检索结果-南通市图书馆

Rapid and efficient characterization of cervical collagen orientation using linearly polarized colposcopic images

Journal of Innovative Optical Health Sciences 2023年第5期16卷 21-31页

作者： Cat Phan Ngoc Khuong Dung Nguyen Huu Quang Hai Pham Thanh Long Nguyen Quynh Nguyen Ngoc Duc Le Huynh Tien Tran Van tu ly anh Department of Applied Physics Ho Chi Minh City University of Technology 268 ly Thuong Kiet Street District 10 Ho Chi Minh City 700000Vietnam Quality Management Department Tu Du Hospital 284 Cong QuynhDistrict 1 Ho Chi Minh City 700000Vietnam Department of Biomedical Engineering Nguyen Tat Thanh University 300A Nguyen Tat Thanh District 4Ho Chi Minh City 700000Vietnam Faculty of Science and Technology Jean Monnet University 11 Rue du Docteur Annino Saint Etienne 42000France

Collagen provides tissue strength and structural *** fication of the orientated dispersion of collagen fibers is an important factor when studying the mechanical properties of the *** this study,for the first time,a new method for rapid characterization of the collagen fiber orientations of the cervix using linearly polarized light colposcopy is presented.A total of 24 colposcopic images were captured using a cross-polarized imaging system with white LED light *** the preprocessing stage,the Red channel of the RGB image was chosen,which contains no information of the blood vessels because of the low-absorption of blood cells in the red ***,which is an ImageJ plug-in,was used to estimate the local orientation of the collagen *** result shows that in the nonpregnant cervix,the middle zone(Zone 2)has circumferentially aligned collagen fibers while the inner zone(Zone 1)has randomly *** collagen fiber dispersion in Zone 2 is much smaller than that in Zone 1 at all four quadrants region(anterior,posterior,left,and right quadrant).This new analysis technique could potentially combine with diagnostic tools to provide a quantitative platform of collagen fibers in the clinic.

关键词： Cervix collagen fibers collagen orientation coherency cross-polarized imaging colposcopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach

引用

Defence Technology（防务技术） 2024年第8期38卷 171-193页

作者： Thuy Tran Thi Thu tu Nguyen anh Hue Nguyen Thi Hong Nguyen Thi School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Technical Fundamental University of Transport TechnologyHanoiViet Nam Faculty of Mechanical Engineering Thuyloi University175 Tay SonDong DaHanoiViet Nam

Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures.

关键词： Blast load Modified first-order shear theory Biological composite structures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical review and literature analysis of hepatic epithelioid angiomyolipoma in alcoholic cirrhosis: A case report

引用

World Journal of Clinical Cases 2024年第14期12卷 2382-2388页

作者： Jing-Qiang Guo Jia-Hui Zhou Kun Zhang Xin-Liang Lv Chao-Yong tu Department of Hepatobiliary and Pancreatic Surgery Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack ***,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis *** article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this *** SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the *** on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was *** pathology showed *** outpatient follow-up,the patient showed no sign of *** HEA is difficult to make a definite diagnosis before *** has the poten-tial for malignant *** conditions permit,surgical treatment is recom-mended.

关键词： Hepatic epithelioid angiomyolipoma Alcoholic cirrhosis Magnetic resonance imaging Computed tomography Immunohistochemistry Misdiagnose analysis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting shear strength of slender beams without reinforcement using hybrid gradient boosting trees and optimization algorithms

引用

Frontiers of Structural and Civil Engineering 2022年第10期16卷 1267-1286页

作者： Thuy-anh NGUYEN Hai-Bang ly Van Quan TRAN Department of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam

Shear failure of slender reinforced concrete beams without stirrups has surely been a complicated occurrence that has proven challenging to adequately *** primary purpose of this work is to develop machine learning models capable of reliably predicting the shear strength of non-shear-reinforced slender beams(SB).A database encompassing 1118 experimental findings from the relevant literature was compiled,containing eight distinct *** Boosting(GB)technique was developed and evaluated in combination with three different optimization algorithms,namely Particle Swarm Optimization(PSO),Random Annealing Optimization(RA),and Simulated Annealing Optimization(SA).The findings suggested that GB-SA could deliver strong prediction results and effectively generalizes the connection between the input and output *** values and two-dimensional PDP analysis were then carried *** may use the findings in this work to define beam’s geometrical components and material used to achieve the desired shear strength of SB without reinforcement.

关键词： slender beam shear strength gradient boosting optimization algorithms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theaflavin-3，3′-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating SERCA2

引用

Food Science and Human Wellness 2024年

作者： Kaixi Wang Huanqing Zhu Jiaxin Kang Shuna Chen Puming He Youying tu Bo Li Department of Tea Science， College of Agriculture and Biotechnology， Zhejiang University

