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Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators

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Cancer Drug Resistance 2019年第3期2卷 710-743页

作者： Silvia dei Laura Braconi Maria Novella Romanelli Elisabetta Teodori Department of Neuroscience PsychologyDrug Research and Child’s Health-Section of Pharmaceutical and Nutraceutical SciencesUniversity of Florencevia Ugo Schiff 6Sesto Fiorentino(FI)50019Italy

The development of multidrug resistance (MDR) is one of the major challenges to the success of chemotherapy treatment of cancer. This phenomenon is often associated with the overexpression of the ATP-binding cassette (ABC) transporters P-gp (P-glycoprotein, ABCB1), multidrug resistance-associated protein 1, ABCC1 and breast cancer resistance protein, ABCG2 (BCRP). These transporters are constitutively expressed in many tissues playing relevant protective roles by the regulation of the permeability of biological membranes, but they are also overexpressed in malignant tissues. P-gp is the first efflux transporter discovered to be involved in cancer drug resistance, and over the years, inhibitors of this pump have been disclosed to administer them in combination with chemotherapeutic agents. Three generations of inhibitors of P-gp have been examined in preclinical and clinical studies;however, these trials have largely failed to demonstrate that coadministration of pump inhibitors elicits an improvement in therapeutic efficacy of antitumor agents, although some of the latest compounds show better results. Therefore, new and innovative strategies, such as the fallback to natural products and the discover of dual activity ligands emerged as new perspectives. BCRP is the most recently ABC protein identified to be involved in multidrug resistance. It is overexpressed in several haematological and solid tumours together with P-gp, threatening the therapeutic effectiveness of different chemotherapeutic drugs. The chemistry of recently described BCRP inhibitors and dual P-gp/BCRP inhibitors, as well as their preliminary pharmacological evaluation are discussed, and the most recent advances concerning these kinds of MDR modulators are reviewed.

关键词： Cancer multidrug resistance multidrug resistance modulators ATP-binding cassette transporter inhibitors P-glycoprotein multidrug resistance-associated proteins breast cancer resistance protein

COVID-19 in a pregnant kidney transplant recipient-what we need to know:A case report

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World Journal of Transplantation 2022年第10期12卷 325-330页

作者： Roberta Angelico Maria Luisa Framarino-dei-Malatesta Giuseppe Iaria Department of Surgical Sciences HPB and Transplant UnitUniversity of Rome Tor VergataRome 00100Italy Department of Gynecologic-Obstetrical and Urologic Sciences Policlinico Umbero ISapienza University of RomeRome 00100Italy Kidney Transplant Unit San Camillo ForlaniniRome 00100Italy

BACKGROUND In the era of the coronavirus disease 2019(COVID-19)pandemic,kidney transplant recipients are more susceptible to severe acute respiratory syndrome coronavirus(SARS-CoV-2)infection,developing severe morbidity and graft *** women are also more likely to develop severe COVID-19 disease,causing pregnancy complications such as preterm births and acute kidney *** SUMMARY Herein,we report the case of a pregnant woman with a third kidney transplantation who developed COVID-19 *** reduction of immunosuppressive drugs and strict monitoring of trough blood levels were needed to avoid severe SARS-CoV-2-related complications,and permitted to continue a healthy pregnancy and maintain good graft *** such a complex scenario,the concomitance of COVID-19-related morbidity,the risk of acute rejection in the hyperimmune recipient,graft dysfunction and pregnancy complications make the management of immunosuppression a very difficult task and clinicians must be *** Tailoring the immunosuppressive regimen is a key factor affecting both the graft outcome and pregnancy safety.

关键词： Kidney transplantation Pregnancy SARS-CoV-2 infection COVID-19 disease Immunosuppression Complications Case report

The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients

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World Journal of Gastroenterology 2006年第22期12卷 3597-3601页

作者： Peter Schemmer Frank Decker Genevieve dei-Anane Volkmar Henschel Klaus Buhl Christian Herfarth Stefan Riedl Deptartment of General Surgery Ruprecht-Karls-University 69120 HeidelbergGermany Volkmar HenschelInstitute for Statistics and Medical BiometryRuprecht-Karls-University69120 HeidelbergGermany Institute for Statistics and Medical Biometry Ruprecht-Karls-University 69120 HeidelbergGermany Deptartment of General Surgery Ruprecht-Karls-University 69120 HeidelbergGermany

