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Factors predicting upstaging from clinical N0 to pN2a/N3a in breast cancer patients

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World Journal of Clinical Oncology 2022年第9期13卷 748-757页

作者： Goshi Oda tsuyoshi nakagawa Hiroki Mori Iichiro Onishi Tomoyuki Fujioka Mio Mori Kazunori Kubota Ryoichi Hanazawa Akihiro Hirakawa Toshiaki Ishikawa Kentaro Okamoto Hiroyuki Uetakesszsz Department of Breast Surgery Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Plastic and Reconstructive Surgery Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Pathology Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Radiology Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Clinical Biostatistics Tokyo Medical and Dental UniversityTokyo 1138519Japan Department of Specialized Surgeries Tokyo Medical and Dental UniversityTokyo 1138519Japan

BACKGROUND With sentinel node metastasis in breast cancer(BC)patients,axillary lymph node(ALN)dissection is often omitted from cases with breast-conserving *** of lymph node dissection reduces the invasiveness of surgery to the patient,but it also obscures the number of metastases to non-sentinel *** possibility of finding≥4 lymph nodes(pN2a/pN3a)preoperatively is important given the ramifications for postoperative *** To search for clinicopathological factors that predicts upstaging from N0 to pN2a/*** Patients who were sentinel lymph node(SLN)-positive and underwent ALN dissection between September 2007 and August 2018 were selected by retrospective chart *** patients had BC diagnosed preoperatively as N0 with axillary evaluation by fluorodeoxyglucose(FDG) positron emission tomography/computed tomography and ultrasound (US)examination. When suspicious FDG accumulation was found in ALN, the presence of metastasiswas reevaluated by second US. We examined predictors of upstaging from N0 to pN2a/*** 135 patients, we identified 1-3 ALNs (pN1) in 113 patients and ³4 ALNs (pN2a/pN3a) in22 patients. Multivariate analysis identified the total number of SLN metastasis, the maximaldiameter of metastasis in the SLN (SLNDmax), and FDG accumulation of ALN as predictors ofupstaging to pN2a/*** identified factors involved in upstaging from N0 to pN2a/pN3a. The SLNDmax and numberof SLN metastasis are predictors of ≥ 4 ALNs (pN2a/pN3a) and predictors of metastasis to nonsentinelnodes, which have been reported in the past. Attention should be given to axillaryaccumulations of FDG, even when faint.

关键词： Breast cancer Axillary lymph node metastasis Positron emission tomography/computed tomography Sentinel lymph node Predictive factors of lymphnode metastasis Standardized uptake value max Diameter of sentinel lyphonode metastasis

Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography: Results from a retrospective study

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World Journal of Radiology 2016年第8期8卷 743-749页

作者： Tomoyuki Fujioka Kazunori Kubota Akira Toriihara Youichi Machida Kaori Okazawa tsuyoshi nakagawa Yukihisa Saida Ukihide Tateishi Department of Diagnostic Radiology Tokyo Medical and Dental University Department of Radiology Kameda Kyobashi Clinic Department of Breast Surgery Tokyo Medical and Dental University

AIM To clarify clinicopathological features of ductal carcinoma in situ(DCIS) visualized on [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography(FDG-PET/CT).METHODS This study retrospectively reviewed 52 consecutive tumors in 50 patients with pathologically proven pure DCIS who underwent [F-18] FDG-PET/CT before surgery. [F-18] FDG-PET/CT was performed after biopsy in all patients. The mean interval from biopsy to [F-18] FDGPET/CT was 29.2 d. [F-18] FDG uptake by visual analysis and maximum standardized uptake value(SUVmax) was compared with clinicopathological ***[F-18] FDG uptake was visualized in 28 lesions(53.8%) and the mean and standard deviation of SUVmax was 1.63 and 0.90. On univariate analysis, visual analysis and the SUVmax were associated with symptomatic presentation(P = 0.012 and 0.002, respectively), palpability(P = 0.030 and 0.024, respectively), use of core-needle biopsy(CNB)(P = 0.023 and 0.012, respectively), ultrasound-guided biopsy(P = 0.040 and 0.006, respectively), enhancing lesion ≥ 20 mm on magnetic resonance imaging(MRI)(P = 0.001 and 0.010, respectively), tumor size ≥ 20 mm on histopathology(P = 0.002 and 0.008, respectively). However, [F-18] FDG uptake parameters were not significantly associated with age, presence of calcification on mammography, mass formation on MRI, presence of comedo necrosis, hormone status(estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), and nuclear grade. The factors significantly associated with visual analysis and SUVmax were symptomatic presentation(P = 0.019 and 0.001, respectively), use of CNB(P = 0.001 and 0.031, respectively), and enhancing lesion ≥ 20 mm on MRI(P = 0.001 and 0.049, respectively) on multivariate *** Although DCIS of breast is generally non-avid tumor, symptomatic and large tumors(≥ 20 mm) tend to be visualized on [F-18] FDG-PET/CT.

