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Association between change in HDL-C and vascular events in patients treated with statins: Report from the UK general practice research database

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World Journal of Cardiovascular Diseases 2012年第2期2卷 64-73页

作者： Lori D. Bash tun-ying hsu Vasilisa Sazonov Baishali Ambegaonkar Department of Epidemiology University of Medicine and Dentistry of New Jersey Piscataway USA Global Health Outcomes Merck & Co. Inc. Whitehouse Station USA

Dyslipidemia, including low levels of high-density lipoprotein cholesterol (HDL-C), is a relatively well-established risk factor for cardiovascular disease. However, the independent association between changes in HDL-C and the subsequent risk of cardiovascular events has not been well studied. The retrospective cohort analysis was conducted to evaluate the association between changes in HDL-C and cardiovascular (CV) and/or cerebrovascular (CB) events among statin-treated patients. Patient demo-graphics, clinical characteristics, laboratory data, and CV/CB events, were collected from the UK General Practice Research Database. The association between the risk of an incident event and changes in patients’ HDL-C was estimated using multivariate Cox pro-portional hazards models. Among 17,923 statin-treated patients with an average follow-up of 1.9 years, there were 815 CV events and 220 CB events. The average change in HDL-C experienced was 0.4 mg/dL, ranging from 11 mg/dL average decrease in the lowest change quartile to 12 mg/dL average increase in the highest change quartile. CV events occurred at an average overall rate of 21 per 1000 person-years and 17 per 1000 person-years among individuals in the highest quartile of change in HDL-C levels. Fully adjusted Cox regression estimated a 6% decrease in hazards (HR, 0.94;95% CI, 0.90, 0.98) of a subsequent CV event associated with each 5 mg/dL increase in HDL-C. Similar results (HR: 0.95, 95% CI, 0.92, 0.98) were observed when assessing the association with changes in HDL-C and the composite outcome of CV/CB event. Among statin-treated patients from UK clinical practices, increases in HDL-C were associated with a significantly decreased relative risk of experiencing CV/CB events with a more pronounced effect on CV events. Therefore, a more aggressive treatment to increase HDL-C could benefit patients by reducing the risk of CV/CB events.

关键词： LDL-C HDL-C CV and CB Event and LMT

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High-performance Bi_(2)S_(3)/ZnO photoanode enabled by interfacial engineering with oxyanion for efficient photoelectrochemical water oxidation

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Nano Research 2024年第7期17卷 5996-6005页

作者： ying-Chu Chen Hsiang-Yu Jui Yichen Feng Yun-Hsiang Lu Yu-Kuei hsu Department of Chemical Engineering&Biotechnology "National Taipei University of Technology"No.1Sec.3Zhong-Xiao E.Rd.Da'an Dist.Taipei City 10608TaiwanChina Department of Opto-Electronic Engineering "National Dong Hwa University"No.1Sec.2Da Hsueh RoadShoufengHualien 97401TaiwanChina China-UK Low Carbon College Shanghai Jiao Tong UniversityNo.3Yinlian RoadLingangShanghai 201306China

In the present contribution,we demonstrate that the sluggish kinetics of oxygen evolution reaction(OER)over the bismuth sulfide(Bi_(2)S_(3))photoanode,which severely restricts its photoelectrochemical activity,is markedly accelerated by employing a sulfatecontaining ***-principle calculation points to the spontaneous adsorption of sulfate(SO_(4)^(2−))on Bi_(2)S_(3)and its capacity of stabilizing the OER intermediates through hydrogen bonding,which is further reinforced by increasing the local density of states near the Fermi level of Bi_(2)S_(3).Meanwhile,the electron transfer is also promoted to synergistically render the ratedetermining step(from O*to OOH*)of OER over Bi_(2)S_(3)kinetically *** but not least,benefitting from such enhanced OER activity and efficient charge separation resulted from depositing Bi_(2)S_(3)on the zinc oxide nanorods(ZnO NRs),forming a core–shell heterojunction,its photocurrent density achieves 8.61 mA·cm^(−2)at 1.23 VRHE,far surpassing those reported for additional Bi_(2)S_(3)-based and several state-of-the-art photoanodes in the literature and further exceeding their theoretical *** great promise of the Bi_(2)S_(3)/ZnO NRs is in view of such outperformance,the superior Faradaic yield of oxygen of more than~80%and the outstanding half-cell applied bias photon-to-current efficiency of~1%well corroborated.

关键词： photoelectrochemical water oxidation oxyanion adsorption electronic structure regulation oxygen evolution reaction(OER)intermediates stabilization Bi_(2)S_(3)

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Non-volatile dynamically switchable color display via chalcogenide stepwise cavity resonators

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Opto-Electronic Advances 2024年第1期7卷 16-27页

作者： Kuan Liu Zhenyuan Lin Bing Han Minghui Hong tun Cao School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China Pen-tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Institute of Laser Engineering Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic *** trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying ***,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity *** device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost *** switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively *** color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase ***,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far *** minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) *** switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,***,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.

