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Astrocytic calcium waves:unveiling th.ir roles in sleep and arousal modulation

Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.h.ang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University Sch.ol of Medicine TempleTXUSA Texas A&M University Sch.ol of Ph.rmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for th. brain’s *** astrocyte activities is crucial for compreh.nding th. complex neural network,particularly th. population-level functions of neurons in different cortical states and associated beh.viors in *** on animal sleep and wakefulness h.ve revealed distinct cortical synch.ony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research.on astrocyte activation during cortical state transitions h.s emph.sized th. influence of norepineph.ine as a neurotransmitter and calcium waves as key components of ion ch.nnel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring th. involvement of noradrenaline signaling,ion ch.nnels,and glutamatergic signaling in different cortical *** findings h.gh.igh. th. significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling path.ays sh.ws promise for treating sleep disorders and arousal *** research.is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future h.man studies to compreh.nsively investigate neuron-astrocyte interactions and pave th. way for th.rapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepineph.ine sleep wakefulness

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Bioph.toelectroch.mistry:An emerging frontier for ch.nneling ph.toelectric effect into darkness zone of soils and sediments

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Pedosph.re 2024年第1期34卷 5-8页

作者： Jie YE Sh.ngui Zh.U Kenneth.h.NEALSON Ch.istoph.r RENSING Fujian Provincial Key Laboratory of Soil Environmental h.alth.and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China Department of Earth.Science University of Southern CaliforniaLos Angeles CA 90007USA

Solar energy captured by ph.tosynth.tic plants in th. ph.tic zone is recognized as th. main driver for th. formation of organic matter utilized by soil communities. h.wever, th. contribution of organic transformation to th. linkage of solar energy and microbial metabolism of soils is reduced wh.n th. vadose zone is saturated. In contrast to th. conventional bioph.toelectroch.mistry via ph.tosynth.sis with.ph.toplankton during th. periodic saturation of soils, recent studies suggest th.t non-ph.totroph.c microorganisms in soils and sediments are able to conduct ligh.-dependent metabolism to sustain th.ir functionality with.ph.tosensitizers under illumination. Th.se interactions and processes utilize long-distance electron transfer networks to interconnect diverse electron transfer ch.ins th.t ch.nnel ph.toexcited electrons into th. opaque zone for soil communities. Such.an emerging process not only allows for a better understanding of biogeoch.mical processes such.as soil carbon sequestration and mitigation, but also sh.ws great potential for environmental treatment such.as th. bioremediation of contaminated soils. Th.refore, we suggest th.t bioph.toelectroch.mistry via ph.toelectric effect can h.ve significant, h.retofore unappreciated, th.oretical and practical values.

关键词： soils soil metabolism

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威尔是如何逃出矿井的

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快乐语文 2024年第1期 66-67页

作者： []威廉.h.麦加菲不详

威尔的姨妈给他一个小本子作为生日礼物,在本子中间有一支铅笔,威尔非常喜欢这个小本子,所以他总是把它带在身上。一天,妈妈非常忙,没空搭理威尔。于是威尔叫上他的狗:“来吧,卡珀,我们出去玩。”当妈妈发现威尔不见了时,她便到屋里去找... 详细信息

威尔的姨妈给他一个小本子作为生日礼物,在本子中间有一支铅笔,威尔非常喜欢这个小本子,所以他总是把它带在身上。一天,妈妈非常忙,没空搭理威尔。于是威尔叫上他的狗:“来吧,卡珀,我们出去玩。”当妈妈发现威尔不见了时,她便到屋里去找,但是怎么也找不到。但她知道卡珀跟他在一起,所以稍稍放了点心,想威尔可能一会儿玩够了就会回来。

关键词：生日礼物威尔本子妈妈

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Multiple scales meth.d for analyzing a forced damped rotational pendulum oscillatorwith.allows

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Communications in Th.oretical Ph.sics 2024年第5期76卷 58-67页

作者： h.ifa A Alyousef Alvaro h.Salas B M Alotaibi S A El-Tantawy Department of Ph.sics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Math.matics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Ph.sics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research.Center for Ph.sics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

Th.s study reports th. analytical solution for a generalized rotational pendulum system with.gallows and periodic excited *** multiple scales meth.d(MSM)is applied to solve th. proposed *** types of rotational pendulum oscillators are studied and talked about in *** include th. forced damped rotating pendulum oscillator with.gallows,th. damped standard simple pendulum oscillator,and th. damped rotating pendulum oscillator with.ut *** MSM first-order approximations for all th. cases mentioned are derived in *** obtained results are illustrated with.concrete numerical *** first-order MSM approximations are compared to th. fourth.order Runge-Kutta(RK4)numerical ***,th. maximum error is estimated for th. first-order approximations obtained th.ough.th. MSM,compared to th. numerical approximations obtained by th. RK4 ***,we conducted a comparative analysis of th. outcomes obtained by th. used meth.d(MSM)and h.-MSM to ascertain th.ir respective levels of *** proposed meth.d can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales meth.d approximate solution damped oscillations forced pendulum with.gallows h.-multiple scales meth.d

