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世界核心医学期刊文摘(神经病学分册) 2006年第10期 32-33页

作者： tyler k.l. Pape J. GoodyR.J. 赵天智 Neurology B- 182 University of Colorado Health Sciences Center 4200 East 9th Avenue Denver CO 80262 United States Dr.

Objective: To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome. Methods: CSF samples from 334 WNV- infected hospitalized patients were analyzed. Information was available and extracted from the medical records of 250 of these patients, and CSF parameters correlated with clinical and epidemiologic features of disease (e.g., patient age, sex, outcome). Results: Patients with meningitis had a mean of 226 cells/mm3,and those with encephalitis had a mean of 227 cells/*** percent of meningitis patients and 5% of encephalitis patients had fewer than 5 cells/mm3, and approximately 8% of both groups had more than 500 cells/mm3. Patients with meningitis had a mean of 41% neutrophils, and those with encephalitis had 45% . Forty- five percent of meningitis patients and 37% of encephalitis patients had at least 50% neutrophils in their initial CSF specimen. Neither the mean percent neutrophils nor their distribution differed significantly between groups. Forty- seven percent of encephalitis patients and 16% of meningitis patients had CSF protein of 100 mg/dl or greater (p lthough specific CSF parameters, including nucleated cell count and protein concentration, correlated significantly with outcome, multivariate analysis suggested that their total predictive value was modest. Age was an additional predictor of outcome independent of CSF variables in all patients. Conclusions: Serologically confirmed West Nile virus meningitis and encephalitis produce similar degrees of CSF pleocytosis and are frequently associated with substantial CSF neutrophilia. Patients with encephalitis have higher CSF protein concentrations and are more lik.l. to have adverse outcomes, including admission to long- term care facilities or even death after their acute illness. CSF findings were only a modest predictor of disease outcome, with patient age adding importan

关键词：脑炎 CSF 患者病毒性脑膜炎血清学检查结果尼罗河

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那他珠单抗与β-1a干扰素联合治疗多发性硬化症导致的进行性多灶性脑白质病

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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 4-4页

作者： kleinschmidt-De Masters B.k. tyler k.l. 郭俊 Dr. Department of Pathology B216 University of Colorado Health Sciences Center 4200 E. 9th Ave. Denver CO 80262 United States

A 46-year-old woman with relapsing-remitting multiple sclerosis died from progressive multifocal leukoencephalopathy (PMl) after having received 37 doses of natalizumab (300 mg every four weeks) as part of a clinical trial of natalizumab and interferon beta-1a. PMl was diagnosed on the basis of the finding of JC viral DNA in cerebrospinal fluid on polymerase-chain-reaction assay and was confirmed at autopsy. Nearly every tissue section from bilateral cerebral hemispheres contained either macroscopic or microscopic PMl lesions. There was extensive tissue destruction and cavitation in the left frontoparietal area, large numbers of bizarre astrocytes, and inclusion-bearing oligodendrocytes, which were positive for JC virus DNA on in situ hybridization.

关键词：多发性硬化症干扰素联合星形胶质细胞左侧额空洞形成两侧大脑半球组织破坏组织切片原位杂交临床试验

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： tyler A.Smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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教师主观幸福感量表的中文修订

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中国临床心理学杂志 2024年第4期32卷 887-892页

作者：谢家树柳剑锋林欣欣 Chunyan Yang 魏宇民蔺璐璐 Quennie Dong tyler l.Renshaw 湖南师范大学心理学系湖南师范大学认知与人类行为湖南省重点实验室长沙410081 上海市嘉定区武宁路实验小学上海201824 College of Education University of MarylandCollege ParkMD20742 中南林业科技大学心理健康教育中心长沙410004 Berk.l.y School of Education University of CaliforniaBerkeleyCA94720 Utah State University Psychology Department LoganUT84322

目的:检验教师主观幸福感量表(Teacher Subjective Well-being Questionnaire,TSWQ)中文修订版信度、效度及其跨教师性别、跨任教学段的测量等值性。方法:应用中文版TSWQ对来自全国9省份56所中学的1463名教师进行测量,以中小学教师职业... 详细信息

目的:检验教师主观幸福感量表(Teacher Subjective Well-being Questionnaire,TSWQ)中文修订版信度、效度及其跨教师性别、跨任教学段的测量等值性。方法:应用中文版TSWQ对来自全国9省份56所中学的1463名教师进行测量,以中小学教师职业倦怠量表和特拉华校园氛围量表-教工卷为效标工具,一个月后随机抽取55名教师进行重测。结果:(1)验证性因素分析结果支持一阶二因子模型。(2)中文版TSWQ总分与教师校园氛围感知、个人成就感显著正相关(r=0.465,P<0.01;r=0.416,P<0.01),与情绪衰竭、非人性化显著负相关(r=-0.226,P<0.01;r=-0.232,P<0.01)。(3)中文版TSWQ总量表的Cronbach’sα系数为0.898,四周后的重测信度为0.813。(4)多组验证性因素分析结果显示,中文版TSWQ跨性别和跨任教学段的测量等值性假设成立。(5)在教师主观幸福感量表的教学效能感维度存在显著性别差异,男教师教学效能感优于女教师。结论:中文版TSWQ信度与效度良好,可在不同教师性别、任教学段之间进行跨组比较,是研究我国教师主观幸福感的可靠工具。

