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Adult sigmoid intussusception resembling rectal prolapse:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1163-1168页

作者： tsung-jung Tsai Yu Shih Liu Department of Surgery Changhua Christian HospitalChanghua 500209Taiwan Department of Colorectal Surgery Changhua Christian HospitalChanghua 500209Taiwan

BACKGROUND Rectal prolapse arises from benign *** symptoms of internal intussusception mirror those of rectal prolapse,a misdiagnosis is possible,especially under limited clinical *** is crucial to recognize and differentiate rectal prolapse from internal intussusception because the two diagnoses have different ***,we describe a case of adult sigmoid intussusception presenting as rectal *** SUMMARY A 64-year-old woman with no known medical history visited a gastrointestinal outpatient department due to hard bloody stool defecation for 1 wk followed by constipation for 3 *** revealed a huge polypoid ulcerated tumor at the sigmoid colon with lumen *** patient was admitted due to postprocedural dull abdominal *** to failed colonoscopy reduction and stent insertion,the patient underwent sigmoid colon resection with primary end-to-end anastomosis,with the transverse colostomy pathological report showing adenocarcinoma,*** recovered well from the operation and was discharged with regular outpatient clinic *** Presentation and manifestation of sigmoid intussusception may resemble that of rectal prolapse,necessitating careful observation due to distinct prognostic implications.

关键词： Sigmoid intussusception Rectal prolapse Endoscopic reduction Adenocarcinoma Case report

CYP2C19 polymorphism has no influence on rabeprazole-based hybrid therapy for Helicobacter pylori eradication

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World Journal of Clinical Cases 2018年第12期6卷 514-520页

作者： tsung-jung lin Hsi-Chang Lee Chih-lin lin Chung-Kwe Wang Kuan-Yang Chen Deng-Chyang Wu Department of Health care and Social Work Taipei University of Marine Technology Department of Gastroenterology Taipei City Hospital Institute of Clinical Medicine National YangMing University Institute of Neuroscience National Chengchi University Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Division of Internal Medicine Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical University Center for Infectious Disease and Cancer Research Kaohsiung Medical University

AIM To evaluate the impact of cytochrome P450 2C19(CYP2C19) and interleukin-1β(IL-1β) polymorphisms on the efficacy of Helicobacter pylori(H. pylori) eradication by using rabeprazole-based hybrid *** A total of 88 H. pylori-infected patients were recruited to receive 14-d of hybrid therapy from March 2013 to May 2014. Three patients were excluded from analysis because of incomplete compliance. Either a follow-up endoscopy or 13 C-urea test was performed to determine the results of H. pylori eradication therapy. The genotypes of CYP2C19 and IL-1β were analyzed to investigate the impact on treatment effect. RESULTS The total eradication rate of H. pylori was 92.94%(79/85). According to the CYP2C19 genotypes, the rates of H. pylori eradication were 89.19% in extensive metabolizers(EM) and 95.83% in non-EM. The *** eradication rates regarding the IL-1β genotypes were 92.59% in the normal acid secretion group and 93.10% in the low acid secretion group. After multivariable logistic regression analysis, both the genotypes of CYP2C19 and IL-1β had no significant influences on the eradication rates of H. *** The CYP2C19 and IL-1β polymorphisms are not significantly independent factors of *** eradication using rabeprazole-based hybrid therapy.

关键词： Helicobacter pylori Cytochrome P450 2C19 Interleukin-1β Hybrid therapy Rabeprazole

Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

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World Journal of Gastroenterology 2006年第30期12卷 4897-4901页

作者： tsung-jung lin Li-Ying Liao Shyr-Yi lin Chih-lin lin Ting-An Chang Department of Gastroenterology Ren-Ai Branch Taipei City Hospital TaipeiTaiwan China Graduate Institute of Medical Sciences Taipei Medical University Taipei Taiwan China Department of Pathology Ren-Ai Branch Taipei City Hospital Taipei Taiwan China

瞄准：与长期的丙肝(CHC ) 在病人在肝的纤维变性，浆液铁索引，和肝的铁店之中评估协会。方法：32 个 CHC 病人在我们的学习被包括。纤维变性和发炎活动的组织学的度根据 Metavir 系统被估计。包括含铁锡，铁和转铁蛋白浸透的浆液铁索... 详细信息

