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Canonical metrics on complex manifold

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Science China Mathematics 2008年第4期51卷 503-508页

作者： YAU shing-Tung(Yau S.-T.) Department of Mathematics Harvard University

Complex manifolds are topological spaces that are covered by coordinate charts where the coordinate changes are given by holomorphic *** example,Riemann surfaces are one dimensional complex *** order to understand complex manifolds,it is useful to introduce metrics that are compatible with the complex *** general,we should have a pair(M,ds^2_M)where ds^2_M is the *** metric is said to be canonical if any biholomorphisms of the complex manifolds are automatically *** metrics can naturally be used to describe invariants of the complex structures of the manifold.

关键词：云门

The Hong Kong consensus statements on unresectable hepatocellular carcinoma:narrative review and update for 2021

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 366-385页

作者： Tan-To cheung Simon Chun-Ho Yu Stephen L.Chan Ronnie T.P.Poon Philip Kwok Ann-shing Lee Anna Tai Derek Tam Chin-cheung cheung Tak-Wing Lai Nam-Hung Chia Ada Law Tracy Shum Yim-Kwan Lam Vince Lau Victor Lee Charing Chong Chung-Ngai Tang Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Department of Imaging&Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Translational Oncology and Department of Clinical Oncology Sir YK Pao Centre for CancerPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Radiology and Imaging Queen Elizabeth HospitalHong KongChina Department of Clinical Oncology Tuen Mun HospitalHong KongChina Department of Clinical Oncology Queen Elizabeth HospitalHong KongChina Department of Surgery United Christian HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Surgery Queen Elizabeth HospitalHong KongChina Department of Clinical Oncology Pamela Youde Nethersole Eastern HospitalHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina Department of Medicine and Geriatrics United Christian HospitalHong KongChina Department of Radiology Queen Mary HospitalHong KongChina Department of Clinical Oncology Queen Mary HospitalThe University of Hong KongHong KongChina Department of Surgery Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Surgery Pamela Youde Nethersole Eastern HospitalHong KongChina Department of Medicine Queen Mary HospitalThe University of Hong KongHong KongChina

Background and Objective:Hong Kong,like many parts of Asia,faces a high burden of hepatocellular carcinoma(HCC)caused by high endemic rates of hepatitis B virus *** Kong clinicians have developed a high level of expertise in HCC treatment across surgical,transarterial,ablative,radiotherapeutic and systemic *** publication summarizes the latest evidence-based recommendations on how these modalities should be ***:In two meetings held in 2020,a multidisciplinary panel of surgeons,oncologists and interventional radiologists performed a narrative review of evidence on the management of HCC,with an emphasis on treatment of HCC not amenable to surgical *** attention was paid to new evidence published since the previous version of these statements in *** Content and Findings:The expert panel has formulated 60 consensus statements to guide the staging and treatment of unresectable *** the previous version of these statements,considerable additions have been made to the recommendations on use of targeted therapies and immunotherapies because of the large volume of new ***:Our consensus statements offer guidance on how to select HCC patients for surgical or non-surgical treatment and for choosing among non-surgical modalities for patients who are not candidates for *** particular,there is a need for more evidence to aid physicians in the selection of second-line systemic therapies,as currently most data are limited to patients with disease progression on first-line sorafenib.

关键词： Hepatocellular carcinoma(HCC) Hong Kong guidelines consensus

Total Syntheses of ( + )-Goniotriol and ( + )- 8-Acetylgoniotriol

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Chemical Research in Chinese Universities 1993年第2期9卷 152-153页

作者： shing T. K. M. Departmeat of Chemistry The Chinese University of Hong Kong HKwo styryl-pyrones (+)-goniotriol (1) and (+)-8-acetylgoniotriol (2) which are cytotoxic to human turnout cells were isolated from the ethanolic extracts of the stem bark of Goniothalamus giganteus Hook. F. Thomas (Annonaceae) in addition (+)-goniotriol was also isolated from the leaves and twigs of Goniothalamus

Two styryl-pyrones, (+)-goniotriol (1) and (+)-8-acetylgoniotriol (2), which are cytotoxic to human turnout cells, were isolated from the ethanolic extracts of the stem bark of Goniothalamus giganteus Hook. F., Thomas... 详细信息