AIM： To analyze the importance in predicting patients risk of mortality due to upper gastrointestinal （UGI） bleeding under today＇s therapeutic regimen. METHODS： From 1998 to 2001, 121 patients with the diagnosis of UGI bleeding were treated in our hospital. Based on the patients＇ data, a retrospective multivariate data analysis with initially more than 270 single factors was performed. Subsequently, the following potential risk factors underwent a logistic regression analysis： age, gender, initial hemoglobin, coumarines, liver cirrhosis, prothrombin time （PT）, gastric ulcer （small curvature）, duodenal ulcer （bulbus back wall）, Forrest classification, vascular stump, variceal bleeding, MalloryWeiss syndrome, RBC substitution, recurrent bleeding, conservative and surgical therapy. RESULTS： Seventy male （58%） and 51 female （42%） patients with a median age of 70 （range： 21-96） years were treated. Their in-hospital mortality was 14%. While 12% （11/91） of the patients died after conservative therapy, 20% （6/30） died after undergoing surgical therapy. UGI bleeding occurred due to duodenal ulcer （n = 36; 30%）, gastric ulcer （n = 35; 29%）, esophageal varicosis （n = 12; 10%）, Mallory-Weiss syndrome （n = 8, 7%）, erosive lesions of the mucosa （n = 20; 17%）, cancer （n = 5; 4%）, coagulopathy （n = 4; 3%）, lymphoma （n = 2; 2%）, benign tumor （n = 2; 2%） and unknown reason （n = 1, 1%）. A logistic regression analysis of all aforementioned factors revealed that liver cirrhosis and duodenal ulcer （bulbus back wall） were associated risk factors for a fatal course after UGI bleeding. Prior to endoscopy, only liver cirrhosis was an assessable risk factor. Thereafter, liver cirrhosis, the location of a bleeding ulcer （bulbus back wall） andpatients＇ gender （male） were of prognostic importance for the clinical outcome （mortality） of patients with a bleeding ulcer.CONCLUSION： Most prognostic parameters used in clinical routine today are not reliable enough in predicting a patient＇s vital

关键词： UGT bleeding Mortality Risk factors

Black locust(Robinia pseudoacacia L.)as a multi-purpose tree species in Hungary and Romania:a review

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Journal of Forestry Research 2018年第6期29卷 1449-1463页

作者： Valeriu-Norocel Nicolescu Cornelia Hernea Beatrix Bakti Zsolt Keseru Borbála Antal Károly Rédei Faculty of Silviculture and Forest Engineering Transylvania University of BrassovSirul Beethoven no.1500123 BrasovRomania Faculty of Horticulture and Forestry Banat’s University of Agricultural Sciences and Veterinary Medicine“King Michael I of Romania”from Timi.oaraCalea Aradului 119300645 TimisoaraRomania Department of Plantation Forestry National Agricultural Research and Innovation Centre Forest Research InstituteFarkasszigetPu¨spo¨klada′ny 4150Hungary Hungarian Horticultural Propagation Material Non-profit Ltd. Sa′rva′rBudapestHungary

Black locust(Robinia pseudoacacia L.) was the first North-American tree species imported to Europe at the beginning of the seventeenth century. It is commonly planted worldwide because of its adaptability to environmental stresses, its valuable wood, easy propagation, frequent and abundant seed production, excellent coppicing,high seedling survival, and relatively high wood yield. In Europe, Romania and Hungary have the most highly-developed black locust growing techniques and *** a result of increasing interest in black locust in many countries, this review aims to provide a comprehensive overview of state-of-the-art site requirements, propagation, improvement and management(including growth and yield as well as use in energy plantations).

关键词： Robinia pseudoacacia Site requirements Selection Propagation Silviculture

Uncommon cause of voiding dysfunction in a female patient-vaginal abscess: A case report

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World Journal of Clinical Cases 2018年第16期6卷 1199-1201页

作者： Chia-Chi Yeh Stephen Shei-dei Yang Su-Cheng Huang Yi-Chun Wang Department of Family Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation Department of Urology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation Department of Obstetrics and Gynecology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Department of Nephrology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation School of Medicine Tzu Chi University

BACKGROUND Vaginal abscess is a treatable disease and should be considered in female patients with voiding difficulties and perineal tenderness. There are no reported cases of vaginal abscess causing voiding dysfunction in the absence of a previous surgery. Early diagnosis and drainage of vaginal abscesses may lead to excellent *** SUMMARY We presented a case of vaginal abscess that caused voiding dysfunction without surgery history. A 64-yearold woman had a past history of type 2 diabetes mellitus. She came to our clinic following urinary difficulty with perineal tenderness. Bladder ultrasonography revealed a pelvic cystic lesion with a mass effect on the bladder. The presence of a vaginal abscess was suspected following pelvic examination and transvaginal *** transvaginal drainage of the vaginal abscess and a full course of antibiotic treatment, she recovered well without any urination symptoms. CONCLUSION Voiding dysfunction caused by vaginal abscess is rare but should be considered in female patients with perineal tenderness.