Theaflavins from black tea effectively improve insulin secretion in obesity and diabetes， but the molecular mechanisms are unclear. Here， the palmitic acid (PA)-induced pancreatic β-TC-6 cells and high fat-/high glucose-induced zebrafish were used. The effects of theaflavin-3，3′-digallate (TF3) on glucolipotoxicity-induced insulin secretion dysfunction， ferroptosis and endoplasmic reticulum (ER) stress were investigated by a variety of molecular biological approaches， inductively coupled plasma-mass spectrometry， transmission electron microscopy and widely targeted metabolomics analysis. TF3 was found to potently inhibit glucolipotoxicity-induced insulin secretion dysfunction and ferroptosis in β-TC-6 cells and zebrafish， with increasing glutathione peroxidase 4 (GPX4) expression， suppressing lipid peroxidation and iron accumulation and protecting mitochondria. Additionally， TF3 attenuated ER stress by regulating three unfolded protein response (UPR) pathways in β-TC-6 cells， and significantly modulated linoleic acid metabolism and L-kynurenine (Kyn) signalling in zebrafish. The expression of sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) was obviously enhanced by TF3. Thapsigargin (Tg)， a SERCA2 inhibitor， remarkably reversed the effects of TF3 on insulin production， ferroptosis， ER stress and the Kyn signalling. Together， this work revealed for the first time the critical role of SERCA2 in ferroptosis regulation， and demonstrated TF3 targeted SERCA2 to inhibit ER stress and ferroptosis， thereby protecting β-cell secretory function from glucolipotoxicity.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A hybrid machine learning model to estimate self-compacting concrete compressive strength

引用

Frontiers of Structural and Civil Engineering 2022年第8期16卷 990-1002页

作者： Hai-Bang ly Thuy-anh NGUYEN Binh Thai PHAM May Huu NGUYEN Civil Engineering Department University of Transport TechnologyHanoi 100000Vietnam Civil and Environmental Engineering Program Graduate School of Advanced Science and EngineeringHiroshima UniversityHiroshima 739-8527Japan

This study examined the feasibility of using the grey wolf optimizer(GWO)and artificial neural network(ANN)to predict the compressive strength(CS)of self-compacting concrete(SCC).The ANN-GWO model was created using 115 samples from different sources,taking into account nine key SCC *** validation of the proposed model was evaluated via six indices,including correlation coefficient(R),mean squared error,mean absolute error(MAE),IA,Slope,and mean absolute percentage *** addition,the importance of the parameters affecting the CS of SCC was investigated utilizing partial dependence *** results proved that the proposed ANN-GWO algorithm is a reliable predictor for SCC’s *** that,an examination of the parameters impacting the CS of SCC was provided.

关键词： artificial neural network grey wolf optimize algorithm compressive strength self-compacting concrete

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of different machine learning techniques in predicting the compressive strength of self-compacting concrete

引用

Frontiers of Structural and Civil Engineering 2022年第7期16卷 928-945页

作者： Van Quan TRAN Hai-Van Thi MAI Thuy-anh NGUYEN Hai-Bang ly Faculty of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam

The compressive strength of self-compacting concrete(SCC)needs to be determined during the construction design *** paper shows that the compressive strength of SCC(CS of SCC)can be successfully predicted from mix design and curing age by a machine learning(ML)technique named the Extreme Gradient Boosting(XGB)algorithm,including non-hybrid and hybrid *** ML techniques,such as Linear regression(LR),K-Nearest Neighbors(KNN),Support Vector Machine(SVM),Decision Trees(DTR),Random Forest(RF),Gradient Boosting(GB),and Artificial Neural Network using two training algorithms LBFGS and SGD(denoted as ANN_LBFGS and ANN_SGD),are also compared with the XGB ***,the hybrid models of eight ML techniques and Particle Swarm Optimization(PSO)are constructed to highlight the reliability and accuracy of SCC compressive strength prediction by the XGB_PSO hybrid *** highest number of SCC samples available in the literature is collected for building the ML *** with previously published works’performance,the proposed XGB method,both hybrid and non-hybrid models,is the most reliable and robust of the examined techniques,and is more accurate than existing ML methods(R2=0.9644,RMSE=4.7801,and MAE=3.4832).Therefore,the XGB model can be used as a practical tool for engineers in predicting the CS of SCC.

关键词： compressive strength self-compacting concrete machine learning techniques particle swarm optimization extreme gradient boosting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao Chen Jiayi Ding Feng Zhang Shunyang Chen Xin Hu Shiji Fang Lin Shen Chenying Lu Zhongwei Zhao Jianfei tu Gaofeng Shu Minjiang Chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep Reinforcement Learning Based Decision‑Making Strategy of Autonomous Vehicle in Highway Uncertain Driving Environments

引用

Automotive Innovation 2023年第3期6卷 438-452页

作者： Huifan Deng Youqun Zhao Qiuwei Wang anh‑tu Nguyen Department of Vehicle Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Laboratory LAMIH‑CNRS UMR 8201Universite Polytechnique Hauts-de-France59300 ValenciennesHauts‑de‑FranceFrance INSA Hauts-de-France 59300 ValenciennesFrance

Uncertain environment on multi-lane highway,e.g.,the stochastic lane-change maneuver of surrounding vehicles,is a big challenge for achieving safe automated highway *** improve the driving safety,a heuristic reinforcement learning decision-making framework with integrated risk assessment is ***,the framework includes a long short-term memory model to predict the trajectory of surrounding vehicles and a future integrated risk assessment model to estimate the possible driving ***,a heuristic decaying state entropy deep reinforcement learning algorithm is introduced to address the exploration and exploitation dilemma of reinforcement ***,the framework also includes a rule-based vehicle decision model for interaction decision problems with surrounding *** proposed framework is validated in both low-density and high-density traffic *** results show that the traffic efficiency and vehicle safety are both improved compared to the common dueling double deep Q-Network method and rule-based method.

关键词： Automated driving Decision making Uncertain driving environments Reinforcement learning Multi-lane traffic Integrated risk assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

引用

Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li Ruiqiang Ye Wenzhen Chen Yuqing Huang Yue Yuan Yi Zhang Huayi Hu Peng Zheng Zhongming Fang Zeng Tao Shiyong Song Ronghui Pan Jian Zhang Jumim tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang University Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-MAF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3 at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：