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Cell Research 2000年第3期10卷 161-167页

作者： YIN XIAO-MING (Department of pathology, university of pittsburgh School of Medicine, 3550 Terrace Street, pittsburgh, pa 152.1, usa) Departmentofpathology UniversityofPittsburghSchoolofMedicinePA15261USA.xmyin@pitt.edu

Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases.

关键词： Apoptosis Bcl-2 family proteins Bid Fas TNF.

The enigmatic role of angiopoietin-1 in tumor angiogenesis

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Cell Research 2003年第5期13卷 309-317页

作者： LINDA J METHENY-BARLOW~1, Lu YUAN LI~(2*) 1 Department of Oncology, Georgetown university Medical Center, Washington, DC 20007, usa 2 university of pittsburgh Medical Center, pittsburgh, pa 15213, usa. E-mail." lil@upmc.edu 1Department of Oncology Georgetown University Medical Center Washington DC 20007 USA 2university of pittsburgh Medical Center Pittsburgh PA 15213 USA. E-mail: lil@upmc.edu

A tumor vasculature is highly unstable and immature, characterized by a high proliferation rate of endothelial cells, hyper-permeability, and chaotic blood flow. The dysfunctional vasculature gives rise to continual plasma leakage and hypoxia in the tumor, resulting in constant on-sets of inflammation and angiogenesis. Tumors are thus likened to wounds that will not heal. The lack of functional mural cells, including pericytes and vascular smooth muscle cells, in tumor vascular structure contributes significantly to the abnormality of tumor vessels. Angiopoietin-1 (Ang1) is a physiological angiogenesis promoter during embryonic development. The function of Ang1 is essential to endothelial cell survival, vascular branching, and pericyte recruitment. However, an increasing amount of experimental data suggest that Ang1-stimulated association of mural cells with endothelial cells lead to stabilization of newly formed blood vessels. This in turn may limit the otherwise continuous angiogenesis in the tumor, a

关键词： angiopoietin angiogenesis cancer endothelial cells mural cells.

Liver retransplantation: indications and outcomes

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Hepatobiliary & pancreatic Diseases International 2004年第2期3卷 175-178页

作者： Zi-Fa Wang and Chang Liu pittsburgh, usa Department ot Surgery, university of pittsburgh Me- dical Center, pittsburgh, pa 15213, usa Division of Hepa- tobiliary Surgery . First Hospital, Xi’ an Jiaotong university , Xi’ an 710061, China Department of Surgery University of Pittsburgh NW607 Montefiore University Hospital 3459 Fifth Avenue Pittsburgh PA 15213 USA. ziw3@pitt.edu

BACKGROUND: Liver transplantation is a life-saving the- rapeutic modality for patients with end-stage liver diseases. After liver transplantation, however, more than 10% pa- tients may lose the grafts caused by a variety of reasons. This review covers the most frequent indications for liver retransplantation as well as the results and specific problems with each indication. DATA RESOURCES: Searching MEDLINE (1997-2003) for articles on liver retransplantation. RESULTS: The most frequent indications of liver retrans- plantation are primary non-function, hepatic artery throm- bosis, graft rejection and recurrent diseases. The results af- ter liver retransplantation remain inferior to those after first transplantation. CONCLUSION: Liver retransplantation, which is the only means of prolonging survival in those patients whose initial graft has failed, makes an important contribution to overall survival.

关键词： liver retransplantation primary non-function hepatic artery thrombosis rejection recurrent diseases

L^p-Boundedness of Marcinkiewicz Integrals with Hardy Space Function Kernels

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Acta Mathematica Sinica,English Series 2000年第4期16卷 593-600页

作者： Yong Ding Department of Mathematics, Beijing Normal university, Beijing 100875, P. R. China Dashan Fan Department of Mathematics, Anhui university and university of Wisconsin-Milwaukee. MW 53201 usa Yibiao pan Department of Mathematics, university of pittsburgh. pittsburgh. Pennsylvania 15260. usa Department of Mathematics Beijing Normal University Beijing 100875 P. R. China Department of Mathematics Anhui University and University of Wisconsin-Milwaukee Wisconsin MW 53201 USA Department of Mathematics University of Pittsburgh Pittsburgh USA

We give the Lp-boundedness for a class of Marcinkiewicz integral operators μΩ, μΩ.λ and μΩ.S related to the Littlewood-paley g-function, gλ-function and the area integral S, respectively. These operators have the kernel functions Ω∈H1(Sn-1), the Hardy space on Sn-1. The results in this paper substantially improve and extend the known results.

