KLINGELHOFER Ruth MULLER Nepal Health Research Council(NHRC) Kathmandu44600Nepal Global Institute for Interdisciplinary Studies(GIIS) Kathmandu44600Nepal Institute of Occupational Social and Environmental MedicineGoethe UniversityFrankfurt am Main60590Germany Institute for Atmospheric and Environmental Sciences(IAU) Goethe UniversityFrankfurt am Main60438Germany Department of Biomedical Sciences Institute of Environment and Sustainable DevelopmentUniversity of AntwerpAntwerp2000Belgium Department of Primary Care and Public Health School of Public HealthImperial College LondonLondonW2 IPGUnited Kingdom Department of Biomedical Sciences Institute of Tropical MedicineAntwerp2000Belgium International Centre for Integrated Mountain Development(ICIMOD) Kathmandu44600Nepal Department of Vector Biology and Control National Institute for Communicable Disease Control and PreventionChina CDCBeijing102206China WHO Collaborating Centre for Vector Surveillance and Management Beijing102206China Department of Health Policy&Management School of Public HealthSun Yat-sen UniversityGuangzhou510275China Department of Epidemiology and Public Health(EPH) Swiss Tropical and Public Health Institute(Swiss TPH)Basel4051Switzerland University of Basel Basel4001Switzerland Department of Global Health University of WashingtonSeattleWA98104USA

Observed weather and projected climate change suggest an increase in the transmission of vector-borne diseases(VBDs)in the Hindu Kush Himalayan(HKH)*** this study,we systematically explore the literature for empiric associations between the climate variables and specific VBDs and their vectors in the HKH *** conducted a systematic synthesis of the published literature on climate variables,VBDs and vectors in the HKH region until the 8th of December *** majority of studies show significant positive associations of VBDs with climatic factors,such as temperature,precipitation,relative humidity,*** systematic review allowed us to identify the most significant variables to be considered for evidence-based trend estimates of the effects of climate change on VBDs and their vectors in the HKH *** evidence-based trend was set into the context of climate change as well as the observed expansion of VBDs and disease vectors in the HKH *** geographic range of VBDs expanded into previously considered non-endemic areas of highlands(mountains)in the HKH region.B ased on scarce,but clear evidence of a positive relationship of most climate variables and VBDs and the observed climatic changes,we strongly recommend an expansion of vector control and surveillance programmes in areas of the HKH region that were previously considered to be non-endemic.

关键词： Chikungunya Dengue Filariasis High altitude Himalayas Leishmaniasis Mountain Mosquito Malaria Sandfly

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