关键词： tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials

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Advancing cancer nanomedicine with machine learning

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4183-4185页

作者： Xifeng Qin tun Lu Zhiqing Pang School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China School of Computer Science Fudan UniversityShanghai 200438China

Nanomedicine,a captivating and highly promising field in biomedicine,is driving the transformation of medical technologies and treatments,catalyzing revolutionary advancements in areas such as cancer therapy,drug delivery,diagnostics,and *** the notable progress in nanomedicine to tackle the complexities of various diseases,the biomedical sector is presented with abundant opportunities for innovation and *** this process,machine learning(ML)and artificial intelligence(AI)emerge as pivotal themes in the realm of science and *** are reshaping our lifestyles and workplaces with unparalleled rapidity and magnitude,while also providing fresh possibilities and potentials for the evolution of nanomedicine。

关键词： Machine learning Artificial intelligence Nanomedicine Drug design Cancer treatment

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What role do emission trading schemes,energy innovation,and technology transfer play in sustainable recovery?A perspective from BRICS economies

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Geoscience Frontiers 2024年第4期15卷 505-517页

作者： YunQian Zhang Ching-Chi hsu School of Finance Fuzhou University of International Studies and TradeFuzhou 350202China City University of Macao Avenida Padre Tomás Pereira TaipaMacaoChina Carbon Economy Research Center Fuzhou University of International Studies and TradeFuzhou 350202China

To ensure long-run sustainability,it is imperative to achieve the goal of zero-carbon emissions without compromising economic *** whether BRICS economies,which are an attractive set of countries due to their rapid economic growth and high emissions,can shift towards sustainability with the support of policy measures,is a question which needs to be *** article investigates the impact of emission trading schemes,energy innovation,technology transfer,population growth,and inflation on the economic performance of BRICS economies(2001-2020).The outcomes of the CS-ARDL and PMG estimators reveal that carbon taxes,carbon finance,energy innovation,technology transfer,population growth,and inflation have positive effects on economic *** light of the evidence,policy insights are recommended to achieve a win-win situation for economic and environmental performance.

关键词： Emission trading schemes Carbon taxes Carbon finance Energy innovation Technology transfer Economic performance

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A Novel Method for Forecasting Freak Wave Occurrence in A Short Crested Coastal Sea

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China Ocean Engineering 2024年第1期38卷 104-116页

作者： WANG ying-guang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In order to forecast the distribution of crest amplitudes and the occurrence of freak waves in a short crested coastal sea,a novel transformed linear simulation method is initially proposed in this paper.A Hermite transformation model expressed as a monotonic cubic polynomial serves as the foundation for the novel simulation *** wave crest amplitude exceedance probabilities of two sea states-one with a directional wave spectrum based on the measured wave elevation data at the Yura coast and the other with a typical directional JONSWAP wave spectrum-have been predicted using the novel simulation method that has been *** likelihood that a particular critical wave crest amplitude will be exceeded is directly correlated with the probability that freak waves will *** is shown that the novel simulation approach suggested can provide predictions that are more precise than those obtained from the Rayleigh crest amplitude distribution model,the Jahns and Wheeler crest amplitude distribution model,or the conventional linear simulation *** study also demonstrated that the nonlinear simulation method is less effective than the novel simulation method in terms of efficiency.

关键词： wave crest amplitude freak waves short crested sea transformed linear simulation

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Light People:*** D C Bradley(FRS)

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Light(Science & Applications) 2024年第9期13卷 1704-1719页

作者： Ruidong Xia ying Hu Key Laboratory for Organic Electronics&Information Displays(KLOEID) Jiangsu-Singapore Joint Research Center for Organic/Bio Electronics&Information DisplaysInstitute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China Executive Management College of CHN ENERGY North District of Future Science CityChangping DistrictNo.7 Binhe AvenueBeijing 102211China