关键词： Marcinkiewicz integral g-function g_λ~*-function Area integral H^1 space Rough kernel

Magnetic Properties and Thermal Stability of Pr_(1-x)La_xCo_(5-y)Alloys

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Journal of Materials Science & Technology 1995年第6期11卷 463-465页

作者： Fazeng LIAN (Dept. of Materials Science and Engineering, Northeastern university, Shenyang, 110006, China)Meiqing HUANG, S.Simizu and W.E.Wallace (Carnegie Mellon Institute, Carnegie Mellon university, pittsburgh, pa 15213, usa) Northeastern Univ Shanghai China

Pr1-xLaxCo5-y (x=0, 0.15. 0.25, 0.35,1.0, y=0.5, 0.7, 0.9, 1.0) alloys were investigated. The effect of the variation of x and y on magnetic properties and thermal stability of the alloys were studied. The magnetic properties for the Pr0.85La0.15Co4.3 and Pr0.75La0.25Co4.1 magnets are iHc=368 kA/m, Br=0.91 T, (BH)max=145.6 kJ/m3, αBr=-0.03%/℃ and iHc=568 kA/m,Br=0.8 T, (BH)max=127.2 kJ/m3,αBr,=-0.06%/℃, respectively The phase structures of as-cast alloys and magnets were investigated

关键词： La x)La_xCo Magnetic Properties and Thermal Stability of Pr y)Alloys

Top 10 Influential Events in carbon neutrality and climate change response for 2023

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Frontiers in Energy 2024年第1期18卷 1-3页

作者： Research Institute of Carbon Neutrality of Shanghai Jiao Tong university Research Institute of Carbon Neutrality Shanghai Jiao Tong UniversityShanghai 200240China

In 2023, the global community intensified its efforts towards achieving carbon neutrality and addressing climate change, witnessing several impactful events. Research Institute of Carbon Neutrality, Shanghai Jiao Tong university compiled the Top 10 Events (in chronological order) in the field of global carbon neutrality and climate change response for 2023, to share with readers these significant moments that document the ongoing ambition and collective efforts of human society.

关键词： neutral collective intensified

Roles of Cell Cycle Inhibitors in Stem Cell Regulation

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Roles of Cell Cycle Inhibitors in Stem Cell Regulation

NUMERICAL STURDY OF GRAVITATIONAL GRANULAR FLOW

第九届全国实验血液学会议

作者： Tao Cheng university of pittsburgh Cancer Institute, pittsburgh, pa 15213, usa

＜正＞ Therapeutic promises of adult stem cells from a variety of tissue types have gained strong experimentalsuppoft in the last few ***,hurdles remain for stem cell manipulation in vitro and tissueregeneration in vivo due to a limited understanding of their molecular *** regarding specificcell cycle control in stem and progenitor cell populations may provide one basis for designing rational stemcell manipulation *** my talk,I will describe the unique cell cycle kinetics of stem cells In vivo andex vivo,briefly introduce the current understanding of general cell cycle regulation in mammalian cells,and

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Journal of Hydrodynamics 1997年第3期9卷 101-110页

作者： K. R. RajagopalDepartment of Mechanical Engineering, university of pittsburgh, pa152.1 ,usa(G. Q.ChenCentre for Environmental Sciences, Peking university, Beijing 100871,P. R. ChinaR. RamaDepartment of Mechanical Engineering, university of pittsburgh, pal5261 ,usa

The mechanics of flowing granular materials such as coal,sand, metal ores etc. , has received considerable attention in the recent years as it has relevance to several important technological problems. The governing equations for the flow of granular materials, are derived using a model based on the kinetic theory approach [cf. Boyle and Mas-soudi (1990)]. For a fully developed flow of these meterials down an inclined plane, the equations reduce to a system of coupled non-linear ordinary differential equations. The resulting boundary value problem is solved numerically and a parametric study is carried out to delineate how the various non-dimensional parameters affect the structure of the solution.

关键词： numerical study granular flow

A triangular architectural relation model among sustainability,beauty,and power

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Frontiers of Architectural Research 2024年第4期13卷 699-711页

作者： Ján Legény RobertŠpaček TomášHubinský Lucia Benkovičová Faculty of Architecture and Design Slovak University of Technology in BratislavaBratislavaSlovakia

Sustainability,beauty,and power are notions that hit our contemporary perception every ***,they have been an integral part of architecture and urban planning in various forms since the *** paper presents their fundamental descriptions,followed by an assessment of their mutual relations and impact on architecture through a triangular architectural relation model developed by the authors of the *** the theoretical thought experiment,it highlights eight boundary models along with their main characteristics,in particular,the implosion,explosion,shared-control,utilitarian,no-control,supremacy,inside-forced,and outside-forced architectural related *** models can help predict future events,explain past events,make decisions,and plan strategies,or reveal problems and propose new *** applications include determination of the causes of certain results or finding out the responsibility and mechanisms that led to *** authors are of the opinion that the mutual denominator of sustainability,beauty,and power represents ethics that should be forced in architectural education and practice.

关键词： Triangular architectural relation model Sustainability Beauty Power Thought experiment Interpretation

Error Estimates for Finite-Element Navier-Stokes Solvers without Standard Inf-Sup Conditions

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Chinese Annals of Mathematics,Series B 2009年第6期30卷 743-768页

作者： Robert L.PEGO Department of Mathematical Sciences and Center for Nonlinear Analysis Carnegie Mellon University PittsburghPA 15213USA

The authors establish error estimates for recently developed finite-element methods for incompressible viscous flow in domains with no-slip boundary *** methods arise by discretization of a well-posed extended Navier-Stokes dynamics for which pressure is determined from current velocity and force *** methods use C1 elements for velocity and C0 elements for pressure.A stability estimate is proved for a related finite-element projection method close to classical time-splitting methods of Orszag,Israeli,DeVille and Karniadakis.

关键词： Time-dependent incompressible flow Projection method Backward facing step Driven cavity Stokes pressure Leray projection Obtuse corner Recycling