瞄准：与长期的丙肝(CHC ) 在病人在肝的纤维变性，浆液铁索引，和肝的铁店之中评估协会。方法：32 个 CHC 病人在我们的学习被包括。纤维变性和发炎活动的组织学的度根据 Metavir 系统被估计。包括含铁锡，铁和转铁蛋白浸透的浆液铁索引被测量。肝的铁免职被 Perl 的污点分级。结果：有严重肝的纤维变性的 CHC 病人(n = 16 ) 是比有温和纤维变性的 CHC 病人显著地旧的(n = 16 )(P = 0.024 ) 。浆液铁索引，增加的浆液铁店和积极的肝的铁污点不在二个组之间是显著地不同的。在里面多变量逻辑回归分析，在活体检视的年龄是严重肝的纤维变性的一个独立预言者(机会比率 = 1.312；P = 0.035 ) 。积极的肝的铁污点显著地与丙氨酸 aminotransferase (中高音) 的价值被联系(P = 0.017 ) ，含铁锡(P = 0.008 ) ，浆液铁(P = 0.019 ) 并且转铁蛋白浸透(P = 0.003 ) 。含铁听水平与中高音的价值显示出重要关联(r = 0.531；P = 0.003 ) ，铁(r = 0.467；P = 0.011 ) 并且转铁蛋白浸透(r = 0.556；P = 0.002 ) 。结论：我们的调查结果建议丙肝病毒(HCV ) 的严厉联系了肝损伤在活体检视与耐心的年龄被联系。有浆液的两个浆液铁索引和肝的铁免职表演关联长期的肝疾病索引，但是不与肝组织学的等级和舞台有关。

关键词：肝纤维化丙型病毒肝炎治疗临床

Usefulness of serum des-γ-carboxy prothrombin in detection of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第39期11卷 6115-6119页

作者： Chaur-Shine Wang Chin-lin lin Hsi-Chang Lee Kuan-Yang Chen Ming-Feng Chiang Hung-Sheng Chen tsung-jung lin Department of Gastroenterology Ren-Ai Branch Taipei City HospitalTaipeiTaiwanChina

AIM: To evaluate whether DCP is better than AFP for differentiating HCC from nonmalignant liver disease and further evaluate the usefulness of DCP in early diagnosis of small ***: Serum DCP and AFP levels were determined in 127 patients. Among these patients, 32 were with noncirrhotic chronic hepatitis, 34 were with compensated cirrhosis, and 61 were with HCC. The cut-off value for the DCP and AFP were set as 40 mAU/mL and 20 ng/mL,respectively. To compare the diagnostic value of DCP and AFP in distinguishing HCC from nonmalignant chronic liver disease, receiver operating characteristic (ROC) curves were constructed for each ***: The accuracy, sensitivity, and specificity of DCP were higher than AFP in detecting HCC (81.9%, 77%,and 86.4% vs 68.5%, 59%, and 77.3%, respectively).The area under the ROC (AUROC) curves revealed that DCP had a better accuracy than AFP in diagnosis of HCC (0.85 [95%CT, 0.78-0.91] vs 0.73 [95%CI, 0.65-0.81],P = 0.013). In 39 patients with solitary HCC, the positive rates of DCP were 100% in patients with tumor size larger than 3 cm, 66.7% in patients with tumor size 2-3 cm and50% in patients with tumor size less than 2 cm. The positive rates of AFP in patients with tumor size larger than 3 cm, 2-3 cm and less than 2 cm were 55.6%, 50%,and 33.3%, respectively. The median level of DCP in HCC patients with tumor size larger than 3 cm was significantly higher than those with tumor size 2-3 cm and those with the size of less than 2 ***: Our study indicates that DCP has a better diagnostic value than AFP in differentiating HCC from nonmalignant chronic liver disease. DCP has not only a stronger correlation with HCC than AFP in tumor size but also more effectiveness than AFP in detecting small size of HCC.