关键词： ( + )-Goniotriol ( + )-8-Acetylgoniotriol Total syntheses

Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5481-5494页

作者： Ashok Iyaswamy Abhimanyu Thakur Xin-Jie Guan Senthilkumar Krishnamoorthi tsz Yan Fung Kejia Lu Isha Gaurav Zhijun Yang Cheng-Fu Su Kwok-Fai Lau Kui Zhang Roy Chun-Laam Ng Qizhou Lian King-Ho cheung Keqiang Ye Huanhuan Joyce Chen Min Li Mr.&Mrs.Ko Chi-Ming Centre for Parkinson’s Disease Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Pritzker School of Molecular Engineering The University of ChicagoChicagoILUSA Ben May Department for Cancer Research The University of ChicagoChicagoILUSA School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SARChina School of Life Sciences The Chinese University of Hong KongHong Kong SARChina Division of Neuroscience School of Biological SciencesFaculty of BiologyMedicine and HealthManchester Academic Health Science CentreUniversity of ManchesterManchesterUnited Kingdom Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Prenatal Diagnostic Center and Cord Blood Bank Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina HKUMed Laboratory of Cellular Therapeutics the University of Hong KongPok Fu LamHong Kong SARChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques,hyperphosphorylated tau protein,and neurofibrillary tangles in the *** overexpression of amyloid-βprecursor protein(APP)in an AD brain results in the binding of APP intracellular domain(AICD)to Fe65 protein via the C-terminal Fe65-PTB2 interaction,which then triggers the secretion of amyloid-βand the consequent pathogenesis of ***,targeting the interaction between APP and Fe65 can offer a promising therapeutic approach for ***,exosome,a type of extracellular vesicle with diameter around 30–200 nm,has gained much attention as a potential delivery tool for brain diseases,including AD,due to their ability to cross the blood–brain barrier,their efficient uptake by autologous cells,and their ability to be surface-modified with target-specific receptor ***,the engineering of hippocampus neuron cell-derived exosomes to overexpress Fe65,enabled the development of a novel exosome-based targeted drug delivery system,which carried Corynoxine-B(Cory-B,an autophagy inducer)to the APP overexpressed-neuron cells in the brain of AD *** Fe65-engineered HT22 hippocampus neuron cell-derived exosomes(Fe65-EXO)loaded with Cory-B(Fe65-EXO-Cory-B)hijacked the signaling and blocked the natural interaction between Fe65 and APP,enabling APP-targeted delivery of ***,Fe65-EXO-Cory-B induced autophagy in APP-expressing neuronal cells,leading to amelioration of the cognitive decline and pathogenesis in AD mice,demonstrating the potential of Fe65-EXO-Cory-B as an effective therapeutic intervention for AD.

关键词： Alzheimer gained loaded

Distinctive characteristics and functions of multiple mitochondrial Ca^(2+) influx mechanisms

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Science China(Life Sciences) 2011年第8期54卷 763-769页

作者： Shi PAN Shin-Young RYU Shey-shing SHE~ Center for Translational Medicine Department of Medieine Thomas Jefferson University Philadelphia PA 19107 USA Department of Physiology Seoul National University College of Medicine Seoul 110-799 Republic of Korea

Intracellular Ca2+ is vital for cell *** of Ca2+ homeostasis contributes to human diseases such as heart failure,neuron-degeneration,and *** ensure an effective intracellular Ca2+ dynamics,various Ca2+ transport proteins localized in different cellular regions have to work in *** central role of mitochondrial Ca2+ transport mechanisms in responding to physiological Ca2+ pulses in cytosol is to take up Ca2+ for regulating energy production and shaping the amplitude and duration of Ca2+ transients in various *** the discovery that isolated mitochondria can take up large quantities of Ca2+ approximately 5 decades ago,extensive studies have been focused on the functional characterization and implication of ion channels that dictate Ca2+ transport across the inner mitochondrial *** mitochondrial Ca2+ uptake sensitive to non-specific inhibitors ruthenium red and Ru360 has long been considered as the activity of mitochondrial Ca2+ uniporter(MCU) .The general consensus is that MCU is dominantly or exclusively responsible for the mitochondrial Ca2+ *** multiple Ca2+ influx mechanisms(e.g.L-,T-,and N-type Ca2+ channel) have their unique functions in the plasma membrane,it is plausible that mitochondrial inner membrane has more than just MCU to decode complex intracellular Ca2+ signaling in various cell *** the last decade,four molecular identities related to mitochondrial Ca2+ influx mechanisms have been *** are mitochondrial ryanodine receptor,mitochondrial uncoupling proteins,LETM1(Ca2+ /H+ exchanger) ,and MCU and its Ca2+ sensing regulatory subunit ***,we briefly review recent progress in these and other reported mitochondrial Ca2+ influx pathways and their differences in kinetics,Ca2+ dependence,and pharmacological *** potential physiological and pathological implications are also discussed.

关键词： mitochondrial calcium channels calcium transport mitochondria heart ryanodine receptor

The thylakoid membrane protein NTA1 is an assembly factor of the cytochrome b6f complex essential for chloroplast development in Arabidopsis

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Plant Communications 2023年第1期4卷 287-303页

作者： Na Li Wing shing Wong Lei Feng Chunming Wang King shing Wong Nianhui Zhang Wei Yang Yueming Jiang Liwen Jiang Jun-Xian He School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuanChina Guangdong Provincial Key Laboratory of Applied Botany&Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement Core Botanical GardensSouth China Botanical GardenChinese Academy of SciencesGuangzhouChina

