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A Modelling Study on PM_(2.5)-Related Health Impacts from Climate Change and Air Pollution Emission Control--China,2010s and 2040s

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China CDC weekly 2021年第23期3卷 500-506页

作者： Jing Huang Heng Tian Jiawei Wang Teng Yang Yiran Peng Shaowei Wu tzung-may fu Guoxing Li Department of Occupational and Environmental Health Sciences Peking University School of Public HealthBeijingChina Beijing Goldwind Science&Creation Windpower Equipment Co. LtdBeijingChina Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijingChina Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxiChina School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhenGuangdongChina

What is already known about this topic?Climate change and air pollution are two important environmental issues in *** is important to investigate particulate matter with aerodynamic diameter less than 2.5μm(PM2.5)-related health impacts from climate change and air pollution emission *** is added by this report?Deaths and years of life lost related to PM2.5 would increase in climate change scenario,although emission control would outweigh the influence of climate *** are the implications for public health practice?More targeted actions should be taken to meet challenges of exacerbated PM2.5 pollutions and its health impacts related to climate change in the future.

关键词： pollution China. Pollution

Dissecting the contributions of organic nitrogen aerosols to global atmospheric nitrogen deposition and implications for ecosystems

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National Science Review 2023年第12期10卷 124-136页

作者： Yumin Li tzung-may fu Jian Zhen Yu Xu Yu Qi Chen Ruqian Miao Yang Zhou Aoxing Zhang Jianhuai Ye Xin Yang Shu Tao Hongbin Liu Weiqi Yao Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks School of Environmental Science and Engineering Southern University of Science and Technology Guangdong Provincial Observation and Research Station for Coastal Atmosphere and Climate of the Greater Bay Area Southern University of Science and Technology Division of Environment and Sustainability Hong Kong University of Science and Technology National Center for Applied Mathematics Shenzhen Department of Chemistry Hong Kong University of Science and Technology State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Laboratory for Regional Pollution Control College of Environmental Sciences and Engineering Peking University Frontier Science Center for Deep Ocean Multispheres and Earth System and Physical Oceanography Laboratory Ocean University of China College of Oceanic and Atmospheric Sciences Ocean University of China Department of Ocean Science Hong Kong University of Science and Technology Department of Ocean Science and Engineering Southern University of Science and Technology

Atmospheric deposition of particulate organic nitrogen(ONp) is a significant process in the global nitrogen cycle and may be pivotally important for N-limited ***,past models largely overlo oked the spatial and chemical inhomogeneity of atmospheric ONpand were thus deficient in assessing global *** constructed a comprehensive global model of atmospheric gaseous and particulate organic nitrogen(ON),including the latest knowledge on emissions and secondary *** this model,we simulated global atmospheric ONpabundances consistent with *** estimated global atmospheric ON deposition was 26 Tg N yr-1,predominantly in the form of ONp(23 Tg N yr-1)and mostly from wildfires(37%),oceans(22%) and aqueous productions(17%).Globally,ONpcontributed as much as 40% to 80% of the total N deposition downwind of biomass-burning *** ONpdeposition thus constituted the dominant external N supply to the N-limited boreal forests,tundras and the Arctic Ocean,and its importance maybe amplified in a future warming climate.

关键词： organic nitrogen aerosol secondary organic nitrogen biomass burning

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong tzung-may fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Air-Sea Exchange of Volatile Organic Compounds: A New Model with Microlayer Effects

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Atmospheric and Oceanic Science Letters 2013年第2期6卷 97-102页

作者： HE Cen-Lin fu tzung-may College of Urban and Environmental Science Peking University Department of Atmospheric and Oceanic Sciences & Laboratory for Climate and Ocean-Atmosphere Studies School of Physics Peking University

The authors propose a new "three-layer" conceptual model for the air-sea exchange of organic gases, which includes a dynamic surface microlayer with photochemical and biological processes. A parameterization of this three-layer model is presented, which was used to calculate the air-sea fluxes of acetone over the Pacific Ocean. The air-sea fluxes of acetone calculated by the three-layer model are in the same direction but possess half the magnitude of the fluxes calculated by the traditional two-layer model in the absence of photochemical and biological processes. However, photochemical and biological processes impacting acetone in the microlayer can greatly vary the calculated fluxes in the three-layer model, even reversing their direction under favorable conditions. Our model may help explain the discrepancies between measured and calculated acetone fluxes in previous studies. More measurements are needed to validate our conceptual model and provide constraints on the model parameters.