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Cancer cell cycle h.terogeneity as a critical determinant of th.rapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrah.m h.Maleki Ah.ad Reza Bah.ami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Th.rapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral Sch.ol of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotech.ology Research.Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Th.rapeutics Research.Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research.Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor h.terogeneity is now arguably one of th. most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are h.gh.y diverse at genetic,epigenetic,and ph.notypic levels,intra-tumor h.terogeneity can be assumed as an important contributing factor to th. nullification of ch.moth.rapeutic effects,and recurrence of th. *** on th. role of h.terogeneous subpopulations of cancer cells with.varying cell-cycle dynamics and beh.vior during cancer progression and treatment;h.rein,we aim to establish.a compreh.nsive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells th.t play pivotal roles in reducing th. effects of ch.moth.rapy:"resistant"and"tolerant"***,th.s review also h.gh.igh.s th. impact of th. quiescent ph.se of th. cell cycle as a survival mech.nism for cancer *** understanding th. mech.nisms under-lying th. quiescence,it provides an insigh.ful perspective on cancer stem cells(CsCs)and th.ir dual and intertwined functions based on th.ir cell cycle state in response to ***-over,CSCs,epith.lial-mesench.mal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),wh.ch.are mostly in a quiescent state of th. cell cycle are proved to h.ve multiple biological links and can be implicated in our viewpoint of cell cycle h.terogeneity in ***,increasing our knowledge of cell cycle h.terogeneity is a key to identifying new th.rapeutic solutions,and th.s emerging concept may provide us with.new opportunities to prevent th. dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle h.terogeneity Quiescence Th.rapy resistance Th.rapy tolerance Tumor dormancy

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Exploring Variability in Sea Level at a Tide Gauge Station th.ough.Control Ch.rts

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Journal of Environmental & Earth.Sciences 2024年第1期6卷 11-18页

作者： h.Bâkiİz Independent Sch.lar Boca Raton Florida33496USA

Monitoring temporal ch.nges in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such.as trend,acceleration,periodic oscillations,and random *** th.m,th. non-stationary nature of th. random sea level variations of known or unknown origin at coastal regions h.s been long recognized by th. sea level *** study proposes th. analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control *** approach.is demonstrated using Key West,Florida tide gauge *** mean and standard errors of 5-year-long subgroups of th. residuals revealed th.t sea level ch.nges at th.s location h.ve been progressively intensifying from 1913 to th. *** oscillations in sea level at th.s locality may be attributed partly to th. th.rmal expansion of seawater with.increasing temperatures causing larger buoyancy-related sea level fluctuations as well as th. intensification of atmosph.ric events including wind patterns and th. impact of ch.nges in inverted barometer effects th.t will alter coastal risk assessments for th. future.

关键词： Climate ch.nge Sea level variance X-bar S control ch.rts

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Common coupled fixed point th.orem for two pairs compatible and sub-sequentially continuous mapping

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Journal of Ocean Engineering and Science 2024年第4期9卷 401-407页

作者： h.M.Abu-Donia Mona S.Bakry h.A.Atia Omnia M.A.Kh.ter Ragh.a A.M.Attia Department of Math.matics Faculty of ScienceZagazig UniversityZagazigEgypt Department of Math.matics Faculty of ScienceTanta UniversityTantaEgypt Department of Basic Science Zagazig Higher Institute of Engineering and TechnologyZagazigEgypt Department of Basic Science Higher Technological Institute 10th of Ramadan CityEl Sharqia 44634Egypt

Th.s study establish.s a common coupled fixed point for two pairs of compatible and sequentially continuous mappings in th. intuitionistic fuzzy metric space th.t satisfy th.φ-contractive *** basic definitions and th.orems h.ve been used from some recent scientific papers about th. binary operator,t-norm,t-conorm,intuitionistic fuzzy metric space,and compatible mapping for reach.ng to th. paper’s purpose.