Editorial,The invention of organic light emitting diodes(LEDs)led to enormous excitement in both academe and industry in the late 1980’***,large area solution processability,roll-to-roll printing,low cost,and environmentally friendly are some of the advantages of organic semiconductor materials,which brought a new horizon for *** with the achievement of organic solar cells,transistors,lasers,and amplifiers,this has demonstrated potential applications of organic semiconductors in displays,lighting,solar energy generation,electronics,sensing and imaging,and many aspects of *** an enlightened conversation with Light:Science&Applications,*** Bradley(FRS),a pioneer in the field,shared his deep insights on past,current,and future exciting developments of organic optoelectronic materials and *** particular,he expressed his opinion on the hot topics related to organic optoelectronics research and application,such as the relationship between organic and inorganic semiconductors and the challenge of electrically pumped organic *** a successful scientist,Donal has also been co-founder of several organic optoelectronics innovation companies and research centers and a long-term academic administrator serving as a Head of Department,Centre Director,and Vice-Rector for Research at Imperial College,Head of the Mathematical,Physical,and Life Sciences Division at the University of Oxford,Vice-President for Research at King Abdullah University of Science and Technology and now Vice-President for Research and Innovation at NEOM U and Executive Director of the NEOM Education,Research and Innovation *** this interview,we also explore the major roles and events in Donal’s career experience from the invention of the first conjugated polymer LED in the world to the set-up of entrepreneurial companies,from Cambridge to Sheffield,Imperial College,and Oxford,from the UK to overseas,and from the establishment of the Cent

关键词： companies Director Bradley

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Classification of knowledge graph completeness measurement techniques

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Journal of Systems Engineering and Electronics 2024年第1期35卷 154-162页

作者： ZHANG ying XIAO Gang Institute of Systems Engineering Academy of Military SciencesBeijing 100107China

At present,although knowledge graphs have been widely used in various fields such as recommendation systems,question and answer systems,and intelligent search,there are always quality problems such as knowledge omissions and *** assessment and control,as an important means to ensure the quality of knowledge,can make the applications based on knowledge graphs more complete and more accurate by reasonably assessing the knowledge graphs and fixing and improving the quality problems at the same ***,as an indispensable part of the knowledge graph construction process,the results of quality assessment and control determine the usefulness of the knowledge *** them,the assessment and enhancement of completeness,as an important part of the assessment and control phase,determine whether the knowledge graph can fully reflect objective phenomena and reveal potential connections among *** this paper,we review specific techniques of completeness assessment and classify completeness assessment techniques in terms of closed world assumptions,open world assumptions,and partial completeness *** purpose of this paper is to further promote the development of knowledge graph quality control and to lay the foundation for subsequent research on the completeness assessment of knowledge graphs by reviewing and classifying completeness assessment techniques.

关键词： quality assessment completeness assessment closed world assumptions open world assumption partial completeness assumption

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Learning layout generation for virtual worlds

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Computational Visual Media 2024年第3期10卷 577-592页

作者： Weihao Cheng ying Shan ARC Lab TencentShenzhen 518057China

The emergence of the metaverse has ledto the rapidly increasing demand for the generation ofextensive 3D worlds. We consider that an engagingworld is built upon a rational layout of multiple landuse areas (e.g., forest, meadow, and farmland). Tothis end, we propose a generative model of landuse distribution that learns from geographic *** model is based on a transformer architecturethat generates a 2D map of the land-use layout,which can be conditioned on spatial and semanticcontrols, depending on whether either one or bothare provided. This model enables diverse layoutgeneration with user control and layout expansion byextending borders with partial inputs. To generatehigh-quality and satisfactory layouts, we devise ageometric objective function that supervises the modelto perceive layout shapes and regularize generationsusing geometric priors. Additionally, we devise aplanning objective function that supervises the modelto perceive progressive composition demands andsuppress generations deviating from controls. Toevaluate the spatial distribution of the generations, wetrain an autoencoder to embed land-use layouts intovectors to enable comparison between the real andgenerated data using the Wasserstein metric, which isinspired by the Fr´echet inception distance.

关键词： layout generation virtual worlds Transformer land-use

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Light People:Professor Che Ting Chan,curiosity drives to create the impossibilities

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Light(Science & Applications) 2024年第7期13卷 1229-1233页

作者： Tingting Sun ying Xiong Light Publishing Group Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesNo.3888 Dong Nanhu RoadChangchun 130033China College of Intelligence Science and Technology National University of Defense TechnologyNo.109 Deya RoadChangsha 410073China

Editorial“When something is said to be impossible,there are two points for researchers to initially clarify:whether it really is forbidden by the laws of nature;or whether it is simply that no material that currently exists in nature can do that.”Metamaterials are such magical beings,which have physical properties like invisibility,negative refraction,super-resolution,and perfect absorption that are absent from natural *** has been rated by Science as one of the top ten scientific and technological breakthroughs affecting human beings in the 21st *** this issue of Light People,we spoke with a“magic”creator,Professor Che Ting Chan,the Associate VicePresident(Research&Development)of the Hong Kong University of Science and Technology(HKUST),Member of the Hong Kong Academy of Sciences and Fellow of the American Physical *** has researched a number of theoretical problems in material physics,investigated the theory behind what they seek to achieve,and modulated light(electromagnetism)and acoustic waves through *** the following,let’s take a closer look at Professor Che Ting Chan’s research life,and appreciate his style and the background of his accomplishment.

关键词： breakthrough closer visibility

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