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Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： Li-hua Zhu Yu-pei Liang Lian yang Feng Zhu Li-jun Jia He-gen Li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

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Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota

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Journal of Animal Science and Biotechnology 2024年第1期15卷 277-294页

作者： Xinyue yang Depeng Li Meihong Zhang Yuqing Feng Xiaolu Jin Dan Liu Yuming Guo Yongfei Hu State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Ginkgo biloba extract(GBE)is evidenced to be effective in the prevention and alleviation of metabolic disorders,including obesity,diabetes and fatty liver ***,the role of GBE in alleviating fatty liver hemorrhagic syndrome(FLHS)in laying hens and the underlying mechanisms remain to be ***,we investigated the effects of GBE on relieving FLHS with an emphasis on the modulatory role of GBE in chicken gut *** The results showed that GBE treatment ameliorated biochemical blood indicators in high-fat diet(HFD)-induced FLHS laying hen model by decreasing the levels of TG,TC,ALT and *** lipid accumulation and pathological score of liver were also relieved after GBE ***,GBE treatment enhanced the antioxidant activity of liver and serum by increasing GSH,SOD,T-AOC,GSH-PX and reducing MDA,and downregulated the expression of genes related to lipid synthesis(FAS,LXRα,GPAT1,PPARγand Ch REBP1)and inflammatory cytokines(TNF-α,IL-6,TLR4 and NF-κB)in the *** profiling analysis revealed that GBE treatment reshaped the HFD-perturbed gut microbiota,particularly elevated the abundance of Megasphaera in the ***,targeted metabolomic analysis of SCFAs revealed that GBE treatment significantly promoted the production of total SCFAs,acetate and propionate,which were positively correlated with the GBE-enriched gut ***,we confirmed that the GBE-altered gut microbiota was sufficient to alleviate FLHS by fecal microbiota transplantation(FMT).Conclusions We provided evidence that GBE alleviated FLHS in HFD-induced laying hens through reshaping the composition of gut *** findings shed light on mechanism underlying the anti-FLHS efficacy of GBE and lay foundations for future use of GBE as additive to prevent and control FLHS in laying hen industry.

关键词： Antioxidation Fecal microbiota transplantation FLHS Ginkgo biloba extract Inflammation Megasphaera

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Enhancing Geological Understanding and Identifying Gold Anomalies in the Ailaoshan Orogen

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 441-453页

作者： ZHAO Shiyu yang Lin SONG Yiwei DONG Yuntao FENG Lihao LI Huajian WU Junyu WANG Qingfei State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China Xi’an Center of Mineral Resources Survey China Geological SurveyXi’an 710010China Yunnan Gold Mining Industry Group Kunming 650299China Jiangxi Provincial Key Laboratory of Genesis and Prospect for Strategic Minerals East China University of TechnologyNanchang 330013China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China

The Ailaoshan Orogen in the southeastern Tibet Plateau,situated between the yangtze and Simao blocks,underwent a complex structural,magmatic,and metamorphic evolution resulting in different tectonic subzones with varying structural lineaments and elemental *** elements can conceal or reduce anomalies due to the mutual effect between different anomaly *** the whole zone into subzones based on tectonic settings,ore cluster areas,or sample catchment basins(Scb),geochemical and structural anomalies associated with gold(Au)mineralization have been identified utilizing mean plus twice standard deviations(Mean+2STD),factor analysis(FA),concentration-area(CA)modeling of stream sediment geochemical data,and lineament density in both the Ailaoshan Orogen and the individual *** FA in the divided 98 Scbs with 6 Scbs containing Au deposits can roughly ascertain unknown rock types,identify specific element associations of known rocks and discern the porphyry or skarn-type Au *** with methods of Mean+2STD and C-A model of data in the whole orogen,which mistake the anomalies as background or act the background as anomalies,the combined methods of FA and C-A in the separate subzones or Scbs works well in regional metallogenic potential *** of lineament densities with a 10-km circle diameter is not suitable to locate Au deposits because of the delineated large areas of medium-high lineament *** contrast,the use of circle diameters of 1.3 km or 1.7 km in the ore cluster scale delineates areas with a higher concentration of lineament density,consistent with the locations of known Au *** analyzing the map of faults and Au anomalies,two potential prospecting targets,Scbs 1 and 63 with a sandstone as a potential host rock for Au,have been identified in the Ailaoshan *** use of combined methods in the divided subzones proved to be more effective in improving geological understanding and identifying

关键词： minerology geochemistry gold stream sediment sample catchment basin concentration-area model lineament density Ailaoshan Orogen

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Role of tannin pretreatment in flotation separation of magnesite and dolomite

