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Infectious Diseases of Poverty 2022年第5期11卷 87-89页

作者： Akinola Stephen Oluwole Uwem Friday Ekpo Obiageli Josephine Nebe Nse Michael Akpan Solomon Monday Jacob uche veronica amazigo John Russell Stothard Department of Pure and Applied Zoology Federal University of AgricultureAbeokutaOgun StateNigeria Neglected Tropical Disease Control Division Department of Public HealthFederal Ministry of HealthAbujaNigeria Pan-African Community Initiative on Education and Health(PACIEH) EnuguNigeria Department of Tropical Disease Biology Liverpool School of Tropical MedicineLiverpool L35QAUK.

Background With some 134,073,166 people living in endemic communities at risk of infection[1],Nigeria is the most endemic country in Africa and requires preventive chemotherapy(PC)for a total of 26.3 million persons[2].The National Schistosomiasis Elimination Programme(NSCHEP),with the support of international partners,has been implementing PC in Nigeria since 2009 and most recently will need to revise its current strategy(Additional file 1).For example,the new World Health Organization(WHO)guideline has six key recommendations that will dramatically change the implementation of schistosomiasis elimination in endemic countries[3].However,its impact and programmatic implications will vary from country to country,hence the need for a country-specific analysis.

关键词： schistosomiasis Schistosomiasis Nigeria

Morphometry and Significance of Collodiaphyseal Angle among Bini Tribe in Southern Nigeria

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Journal of Forensic Science and Medicine 2024年第1期10卷 20-23页

作者： Dayo Rotimi Omotoso uche Christiana Okwuonu Emmanuel Olusola Yawson Paul Olugbemiga Awoniran Department of Human Anatomy Redeemer’s UniversityEdeOsun StateNigeria Department of Anatomy Igbinedion UniversityOkadaEdo StateNigeria

Introduction:The collodiaphyseal angle(CDA)is an angle formed between the femoral neck and femoral shaft *** is a vital determinant of femoral neck fracture as narrower angle is often used as a predictor of stress *** is also important in orthopedic treatment planning,especially hip replacement ***:This study was carried out to evaluate the CDA values among the Bini tribe and elucidate its ***:This study employed 200 anterior-posterior pelvic radiographs of the Bini tribe(100 males and 100 females)aged between 25 and 55 years obtained from selected radiological diagnostic centers in Benin City,Nigeria,after obtaining the Institutional Ethical *** were used to evaluate the right and left CDA as an angle formed by intersection of the femoral neck and shaft axes and measured using the *** were statistically analyzed using IBM-SPSS(version 20)with the mean,standard deviation,and range evaluated,and side and gender comparisons were done using t-test,and P0.05).Conclusion:The CDA can be employed as a morphometric indicator of sexual differences and for other clinical applications.

关键词： Bini tribe collodiaphyseal angle human morphometry Nigeria

Evaluation of Phytochemical Contents and Antimicrobial Activities of Pandiaka heudelotii

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Advances in Biological Chemistry 2024年第2期14卷 55-63页

作者： Ikenna Obiora Alaekwe uche Eunice Ekpunobi Vincent Ishmel Egbulefu Ajiwe Chinedu Chris Aguoma Jamilu Ahmad Department of Chemistry Federal University Gusau Gusau Nigeria Department of Pure and Industrial Chemistry Nnamdi Azikiwe University Awka Awka Nigeria

The work investigated the secondary metabolites present in different parts of the Pandiaka heudelotii plant harvested from Ezira, Orumba south local government area of Anambra state, southeastern Nigeria as well as their antimicrobial activity. The objectives were to extract, determine the phytochemicals present, evaluate the antimicrobial potential and determine the zones of inhibition of the root, stem and leaf extracts of the plant. The emergence of antibiotics has decreased the spread and severity of a wide range of diseases. Plant extracts were tested for antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Streptococcus pyogenes, Bacillus subtelis, Pseudomonas aerogenes, Salmonella typhi, Aspergillus flavus, Aspergillus niger and Candida albicans. The zone of inhibition of extracts was compared with that of standard drugs like Erythromycin, Ciprofloxacin, Fulcin and Fluconazole. The result revealed the inhibition of bacterial and fungal growth with some test organisms. The microbial activity of the plant parts may be due to the presence of various secondary metabolites. The ethyl acetate extracts of Pandiaka heudelotii stood out with a minimum inhibitory concentration (MIC) range of 5 - 10 mg/mL and a minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC) of 10 - 20 mg/ml against some test organisms. The plant can thus be worked upon to discover biologically active natural products that may serve as a prelude to the development of new pharmaceutical research undertakings.