关键词： air-sea transfer organic gas two-layer model,microlayer surface renewal

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Epigenetic remodeling by DNA glycosylases during rice reproduction

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Molecular Plant 2021年第9期14卷 1433-1435页

作者： Mingzhuo Li Qirui Cui Xiang-Qian Zhang tzung-fu Hsieh Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC 27695USA Plants for Human Health Institute North Carolina State UniversityNorth Carolina Research CampusKannapolisNC 28081USA College of Forestry and Landscape Architecture South China Agricultural University510642 GuangzhouChina

Cytosine methylation is a covale nt modificatio n of DNA that regulates important processes in eukaryotic genomes,including gene transcription,transposon silencing,and genomic imprinting(Law and Jacobsen,2010).DNA methylation patterns are faithfully duplicated upon cell division to ensure genome integrity and to maintain lineage-specific cell ***,DNA methylation also needs to be dynamically reprogramed or reconfigured during development to allow establishment of new cellular identity and transcriptional state,which plays a prominent role in animal development and reproduction,and is increasingly being appreciated for reproductive success in flowering plants(Walker et al.,2018;Ono and Kinoshita,2021).

关键词： al. remodeling maintain

有机气溶胶对中国境内云凝结核数量的贡献研究

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北京大学学报（自然科学版） 2015年第1期51卷 13-23页

作者：邢莉傅宗玫北京大学物理学院大气与海洋科学系气候与海-气实验室北京100871

根据κ-Khler理论,利用2006年中国境内气溶胶浓度的数值模拟结果,计算总体气溶胶活化为云凝结核的数浓度,并评估有机气溶胶对云凝结核数量的贡献。中国境内云凝结核数浓度总体呈东部高西部低的分布,这与东部受到更多人为源排放影响、... 详细信息

根据κ-Khler理论,利用2006年中国境内气溶胶浓度的数值模拟结果,计算总体气溶胶活化为云凝结核的数浓度,并评估有机气溶胶对云凝结核数量的贡献。中国境内云凝结核数浓度总体呈东部高西部低的分布,这与东部受到更多人为源排放影响、气溶胶浓度高有关。假设气溶胶各类化学组分彼此外混合,则各季节云凝结核数浓度为0.9×10^3~1.2×10^3 cm^-3,有机气溶胶对云凝结核数量贡献全年平均为30%。假设气溶胶中有机组分彼此内混合并与其他组分外混合,则各季节云凝结核数浓度为0.9×10^3~1.1×10^3 cm^-3,有机气溶胶对云凝结核数量的贡献全年平均28%。尽管有机气溶胶对云凝结核数量的年平均贡献相差不大,但夏季和冬季的贡献有较大差异,原因在于夏季有更多的二次有机气溶胶生成,而冬季更多的是一次有机气溶胶排放。因此,有机气溶胶是中国云凝结核的重要来源,并且有机气溶胶的混合状态对云凝结核数量有很大的影响。

关键词：云凝结核数浓度有机气溶胶混合状态

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Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems

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Molecular Plant 2018年第2期11卷 245-256页

作者： Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong tzung-fu Hsieh Daniel F. Voytas Yong Zhang Yiping Qi Department of Biology East Carolina University Greenville NC 27858 USA Department of Biotechnology School of Life Science and Technology Center for informational Biology University of Electronic Science and Technology of ChinaChengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Department of Plant and Microbial Biology and Plants for Human Health Institute North Carolina State University North Carolina Research Campus KannapolisNC 28O81 USA Department of Genetics Ceil Biology and Development Center for Genome Engineering University of Minnesota Minneapolis MN 55455 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

User-friendly tools for robust transcriptional activation of endogenous genes are highly demanded in plants. We previously showed that a dCas9-VP64 system consisting of the deactivated CRISPR- associated protein 9 （dCasg） fused with four tandem repeats of the transcriptional activator VP16 0/1=64） could be used for transcriptional activation of endogenous genes in plants. In this study, we developed a second generation of vector systems for enhanced transcriptional activation in plants. We tested multiple strategies for dCasg-based transcriptional activation, and found that simultaneous recruitment of VP64 by dCas9 and a modified guide RNA scaffold gRNA2.0 （designated CRISPR-Act2.0） yielded stronger transcrip- tional activation than the dCas9-VP64 system. Moreover, we developed a multiplex transcription activator- likeeffector activation （mTALE-Act） system for simultaneous activation of up to four genes in plants. Our results suggest that mTALE-Act is even more effective than CRISPR-Act2.0 in most cases tested. In addition, we explored tissue-specific gene activation using positive feedback loops. Interestingly, our study revealed that certain endogenous genes are more amenable than others to transcriptional activation, and tightly regulated genes may cause target gene silencing when perturbed by activation probes. Hence, these new tools could be used to investigate gene regulatory networks and their control mechanisms. Assembly of multiplex CRISPR-Act2.0 and mTALE-Act systems are both based on streamlined and PCR-independent Golden Gate and Gateway cloning strategies, which will facilitate transcriptional activation applications in both dicots and monocots.