关键词： Vaginal abscess Voiding dysfunction Female Case report

Early evaluation of micropropagated black locust (Robinia pseudoacacia L.) clones in Hungary

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Forestry Studies in China 2013年第1期15卷 81-84页

作者： Károly Rdei Zsolt KESER János RSó Forest Research Institute Department of Plantation Forestry

In Hungary, black locust （Robinia pseudoacacia L.） is one of the most important exotic species, forming entire stands. Its importance is increasing in many other countries. As a result of a new selection program eight black lo- cust clones have been improved for establishing clone trials and a seed orchard. In this study juvenile growth and stem quality of micropropagated clones of black locust were evaluated on a marginal site in central Hungary. At ten years old, the clones ＇MB17D3/4＇ and ＇PV201E2/4＇ appeared to be especially promising for high quality wood production under arid hydrological conditions. A tissue culture method can be considered a suitable tool of propagating superior individual trees and offers new prospects for the rapid cloning of selected genotypes.

关键词： Robinia pseudoacacia L. micropropagation clone trial

The Nature, Philosophy, and Sustaining Factors of the Theology of Wealth in Africa： Theological Reflections

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Journal of Philosophy Study 2014年第6期4卷 391-402页

作者： Daniel dei Robert Osei-Bonsu Valley View University

This paper is a theological reflection on the theology of wealth in Africa--its nature, philosophy, and sustaining factors. Through the methodology of theological reflections, the paper finds out that the theology of wealth, though difficult to describe, is sustained on the African continent by economic hardship, the influence of some preachers of the theology of wealth, and the availability of improved facilities for disseminating the content of the theology of wealth. It also finds out that the entire philosophy of the theology of wealth is biblically, theologically, and ethically deficient. Biblically, it adapts parts of scripture to suit its teachings. Theologically, it puts forth viewpoints that are foreign to theological thought. Ethically, it is a means of exploiting congregants. The paper concludes with a recommendation that the content and nature of the theology of wealth must be highlighted and thoroughly explained to both clergy and membership of different denominations so that all will be safeguarded against the impact of this false gospel on their lives.

关键词： Africa Christianity wealth flamboyance theology economic success materialism penteco-charismatic

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意大利工业区与华人的双重挑战

华侨华人历史研究 2011年第2期 9-16页

作者： Gabi dei Ottati 张铭意大利佛罗伦萨大学经济学院经济系中国华侨华人历史研究所北京100007

论文分析了全球性竞争压力对工业区适应机制的影响及工业区的竞争优势以及工业区内部形成的华人经济的潜在威胁,探讨了在新的条件下将这种威胁转化为新的发展机遇的可能性。认为华人经济的特殊优势使华人企业越来越活跃,但却使当地企业... 详细信息

论文分析了全球性竞争压力对工业区适应机制的影响及工业区的竞争优势以及工业区内部形成的华人经济的潜在威胁,探讨了在新的条件下将这种威胁转化为新的发展机遇的可能性。认为华人经济的特殊优势使华人企业越来越活跃,但却使当地企业日益萎缩。这反过来又促使当地经济整体进行转型;华人企业家的某些优势在于其跨地区和跨国网络;华人移民对其祖籍国潜在商业伙伴的能力和品德有深度了解,如果能发挥中介作用,意大利当地企业就能使其工业生产及产品销售国际化。

关键词：意大利华人研究工业区华人经济华人企业

Terzo elenco(a cura di GIUSEPPE BERRUTI)

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Natural Disaster Reduction in China 1978年第1期 217-221页

作者： CATASTO dei LAGHI BRESCIANI

Il terzo elenco di laghi *** segue quelli pubblicati suinumeri 13 e 14 di Natura *** l’attività svolta in questocampo dal Centro Studi Naturalistici Bresciani nel *** leavverse condizioni meteorologiche dell’anno passato,che hanno creato al-cune difficoltà di rilevamento a causa del permanere della copertura *** sono potuti raccogliere i dati relativi a 29 Iaghetti,tutti ubicati nel bacinodel *** questi,il numero di laghi finora rilevati assomma a 100,di cui 81 nel bacino del *** e 19 in quello del ***.

关键词： Ta SE Terzo elenco a cura di GIUSEPPE BERRUTI ENE 君一