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 452-461页

作者： Xiufeng Gong Jin Yao Jun Guo Bin yang Haoran Sun Wanzhong Yin Yulian Wang Yafeng Fu School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Solid Waste Treatment and Resource Utilization of the Ministry of Education Southwest University of Science and TechnologyMianyang 621010China School of Chemical Engineering China University of Mining and TechnologyXuzhou 221116China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Flotation separation of magnesite and its calcium-containing carbonate minerals is a difficult ***,new regulat-ors have been proposed for magnesite flotation decalcification,although traditional regulators such as tannin,water glass,sodium carbon-ate,and sodium hexametaphosphate are more widely used in ***,they are rarely used as the main regulators in research because they perform poorly in magnesite and dolomite single-mineral flotation *** by the limonite presedimentation method and the addition of a regulator to magnesite slurry mixing,we used a tannin pretreatment method for separating magnesite and *** experiments confirmed that the tannin pretreatment method selectively and largely reduces the flotation recovery rate of dolomite without affecting the flotation recovery rate of ***,the contact angles of the tannin-pretreated magnesite and dolomite increased and decreased,respectively,in the presence of *** potential and Fourier transform infrared analyses showed that the tannin pretreatment method efficiently hinders NaOl adsorption on the dolomite surface but does not affect NaOl adsorption on the magnesite surface.X-ray photoelectron spectroscopy and density functional theory calculations confirmed that tannin interacts more strongly with dolomite than with magnesite.

关键词： tannin pretreatment selective inhibition flotation separation magnesite dolomite

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Mutations of voltage-gated sodium channel contribute to pyrethroid resistance in Panonychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng Pan Qiu-Juan Luo Andrias O.O'Reilly Guo-Rui Yuan Jin-Jun Wang wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in Panonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to pyrethroids has evolved in some ***,the resistance to the pyrethroid fenpropathrin was investigated and 7 out of 8 field-collected populations of P citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the susceptible(SS)comparison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested populations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field populations.L1031V and F1751I were present in all populations at frequencies of 11.6%-82.1%and 0.5%-31.8%,respectively,whereas the F1747L mutation was only present in 12 populations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenpropathrin and these flies also exhibited reduced mortality after exposure to the pyrethroids permethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with pyrethroids,which are lost with mutation,whereas L1031 mutation may diminish pyrethroid effects through an allosteric ***,the results provide molecular markers for monitoring pest resistance to pyrethroids and offer new insights into the basis of pyrethroid actions on sodium channels.

关键词： amplicon sequencing kdr mutation molecular docking Panonychus citri pyrethroid resistance transgenic flies

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Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular weight Polyethylene/Graphene Composites as High-performance Light-weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi Huang Xiao-Xiao Liu Lan-wei Li Guang-Ming Huang Zhao-Xia Huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

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Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae

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Journal of Genetics and Genomics 2024年第5期51卷 554-565页

作者： Xue Liu weixiong Zhang Yongting Zhang Jing yang Peng Zeng Zunzhe Tian weibang Sun Jing Cai Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'anShaanxi 710072China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

The Fagaceae,a plant family with a wide distribution and diverse adaptability,has garnered significant interest as a subject of study in plant speciation and ***,certain Fagaceae species are regarded as highly valuable wood resources due to the exceptional quality of their *** this study,we present two high-quality,chromosome-scale genome sequences for Quercus sichourensis(848.75 Mb)and Quercus rex(883.46 Mb).Comparative genomics analysis reveals that the difference in the number of plant disease resistance genes and the nonsynonymous and synonymous substitution ratio(Ka/Ks)of protein-coding genes among Fagaceae species are related to different environmental ***,most genes related to starch synthesis in the investigated Quercoideae species are located on a single chromosome,as compared to the outgroup species,Fagus ***,resequencing and population analysis of *** and *** reveal that *** has lower genetic diversity and higher deleterious mutations compared to *** high-quality,chromosome-level genomes and the population genomic analysis of the critically endangered *** and *** will provide an invaluable resource as well as insights for future study in these two species,even the genus Quercus,to facilitate their conservation.

