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Characteristics of Traditional Chinese Medicine Use in Patients with Rheumatoid Arthritis in Taiwan:a Nationwide Population-Based Study

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Characteristics of Traditional Chinese Medicine Use in Patie...

第十四届全国中药和天然药物学术研讨会

作者： ming-Cheng Huang Fu-tzu Pai Hen-Hong Chang Hung-Rong Yen Yu-Chen Lee Mao-Feng Sun China Medical University Hospital Chang Gung University China Medical University

Objective Nationwide study of current traditional Chinese medicine（TCM） usage trend among patients with rheumatoid arthritis（RA） is *** aim of this study is to evaluate the application of TCM among RA patients in *** and Methods This study examined datasets from the National Health Insurance Research Database in ***（n=25,263） newly diagnosed as RA and proven as catastrophic illness commissioned by rheumatologists between January 2001 and December 2009 were included in this *** who had at least one TCM outpatient clinical record were defined as TCM users（n=6981）,whereas those without TCM outpatient records were defined as non-TCM users（n=18372）.The demographic data,treatment modalities,disease distributions,comorbidities,and prescription pattern of the TCM users were *** TCM users were younger than non-TCM user（mean age:49.6 versus 54.0）.The ratio of female to male in TCM users was higher than non-TCM users（5:1 vs.3:1）.The average interval between RA onset and the first TCM clinical visit was 23.4 *** remedies were the most commonly used therapeutic approach（76.4%）,followed by combined herbal remedies and acupuncture（21.1%）,and acupuncture or traumatology alone（2.5%）.The most commonly prescribed formulas were Shang-Zhong-Xia-Tong-Yong-Tong-Feng-Wan,Jia-Wei-Xiao-Yao-San and Liu-Wei-Di-Huang-Wan,whereas Rhizoma Corydalis,Radix Clematidis and Caulis Spatholobi were the three most frequently prescribed single *** who had allergic rhinitis,disorders of menstruation or anxiety and depression were prone to have more TCM visits compared to non-TCM *** Our population-based study revealed the high prevalence and specific usage patterns of TCM in the RA patients in *** results provided valuable information for further pharmacologic investigation and clinical studies on the treatment of RA.

关键词： Complementary and alternative medicine National Health Insurance Database Rheumatoid arthritis Traditional Chinese medicine

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土壤初始温度模型

湖南大学学报（自然科学版） 2007年第7期34卷 27-29页

作者：陈友明王宇航莫志姣湖南大学土木工程学院湖南长沙410082

通过热传导理论,建立了地下土壤初始温度分布的理论计算模型,并将模型的全年模拟结果与全年实测值进行了对比.结果表明,地下土壤温度分布模型的计算值与实测值十分吻合,说明理论模型是正确的.模拟结果表明,当土壤深度达到10 m时,土壤全... 详细信息

通过热传导理论,建立了地下土壤初始温度分布的理论计算模型,并将模型的全年模拟结果与全年实测值进行了对比.结果表明,地下土壤温度分布模型的计算值与实测值十分吻合,说明理论模型是正确的.模拟结果表明,当土壤深度达到10 m时,土壤全年温度趋于稳定.该理论模型可应用于土壤源热泵系统的分析和设计中.

关键词：理论模型土壤源热泵土壤温度分布实测值

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Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph jao-Yiu Sung ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

Does the Adjunctive Traditional Chinese Medicine Use Reduce the Need for Surgery in Patients with Osteoarthritis?-A Nationwide Population-Based Study in Taiwan

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Does the Adjunctive Traditional Chinese Medicine Use Reduce ...

Experience with Open and Laparoscopic Surgery for Primary Gastric Stromal Tumors in a Single Institute

第十四届全国中药和天然药物学术研讨会

作者： Fu-tzu Pai ming-Cheng Huang Ching-Hsuan Huang Yu-Chen Lee Mao-Feng Sun Hen-Hong Chang Hung-Rong Yen China Medical University Hospital Chang Gung University China Medical University

