检索结果-南通市图书馆

Recent Advances in Noninvasive Cardiac Imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardiovascular Innovations and Applications 2016年第B12期2卷 1-3页

作者： Christopher M.kramer University of Virginia Health System CharlottesvilleVAUSA

In the last several years,the rate of innovation in cardiac imaging techniques has accelerated signifi *** have been seen in all 4 major modalities;echocardiography,nuclear(positron emission tomography(PET)and single photon emission computed tomography(SPECT),cardiac magnetic resonance imaging(CMR),and computed tomographic angiography(CTA).This issue of Cardiovascular Innovations and Applications will highlight many of these advances.

关键词： Noninvasive Cardiac Imaging echocardiography nuclear positron emission tomography(PET) single photon emission computed tomography(SPECT)

The solitaire mystery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The solitaire mystery

Establishment,functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line

作者： Jostein Gaarder illustrations by Hilda kramer translated by Sarah Jane Hails.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第33期24卷 3749-3759页

作者： Michael Gock Christina S Mullins Christine Harnack Friedrich Prall Robert Ramer Anja Goder Oliver H kramer Ernst Klar Michael Linnebacher Department of General Surgery University of RostockRostock 18055Germany Department of General Surgery Section of Molecular Oncology and ImmunotherapyUniversity of RostockRostock 18055Germany Institute of Pathology University of RostockRostock 18055Germany Institute of Pharmacology University of RostockRostock 18055Germany Institute of Toxicology University Medical Center MainzMainz 55131Germany

AIM To establish cell line and patient-derived xenograft(PDX) models for neuroendocrine carcinomas(NEC) which is highly desirable for gaining insight into tumor development as well as preclinical research includingbiomarker testing and drug response *** Cell line establishment was conducted from direct in vitro culturing of colonic NEC tissue(HROC57). A PDX could also successfully be established from vitally frozen tumor samples. Morphological features, invasive and migratory behavior of the HROC57 cells as well as expression of neuroendocrine markers were vastly analyzed. Phenotypic analysis was done by microscopy and multicolor flow cytometry. The extensive molecular-pathological profiling included mutation analysis, assessment of chromosomal and microsatellite instability; and in addition, fingerprinting(i.e., STR analysis) was performed from the cell line in direct comparison to primary patient-derived tissues and the PDX model established. Drug responsiveness was examined for a panel of chemotherapeutics in clinical use for the treatment of solid *** The established cell line HROC57 showed distinct morphological and molecular features of a poorly differentiated large-cell NEC with KI-67 > 50%. Molecular-pathological analysis revealed a Cp G island promoter methylation positive cell line with microsatellite instability being absent. The following mutation profile was observed: KRAS(wt), BRAF(mut). A high sensitivity to etoposide, cisplatin and 5-FU could be demonstrated while it was more resistant towards rapamycin. CONCLUSION We successfully established and characterized a novel patient-derived NEC cell line in parallel to a PDX model as a useful tool for further analysis of the biological characteristics and for development of novel diagnostic and therapeutic options for NEC.

关键词： Patient-derived tumor model Large cell neuroendocrine carcinoma Individualized medicine

Latest Developments in Hot Rolling Technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Latest Developments in Hot Rolling Technology

Design of refractory multi-principal-element alloys for high-temperature applications

技术创新与循环经济——第二届宝钢学术年会

作者： Stephan kramer SMS Demag Aktiengesellschaft Executive Vice PresidentHot Rolling Mills Division

＜正＞Innovation and evolution of equipment,process technology and services for flat rolling mills are widely being driven by the market *** the late 80 ies,the requirements for flat rolled products have significantly increased. Today,key topics for steel product producers are enlargement of the product mix（new steel grades and/ or wider range of product sizes,thinner-wider-harder）,tight dimensional tolerances,homogenous and fit-topurpose mechanical properties such as strength and formability,prime surface quality,maximum product yield and high process efficiency. These requirements go in-line with the general trends for weight reduction,energy saving,environmental compatibility and enhanced product and process safety. The increased requirements for flat rolled products are reflected by increased requirements to rolling mill equipment,automation,and process *** application of powerful computational tools and methods is necessary for proper equipment and software design and process ***,the complete rolling process can be simulated off-line with a high accuracy,thus allowing for reliable off-line process and plant design. Based on the market requirements,after extensive research and development work,SMS Demag have introduced system solutions for the production of hot and cold rolled steel products,comprising properly designed equipment, powerful automation tools（including technological control systems and mathematical process models） and the relevant process ***,the complete product mix for hot and cold rolling mills including the new,complex,steel grades can be produced efficiently with a high product quality and productivity. This paper illustrates examples of state-of-the-art and new solutions for hot rolling mill equipment and *** particular,the increasingly strong interaction between mechanical and electrical equipment,automation, and process technology is being pointed out.