关键词：血清 des-γ-凝血素肝细胞癌病理机制慢性肝疾病

Simple bone cysts of the proximal humerus presented with limb length discrepancy:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1130-1137页

作者： Cing Syue lin Shang Ming lin Syang-Peng Rwei Chin-Wen Chen tsung-Yu Lan Department of Orthopedic Surgery Far Eastern Memorial HospitalNew Taipei City 220Taiwan Department of Materials and Textiles Asia Eastern University of Science and TechnologyNew Taipei City 220Taiwan Institute of Organic and Polymeric Materials National Taipei University of TechnologyTaipei City 10608Taiwan

BACKGROUND Simple bone cysts(SBC)are benign tumor-like bone lesions typically identified in *** SBC may lead to growth disturbances or growth arrest,such cases are *** mechanisms behind these observations remain ***,research on the etiology of SBC remains inconclusive,and there has been no consensus on the appropriate timing and methodology for *** SUMMARY Here,we present our experience in the successful surgical management of a 10-year-old girl with SBC,who presented with a pathological fracture complicated by malunion of the displaced fracture,varus deformity,and limb length *** hypothesized two possible etiologies for the patient’s growth arrest and subsequent humerus varus deformity:(1)Direct disruption of the physis by fluid from the cyst itself;and(2)damage to the epiphysis due to repetitive pathological fractures associated with *** addressing this case,surgical intervention was undertaken to correct the proximal humerus varus *** approach offered the advantages of simultaneously correcting angular abnormalities,achieving mild limb lengthening,providing definitive SBC treatment,and reducing the overall treatment *** As per current literature,acute correction of acute angular deformity in proximal humeral SBC is not well ***,in this specific case,acute correction was considered an optimal solution.

关键词： Bone cyst Solitary cysts Benign Humerus Growth arrest Limb length discrepancy Case report

Hybrid vs sequential therapy for eradication of Helicobacter pylori in Taiwan: a prospective randomized trial

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World Journal of Gastroenterology 2015年第36期21卷 10435-10442页

作者： Kuan-Yang Chen tsung-jung lin Chin-lin lin Hsi-Chang Lee Chung-Kwe Wang Deng-Chyang Wu Institute of Clinical Medicine National YangMing University Institute of Neuroscience National Chengchi University Liver Center Department of GastroenterologyRen-Ai BranchTaipei City Hospital Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang HospitalKaohsiung Medical University Center for Stem Cell Research Kaohsiung Medical University Hospital Department of Medicine Faculty of MedicineCollege of MedicineKaohsiung Medical University Center for Infectious Disease and Cancer Research Kaohsiung Medical University

AIM: To evaluate the efficacy of sequential vs hybrid therapy in patients with Helicobacter pylori(H. pylori) ***: From March 2013 to May 2014,one hundred and seventy-five H. pylori infected patients who had not been treated for H. pylori before wererandomized to receive either sequential therapy(rabeprazole 20 mg and amoxicillin 1 g twice daily for 5 d,followed by rabeprazole 20 mg,clarithromycin 500 mg and metronidazole 500 mg twice daily for 5 d) or hybrid therapy(rabeprazole 20 mg and amoxicillin 1 g for 7 d,followed by rabeprazole 20 mg,amoxicillin 1 g,clarithromycin 500 mg and metronidazole 500 mg twice daily for 7 d). H. pylori status was confirmed by positive results of both rapid urease test and histology examination or a positive result of culture. Eradication efficacy was assessed by follow-up endoscopy with rapid urease test and histological examination 8 wk after the end of anti-H. pylori therapy,or 13C-urea breath test at least 4 wk after completion of treatment. The primary outcome was H. pylori eradication by intension-to-treat(ITT) and per-protocol(PP) ***: One hundred and sixty-seven patients(83 patients in the sequential group and 84 patients in the hybrid group) completed the study. The compliance rates were 97.6% and 97.7% for the two groups,respectively. The eradication rate was 78.2% for the sequential group and 92% for the hybrid group by ITT analysis(P = 0.01). The eradication rate was 81.9% for the sequential group and 96.4% for the hybrid group by PP analysis(P = 0.01). Univariate analysis for the clinical and bacterial factors did not identify any risk factors associated with treatment failure. Severe adverse events were observed in 2.3% of patients in the sequential group and 2.4% of those in the hybrid ***: Due to a grade A(> 95%) success rate for H. pylori eradication by PP analysis,similar compliance and adverse events,hybrid therapy seems to be an appropriate eradication regimen in Taiwan.