Objective Osteoarthritis（OA）is a common illness in the aged ***,large-scale study of traditional Chinese medicine（TCM）use among patients with osteoarthritis（OA）is *** aim of this study is to investigate the TCM use among OA patients in *** and Methods This study analyzed datasets from the National Health Insurance Research Database in ***（n=97,769）newly diagnosed as OA between January 2000 and December2010 were included in this *** who had at least one TCM outpatient clinical record after OA diagnosis were defined as TCM users（n=5,182）,whereas those without TCM outpatient records were defined as non-TCM users（n=95,287）.The demographic data,treatment modalities,disease distributions,comorbidities,prescription pattern and the need for total knee replacement surgery of the TCM users were *** TCM users tended to be younger,female,and live in highly urbanized *** average interval between OA onset and the first TCM clinical visit was 9.63 *** remedies were the most commonly used therapeutic approach（75.7%）,followed by combined herbal remedies and acupuncture（21.1%）,and acupuncture or traumatology alone（3.2%）.The most commonly prescribed formulas were Gui-Lu-Er-Xian-Jiao,Du-Huo-Ji-Sheng-Tang and Dang-Gui-Nian-Tong-Tang,whereas Cortex Eucommiae,Radix Salviae Miltiorrhizae and Rhizoma Corydalis were the three most frequently prescribed single *** who had adjunctive TCM use has no decreased need for total knee replacement surgery（adjusted hazard ratio 1.11（0.99,1.24））.Conclusion Adjunctive TCM use didn’t reduce the need for total knee replacement in patients with *** outcome improvement such as quality of life should be *** results also provided valuable information for further pharmacologic investigation and clinical studies on the treatment of OA.

关键词： National Health Insurance Database Osteoarthritis Traditional Chinese medicine

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Surgical Science 2017年第6期8卷 229-239页

作者： Yi-Hsuan Hu Kuo-Hung Huang Yuan-tzu Lan Jen-Hao Chen Su-Shun Lo Anna Fen-Yau Li Shih-Hwa Chiou Chew-Wun Wu Yi-ming Shyr Wen-Liang Fang Division of General Surgery Department of Surgery Taipei Veterans General Hospital Taiwan Division of General Surgery Department of Surgery Cardinal Tien Hospital Taiwan Division of Colon & Rectal Surgery Department of Surgery Taipei Veterans General Hospital Taiwan Department of Pathology Taipei Veterans General Hospital Taiwan National Yang-ming University Taiwan Institute of Clinical Medicine School of Medicine National Yang-Ming University Taiwan Cheng Hsin General Hospital Taiwan National Yang-ming University Hospital Taiwan Department of Medical Research and Education Taipei Veterans General Hospital Taiwan Institute of Pharmacology National Yang-Ming University Taiwan

Laparoscopic surgery has become increasingly popular in the management of gastric gastrointestinal stromal tumors (GISTs) in recent years. One hundred and forty-five patients underwent curative resections of primary gastric stromal tumors between September 2002 and March 2012 were assigned to either an open surgery group (n = 99) or a laparoscopic surgery group (n = 46). In the open surgery group, there was a significantly higher number of samples with a mitotic index ≥ 10 (16.1% vs. 0%), more tumors located in the gastric cardia (13.1% vs. 6.5%), greater operative blood loss (80 mL vs. 50 mL) and a longer postoperative hospital stay (10 days vs. 6 days) than in the laparoscopic group. The surgical morbidity and mortality were 6.1% and 0% in the open group, whereas no complication or mortality in the laparoscopic group. Ten patients in the open group had tumor recurrences and no recurrence in the laparoscopic group. Multivariate analysis showed that tumor size and mitotic index were two independent risk factors associated with tumor recurrence. The 3-year disease-free survival rates and 5-year overall survival rates were similar between the two groups. The laparoscopic approach is a safe alternative procedure for gastric GISTs.

关键词： GIST Open Laparoscopic Tumor Size Mitotic Index

新竹地区大气环境纳米微粒粒径分布及数目浓度变化研究

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过程工程学报 2006年第Z2期6卷 143-149页

作者：陈姿名简弘民黄俊超工业技术研究院能源与环境研究所

监测了新竹地区不同区域的纳米微粒粒径分布及数目浓度变化,分别针对光复国宅(住宅区)、食品路及西大路口(道路)、湖口工业区(工业区)及宝山水库(水源集水区)等区域进行纳米微粒背景值测量.在粒径分布方面,<100nm以下微粒以食品路及西... 详细信息

监测了新竹地区不同区域的纳米微粒粒径分布及数目浓度变化,分别针对光复国宅(住宅区)、食品路及西大路口(道路)、湖口工业区(工业区)及宝山水库(水源集水区)等区域进行纳米微粒背景值测量.在粒径分布方面,<100nm以下微粒以食品路及西大路口浓度最高,其次为湖口工业区,各占当日总浓度90%以上.而光复国宅及宝山水库则分别占有80%以上及60%以上比例.其中<15nm以下微粒分别为食品路及西大路口占26%,湖口工业区占18%,光复国宅占有14%及宝山水库则占了5%.在数目浓度方面,以粒径6～225nm的日平均值来看,这四个采样点中,以食品路及西大路交叉口所测量到总数目浓度最高(5.58×105cm-3),其次为湖口工业区的3.64×104cm-3,第三为光复国宅总浓度1.27×104cm-3,总浓度最低者为宝山水库只有1.07×104cm-3.以粒径15～661nm的日平均值来看,仍以食品路及西大路交叉口所测量到总数目浓度最高,约7.31×104cm-3,其次为湖口工业区的3.05×104cm-3,第三为宝山水库总浓度为1.254×104cm-3,总浓度最低者为光复国宅1.25×104cm-3.