The cytochrome b_(6f)(Cyt b_(6f))complex is a multisubunit protein complex in chloroplast thylakoid membranes required for photosynthetic electron *** we report the isolation and characterization of the new tiny albino 1(nta1)mutant in Arabidopsis,which has severe defects in Cyt b_(6f) accumulation and chloroplast *** cloning revealed that the nta1 phenotype was caused by disruption of a single nuclear gene,NTA1,which encodes an integral thylakoid membrane protein conserved across green algae and *** of NTA1 completely rescued the nta1 phenotype,and knockout of NTA1 in wild-type plants recapitulated the mutant *** of NTA1 function severely impaired the accumulation of multiprotein complexes related to photosynthesis in thylakoid membranes,particularly the components of Cyt b_(6f).NTA1 was shown to directly interact with four subunits(Cyt b6/PetB,PetD,PetG,and PetN)of Cyt b_(6f) through the DUF1279 domain and C-terminal sequence to mediate their *** together,our results identify NTA1 as a new and key regulator of chloroplast development that plays essential roles in assembly of the Cyt b_(6f) complex by interacting with multiple Cyt b_(6f) subunits.

关键词： albino mutant chloroplast development cytochrome b6f complex assembly factor Arabidopsis thaliana

Synthesis and blue light-emitting properties of 4,4'-bis(diphenylamino)-quinque(p-phenyl)s

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Chinese Chemical Letters 2007年第7期18卷 823-826页

作者： Zhong Hui Li Mo Jun Xiong Man shing Wong Department of Chemistry Sichuan College of Education Chengdu 610041 China West China School of Pharmacy Sichuan University Chengdu 610041 China Department of Chemistry Hong Kong Baptist University Hong Kong China

An excellent organic blue light-emitting diode based on 4,4＇-bis（diphenylamino）-quinque（p-phenylene）s （OPP（5）-NPh） with a maximum luminance of up to 5000 cd/m^2 and a luminanous efficiency of 1.3 cd/A was reported. This diode was made by using a wide band-gap hole-blocking layer, F-TBB instead of PBD in the OLED devices. We attribute the good performance to the one trade-off involved in the use of F-TBB to obtain higher luminance is the increased turn-on voltages and slightly decreased device efficiencies.

关键词： 4,4'-Bis(diphenylamino)-quinque(p-phenylene)s Synthesis Organic light-emitting diode (OLED) Optical properties

Selenium-induced Changes in Activities of Antioxidant Enzymes and Content of Photosynthetic Pigments in Spirulina platensis

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Journal of Integrative Plant Biology 2008年第1期50卷 40-48页

作者： Tian-Feng Chen Wen-Jie Zheng Yum-shing Wong Fang Yang Department of Biology The Chinese University of Hong Kong Hong Kong SAR China Department of Chemistry Jinan University Guangzhou 510632 China

Spirulina platensis exposed to various selenium （Se） concentrations （0, 10, 20, 40, 80, 150, 175, 200, 250 mg/L） accumulated high amounts of Se in a dose- and time-dependent manner. Under low Se concentrations （〈150 mg/L）, Se induced increases in biomass concentration, content of photosynthetic pigments, and activities of glutathione peroxidase （GPX）, superoxide dismutase （SOD）, catalase （CAT） and Gua-dep peroxidases （POD）, which indicates that antioxidant enzymes play an important role in protecting cells from Se stress. Higher Se concentrations （≥175 mg/L） led to higher Se accumulation and increases in activities of GPX, SOD, CAT and POD, but also induced lipid peroxidation （LPO） coupled with potassium leakage and decreases in biomass concentration and contents of photosynthetic pigment. The results indicate that increases in activities of the antioxidant enzymes were not sufficient to protect cell membranes against Se stress. Time-dependent variations in the activities of antioxidant enzymes, contents of chlorophyll a and carotenoid and the LPO level were also investigated under representative Se concentrations of 40 and 200mg/L. Opposite variation trends between SOD-CAT activities, and GPX-POD-APX activities were observed during the growth cycles. The results showed that the prevention of damage to cell membranes of S. platensis cells could be achieved by cooperative effects of SOD-CAT and GPX-POD-APX enzymes. This study concludes that S. platensis possessed tolerance to Se and could protect itself from phytotoxicity induced by Se by altering various metabolic processes.

关键词： accumulation antioxidant enzymes photosynthetic pigments selenium Spirulina platensis.

Isolated right coronary artery bypass grafting via minimally invasive approach in two elderly patients with failed percutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第7期19卷 555-558页

作者： An shing Ang Ilias Skaltsiotis Theodore Kofidis Hee Hwa Ho Department of Cardiology Tan Tock Seng HospitalSingapore Department of Cardiac Thoracic and Vascular SurgeryNational University HospitalNational University Health SystemSingapore

Coronary artery bypass grafting(CABG)tra-ditionally involves revascularization of the left anterior descending artery(LAD)as it is usually of greater prognostic value.[1]Isolated CABG for non-LAD lesions have also been descri-bed in ***,these were often in the setting of re-do CABG[2,3]or in patients with isol-ated right sided coronary lesion and concomitant valvular heart disease.

关键词： coronary bypass patients