关键词： Pharmaceuticals Secondary Metabolites Antibiotics Pandiaka heudelotii Bacteria

Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs:Multi-year sampling

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Water Biology and Security 2024年第1期3卷 28-36页

作者： Florencia Soledad Alvarez Dalinger Borja Claudia Nidia veronica Laura Lozano Liliana Beatriz Morana María Monica Salusso Facultad de Ciencias Naturales Universidad Nacional de SaltaAvenida Bolivia 5150Salta4400Argentina Consejo Nacional de Investigaciones Científicas y T'ecnicas(CONICET) Godoy Cruz 2290Ciudad Autonoma de Buenos AiresArgentina

Harmful algal blooms are important threats to reservoir *** a 15-year period,we sampled five Argentinian reservoirs to identify the responsible species for harmful algal blooms and determine the water quality factors driving their *** reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic *** blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii,Aphanizomenon gracile,and Microcystis *** contrast,dinoflagellate blooms were predominantly characterized by *** cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions,whereas dinoflagellate blooms occurred where temperatures were *** most intense blooms occurred during the summer,and although cyanobacterial and chlorophyte blooms co-occurred,they never coexisted with dinoflagellate *** identified cyanotoxins in the reservoirs over the past three years,a phenomenon previously unreported in the *** that these reservoirs are drinking water sources for human populations,ongoing and systematic monitoring is needed to protect public *** the proliferation of algae and cyanobacteria in reservoirs requires resource management at the watershed level,and in the case of the Itiyuro and El Limon,requires binational management with Bolivia.

关键词： HABs Freshwater South America Toxins

Assessment of Heavy Metal Exposure in Soils of Ihwrekreka Communities, Delta State, Nigeria

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Journal of Geoscience and Environment Protection 2024年第3期12卷 279-303页

作者： Adedoyin Olubunmi Bankole Akinyemi Olufemi Ogunkeyede Taofik Adewale Adedosu uche Udeochu Harrison Agboro Efe Jeffery Isukuru Department of Environmental Management and Toxicology College of Science Federal University of Petroleum Resources Effurun Delta State Nigeria Department of Chemistry Faculty of Science Ladoke Akintola University Oyo State Nigeria Chemistry Program Division of Science and Mathematics College of Arts and Sciences University of the District of Columbia Washington District of Columbia USA Department of Biology and Environmental Science College of Arts and Sciences University of New Haven West Haven CT USA

Crude oil pollution in the Niger Delta, perpetrated by both local communities and industrial actors, has brought about soil pollution with its consequent ecological, human health and food challenges. The purpose of this research was to examine the concentration and distribution of heavy metals in soil from communities contaminated by crude oil in Niger Delta, and to evaluate the potential health risks to residents from exposure to these contaminants. To achieve this, soil samples were collected from the Ihwrekreka community and analyzed for heavy metal content using inductively coupled plasma mass spectrometry (ICP-MS). The analytical results in mg/kg revealed a significant metals pollution level derived from the oil spill in the soil ranging from 4.85 - 17,078 (Cu), 1.01 - 16.1 (Cd), 0.22 - 36.8 (Cr), 8.28 - 40.9 (Ni), 7.51 - 6474 (Pb), and 8.84 - 12,851 (Zn) respectively. Most of the metals were above the permissible limits of World Health Organization, with Cu, Zn, and Pb as the most contaminating metals. Lead was found to be the main contributor to the hazard index (HI) values for both children and adults in the study area, with its concentration exceeding the permitted limits set by the WHO and the EC. The hazard index (HI) values of Pb, Cu, Zn, Cd, Ni, and Cr were significantly higher than 1. These findings suggest that the release of heavy metals from an oil-contaminated site may pose a risk to human health and the environment.

关键词： Cancer Exposure Pathway Toxic Metals Health Risks

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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自动化技术助力绿氢安全高效生产

流程工业 2024年第5期 32-34页

作者： veronica Constantin 艾默生

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战... 详细信息

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战。氢作为一种能源载体,如同所有可燃物质一样,具有相应的潜在危险。其高度易燃的特性意味着即使氢气与空气的混合比例很低——低至空气中氢气含量达到4%时,就足以构成爆炸风险。

关键词：自动化技术经济转型能源载体潜在危险氢气含量混合比例清洁燃料安全挑战

尼日利亚Gwagwalada原发性开角型青光眼患者的社会人口学和临床特征

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国际眼科杂志 2024年第7期24卷 1005-1012页

作者： Abdulkabir Ayansiji Ayanniyi Abdulraheem Olarongbe Mahmoud Yetunde Olamide JohnSam Rauf Ibrahim Rauf David Paul Ejeba Rosita Ujunwa Akasike-Enuh Emmanuel Oluwatosin Bisiriyu Margaret uche Afam-Osemene Eunice Adamma Chijioke Pankyes Amos Damter Nkosi Linus Agwadu 阿布贾大学眼科尼日利亚阿布贾902101 阿布贾教学医院眼科尼日利亚Gwagwalada902101 伊洛林大学眼科尼日利亚伊洛林240003 阿布贾大学统计学教研室尼日利亚阿布贾902101