关键词： conventional hot strip mill compact mill product mix new steel grades CSP steckel mill mill automation innovative solutions simulation mechatronic technological process models material model product quality

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 884-893页

作者： Gaoyuan Ouyang Prashant Singh Ranran Su Duane D.Johnson Matthew J.kramer John H.Perepezko Oleg N.Senkov Daniel Miracle Jun Cui Division of Materials Science and Engineering Ames LaboratoryAmesIA 50011USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Department of Materials Science and Engineering Iowa State UniversityAmesIA 50011USA Air Force Research Laboratory Materials and Manufacturing DirectorateWright-Patterson Air Force BaseDaytonOH 45433USA

Refractory multi-principal-element alloys(RMPEAs)exhibit high specific strength at elevated temperatures(T).However,current RMPEAs lack a balance of room-temperature(RT)ductility,high-T strength,and high-T creep *** density-functional theory methods,we scanned composition space using four criteria:(1)formation energies for operational stability:-150250 GPa;(3)inverse Pugh ratio for ductility:G/B2500°*** rapid bulk alloy synthesis and characterization,we validated theory and down-selected promising alloy compositions and discovered Mo72.3W12.8Ta10.0Ti2.5Zr2.5 having well-balanced RT and high-T mechanical *** alloy has comparable high-T compressive strength to well-known MoNbTaW but is more ductile and more creep *** is also superior to a commercial Mo-based refractory alloy and a nickel-based superalloy(Haynes-282)with improved high-T tensile strength and creep resistance.

关键词： creep alloy alloys

Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2018年第4期10卷 263-272页

作者： Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.kramer Jorge Frias-Lopez Forsyth Institute 245 First StreetCambridgeMA 02142USA Boston University Henry M.Goldman School of Dental Medicine 100 East Newton StreetBostonMA 02118USA Department of Integrative Physiology and Pathobiology Tufts University School of Medicine136 Harrison AvenueBostonMA 02111USA Department of Oral Biology College of DentistryUniversity of Florida1395 Center DriveGainesvilleFL 32610-0424USA

Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients.

关键词： profiles analyses

Standing Tall Little Person,Big Lesson

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新东方英语（中英文版） 2007年第4期 48-49页

作者： Darryl kramer 雨花石

Because God made her that *** doesn’t have to reach over to pick up the laundry like your mom does.

关键词：身高软骨发育不全侏儒症雨花石矮子羞愧滑行声音性格儿童

Intraoperative Rise of Surface Temperature Monitors Success of Sympathectomy in Palmoaxillary Hyperhidrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Thoracic Surgery 2013年第1期3卷 8-14页

作者： Sebastian kramer Axel Skuballa Uwe Eichfeld Department of Thoracic Surgery Klinikum *** gGmbHLeipzigGermany Department of Surgery II AbdominalTrans-plantThoracic and Vascular SurgeryUniversity Hospital LeipzigLeipzigGermany.

Objectives: Patients with hyperhidrosis suffer from an extreme perspiration that cannot be aligned with natural or situational standards. Endoscopic sympathectomy is a meaningful option for palmar and axillary hyperhidrosis. A standardized method of monitoring the immediate intraoperative success has not been established yet. The presented investigation shows one proposed sollution by monitoring skin surface temperature. The main aspect is to demonstrate a significant rise in temperature with utility for monitoring the immediate success of surgery. Methods: Twenty patients with primary hyperhidrosis were observed and treated in a standardized setting against a control group (n = 10). We obtained diverse data that permit determination of a point of time of measurement of surface temperature and definition of a degree of temperature variance. Results: After 5 minutes a significant change of 0.5? Celcius was noted on the palms;after 10 minutes on average 1.2? Celcius. Axillary temperature had significantly changed after 10 minutes with a mean temperature variation of 0.8? Celcius on the right side and 0.6? Celcius on the left side. Conclusions: Under consideration of appropriate time intervals of measurement and determined changes in surface temperature an early control of correct clip application in ETS is possible. In the palmar aspect an increase of 0.5? Celcius at an 5 minutes interval, and more than 1? Celcius at 10 minutes after placement of the clip as compared to basic values before application of the clip can be proposed.

关键词： Hyperhidrosis Sympathectomy Temperature Monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

这只需要一个微笑

疯狂英语（初中天地） 2006年第1期 54-56页

作者： Katie kramer 小虎

19岁的卡蒂总是觉得生活还有比参加晚会、逛街购物和驾驶酷车更有意义的事情。当她飞越半个地球去帮助贫穷的孩子时,她终于找到了自己一直没得到的东西。

关键词：营养不良