关键词： Helicobacter pylori Sequential therapy Hybrid ther

Prevalence of HFE mutations and relation to serum (?)ron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan

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World Journal of Gastroenterology 2005年第25期11卷 3905-3908页

作者： tsung-jung lin Chih-lin lin Chaur-Shine Wang Division of Gastroenterology

AIM: To assess the prevalence of the two mutations, C282Y and H63D of HFE gene, in healthy subjects, patients with chronic hepatitis C (CHC), and patients with nonalcoholic fatty liver disease (NAFLD) in Taiwan and to explore the contribution of the HFE mutation on serum iron stores in CHC and NAFLD ***: We examined C282Y and H63D mutations of HFE gene in 125 healthy subjects, 29 patients with CHC,and 33 patients with NAFLD. The serum iron markers,including ferritin, iron, and total iron binding capacity (TIBC),were assessed in all ***: All of the healthy subjects and patients were free from C282Y mutation. The prevalence of H63D heterozygosity was 4/125 (3.20%) in healthy subjects, 2/29(6.90%) in CHC group, and 1/33 (3.03%) in NAFLD *** healthy subjects showed no significant difference in the prevalence of H63D mutation as compared with the CHC or NAFLD group. Increased serum iron store was found in 34.48% of CHC patients and 36.36% of NAFLD *** three patients of H63D heterozygosity, only one CHC patient had increased serum iron store. There was no significant difference in the prevalence of HFE mutations between patients with increased serum iron store and those without in CHC or NAFLD ***: The HFE mutations may not contribute to iron accumulation in the CHC or NAFLD group even when serum iron overload is observed in more than one-third of these patients in Taiwan.

关键词：基因突变丙型肝炎非酒精性脂肪肝台湾省中国

AGV Scheduling Optimization of Automated Port Based on Disruption Management

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Journal of Transportation Technologies 2024年第3期14卷 423-444页

作者： Ching-Kuei Kao Qi-Er Ke King-Zoo Tang Peng-jung lin Key Laboratory of LNG Industry Chain Fujian University of Technology Fuzhou China Department of Logistics Management Fujian University of Technology Fuzhou China Department of Information Management Taiwan Chung Cheng University Chiayi Metaverse and New Media College Yango University Fuzhou China

The recent rapid development of China’s foreign trade has led to the significant increase in waterway transportation and automated container ports. Automated terminals can significantly improve the loading and unloading efficiency of container terminals. These terminals can also increase the port’s transportation volume while ensuring the quality of cargo loading and unloading, which has become an inevitable trend in the future development of ports. However, the continuous growth of the port’s transportation volume has increased the horizontal transportation pressure on the automated terminal, and the problems of route conflicts and road locks faced by automated guided vehicles (AGV) have become increasingly prominent. Accordingly, this work takes Xiamen Yuanhai automated container terminal as an example. This work focuses on analyzing the interference problem of path conflict in its horizontal transportation AGV scheduling. Results show that path conflict, the most prominent interference factor, will cause AGV scheduling to be unable to execute the original plan. Consequently, the disruption management was used to establish a disturbance recovery model, and the Dijkstra algorithm for combining with time windows is adopted to plan a conflict-free path. Based on the comparison with the rescheduling method, the research obtains that the deviation of the transportation path and the deviation degree of the transportation path under the disruption management method are much lower than those of the rescheduling method. The transportation path deviation degree of the disruption management method is only 5.56%. Meanwhile, the deviation degree of the transportation path under the rescheduling method is 44.44%.

关键词： Automated Port Disruption Management Automated Guided Vehicle Scheduling Dijkstra Algorithm

Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En Chen Yu-Yang Lu Ruei-Yu Su Hong-Hau Wang Chao-Yang Chen Je-Ming Hu jung-Cheng Kang Kuan-Hsun lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report