关键词： Ductal carcinoma in situ Positron emission tomography Breast cancer [F-18] fluorodeoxyglucosepositron emission tomography/computed tomography

Effects of PBr<sub>3</sub>Addition to Polysilane Thin Films on Structures and Photovoltaic Properties

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Green and Sustainable Chemistry 2017年第1期7卷 20-34页

作者： Junya nakagawa Takeo Oku Atsushi Suzuki tsuyoshi Akiyama Masahiro Yamada Sakiko Fukunishi Kazufumi Kohno Department of Materials Science The University of Shiga Prefecture Hikone Japan Osaka Gas Co. Ltd. Osaka Japan Osaka Gas Chemicals Co. Ltd. Osaka Japan

Organic thin film solar cells are potential next generation solar cells. Many p-type semiconductors have been used in organic solar cells, but there have been far fewer reports involving n-type organic semiconductors. Developing new n-type organic semiconductors is therefore desirable. Polysilane thin films were spin-coated from solutions containing phosphorus (P), and the effects of P addition on film microstructures and electronic properties as n-type semiconductors were investigated. Microstructures of poly-methyl-phenyl-silane (PMPS), dimethyl-polysilane (DMPS) and deca-phenyl-penta-silane (DPPS) thin films were investigated by X-ray diffraction and transmission electron microscopy. PMPS thin films doped with P (PMPS(P)) were amorphous upon annealing at 300°C, while DMPS(P) and DPPS(P) thin films exhibited crystalline structures. PMPS(P) and DMPS(P) thin films exhibited decreased electrical resistances upon P doping. The energy gaps of PMPS(P), DMPS(P) and DPPS(P) were 3.5, 3.9 and 3.8 eV, respectively. Decreased photoluminescence intensities of PMPS, DMPS and DPPS were observed upon P doping. The desorption of phenyl and methyl groups from PMPS(P) thin films was observed from Raman scattering measurements. Solar cells containing polysilane(P)/poly[3-hexylthiophene] heterojunction structures were fabricated and exhibited photovoltaic behavior.

关键词： Microstructure Thin Film Property Polysilane Solar Cell

Hollow Fiber Module Applied for Effective Proliferation and Harvest of Cultured Chondrocytes

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Materials Sciences and Applications 2013年第8期4卷 62-67页

作者： Yoshiyuki Mori Makoto Watanabe Sakae nakagawa Yukiyo Asawa Satoru Nishizawa Kazumi Okubo Hideto Saijo Satoru Nagata Yuko Fujihara tsuyoshi Takato Kazuto Hoshi Department of Cartilage & Bone Regeneration (Fujisoft) Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Cartilage & Bone Regeneration (Fujisoft) Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Tissue Engineering The University of Tokyo Hospital Tokyo Japan Department of Sensory and Motor System Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Sensory and Motor System Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Cartilage & Bone Regeneration (Fujisoft) Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Tissue Engineering The University of Tokyo Hospital Tokyo Japan Department of Sensory and Motor System Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Tissue Engineering The University of Tokyo Hospital Tokyo Japan NAGATA Microtia and Reconstructive Plastic Surgery Clinic Saitama Japan Nomura Unison Co. Ltd Nagano Japan

Steady and useful culture for chondrocytes is essential for cartilage regenerative medicine. However, in conventional plate culture, the chondrocytes become dedifferentiated and lose their ability to make cartilage matrices. Three-dimensional culture mimicking the physiological environment in native chondrocytes is useful to maintain the chondrocyte properties during the proliferation culture. However, the three-dimensional culture is practically a hard task due to difficult harvest of the cells. Thus, we attempted to apply porous materials, hollow fibers for the three-dimensional culture, and developed their module to realize the effective harvest of the cells. Polyethersulfone-based hollow fibers, whose safety and cell affinity were confirmed by the experiment of the coculture with human chondrocytes, were collected to fabricate a module. The hollow fiber module was installed with screw ends, and enabled the easy removal of chondrocytes from the inner unit. Cultured human chondrocytes embedded within collagen hydrogel were put into the outer lumen of the hollow fiber module, while chondrocyte prolfieration medium was perfused through the inner lumen at 0 to 30 mL/min. After 2 weeks’ culture, the flow rate of 3 to 10 mL/min effectively supported the chondrocyte proliferation. Then, long-term culture using the hollow fiber module at flow rate of 5 mL/min was performed, revealing that the cell growth in this module at 3 weeks was approximately twice larger than that in static culture. The numbers of viable cells could be maintained by week 7. The hollow fiber module installed with screw ends can effectively culture and harvest the chondrocytes.

关键词： Hollow Fiber Module Proliferation Cell Culture Chondrocyte Tissue Engineering