关键词： Intuitionistic fuzzy metric space φ-contractive mapping Compatible mappings Couple fixed point

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Correlation of work function and stacking fault energy th.ough.Kelvin probe force microscopy and nanoh.rdness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe Ali Arslan Kaya h.seyin Aydin Jiang Peng Servet Turan Eskiseh.r Tech.ical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey h.seying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskiseh.r Tech.ical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of th. Group 2A elements with.magnesium h.ve been studied th.ough.th. dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated th. difference in th.‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in th. *** was sh.wn th.t th. nano-h.rdness of th. solid-solutionα-Mg ph.se ch.nged in th. order of Mg-Ca>Mg-Sr>***,it was sh.wn,by also considering th. nano-h.rdness levels,th.t SFE of a solid-solution is closely correlated with.its‘Work Function'***-h.rdness measurements on th. eutectics andΔWF difference between eutectic ph.ses enabled an assessment of th. relative bond strength.and th. pertinent electronic structures of th. eutectics in th. th.ee *** with.WF and at least qualitative verification of th.se computed SFE values with.some experimental measurement tech.iques were considered important as th.se computational meth.ds are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by th.s investigation,if th. results of measurement tech.iques can be qualitatively correlated with.th.se of th. computational meth.ds,it can be possible to evaluate th. electronic structures in alloys,starting from binary systems,going to ternary and th.n multi-elemental *** investigation h.s sh.wn th.t such.a qualitative correlation is *** all,th. SFE values are not treated as absolute values but rath.r become essential in comparative investigations wh.n assessing th. influences of alloying elements at a fundamental level,th.t is,free electron density *** study indicated th.t th. principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental meth.ds,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Sh.rt range order Miedema Nanoindentation Eutectics

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Fast efficient ph.ton deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zh. S.M.Weng P.Li X.F.Li h.Ai h.R.Pan Z.M.Sh.ng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research.Center of Laser Fusion of Ch.na Academy of Engineering Ph.sics MianyangSichuan 621900China State key Laboratory of h.gh.Field Laser Ph.sics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

Th. generation of ultrash.rt h.gh.power ligh. sources in th. mid-infrared(mid-IR)to terah.rtz(Th.)range is of interest for applications in a number of fields,from fundamental research.to biology and *** conventional laser tech.ology,ph.ton deceleration in plasma wakes provides an alternative approach.to th. generation of ultrash.rt mid-IR or Th. ***,we present a ph.ton deceleration sch.me for th. efficient generation of ultrash.rt mid-IR or Th. pulses by using an intense driver laser pulse with.a relatively sh.rt wavelength.and a signal laser pulse with.a relatively long *** signal pulse trails th. driver pulse with.an appropriate time delay such.th.t it sits at th. front of th. second wake bubble th.t is driven by th. driver *** to its relatively long wavelength.th. signal pulse will be subjected to a large gradient of th. refractive index in th. plasma wake ***,th. ph.ton deceleration in th. plasma wake becomes faster and more efficient for signal pulses with.longer *** greatly enh.nces th. capacity and efficiency of ph.ton deceleration in th. generation of ultrash.rt h.gh.power ligh. sources in th. long-wavelength.IR and Th. spectral ranges.

关键词： laser ultrash.rt ph.ton

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Net effect of air pollution controls on h.alth.risk in th. Beijing-Tianjin-h.bei region during th. 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Ch.ngqing Lin Peter K.K.Louie Alexis K.h.Lau Jimmy C.h.Fung Zibing Yuan Mingh.i Tao Xuguo Zh.ng Md.Sh.kh.oat h.ssain Ch.ngcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-h.ngkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Math.matics The Hong Kong University of Science and TechnologyHong KongChina Sch.ol of Environment and Energy South China University of TechnologyGuangzhou 510006China h.bei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public h.alth.and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmosph.ric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club Sch.ol of Public h.alth.and Primary Care The Chinese University of Hong KongHong KongChina

Due to th. non-linearity in ozone(O_(3))formation,reducing th. emission of nitrogen oxides(NO_(x))may increase O_(3) *** th. counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous wh.n th. assessments focus on th. ch.nges in pollutant *** th.s study,a risk-based meth.d was used to gauge th. net effect of air pollution controls on mortality risk in th. Beijing–Tianjin–h.bei(BTh.region during th. 2022 Winter Olympics and Paralympics(WOP).Th.s mega-event presents a unique opportunity to investigate th. efficacy of deep cuts in pollutant *** sh.w th.t O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in th. *** to th. active ph.toch.mical formations,O_(3) became th. dominant pollutant th.t affected h.man h.alth.during th. *** th. substantial O_(3) increases,th. h.alth.benefits of NO_(2) reductions overwh.lmed th. adverse h.alth.effects of O_(3) increases in most regions of th. BTh.at 81 out of 112 stations).After considering th. impacts of particulate matter,th. integrated h.alth.risk of air pollution mixtures declined almost everywh.re in th. *** results underscore th. great necessity of ch.nging th. assessment paradigm of pollution control from using concentration-based meth.ds to using risk-based *** with.th. carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to ach.eve synergistic control solutions for air pollution and climate ch.nge.

关键词： Ozone Nitrogen dioxide h.alth.risk Carbon neutrality Mega-events

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