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完美数及其相关问题

数学进展 2024年第4期53卷 673-689页

作者：蔡天新 tyler rOSS 浙江大学数学科学学院杭州浙江310058

完美数问题是最古老的数学问题之一,可能来源于古希腊的毕达哥拉斯学派,被意大利当代数学家奥迪弗雷迪列为面向21世纪的“四大数学难题”之首.本文对古老的完美数问题及相关的梅森素数进行综述,尤其是对其拓展为平方完美数、立方完美数... 详细信息

完美数问题是最古老的数学问题之一,可能来源于古希腊的毕达哥拉斯学派,被意大利当代数学家奥迪弗雷迪列为面向21世纪的“四大数学难题”之首.本文对古老的完美数问题及相关的梅森素数进行综述,尤其是对其拓展为平方完美数、立方完美数及S-完美数以后所产生的问题进行了综述.

关键词：完美数平方完美数立方完美数 S-完美数

Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

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Cancer Communications 2024年第8期44卷 884-888页

作者： Sung Hee Choi Jay Thomas Myers Suzanne Louise Tomchuck Melissa Bonner Saada Eid Daniel tyler Kingsley Kristen Ashley Van Heyst Seong-Jin Kim Byung-Gyu Kim Alex Yee-Chen Huang Department of Pediatrics CaseWestern Reserve University School of MedicineClevelandOhioUSA Case Comprehensive Cancer Center CaseWestern Reserve University School of MedicineClevelandOhioUSA Department of Pathology CaseWestern Reserve University School of MedicineClevelandOhioUSA MedPacto Inc. SeoulRepublic of Korea Center for Pediatric Immunotherapy Angie Fowler AYA Cancer InstituteUH Rainbow Babies and Children’s HospitalClevelandOhioUSA

Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young *** 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma *** survival ou... 详细信息

关键词： osteosarcoma immunity patients

Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

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Chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： Nicholas r.Powell tyler Shugg Jacob Leighty Matthew Martin rolf P.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd C.Skaar Division of Clinical Pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger rNA(mrNA)is endogenously bound by mir-122-5p and rs699 A>G decreases reporter mrNA in the microrNA functional-assay *** AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase mir-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microrNA-binding site in the AGT ***,rs699 A>G increases AGT mrNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mrNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

Cooling High Power Dissipating Artificial Intelligence (AI) Chips Using refrigerant

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Journal of Electronics Cooling and Thermal Control 2024年第2期13卷 35-49页

作者： Waheeb Mukatash Hussameddine Kabbani Jochem Marc Massalt Matthew Moscoso Merari Mejia robles tyler Yang Charlie Nino Department of Mechanical Engineering San Jose State University San Jose USA

High power dissipating artificial intelligence (AI) chips require significant cooling to operate at maximum performance. Current trends regarding the integration of AI, as well as the power/cooling demands of high-performing server systems pose an immense thermal challenge for cooling. The use of refrigerants as a direct-to-chip cooling method is investigated as a potential cooling solution for cooling AI chips. Using a vapor compression refrigeration system (VCrS), the coolant temperature will be sub-ambient thereby increasing the total cooling capacity. Coupled with the implementation of a direct-to-chip boiler, using refrigerants to cool AI server systems can materialize as a potential solution for current AI server cooling demands. In this study, a comparison of 8 different refrigerants: r-134a, r-153a, r-717, r-508B, r-22, r-12, r-410a, and r-1234yf is analyzed for optimal performance. A control theoretical VCrS model is created to assess variable refrigerants under the same operational conditions. From this model, the coefficient of performance (COP), required mass flow rate of refrigerant, work required by the compressor, and overall heat transfer coefficient is determined for all 8 refrigerants. Lastly, a comprehensive analysis is provided to determine the most optimal refrigerants for cooling applications. r-717, commonly known as Ammonia, was found to have the highest COP value thus proving to be the optimal refrigerant for cooling AI chips and high-performing server applications.

关键词： Artificial Intelligence Thermal Control Server Systems Vapor Compression refrigeration Cycle Server Cooling

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural regeneration research 2025年第4期20卷 1192-1206页

作者： tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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教师主观幸福感量表的中文修订

中国临床心理学杂志 2024年第4期32卷 887-892页

作者：谢家树柳剑锋林欣欣 Chunyan Yang 魏宇民蔺璐璐 Quennie Dong tyler L.renshaw 湖南师范大学心理学系湖南师范大学认知与人类行为湖南省重点实验室长沙410081 上海市嘉定区武宁路实验小学上海201824 College of Education University of MarylandCollege ParkMD20742 中南林业科技大学心理健康教育中心长沙410004 Berkeley School of Education University of CaliforniaBerkeleyCA94720 Utah State University Psychology Department LoganUT84322

