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Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics

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Asian Journal of Pharmaceutical Sciences 2018年第5期13卷 498-504页

作者： Sakhiran Sakulwech Nattaya Lourith uracha ruktanonchai Mayuree Kanlayavattanakul School of Cosmetic Science Mae Fah Luang University Phytocosmetics and Cosmeceuticals Research Group Mae Fah Luang University National Nanotechnology Center National Science and Technology Development Agency

Hyaluronic acid(HA, 20–50 kDa) is a hydrophilic macromolecule with anti-wrinkle effects and moisturizing properties. However, its high molecular weight prevents it from penetrating into the deeper layers of the skin and, thus, limits its benefits to topical effects. Thus, the objective of this study is to prepare nanoparticles of quaternized cyclodextrin-grafted chitosan(QCD-g-CS) associated with HA in different molar ratios of QCD-g-CS and HA. The conjugation of the carboxylic moieties of HA and the amides of QCD-g-CS was confirmed by Fourier-transform infrared spectroscopy. Thus, the system was optimized to create nanoparticles with a small size(235.63 ± 21.89 nm), narrow polydispersity index(0.13 ± 0.02), and zeta potential of 16.07 ± 0.65 m V. The association efficiency and loading efficiency were determined by ultra-performance liquid chromatography as 86.77 ± 0.69% and 10.85 ± 0.09%, respectively. The spherical morphology of the obtained nanoparticles was confirmed by transmission electron microscopy. Moreover, the in-vitro hydrating ability was significantly higher( P < 0.001) than that of bulk HA(3.29 ± 0.41 and 1.71 ± 0.05 g water/g sample, respectively). The safety of these nanoparticles at concentrations in the range of 0.01–0.10 mg/ml was confirmed via tests on human skin fibroblasts. Together, these results demonstrate that the developed nanoparticles are promising for future applications in cosmetics.

关键词： Hyaluronic acid QCD-g-CS Polymeric nanoparticles Ionic gelation Delivery system

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Review:Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

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Nano Research 2022年第3期15卷 2196-2225页

作者： Nawamin Sa-nguanmoo Katawut Namdee Mattaka Khongkow uracha ruktanonchai YongXiang Zhao Xing-Jie Liang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Nanotechnology Center(NANOTEC) National Science and Technology Development AgencyPathum Thani 12120Thailand National Center for International Research of Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour Theranostics and TherapyGuangxi Medical UniversityNanning 530021China

Vaccination is the most effective way to prevent coronavirus disease 2019(COVID-19).Vaccine development approaches consist of viral vector vaccines,DNA vaccine,RNA vaccine,live attenuated virus,and recombinant proteins,which elicit a specific immune *** use of nanoparticles displaying antigen is one of the alternative approaches to conventional *** is due to the fact that nano-based vaccines are stable,able to target,form images,and offer an opportunity to enhance the immune *** diameters of ultrafine nanoparticles are in the range of 1–100 *** application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable *** be successful,nanomaterials must be uptaken into the cell,especially into the target and able to modulate cellular functions at the subcellular *** advantages of nano-based vaccines are the ability to protect a cargo such as RNA,DNA,protein,or synthesis substance and have enhanced stability in a broad range of pH,ambient temperatures,and humidity for long-term ***,nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting *** this review,we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver *** discussion about their safe,effective,and affordable vaccines to immunize against COVID-19 will be highlighted.

关键词： COVID-19 SARS-CoV-2 vaccine nanotechnology antigen presenting cells(APCs)

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Cationic liposome of hen egg white lysozyme for enhanced its stability, activity and accessibility in gastro-intestinal tract

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FOOD BIOSCIENCE 2023年第3期53卷 704-714页

作者： Khongkow, Mattaka Rimsueb, Natchanon Jantimaporn, Angkana Janyaphisan, Thitiphorn Woraprayote, Weerapong Visessanguan, Wonnop ruktanonchai, uracha Rungsardthong Natl Sci & Technol Dev Agcy NSTDA Natl Nanotechnol Ctr NANOTEC Pathum Thani 12120 Thailand Natl Sci & Technol Dev Agcy NSTDA Natl Ctr Genet Engn & Biotechnol BIOTEC Pathum Thani 12120 Thailand

Hen egg white lysozyme (HEWL) is a food-derived antimicrobial protein, exhibiting bacteriolytic activity against several bacteria including foodborne enteric pathogens. It has been approved for using in food, pharmacological and therapeutic applications. However, using HEWL through the ingestion is still a challenge due to its poor stability and low bioavailability in the gastro-intestinal tract (GIT). Herein, liposomes incorporating with dimethyl dioctadecyl ammonium bromide (DDAB) were fabricated to encapsulate HEWL (Lip_HEWL_DDAB) for oral delivery. Lip_HEWL_DDAB was spherical with an average diameter of 162.7 +/- 1.6 nm and zeta potential of 37.1 +/- 4.3 mV. The Lip_HEWL_DDAB had high entrapment efficiency of 80% and 11% loading efficiency of HEWL. The formulated Lip_HEWL_DDAB were highly physicochemical stable in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and capable of enhancing the intestinal absorption via their mucoadhesive property while retaining antimicrobial activity against enteric bacteria. HEWL was released from Lip_HEWL_DDAB via diffusion mechanism at higher extent than those without the DDAB. Additionally, the prepared Lip_HEWL_DDAB was non-toxic at below 6.25 mu g/ml to intestinal cells and was able to deliver HEWL across an in vitro intestinal epithelium model, resulting in enhanced anti-microbial/anti-inflammatory activities, compared to their free- and unmodified-liposomal forms. Together, our modified cationic liposome is a new and promising strategy for improving oral delivery of HEWL with enhanced nutraceutical functions.

关键词： Cationic liposome Lysozyme Oral delivery Dimethyl dioctadecyl ammonium bromide (DDAB) Liposome

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