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Association between Toll-Like Receptor 4 (Thr399Ile and Asp299Gly), Toll-Like Receptor 2 196-174 Deletion Polymorphisms with cryptosporidiosis

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Journal of Biosciences and Medicines 2016年第10期4卷 85-96页

作者： Asmita Dey Ujjala ghoshal Vikas Agarwal uday chand ghoshal Departments of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India Departments of Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India Departments of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India

Toll-like receptors (TLRs) 2 and 4 specifically recognize lipopolysaccharide motifs on surfaces of microorganisms. Polymorphims in the TLR genes result in structural variations in the proteins, abnormal host-pathogen interactions and hence, altered immune response. Opportunistic parasite Cryptosporidium spp. infects immuno-compromised patients who present with heterogeneous clinical manifestations ranging from mild infection resolving in a few weeks, to severe form characterized by voluminous diarrhoea, prolonged symptoms and recurrences. The present study investigates the role of TLR2 196_174del, TLR4 Asp299Gly and Thr399Ile polymorphisms in pathogenesis of cryptosporidiosis. Stool samples were collected from 210 immuno-compromised (renal transplant recipients and patients with Human immunodeficiency virus infection) both with and without cryptosporidiosis, and 200 healthy subjects for detection of Cryptosporidium spp. Blood samples were also collected from the patients and healthy subjects for genotyping of Δ22 (TLR2 196_174del) polymorphism, A896G (TLR4 Asp299Gly) and C1196T (Thr399Ile) single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Cryptosporidium spp. was detected in 70 immunocompromised patients, while it was absent in all the healthy controls. No significant difference was observed in Δ22, A896G and C1196T alleles and genotypes (P > 0.05), between cases and controls. Thus, TLR2 196_174del, TLR4 Asp299Gly and Thr399Ile polymorphisms are not significantly associated with the pathogenesis or progression of cryptosporidiosis, in the Indian population included in the study.

关键词： Cryptosporidium HIV Renal Transplant Immuno-Compromised TLR Immune Response

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Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India

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World Journal of Gastroenterology 2008年第10期14卷 1498-1503页

作者： Ashish Saxena Kashi Nath Prasad uday chand ghoshal Monty Roshan Bhagat Narendra Krishnani Nuzhat Husain Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014 India Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014 India Department of Gastroenterology CentralCommand Hospital Lucknow 226002 India Department of Pathology Sanjay GandhiPostgraduate Institute of Medical Sciences Lucknow 226014India Department of Pathology Chhatrapati Shahu Ji Maharaj Medical University Lucknow 226001 India

AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD.

关键词：胃腺癌胃溃疡幽门杆菌感染多态性

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Rice Heat Tolerance Breeding: A Comprehensive Review and Forward Gaze

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Rice science 2024年第4期31卷 375-400,I0022页

作者： Ravindran Lalithambika VISAKH Sreekumar ANAND Sukumaran Nair ARYA Behera SASMITA uday chand JHA Rameswar Prasad SAH Radha BEENA Department of Genetics and Plant Breeding College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India Crop Improvement Division Indian Council of Agricultural Research-National Rice Research InstituteCuttackOdisha 7530006India Department of Plant Breeding and Genetics Indian Institute of Pulse ResearchKanpur 208024India Department of Plant Physiology College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India

The yield potential of rice is seriously affected by heat stress due to climate change. Since rice is a staple food globally, it is imperative to develop heat-resistant rice varieties. Thus, a thorough understanding of the complex molecular mechanisms underlying heat tolerance and the impact of high temperatures on various critical stages of the crop is needed. Adoption of both conventional and innovative breeding strategies offers a long-term advantage over other methods, such as agronomic practices, to counter heat stress. In this review, we summarize the effects of heat stress, regulatory pathways for heat tolerance, phenotyping strategies, and various breeding methods available for developing heat-tolerant rice. We offer perspectives and knowledge to guide future research endeavors aimed at enhancing the ability of rice to withstand heat stress and ultimately benefit humanity.

关键词： genetic mechanism high-temperature stress molecular breeding genomics selection

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Certain Curvature Conditions on P-Sasakian Manifolds Admitting a Quater-Symmetric Metric Connection

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 133-146页

作者： uday chand DE Peibiao ZHAO Krishanu MANDAL Yanling HAN Department of Pure Mathematics University of Calcutta35 Ballygunge Circular RoadKol-700019West BengalIndia Department of Mathematics Nanjing University of Science and TechnologyNanjing 210094China School of Mathematics and Statistics Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

The authors consider a quarter-symmetric metric connection in a P-Sasakian manifold and study the second order parallel tensor in a P-Sasakian manifold with respect to the quarter-symmetric metric connection. Then Ricci semisymmetric P-Sasakian manifold with respect to the quarter-symmetric metric connection is considered. Next the authors study ξ-concircularly flat P-Sasakian manifolds and concircularly semisymmetric P-Sasakian manifolds with respect to the quarter-symmetric metric connection. Furthermore, the authors study P-Sasakian manifolds satisfying the condition Z(ξ,Y)·S=0,where Z,S are the concircular curvature tensor and Ricci tensor respectively with respect to the quarter-symmetric metric connection. Finally, an example of a 5-dimensional P-Sasakian manifold admitting quarter-symmetric metric connection is constructed.

关键词： Quarter-symmetric metric connection P-Sasakian manifold Ricci semisymmetric manifold ξ-Concircularly flat Concircularly semisymmetric

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