关键词： CRISPR gRNA2.0 MS2-VP64 TALE-VP64 multiplex transcriptional activation

天津武清冬季PM_(2.5)含碳组分的逐时观测及分析

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北京大学学报（自然科学版） 2016年第3期52卷 409-419页

作者：徐伟傅宗玫陈晋轩田亨北京大学物理学院大气与海洋科学系气候与海-气实验室北京100871

为了解京津冀地区冬季气溶胶含碳组分浓度及变化特征,2011年12月至2012年1月在天津市武清区针对PM_(2.5)中元素碳(EC)、有机碳(OC)、水溶性有机碳(WSOC)及水溶性离子组分进行实时半在线的逐时浓度综合观测。观测期间EC和OC的平均浓度分... 详细信息

为了解京津冀地区冬季气溶胶含碳组分浓度及变化特征,2011年12月至2012年1月在天津市武清区针对PM_(2.5)中元素碳(EC)、有机碳(OC)、水溶性有机碳(WSOC)及水溶性离子组分进行实时半在线的逐时浓度综合观测。观测期间EC和OC的平均浓度分别为6.0±4.8和21.5±19.2μg C/m^3,分别占PM_(2.5)观测组分总浓度平均值的8%和30%。WSOC平均浓度为14.3±11.8μg C/m^3,占平均OC浓度的67%。观测期间,污染物浓度的大幅变化主要受气象条件控制,OC,EC和WSOC日变化特征相对不显著。观测期间大部分时间OC/EC比值稳定,OC/EC平均值为3.9。通过含碳组分与其他示踪组分的相关性分析,初步判定武清冬季的气溶胶含碳组分主要来自生物质燃烧的一次性排放,且影响当地的气团经过明显老化过程。约一半的OC来自一次生物质燃烧排放,另一半来自二次生成。

关键词：有机碳元素碳水溶性有机碳二次有机气溶胶

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Organophosphate pesticides and new-onset diabetes mellitus:From molecular mechanisms to a possible therapeutic perspective

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World Journal of Diabetes 2021年第11期12卷 1818-1831页

作者： Ya-Ling Chung Yi-Chou Hou I-Kuan Wang Kuo-Cheng Lu tzung-Hai Yen Department of Medical Laboratory Cardinal-Tien HospitalNew Taipei City 231Taiwan Department of Internal Medicine Cardinal Tien HospitalNew Taipei City 231Taiwan Graduate Institute of Clinical Medicine College of MedicineTaipei Medical UniversityTaipei 110Taiwan School of Medicine Fu Jen Catholic UniversityNew Taipei City 24205Taiwan Department of Nephrology China Medical University HospitalTaichung 404Taiwan College of Medicine China Medical UniversityTaichung 404Taiwan Division of Nephrology Department of MedicineFu Jen Catholic University HospitalNew Taipei City 242Taiwan Division of Nephrology Department of MedicineTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 231Taiwan Department of Nephrology Chang Gung Memorial HospitalLinkou 333Taiwan School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 333Taiwan

Organophosphate is a commonly used pesticide in the agricultural *** main action of organophosphate focuses on acetylcholinesterase inhibition,and it therefore contributes to acute cholinergic crisis,intermediate syndrome and delayed *** sporadic case series to epidemiologic studies,organophosphate has been linked to hyperglycemia and the occurrence of newonset diabetes ***-mediated direct damage to pancreatic beta cells,insulin resistance related to systemic inflammation and excessive hepatic gluconeogenesis and polymorphisms of the enzyme governing organophosphate elimination are all possible contributors to the development of newonset diabetes *** date,a preventive strategy for organophosphatemediated new-onset diabetes mellitus is still ***,lowering reactive oxygen species levels may be a practical method to reduce the risk of developing hyperglycemia.

关键词： Organophosphate Pesticide New-onset diabetes mellitus Mechanism Reactive oxygen species