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Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Bioactive Materials 2019年第1期4卷 97-106页

作者： Sandeep Dhall turhan coksaygan Tyler Hoffman Matthew Moorman Anne Lerch Jin-Qiang Kuang Malathi Sathyamoorthy Alla Danilkovitch Osiris Therapeutics Inc.7015 Albert Einstein DrColumbiaMD21046USA University of Maryland 655 W.Baltimore StreetBaltimoreMD21201USA

Post-operative adhesions,a common complication of surgery,cause pain,impair organ functionality,and often require additional surgical *** of inflammation,protection of injured tissue,and rapid tissue repair are critical for adhesion *** barriers are biomaterials used to prevent adhesions by physical separation of opposing injured *** adhesion barriers have poor anti-inflammatory and tissue regenerative *** cord tissue(UT),a part of the placenta,is inherently soft,conforming,biocompatible,and biodegradable,with antimicrobial,anti-inflammatory,and antifibrotic properties,making it an attractive alternative to currently available adhesion *** use of fresh tissue is preferable,availability and short storage time limit its clinical use.A viable cryopreserved UT(vCUT)“point of care”allograft has recently become *** retains the extracellular matrix,growth factors,and native viable cells with the added advantage of a long shelf life at−80℃.In this study,vCUT's anti-adhesion property was evaluated in a rabbit abdominal adhesion *** cecum was abraded on two opposing sides,and vCUT was sutured to the abdominal wall on the treatment side;whereas the contralateral side of the abdomen served as an internal untreated *** and histological evaluation was performed at 7,28,and 67 days *** adhesions were detectable on the vCUT treated side at all time *** scores for adhesion,inflammation,and fibrosis were lower on the vCUT treated side as compared to the control *** conclusion,the data supports the use of vCUT as an adhesion barrier in surgical procedures.

关键词： Placental Cryopreserved Post-surgical Adhesiolysis Inflammation Fibrosis

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