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Development of Chinese medicinal anti-malarial drug artesunate for allergy,asthma and COPD

Development of Chinese medicinal anti-malarial drug artesuna...

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中国药理学会第十一次全国学术会议

作者： WS Fred WONG Eugene WX HO tze khee chan David SW NG Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore

Artesunate is a semi-synthetic derivative of artemisinin,a sesquiterpene trioxane lactone isolated from the herb Artemisia annua *** medicinal plant has been used as a remedy for fevers and chills for centuries in *** is a clinically effective drug for both uncomplicated and severe *** have recently found that artesunate may be effective for allergy,asthma and *** reported for the first time that artesunate effectively reduced ovalbumin-induced inflammatory cell recruitment into bron-choalveolar fluid,IL-4,IL-5,IL-13 and eotaxin production,pulmonary eosinophilia,mucus hypersecretion and airway hyperrespons-iveness in a mouse asthma model probably via inhibition of the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway[Cheng et al. (2011) PLoS ONE 6:e20932].Artesunate significantly suppressed ovalbumin-induced increases in oxidative damage markers 8-isoprostane, 8-hydroxy-2-deoxy-guanosine and 3-nitrotyrosine levels,and pro-oxidants iNOS and NADPH oxidase(NOX 1,2,3 and 4) ***,artesunate markedly suppressed passive cutaneous anaphylaxis,passive systemic anaphylaxis,ovalbumin-induced mast cell degranulation in the airways and serum histamine level,and IgE-mediated mast cell degranulation,probably mediated through reduction of inositol trisphosphate(IP) and intracellular Ca ***,artesunate was able to ameliorate pulmonary cell infiltration in a cigarette smoke induced COPD mouse *** together,our results clearly demonstrate broad-spectrum anti-inflammatory effects of artesunate in mouse models of asthma,allergy and COPD by inhibiting PI3K/Akt and IP/Ca signaling pathways. Our present findings support a novel therapeutic use of artesunate in the treatment of allergy,asthma and COPD.

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