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(POAG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例POAG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史... 详细信息

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(POAG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例POAG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史、眼痒、糖尿病和高血压情况。眼部检查包括视力、中央视野、杯盘比、前房角评估和眼压。结果:平均年龄为49.88±13.75岁,其中男114例(48.5%)。POAG患者包括42个种族,其中伊博人(24/96,25.0%)和约鲁巴人(20/96,20.8%)最为常见。大多数POAG(74/96,77.1%)年龄在40-69岁之间。POAG(73/96,76.0%)有不同程度的视力障碍。POAG组与非青光眼组的对比如下:青光眼阳性家族史(34/96,35.4%)vs(25/139,18.0%;P=0.012);糖尿病史(8/96,8.3%)vs(6/139,4.3%);高血压病史(24/96,25.0%)vs(28/139,20.1%);糖尿病合并高血压病史(1/96,1.0%)vs(4/139,2.9%;P=0.268);使用抗糖尿病药物者(5/96,5.2%)vs(7/139,5.0%);使用降压药者(24/96,25.0%)vs(23/139,16.5%);联合使用抗糖尿病和抗高血压药物者(4/96,4.2%)vs(5/139,3.6%;P=0.328);有眼痒症状者(18/96,18.7%)vs(37/139,26.6%;P=0.328);视力障碍[右眼(RE):51/96,53.1%;左眼(LE):60/96,62.5%]vs(RE:40/139,28.7%;LE:37/139,26.6%;P=0.000);垂直杯盘比>0.4(RE:96/96,100%;LE:96/96,100%)vs(RE:131/139,94.2%;LE:124/139,89.2%)(RE:P=0.307;LE:P=0.006);眼压>22 mmHg(RE:17/96,17.7%;LE:22/96,22.9%)vs(RE:2/139,1.4%;LE:2/139,1.4%;P=0.006)。大多数POAG患者(60/96,62.5%)正在服用抗青光眼药物,(23/96,24.0%)尚未开始用药,P=0.000。许多POAG(32/96,33.3%)正在服用β受体阻滞剂、前列腺素抑制剂和碳酸酐酶抑制剂的联合抗青光眼药物。结论:青光眼具有与其他眼部疾病不同的临床社会人口学特征。许多参与者肯定了青光眼的家族史,大多数青光眼参与者正在接受抗青光眼治疗。包括失明在内的视力障碍与青光眼显著相关。该研究证实,开角型青光眼与高杯盘比和高眼内压有关。

关键词：原发性开角型青光眼尼日利亚青光眼社会人口学

Axonal tuning by GABA_(A) receptor unveils novel tricks from an old dog

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Neural Regeneration Research 2023年第3期18卷 533-534页

作者： veronica Bonalume Valerio Magnaghi Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanItaly

In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011).Axonal computation,indeed,is canonically constituted by the action of voltage-gated ion channels,such as the classic Na+and K+channels,but recent studies demonstrated that it can be modulated by the action of other ion channel pumps,and metabolic factors(Byczkowicz et al.,2019;Zang and Marder.

关键词： tuning action classic

Don’t stop me now, I’m having such a good time! Czechoslovakian wolfdogs renovate the motivation to play with a bow

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Current Zoology 2023年第1期69卷 50-58页

作者： veronica Maglieri Anna Zanoli Fosca Mastrandrea Elisabetta Palagi Unit of Ethology Department of BiologyUniversity of PisaPisa 56126Italy Department of Life Sciences and Systems Biology University of TurinTorino 10123Italy

Dogs engage in play behavior at every age and the play bow is their most iconic playful ***,the function of this posture is still under ***,we selected the Czechoslovakian Wolfdog(CWD)as a model breed to clarify the function of the play *** analyzed frame-by-frame 118 sessions of 24 subjects and recorded 76 play bow *** found that all the play bows were performed in the visual field of the playmate suggesting that the sender takes into account the attentional state of the receiver when releasing the *** drawing survival curves and using log-rank test we found that play bow was mainly performed during a short pause in an ongoing session and that its performance triggered the playmate’s reaction *** findings show that play bow functions in restoring the partner motivation to ***,by using a sequential analysis and a generalized mixed model,we found no evidence supporting the metacommunicative function of the play *** signal did not necessarily precede a contact offensive behavior(e.g.,play biting and play pushing)and it was not affected by the level of asymmetry of the play *** conclusion,in CWDs play bow can be considered a visual signal useful to maintain the motivation to play in the ***,we suggest that the mismatched number of play bows emitted by the 2 players in a given session can be predictive of their different motivations to play.

关键词： Canis lupus familiaris first-order intentionality metacommunication motivation play fighting wolf-like traits