目的:检验教师主观幸福感量表(Teacher Subjective Well-being Questionnaire,TSWQ)中文修订版信度、效度及其跨教师性别、跨任教学段的测量等值性。方法:应用中文版TSWQ对来自全国9省份56所中学的1463名教师进行测量,以中小学教师职业... 详细信息

目的:检验教师主观幸福感量表(Teacher Subjective Well-being Questionnaire,TSWQ)中文修订版信度、效度及其跨教师性别、跨任教学段的测量等值性。方法:应用中文版TSWQ对来自全国9省份56所中学的1463名教师进行测量,以中小学教师职业倦怠量表和特拉华校园氛围量表-教工卷为效标工具,一个月后随机抽取55名教师进行重测。结果:(1)验证性因素分析结果支持一阶二因子模型。(2)中文版TSWQ总分与教师校园氛围感知、个人成就感显著正相关(r=0.465,Pr=0.416,Pr=-0.226,Pr=-0.232,Pronbach’sα系数为0.898,四周后的重测信度为0.813。(4)多组验证性因素分析结果显示,中文版TSWQ跨性别和跨任教学段的测量等值性假设成立。(5)在教师主观幸福感量表的教学效能感维度存在显著性别差异,男教师教学效能感优于女教师。结论:中文版TSWQ信度与效度良好,可在不同教师性别、任教学段之间进行跨组比较,是研究我国教师主观幸福感的可靠工具。

关键词：主观幸福感心理健康信度效度测量等值性教师

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radiographic features and behaviors of neuroendocrine tumors:can we judge a book by its cover?

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 573-574页

作者： tyler J.Mouw Charles r.Scoggins Hiram C.Polk JrMD Department of SurgeryDivision of Surgical OncologyUniversity of LouisvilleLouisvilleKYUSA

Gastrointestinal and pancreatic neuroendocrine tumors are uncommon diseases which can have a varied clinical *** category of tumor includes functional and non-functional variants and despite the common developmental pathway for the cells of origin,the tumor subtypes can demonstrate strikingly different *** to the rarity and heterogeneous courses of this family of tumors.

关键词： tumors neuroendocrine diseases

Formidable females redux:male social integration into female networks and the value of dynamic multilayer networks

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Current Zoology 2021年第1期67卷 49-57页

作者： tyler r.BONNELL ChloéVILETTE Christopher YOUNG Stephanus Peter HENZI ouise BArrETT Department of Psychology University of Lethbridge4401 University DriveLethbridgeT1K 3M4Canada Applied Behavioural Ecology and Ecosystems research Unit University of South AfricaFloridaGautengSouth Africa Endocrine research Laboratory Mammal Research InstituteFaculty of Natural and Agricultural ScienceUniversity of PretoriaPretoriaSouth Africa

The development of multilayer network techniques is a boon for researchers who wish to understand how different interaction layers might influence each other,and how these in turn might influence group ***,we investigate how integration between male and female grooming and aggression interaction networks influences male power trajectories in vervet monkeys Chlorocebus *** previous analyses of this phenomenon used a monolayer approach,and our aim here is to extend these analyses using a dynamic multilayer *** do so,we constructed a temporal series of male and female interaction *** then used a multivariate multilevel autoregression model to compare cross-lagged associations between a male's centrality in the female grooming layer and changes in male Elo *** results confirmed our original findings:changes in male centrality within the female grooming network were weakly but positively tied to changes in their Elo ***,the multilayer network approach offered additional insights into this social process,identifying how changes in a male's centrality cascade through the other network *** dynamic view indicates that the changes in Elo ratings are likely to be short-lived,but that male centrality within the female network had a much stronger impact throughout the multilayer network as a whole,especially on reducing intermale aggression(i.e.,aggression directed by males toward other males).We suggest that multilayer social network approaches can take advantage of increased amounts of social data that are more commonly collected these days,using a variety of *** data are inherently multilevel and multilayered,and thus offer the ability to quantify more precisely the dynamics of animal social behaviors.

关键词： multilayer networks multilevel multivariate autoregressive model primate social dynamics social networks sociality time-aggregated networks vervet monkeys

Emerging role of microrNAs in lipid metabolism

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Acta Pharmaceutica Sinica B 2015年第2期5卷 145-150页

作者： Zhihong Yang tyler Cappello Li Wang Department of Physiology and Neurobiology and the Institute for Systems Genomics University of Connecticut Veterans Affairs Connecticut Healthcare System Department of Internal Medicine Section of Digestive Diseases Yale University

micro rNAs(mi rNAs or mi rs) are small non-coding rNAs that are involved in posttranscriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that mi rNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of mi rNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of mi rNAs expression. We emphasized on several representative mi rNAs that are functionally involved into lipid metabolism, including mi r-33/33 n, mi r122, mi r27a/b, mi r378/378 n, mi r-34 a and mi *** the function of mi rNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease.

关键词： Lipid metabolism microrNAs Nuclear receptors