关键词：主观幸福感心理健康信度效度测量等值性教师

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Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

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World Journal of Gastroenterology 2016年第29期22卷 6742-6756页

作者： tyler J Severson Siddesh Besur Herbert l Bonkovsky Department of Gastroenterology and Hepatology Wake Forest University NC Baptist Medical Center Abdominal Transplant Program Aurora St Luke’s Medical Center

AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease (NAFlD) onset, severity, and outcome through systematic literature ***: The authors conducted both systematic and specific searches of PubMed through December 2015 with special emphasis on more recent data (from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFlD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects ***: We focus particularly on genetic polymorphisms of the following genes: PNPlA3, particularly the p. I148M variant, TM6SF2, particularly the p. E167k variant, and on variants in FTO, lIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on lik.l.hood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFlD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized ***: Polymorphisms and genetic factors of several genes contribute to NAFlD and its end results. These genes hold keys to future improvements in diagnosis and management.

关键词： Genetic polymorphisms Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis PNPlA3 TM6SF2 FTO Cirrhosis Iron metabolism

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Effect of New Auxin Herbicide Formulations on Control of Herbicide Resistant Weeds and on Microbial Activities in the Rhizosphere

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American Journal of Plant Sciences 2016年第17期7卷 2429-2439页

作者： Vijay k. Nandula Heather l. tyler Crop Production Systems Research Unit U.S. Department of Agriculture-Agricultural Research Service Stoneville MS USA

Widespread distribution of glyphosate-resistant weeds in soybean-growing areas across Mississippi has economically affected soybean planting and follow-up crop management operations. New multiple herbicide-resistant crop (including soybean) technologies with associated formulations will soon be commercialized. The objectives of this research were to determine the efficacy of new 2,4-D + glyphosate and dicamba formulations on herbicide resistant weeds, and to determine the impact of the new 2,4-D + glyphosate formulation on microbial communities in the soybean rhizosphere involved in nutrient cycling. New 2,4-D + glyphosate and dicamba formulations registered for use on 2,4-D and dicamba-resistant soybean, respectively, adequately controlled glyphosate resistant and susceptible pigweeds (Palmer amaranth and tall waterhemp) and common ragweed. The 2,4-D + glyphosate formulation did not significantly impact soil microbial activities linked to nutrient cycling in the soybean rhizosphere. These results indicate these new 2,4-D + glyphosate and dicamba formulations can be effective in controlling glyphosate resistant and other herbicide resistant weeds while not having adverse effects on the activities of beneficial soil microorganisms.

关键词： 2 4-D Dicamba Glyphosate Resistance Soil Microbiology Soybean

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Update on endoscopic pancreatic function testing

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World Journal of Gastroenterology 2011年第35期17卷 3957-3961页

作者： tyler Stevens Mansour A Parsi Department of Gastroenterology and Hepatology Digestive Disease Institute The Cleveland Clinic FoundationCleveland OH 44195 United States

Hormone-stimulated pancreatic function tests (PFTs) are considered the gold standard for measuring pancreatic exocrine function. PFTs involve the administration of intravenous secretin or cholecystokinin, followed by collection and analysis of pancreatic secretions. Because exocrine function may decline in the earliest phase of pancreatic fibrosis, PFTs are considered accurate for diagnosing chronic pancreatitis. Unfortunately, these potentially valuable tests are infrequently performed except at specialized centers, because they are time consuming and complicated. To overcome these limitations, endoscopic PFT methods have been developed which include aspiration of pancreatic secretions through the suction channel of the endoscope. The secretin endoscopic pancreatic function test (ePFT) involves collection of duodenal aspirates at 15, 30, 45 and 60 min after secretin stimulation. A bicarbonate concentration greater than 80 mmol/l in any of the samples is considered a normal result. The secretin ePFT has demonstrated good sensitivity and specificity compared with various reference standards, including the "Dreiling tube" secretin PFT, endoscopic ultrasound, and surgical histology. Furthermore, a standard autoanalyzer can be used for bicarbonate analysis, which allows the secretin ePFT to be performed at any hospital. The secretin ePFT may complement imaging tests like endoscopic ultrasound (EUS) in the diagnosis of early chronic *** paper will review the literature validating the use of ePFT in the diagnosis of exocrine insufficiency and chronic pancreatitis. Newer developments will also be discussed, including the feasibility of combined EUS/ ePFT, the use of cholecystokinin alone or in combination with secretin, and the discovery of new protein and lipid pancreatic juice biomarkers which may complement traditional fluid analysis.