关键词： Adaptation Quercus sichourensis Quercusrex Chromosome-scale genome assembly Tandem duplication genes Extremely small populations

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3D electromagnetic modelling for high-temperature superconducting dynamo flux pumps using T-A formulation

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High Voltage 2024年第2期9卷 367-379页

作者： Luning Hao Fangliang Dong Jintao Hu Qi Wang Haigening wei Ismail Patel Adil Shah Yuyang Wu Tim Coombs Department of Engineering University of CambridgeCambridgeUK Plasma Science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

A high-temperature superconducting(HTS)dynamo flux pump can inject DC currents into closed-loop HTS magnets without *** enables the realisation of current-lead-free or even through-wall charging systems for high-field applications such as nuclear magnetic resonance/magnetic resonance imaging(MRI)magnets,fusion reactors and *** have proposed many simulation models to understand the working principle of HTS dynamos,few of which are in 3D because of converging ***,the influences of many key 3D parameters in the HTS dynamo are scarcely *** authors propose an efficient 3D modelling method of the HTS dynamo based on the T-A *** rotating magnets are modelled by a ring-shaped permanent magnet with space-time-variant remanent flux density to avoid moving ***,together with the T-A formulation,makes the 3D model efficient and *** accuracy of the model is verified by the experimental instantaneous and time-integrated dynamic *** this model,the authors present systematic case studies to thoroughly explore the influences of the key parameters of a dynamo flux pump on the dynamic voltage and *** proposed modelling method and results could significantly benefit the design and optimisation of HTS dynamos for high-field magnets.

关键词： formulation magnets pump

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Thermally Conductive and UV-EMI Shielding Electronic Textiles for Unrestricted and Multifaceted Health Monitoring

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Nano-Micro Letters 2024年第10期16卷 149-162页

作者： Yidong Peng Jiancheng Dong Jiayan Long Yuxi Zhang Xinwei Tang Xi Lin Haoran Liu Tuoqi Liu wei Fan Tianxi Liu Yunpeng Huang Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People's Republic of China

Skin-attachable electronics have garnered considerable research attention in health monitoring and artificial intelligence domains,whereas susceptibility to elec-tromagnetic interference(EMI),heat accumulation issues,and ultraviolet(UV)-induced aging problems pose significant constraints on their potential ***,an ultra-elas-tic,highly breathable,and thermal-comfortable epidermal sensor with exceptional UV-EMI shielding performance and remarkable thermal conductivity is developed for high-fidelity monitoring of multiple human electrophysiological *** filling the elastomeric microfibers with thermally conductive boron nitride nanoparticles and bridging the insulating fiber interfaces by plating Ag nanoparticles(NPs),an interwoven thermal con-ducting fiber network(0.72 W m^(-1) K^(-1))is constructed benefiting from the seamless thermal interfaces,facilitating unimpeded heat dissipation for comfort skin *** excitingly,the elastomeric fiber substrates simultaneously achieve outstanding UV protection(UPF=143.1)and EMI shielding(SET>65,X-band)capabilities owing to the high electrical conductivity and surface plasmon resonance of Ag ***,an electronic textile prepared by printing liquid metal on the UV-EMI shielding and thermally conductive nonwoven textile is finally utilized as an advanced epidermal sensor,which succeeds in monitoring different electrophysiological signals under vigorous electromagnetic *** research paves the way for developing protective and environmentally adaptive epidermal electronics for next-generation health regulation.

关键词： Skin electronics Thermal regulating textiles Electromagnetic interference shielding Ultraviolet proof Health monitoring

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Exciting lattice oxygen of nickel–iron bi-metal alkoxide for efficient electrochemical oxygen evolution reaction

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Journal of Energy Chemistry 2024年第1期88卷 194-201,I0005页

作者： Saihang Zhang Senchuan Huang Fengzhan Sun Yinghui Li Li Ren Hao Xu Zhao Li Yifei Liu wei Li Lina Chong Jianxin Zou National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composites Center of Hydrogen ScienceSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsiChEM and State Key Laboratory of Molecular Engineering of PolymersCollege of Chemistry and MaterialsFudan UniversityShanghai 200433China

High efficiency,cost-effective and durable electrocatalysts are of pivotal importance in energy conversion and storage *** electro-oxidation of water to oxygen plays a crucial role in such energy conversion ***,we report a robust method for the synthesis of a bimetallic alkoxide for efficient oxygen evolution reaction(OER)for alkaline electrolysis,which yields current density of 10 mA cm^(-2)at an overpotential of 215 mV in 0.1 M KOH *** catalyst demonstrates an excellent durability for more than 540 h operation with negligible degradation in *** spectra revealed that the catalyst underwent structure reconstruction during OER,evolving into oxyhydroxide,which was the active site proceeding OER in alkaline ***-situ synchrotron X-ray absorption experiment combined with density functional theory calculation suggests a lattice oxygen involved electrocatalytic reaction mechanism for the in-situ generated nickel–iron bimetal-oxyhydroxide *** mechanism together with the synergy between nickel and iron are responsible for the enhanced catalytic activity and *** findings provide promising strategies for the rational design of nonnoble metal OER catalysts.

关键词： Oxygen evolution reaction Nickel-iron bi-metal alkoxide Lattice oxygen-mediated reaction mechanism Alkaline electrolysis Electrocatalysts

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