关键词：大气环境纳米微粒工业区住宅区道路

Factors Affecting Corneal Hysteresis in Taiwanese Adults

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眼科学报 2015年第3期30卷 89-93页

作者： Jia-Kang Wang tzu-Lun Huang Pei-Yuan Su Pei-Yao Chang Department of Ophthalmology Far Eastern Memorial Hospital Department of Medicine National Yang Ming University Department of Healthcare Administration and Department of Nursing Oriental Institute of Technology Department of Medicine National Taiwan University Institute of Medical Sciences Tzu Chi University Department of Medicine Fu Jen Catholic University

Purpose: To investigate the correlation of various corneal hysteresis(CH) factors in Chinese ***: From January 2009 to November 2011, the healthy right eyes of a total of 292 adults were recruited into the study. Goldmann-correlated intraocular pressure(IOPG) and CH were measured using an ocular response analyzer(ORA).Central corneal thickness was measured using the ORA’s integrated handheld ultrasonic pachymeter. The IOLMaster was used to obtain the ocular biometric measurements including axial length, anterior chamber depth, and keratometric *** Pearson correlation coefficient was used to test correlations between CH and quantitative factors. The chi-square test was used to detect differences in categorical ***: Longer axial length(P =0.0001), lower IOPG(P =0.03), older age(P=0.003),and thinner central corneal thickness(P=0.0001) were significantly associated with lower *** anterior chamber depth(P=0.34), gender(P =0.23), and corneal curvature(P=0.18) had no relationship to ***: Various factors including axial length, intraocular pressure, age, and central corneal thickness can affect measurement of corneal biomechanical properties in Chinese *** the anterior chamber depth, gender, and corneal curvature were irrelevant to CH.

关键词： corneal hysteresis biometry ocular response analyzer axial length central corneal thickness

MODELING UNSTEADY TURBIDITY CURRENTS IN A STEEP NARROW RESERVOIR

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International Journal of Sediment Research 1997年第3期 207-215页

作者： Shaohua Marko HSU, Associate Professor, Dr. Department of Hydraulic Engineering, Feng Chia University, Taichung 407, Taiwan, China Wei-Sheng YU Environment Section, Agricultural Engineering Research Center, Chungli, Taiwan, China tzu-ming LIU Graduate stu

Plunging turbidity currents can occur under certain conditions when sediment suspension-laden inflow enters a reservoir. This current submerges into the lower portion of the stratified water body and moves downstream. Clear and turbid Water mix across the interface of upper and lower portions. In cases with steep slopes, clear water is entrained by turbulent eddy down to the turbid portion and therefore the discharge of turdity current increases and concentration diluted. Turbidity current is highly unsteady in flood period. In this article, a one-dimensional unsteady model is developed. Three governing equations, including water continuity, suspended sediment continuity, and momentum equation for sediment-laden flow, are solved by MacCormack scheme. Supplemental equations of ambient-water entrainment, bed-material entrainment in two continuity equations and experimental values of friction coefficient in momentum equation are used in solving the thickness of current, layer-averaged velocity, and layer-averaged concentration at different time and locations. With simplified downstream conditions and a flood hydrograph with constant concentration as upstream conditions, numerical experiments were performed to investigate phenomena difficult to be observed in laboratory and in field.

关键词： Turbidity current Sediment flushing Unsteady flow Numerical modeling

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国际高科技公司企业社会责任策略管理

计算机与现代化 2011年第11期 123-128页

作者：林子铭萧裕中中央大学信息管理系台湾桃园32001

企业社会责任(Corporate Social Responsibility,CSR)的延展力量空前迅速发展,至今已达到一个新的颠峰期,成为企业界在面对全球潮流时必须重视的议题,因此企业领导人应从企业的核心价值与理念寻找结合企业核心技术的策略去落实CSR,才能... 详细信息

企业社会责任(Corporate Social Responsibility,CSR)的延展力量空前迅速发展,至今已达到一个新的颠峰期,成为企业界在面对全球潮流时必须重视的议题,因此企业领导人应从企业的核心价值与理念寻找结合企业核心技术的策略去落实CSR,才能发挥最大效益并永续经营,从过去"must and ought"进阶反思"doing good by doing well",让企业在达到永续发展终极目标的同时也为社会与环境带来正面的价值与影响。其中又以高科技产业受影响最为剧烈,CSR除了已经成为国际标准的共识外,未来更会成为许多国家列为采购对象的必备条件,位于上海的广达上海制造城的企业社会责任是一个具代表性的研究个案,从其中归纳出国际高科技产业对于企业社会责任的策略在做法上和态度上的转变。

关键词：广达上海制造城企业社会责任策略高科技产业