关键词： Endoscopic pancreatic function test Pancreatic function testing Chronic pancreatitis Pancreatic exocrine insufficiency

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Modeling the influence of livestock grazing pressure on grassland bird distributions

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Ecological Processes 2020年第1期9卷 488-498页

作者： Rachel R.Fern Michael l.Morrison William E.Grant Hsiaohsuan Wang tyler A.Campbell Department of Wildlife and Fisheries Sciences Texas A&M UniversityWFES Building2258 TAMU534 John Kimbrough BlvdCollege StationTX 77843-2258USA East Foundation San AntonioTX 78216USA

Background:The influence of vegetative changes due to livestock grazing on grassland birds is well-recognized because these birds are heavily influenced by vegetative ***,species distribution models(SDMs)use direct variables,resources that the animal consumes or requires to persist in an area(e.g.,water)to define and project a species’niche and *** variables,which are features the animal does not consume or require for persistence but with which it may still interact,are often *** objective was to improve the traditional SDMs projecting the distribution of three summer resident South Texas grassland birds(Northern Bobwhite Colinus virginianus,Eastern Meadowlark Sturnella magna,and Cassin’s Sparrow Peucaea cassinii)by incorporating livestock grazing pressure,an indirect variable,into five SDM algorithms:BioClim,generalized linear model,MaxEnt,boosted regression tree,and random *** collected data from the Coloraditas Grazing Research and Demonstration Area(CGRDA),a 7684-ha area located on the San Antonio Viejo Ranch(SAV)in South *** used several relevant environmental characteristics to build SDMs and compared model performance(AUC and TSS)with and without grazing pressure as an indirect ***:Machine learning models(MaxEnt and random forest)had the highest predictive performance for all species,with random forest being the most consistent for each *** and generalized linear model remained constant or only marginally improved with the addition of the grazing ***:Our findings suggest that model selection for SDM should include consideration of species prevalence,and machine-learning algorithms should be preferred when the target species is of low or unknown ***,livestock grazing has measurable influence on grassland bird species’distributions and should be included in SDMs as an indirect variable in addition to associated vegetative changes.

关键词： Birds Grassland Grazing livestock Species distribution model Texas

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Subcutaneous fatty acid composition of steers finished as weanlings or yearlings with and without growth promotants

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Journal of Animal Science and Biotechnology 2014年第1期5卷 98-105页

作者： Cletos Mapiye tyler D Turner John A Basarab Vern S Baron Jennifer l Aalhus Michael ER Dugan Agriculture and Agri-Food Canada Lacombe Research Centre 6000 C & E Trail Lacombe Alberta T4L 1 W1 Canada Alberta Agriculture and Rural Development Lacombe Research Centre 6000 C & E Trail Lacombe Alberta T4L 1 W1 Canada

Background： The current study evaluated the subcutaneous fatty acid （FA） composition of calf- and yearling-fed steer with or without growth promoting implants. Crossbred steers （n = 112; 267 ± 5.0 kg） of the same contemporary group were allocated to one of four production system and implant strategy based treatments in a completely randomized design with a 2 × 2 factorial arrangement of treatments. Results： There were no interactions （P 〉 0.05） between production systems and growth promoting implants for the total and individual subcutaneous FA. Yearling as opposed to calf finishing reduced （P 〈 0.05） subcutaneous proportions of C20：3n-6, trans （t）l 2-18：1, C14：0, several minor cis-monounsaturated FA （c-MUFA; c9-14：1, c11-16：1, cl 1-18：1, cl 2-18：1, cl 3-18：1, c9-20：1 and cl 1-20：1）, and increased （P 〈 0.05） subcutaneous proportions of tl 1 cl 5-18：2, total and individual branched-chain FA. Subcutaneous fat from steers implanted with growth promotants had higher （P 〈 0.05） proportions of total polyunsaturated FA （PUFA）, total n-6 PUFA, C18：2n-6 and individual t-18：1 isomers （t6 to tl0） compared to non-implanted steers. Conclusions： Overall, current findings show that production systems and growth promotants led to only minor differences in subcutaneous FA composition of beef steers.

关键词： Age at feedlot entry Beef Fatty acids Growth implant Steers

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Foliar Dicamba Application Has No lasting Effects on Microbial Activities in the Soybean Rhizosphere

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American Journal of Plant Sciences 2020年第11期11卷 1706-1713页

作者： Heather l. tyler Crop Production Systems Research Unit U.S. Department of Agriculture Agricultural Research Service Stoneville USA

The proliferation of glyphosate-resistant weeds has resulted in significant losses in the productivity of crops such as corn, soybean, and cotton. As a result, new crop varieties with resistance genes from other herbicides, such as 2,4-D and dicamba, have been developed as part of alternative weed control cropping systems. However, little is known about how the application of these herbicides impacts the microorganisms that carry out nutrient cycling in the soil of these cropping systems, particularly in the rhizosphere, the soil compartment immediately adjacent to the root system which is pivotal to plant nutrient uptake. The purpose of the current study was to assess the effects of dicamba on soil enzyme activities linked to C, N, and P cycling in the rhizosphere of resistant soybean plants. While dicamba had no significant effects on the acle="font-family:Verdana;">tivities of enzymes linked to C or P cycling in the rhizosphere, N-acetylglucosaminidase activity was temporarily inhibited, but recovered by three days after application. These results suggest there are no long-lasting negative effects of dicamba in the rhizosphere of treated plants when applied at field rates.

关键词： Dicamba Rhizosphere Soybean Soil Microbial Activities

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